All articles tagged: Clinical Summary

Changes in colchicine pharmacokinetics due to drug-drug interactions did not result in meaningful changes in its safety and effectiveness, according to a secondary analysis of a clinical trial.

Older adults using cannabis received higher doses of inhalational anesthetics during surgery, but the effects may not be clinically significant, a new study found.

The more ultra-processed foods a person consumed, the higher their risk for the inflammatory autoimmune disease.

Low-dose oral metformin was associated with symptomatic improvement, hair regrowth, and gene expression modulation in a case series of patients with treatment-refractory central centrifugal cicatricial alopecia.

Bariatric surgery before pregnancy was associated with a higher risk for premature and small for gestational age infants.

Screening for Cushing syndrome in patients with obesity revealed a low prevalence, with nearly all the risk for the rare endocrine disorder in the metabolically unhealthy obesity phenotype.

The sequence of panretinal photocoagulation and anti-VEGF treatments influences outcomes in patients with proliferative diabetic retinopathy.

Both extreme heat and cold were tied to more severe episodes of Raynaud phenomenon in a study of participants with systemic sclerosis.

More than half of patients with IBD who failed to initially respond to the standard HBV vaccination schedule eventually benefited from enhanced revaccination strategies.

General practitioners found use of the Montreal Cognitive Assessment to be easy and fast, and the test had a high yield.

Post-radiation dental extractions posed an elevated risk for exposed bone and osteoradionecrosis in patients with head and neck cancer.

The risk for any skin cancer was higher among US veterans than among nonveterans, according to a cross-sectional study using nationally representative data collected over 20 years.

Electronic alerts for acute kidney injury were associated with a lower risk for disease progression, increased nephrologist consultations, and reduced NSAID exposure, found an updated meta-analysis.

A new study found a 29.1% incidence of hemodynamic collapse in patients after intubation during critical care transport. Shock index above 1 was a key risk factor.

Use of a cognitive behavioral therapy app called 'Maya' was associated with significantly reduced anxiety symptoms in young adults with anxiety disorders.

Immediate surgery is associated with a lower risk for death than nonsurgical treatment or delayed surgery in patients with frailty.

A new cohort study found no association between a history of migraine and increased risk for Parkinson's disease in women.

Mammogram results that are false positive may discourage women from returning for a future follow-up screening for breast cancer.

Researchers compared outcomes for patients randomized to receive androgen receptor pathway inhibitors, taxanes, or a physician's choice.

Children who transitioned from normal weight to overweight had a higher risk for atopic dermatitis, while those who lost weight appeared to reduce their risk for skin problems.

The presence of rheumatoid arthritis increased the risk for stroke in patients with atrial fibrillation, a retrospective study showed.

Patients with recurrent or metastatic head and neck squamous cell carcinoma can discontinue immune checkpoint inhibitors at 1 or 2 years without negatively impacting survival, a study suggests.

Nearly 80% of patients with uveal melanoma treated with tebentafusp experienced skin reactions in a small cohort study.

In the PULSE-MI trial, prehospital pulse-dose glucocorticoid treatment in STEMI patients did not reduce the final infarct size at 3 months, despite improvements in acute outcomes.

A study found that a range of factors, including younger age, lower income, advanced cancer stages, and higher social vulnerability, contributed to the financial strain.

Impaired central sensitivity to thyroid hormone may increase the risk for mortality in patients with stages 1-4 chronic kidney disease and normal thyroid function.

The risk of developing stage 3b chronic kidney disease was nearly doubled in patients with rheumatoid arthritis who had high disease activity.

Both electronic 3D virtual reality and 2D video devices were equally effective in reducing anxiety in children during the induction of anesthesia.

Increased thiazide doses were associated with a greater decrease in urine calcium and kidney stone events over a 4-year period in adults who had kidney stones.

Olanzapine improved complete response rates and quality of life in patients with solid tumors at moderate risk for chemotherapy-induced nausea and vomiting, new research shows.

This study "provides the largest longitudinal profile" of keratinocyte carcinomas in childhood cancer survivors to date, according to the authors.

The mother's COX1 genotype could influence whether prenatal fish oil supplementation affects the risk for atopic dermatitis in children, a study found.

An online nutrition education program for patients following sleeve gastrectomy attracted substantial interest, primarily among women, and received positive reviews, but more study is needed.

A dietary pattern centered around processed foods was associated with a known microbial signature of CRC and correlated with an elevated risk for its development.

Compared with other methods, urine Gram stain moderately predicted gram-negative bacteria but added little value to UTI diagnosis in the ED, raising questions about its clinical utility.

Systemic sclerosis sine scleroderma may account for almost 10% of cases and shares clinical features with limited cutaneous systemic sclerosis.

A study found a significantly higher risk for several psychiatric disorders in Black children with vitiligo.

Prehospital transcutaneous cardiac pacing led to an increased risk for mortality, with progression to cardiac arrest linked to increased body weight, a non-bradycardic initial heart rate, and hypoxia.

GISTs have increased significantly over the past two decades, with Black patients experiencing higher mortality rates from esophageal and gastric GISTs.

A secondary analysis of the EVEREST trial found that adjuvant everolimus did not provide a recurrence-free or overall survival benefit in patients with localized non–clear cell RCC.

Neither piroxicam nor paracetamol prevented pain recurrence or emergency department readmission within a week of treatment for renal colic, found a randomized controlled trial.

Naloxone administration during out-of-hospital cardiac arrest was found to improve rates of survival and return of spontaneous circulation, suggesting its potential role in cardiac arrest care.

Statin usage in patients with MASLD is associated with a lower long-term risk for all-cause mortality, liver-related events, and progression of liver stiffness.

A higher intake of lignans, found in seeds, whole grains, and coffee and tea, was associated with a decreased risk of developing type 2 diabetes.

A crowdsourced registry study found associations between features of cutaneous neurofibromas and quality of life in patients with neurofibromatosis type 1.

A global study predicted an increase in cancer cases and deaths among men, with significant disparities based on age and the economic status of countries.

A meta-analysis found that high-dose psilocybin for depressive symptoms showed better responses than placebo or escitalopram in antidepressant trials.

The muscles of sedentary men and women with overweight and obesity differ in burning sugar and fatty acids at the start of an exercise program but draw even after training, multi-omics data show.

Participants enrolled in a remote hypertension management program had fewer hospital readmissions and were more likely to take antihypertension medication.

Intermittent and continuous energy restriction are equally effective in reducing BMI in adolescents with obesity.

Exposure to high levels of particulate matter with diameter ≤ 10 μm was associated with an increased risk for giant cell arteritis but not ischemic complications, an observational study showed.

The risk for perioperative mortality in living kidney donors has significantly reduced in the past decade, a study showed.

Intermittently scanned continuous glucose monitoring improved glycaemic outcomes in those older and younger than 65 years, but the older group may need individualised targets.

A support program for children recently diagnosed with juvenile idiopathic arthritis improved their physical, emotional, and psychosocial well-being, a recent study showed.

Adolescent girls experienced shorter menstrual cycles in the 4 months after being vaccinated with the COVID-19 booster vaccine than teens who may have received a vaccine but more than 6 months prior.

Cleveland Clinic–led research identified geographic "hot spots" across the United States where increased colorectal cancer screening is needed to improve outcomes in Hispanic or Latina communities.

Medicare's expanded coverage for semaglutide meant that around one in seven Medicare beneficiaries with a high BMI would be newly eligible for semaglutide treatment.

A minimally invasive biomarker, the apolipoprotein E gene, may help clinicians identify corneal damage in patients with infectious conjunctivitis.

Patients who underwent total thyroidectomy had an increased risk for chronic kidney disease, particularly those who developed hypoparathyroidism.

Regular use of aspirin was associated with significantly greater reduction in risk for colorectal cancer among adults with less healthy lifestyles, a large observational study found.

A new study evaluating long-term survival in clinical practice found that most patients who achieved a complete response on first-line immune checkpoint inhibitors lived beyond 3 years.

Researchers measured loneliness using an 11-item abbreviated version of the UCLA Loneliness Scale in a cohort of patients from the 2008-2018 Health and Retirement Study.

In patients with axial spondyloarthritis, bimekizumab — a dual interleukin-17A/F inhibitor — showed a lower incidence rate of uveitis, suggesting protective effects against acute anterior uveitis.

Capsule endoscopy and double-balloon enteroscopy identified complications beyond the reach of conventional bidirectional endoscopy in patients with celiac disease who have persistent symptoms.

Despite a shift toward performing more initial lobectomies for thyroid cancer following the release of the 2015 ATA guidelines, the rate of late reoperations remained unchanged.

: In patients with acute pancreatitis, concomitant chronic liver disease more than doubles the odds of in-hospital mortality and leads to higher rates of complications.

Clinicians may want to consider initiating microbiologic confirmation of a recurrent urinary tract infection in before prescribing a prophylactic antibiotic.

Zasocitinib showed significant efficacy in treating moderate to severe psoriasis, with 67%-68% of patients on higher doses achieving a PASI 75 score at 12 weeks.

A new clinical report provides recommendations on oral health as an indicator of child abuse and neglect.

This nationwide cohort study based in Denmark may be the first to demonstrate that spouses of patients with cancer have a higher risk for suicide attempts and deaths.

Mindfulness-based interventions via telehealth improved chronic pain among veterans.

Hearing loss and peripheral neuropathy, both common in older adults, were independently and additively associated with premature mortality.

Women with polycystic ovary syndrome showed an increased risk for cardiometabolic diseases, with the risk varying according to phenotype.

COVID-19 vaccination was not associated with increased risk for multiple sclerosis relapse, except in those with high MS activity.

Adding etanercept in patients with early RA who responded insufficiently to initial methotrexate and bridging glucocorticoids did not result in better disease control than leflunomide at 104 weeks.

Smoking cessation reduced the risk for hidradenitis suppurativa, eventually aligning with the risk for never smokers.

Two randomized, double-blind, placebo-controlled phase 3 trials (OASIS 1 and 2) found that the drug was safe and effective over 26 weeks.

Individuals with small, peripheral, node-negative NSCLC and visceral pleural invasion had higher recurrence rates than those without pleural involvement, but similar overall survival rates.

Managing hypertension in older adults may reduce the risk for Alzheimer's disease, a meta-analysis suggested.

GLP-1 RAs were associated with a decreased risk for all-cause mortality and MACE in patients with immune-mediated inflammatory diseases and type 2 diabetes.

SGLT2 inhibitors did not reduce the risk for adverse liver outcomes more than DPP-4 inhibitors in patients with type 2 diabetes and metabolic dysfunction–associated steatotic liver disease.

Researchers compared the efficacy and safety of belzutifan vs everolimus in patients with advanced clear cell renal cell carcinoma.

Roughly 40% of cancer cases and 44% of cancer deaths in the United States in 2019 were attributable to potentially modifiable risk factors, a recent analysis found.

Research showed ethnic disparities in suicide rates among Asian American youths.

Suvorexant offered no significant decrease in delirium in hospitalized patients but was linked to lower incidence in those with mild dementia and certain delirium subtypes.

Low-dose glucocorticoid treatment after cataract surgery was associated with a reduced risk for glaucoma in children with longer axial length.

Sodium-glucose cotransporter 2 inhibitors were associated with lower incidences of type 2 diabetes, all-cause mortality, and heart failure-related adverse outcomes.

Home foreclosure is associated with an increased risk for memory decline in late middle age, new study results suggested, with chronic stress potentially playing a role.

A self-guided smartphone-based behavioral therapy could be a viable treatment for fibromyalgia, a recent study showed.

An analysis of patients with lung metastases from colorectal cancer showed that definitive surgery and ablative radiation offered similar 5-year overall survival benefits.

"These findings indicate that ovarian reserve in sickle cell disease was not reduced by hydroxyurea treatment, transfusion, or vaso-occlusive crisis."

Automated analysis of past CT scans predicted current and future risks for type 2 diabetes better than traditional measures, found a large retrospective study.

Genetic variants associated with Parkinson's disease are far more common than previously thought, occurring in 13% of those with the disease.

Neoadjuvant immunotherapy yielded similar survival and surgical outcomes to upfront surgery in high-risk HCC and could broaden surgical options for traditionally unresectable cases.

A large retrospective study of electronic medical records found better cardiovascular and renal outcomes in patients with type 2 diabetes treated with tirzepatide vs GLP-1 RAs.

Nonstatin cholesterol absorption inhibitors may be associated with a reduced risk for primary liver cancer, whereas bile acid sequestrants may increase that risk.

Non-statin cholesterol absorption inhibitors may be associated with a reduced risk for primary liver cancer, whereas bile acid sequestrants may increase that risk.

Patients with hand osteoarthritis showed a high prevalence of tendon damage and inflammation of the synovial membrane surrounding the tendons.

A new study found that uterus transplants may be a feasible option for women who have uterine-factor infertility and want to give birth.

Just 0.5% of patients receiving SBRT to treat oligometastatic cancer experienced severe adverse events within 6 months, a large real-world trial found.

A pilot study found that guideline–directed medical therapy at ED arrival was suboptimal, but its initiation among appropriate patients at discharge using an EHR-based alert may be feasible and safe.

In patients with acute agitation, 5 mg droperidol reduced the need for rescue sedation in the emergency department, found a study.

The Fracture Risk Assessment Tool had high specificity in predicting major osteoporotic fractures.

A Glasgow Coma Scale score of 3 indicated a low predictive value for diagnosing traumatic brain injury in the prehospital setting.

Although UTI screening has recovered to pre-pandemic levels, medical record coding lags behind.

A recent review suggests that incorporating patient-reported outcome measures into cancer care may improve survival and quality-of-life in the short-term but not hospitalizations.

Two classes of newer medications for glycemic control in type 2 diabetes differed in hyperkalemia risk and discontinuation of renin-angiotensin system inhibitors, a large cohort study found.

Droperidol at doses below the US Food and Drug Administration's safety limit effectively reduced abdominal pain, nausea, and vomiting in patients visiting the emergency department, found a study.

A new stool-based syndecan-2 methylation test may improve the detection of colorectal cancer and advanced colorectal neoplasia, based on a prospective, real-world study.

A meta-analysis found that misoprostol is highly effective in treating NSAID- or aspirin-induced small bowel injuries, whereas rebamipide offers modest protection against such injuries.

Umbilical cord pH levels < 7.2 are linked to increased risk for adverse neonatal outcomes, a new study from Denmark found.

The onset of diabetic neuropathy was not necessary for the deterioration of bones in adolescent girls with T1D.

Researchers studied RNA from tumors of premenopausal women with HR-positive breast cancer.

CPAP treatment was linked to a reduced risk for adverse hypertensive outcomes in pregnant women with obstructive sleep apnea.

Women's parity and genetic susceptibility to the disease modified the association between pill use and risk.

Nonanemic iron deficiency is associated with fatigue and impaired cognitive functioning; yet, up to 70% of cases go undiagnosed in high-risk populations.

British general practitioners are missing long COVID despite clear signs.

Women with endometriosis show a higher risk for all ovarian cancer histotypes compared with those without the condition.

Patients who underwent nipple-sparing mastectomy had higher rates of positive margins and node involvement but were less likely to receive radiation therapy.

Continuous treatment with baricitinib is needed to maintain hair regrowth in patients with severe alopecia areata.

A study identified distinct clinical features and other differences in Hispanic patients with dermatomyositis compared with non-Hispanic patients.

Intermittent fasting reduced body weight and BMI and improved glycemic outcomes in adults with prediabetes or T2D.

Several gastroenteritis-causing infectious agents, including pro-inflammatory bacteria and SARS-CoV-2, were associated with increased odds of developing IBS and functional dyspepsia.

A substantial proportion of patients with psoriasis, uveitis, or colitis and undiagnosed chronic back pain had axial spondyloarthritis, a study involving two multicenter cohorts showed.

Consuming more ultraprocessed food was linked to an increased risk for microvascular complications, especially diabetic kidney disease, in a cohort of patients with T2D.

In a large case-control study, FIT was associated with a 33% reduction in the risk for death from colorectal cancer, supporting its use in population-based screening efforts.

Largest study to date implicates both epilepsy and antiseizure medications for severe maternal and perinatal outcomes.

It produced greater weight loss and reversion to normoglycaemia compared with placebo.

An AI model significantly improved the accuracy of diagnosing solid lesions in the pancreas among both novice and experienced endoscopists in a randomized trial.

Patients with chronic pain receiving opioid analgesics more likely develop opioid dependence, opioid use disorder, and aberrant behaviour, a new study showed.

A higher dose of cisplatin given once every 3 weeks provided better locoregional control than a lower weekly dose in patients with locally advanced head and neck cancer.

A meta-analysis reported increased risk for nausea, pruritus, and urinary retention with intrathecal morphine.

One out of five patients with lupus had organ damage during the first year after diagnosis, with progressively fewer patients developing new damage during later years.

An obesity paradox does exist, but among patients with overweight or obesity, frontline immunotherapy was not associated with a survival benefit compared with chemotherapy, new data suggested.

People diagnosed with a cannabis-related disorder had more than triple the risk for head and neck cancers, a new study found.

A method combining genetics, symptoms, and patient characteristics is moderately successful.

An estimated 15.6 million adults in the United States consumed at least one potentially hepatotoxic botanical product in the past 30 days, with turmeric and green tea being the most common.

People diagnosed with a cannabis-related disorder had more than triple the risk for head and neck cancers, a new study found.

A new study analyzes ferritin cutoffs and their link to diagnosing iron deficiency in people with and without anemia.

Cholesterol deposits over the eyelids were not associated with an increased prevalence of lipid abnormalities or cardiovascular risk in a new study.

Researchers compared outcomes for more than 20,000 women diagnosed with one of three types of breast cancer.

Prenatal exposure to extreme food deprivation led to a more than twofold increased likelihood of developing type 2 diabetes in adulthood.

Buprenorphine combined with naloxone appeared to be a safer choice for pregnant women with opioid use disorder than buprenorphine alone.

Adding oral methotrexate to usual analgesia reduced pain as well as stiffness and functional impairment.

Healthcare providers must be "vigilant" in screening for eating disorders in women with polycystic ovary syndrome, especially to inform lifestyle counseling, say authors of a meta-analysis.

Patients with Crohn's disease who relapsed after achieving surgical remission showed significant microbial dysbiosis in their gut before developing endoscopic recurrence.

Even moderate alcohol consumption increases the odds of fibrosis in patients with MASLD and one or more cardiometabolic risk factors.

A resting heart rate ≥ 80 beats/min increased the risk for mortality and cardiovascular events in Japanese patients with non–dialysis-dependent chronic kidney disease, a study showed.

Novice users with an AI-enabled device arrived at a gestational age that was equivalent to one determined by credentialed sonographers.

Rheumatoid arthritis increased the risk for lung cancer, and this risk was threefold higher in patients with rheumatoid arthritis–associated interstitial lung disease.

The use of bDMARDs in patients with RA may have additional beneficial effects on arterial wall inflammation, independent of systemic inflammation.

Patients with a primary care visit after cancer surgery had a 90-day mortality rate of 0.3% compared with 3.3% for those without.

Over half of patients with symptoms of gastroparesis have low vitamin D levels, which is linked to heightened nausea, vomiting, and gastric neuromuscular dysfunction.

Healing rates were higher with most potassium-competitive acid blockers than with PPIs, particularly in patients with severe erosive esophagitis.

Both chronic and new-onset anxiety are linked to a threefold increased risk for dementia onset later in life, new research showed.

A study found that many breast cancer immunotherapy trials have yielded modest clinical impact, and 25% failed to report outcomes.

Researchers looked for links between providing care for mental health issues and reductions in chemotherapy-related toxicities.

The monoclonal antibody ofatumumab is more effective in achieving a disease-free state in RRMS than the immunomodulatory drug teriflunomide, results of a phase 3 trial suggested.

Romosozumab led to greater increases in bone mineral density at all analyzed bone sites with fewer cardiovascular events than teriparatide in postmenopausal women with osteoporosis.

Peripheral thyroid hormone balance, particularly higher T3 levels, was linked to greater liver fat reduction following a liver-friendly diet in a population with signs of unhealthy aging.

AI offered effective screening for three common eye diseases in children and adolescents using smartphone images taken at home.

After just 3 weeks of treatment, high-dose TBS was associated with significantly improved poststroke upper extremity motor function compared with sham TBS.

Dupilumab maintained its effectiveness in patients with atopic dermatitis for up to 5 years, with adverse events and ineffectiveness being the primary reasons for discontinuation, in a cohort study reflecting daily practice.

Administering anti–IL-6 therapy in later pregnancy may be safe for women who would benefit from it, showed a study that evaluated its safety in critically ill pregnant women with COVID-19.

Uninsured Hispanic patients with stroke are less likely to receive post-acute care, with only 29% discharged to a facility vs 37% of uninsured White patients, new research showed.

BRAF inhibitors raise the risk for uveitis in patients with skin melanoma or lung cancer compared with conventional cytotoxic drugs or immune checkpoint inhibitors.

Use of infliximab biosimilars in the United States rose slowly until three were on the market; it continued to remain low for Medicare than for Medicaid and private insurance beneficiaries in 2022.

Ustekinumab appeared to preserve beta-cell function in children and adolescents with newly diagnosed type 1 diabetes.

A new web-based risk model could help identify patients with resectable pancreatic ductal adenocarcinoma who are unlikely to benefit from surgery.

A study suggested with "moderate to low certainty" that cranberry juice may help prevent UTIs.

Researchers compared metastasis-directed therapy plus systemic therapy with systemic therapy alone in patients with pancreatic cancer.

Weight loss by bariatric surgery may improve hormonal imbalance in severe obesity, especially in women, found a 3-year study.

In this survey study, 39% of the patients with head and neck cancer experienced significant financial hardship owing to cancer treatment-related dental complications.

Many patients with acute pancreatitis experience recurrent episodes, which are associated with a threefold higher incidence rate of developing chronic pancreatitis than a single episode.

A case-control study with 847 participants is the first to identify the importance of hyperarousal.

Young and adult children of mothers with type 1 diabetes (T1D) had nearly half the risk for T1D compared with those with affected fathers, regardless of DNA risk factors.

Researchers identified specific gut microbiota that may be predictive of food addiction and protective against compulsive overeating.

Nemolizumab led to significant improvements in skin clearance and pruritus in adults and adolescents with moderate to severe atopic dermatitis in two phase 3 trials.

Ultrasound-guided upper back nerve block was more effective than ultrasound-guided stellate ganglion block for upper arm pain, showing immediate postprocedural analgesia.

Predictive value of non-specific abdominal symptoms and 19 blood tests in a cohort of nearly 478,000 UK primary care patients.

Researchers included 50 studies in the analysis.

Exposure to multiple air pollutants and genetic susceptibility to lupus increased the risk for systemic lupus erythematosus onset in European adults, a new study reported.

Lebrikizumab and dupilumab showed similar efficacy in patients with atopic dermatitis, with some small differences, in a meta-analysis.

A study found a higher melasma risk associated with several comorbidities, races, and ethnicities.

A study found a higher melasma risk associated with several comorbidities, races, and ethnicities.

A new study finds that hormone receptor positivity does not offer a strong positive prognostic advantage for young women with BRCA-associated breast cancer.

Researchers estimate oncologists' rates of providing cancer therapy in the last 30 days of life.

Initiation of medication for opioid use disorder after a hospital or emergency department visit was linked to lower odds of fatal and nonfatal opioid overdose at 6 months, showed a cohort study.

Older patients, women, and those with vascular comorbidities had an increased risk for stroke after an ED treat-and release visit for a fall, found a study.

Opioid use declined by 15% annually from 2014-2021, following similar trends in the general population.

Researchers collected data on firearm injuries and deaths from 2019 to 2020 in the United States to determine how many injuries occurred among various racial and ethnic groups.

A study found no significant differences in the risk for PsA among patients with psoriasis treated with interleukin (IL)-23 inhibitors and those treated with IL-12/23 inhibitors.

A high dose of upadacitinib resulted in a meaningful clinical response in a study of several patients with long-standing recalcitrant granulomatous cheilitis.

Exercise therapy may be more effective for early-stage knee osteoarthritis such that people with short symptom duration appear to benefit more than those with longer symptom duration.

Applying specific selection criteria for liver transplant to patients with unresectable colorectal liver metastasis leads to higher progression-free and overall survival, according to a new study.

Intravenous magnesium sulfate combined with diclofenac offered superior pain relief for renal colic but at levels below the accepted threshold for clinical importance in a randomized clinical trial.

Patients beginning first-line endocrine and CDK4/6 inhibition for advanced breast cancer experience minimal extra cognitive decline beyond what was already caused by previous treatments.

A meta-analysis found that sepsis alert systems were associated with improved patient outcomes and adherence to sepsis management protocols in emergency departments.

Engaging in lower levels of physical activity levels and spending more time in sedentary behavior increased the risk for all-cause mortality, a new study showed.

Patients with AA are at greater risk for psychiatric and autoimmune comorbidities at the time of diagnosis and during the first year after diagnosis, according to a retrospective cohort study.

Both very high and very low levels of high-density lipoprotein cholesterol were associated with an increased risk for diabetic kidney disease in women, but not men, with T2D.

Hormone-modulating therapy for breast cancer was associated with a reduced risk for dementia in some older women, according to a large retrospective study.

Patients with osteoarthritis or rheumatoid arthritis who had an overall poorer patient status reported a greater prevalence of anxiety, depression, and/or fibromyalgia.

Several socioeconomic and demographic factors, including older age and treatment location, affected the likelihood that patients with metastatic CRC received biomarker testing.