All articles tagged: Inflammatory disorders

The skin is the largest organ of the human body. Not only does it act as the first line of defense against external stressors such as environmental toxins, pathogens and pollutants, our skin can also reveal much about our internal health.

Researchers at Baylor College of Medicine, the University of Michigan and collaborating institutions have discovered that inflammation in the gut leaves long-term marks on intestinal stem cells (ISCs) that reduce their ability to heal the intestine, even after inflammation has receded. This is important because it affects ISCs' response to future challenges. The study appears in Cell Stem Cell.

The number of people in England with food allergies has more than doubled between 2008 and 2018, a new study reveals. The researchers, from Imperial College London, found that rates are highest among preschool children, with 4% having a "probable" food allergy.

Dietary intake of vitamin E may potentially lower the risk for atopic dermatitis, according to a study published online Aug. 9 in Skin Research & Technology.

Research from the lab of Jason Kim, Ph.D., professor of molecular medicine and medicine, identified a novel pathway in the progression of metabolic liver disease that could be targeted for potential therapies.

Higher consumption of alcoholic beverages is associated with a higher risk for gout among both sexes, according to a study published online Aug. 28 in JAMA Network Open.

A new registry study from Karolinska Institutet and Tampere University shows that hospital admissions due to allergic reactions in children have increased in Finland while they have decreased in Sweden. The study, published in the journal Allergy, also shows that the incidence of anaphylaxis is higher in Finland than in Sweden.

Adult patients with inflammatory bowel disease (IBD) and respiratory syncytial virus (RSV) infection have an increased risk for hospitalization, according to a study published online in the August issue of the American Journal of Gastroenterology.

As inflammation is the body's natural immune response to disease or infection, it increases blood flow in the body and helps the body's cells to defend themselves against viruses, infections or cell damage. Fast diagnostics of inflammation is crucial for effective treatments, so it is extremely important to test the levels of inflammatory biomarkers in the body. Researchers from the Institute of P

There is a critical unmet need to help tighten and maintain a healthy intestinal barrier and treat a leaky gut. Researchers have now found that a unique strain of probiotic bacteria, Bifidobacterium bifidum BB1, enhances intestinal barrier function and protects against penetration of bacteria and various harmful agents in the intestine.

Childhood obesity can contribute to the development of common immune-mediated skin diseases (IMSDs), such as alopecia areata, atopic dermatitis, and psoriasis, new research finds. Maintaining a healthy weight could potentially help lower the chances of developing these skin conditions.

New research from the University of Eastern Finland sheds light on the mechanisms associating obesity with inflammation by exploring tiny membrane particles, known as extracellular vesicles, secreted by human adipocytes.

A healthy gut helps lower your risk of developing inflammatory diseases such as inflammatory bowel disease (IBD), a chronic condition that causes inflammation in the digestive tract.

Removing a nuclear bile acid receptor that regulates glucose and lipid stability from the intestine blocks gut inflammation in mice, according to researchers at Children's Hospital Los Angeles. Their findings are published in the American Journal of Physiology-Gastrointestinal and Liver Physiology.

Season of birth, and specifically being born in autumn or winter, is associated with allergic rhinitis and asthma in Finland, a new study by the University of Eastern Finland, the University of Helsinki and Helsinki University Hospital shows. Conversely, being born in summer was associated with the lowest incidence of asthma and allergic rhinitis.

There are racial differences in the frequency of skin biopsy for psoriasis, indicating diagnostic uncertainty, according to a research letter published online Aug 7 in JAMA Dermatology.

Chronic venous insufficiency (CVI), which impacts more than 25 million people, includes varicose and spider veins. They occur when the veins become damaged and can't work as they should.

Early in the COVID-19 pandemic, some children fought off COVID with few, if any, symptoms, only to go into organ failure a few weeks later.

Millions of people worldwide suffer from liver inflammation (hepatitis), an acute or chronic disease with a variety of causes. Liver inflammation frequently occurs in connection with metabolic disorders, for example fatty liver disease. Lysomal acid lipase (LAL) deficiency is a rare metabolic disorder that also causes liver inflammation.

Interleukin-10 (IL-10) is an anti-inflammatory protein that crucially controls intestinal immunity. Children with genetic defects in IL-10, or its receptors, suffer from a severe form of inflammatory bowel disease (IBD) that typically presents within the first few months of life. Symptoms are acute and include bloody diarrhea and severe abdominal pain.

For patients with knee osteoarthritis (KOA), methotrexate added to usual medication is associated with a significant reduction in pain and improvement in stiffness and function at six months, according to a study published online July 30 in the Annals of Internal Medicine.

Earlier this year, Department of Genetics professor Joel Sax, along with Christopher McFarland, assistant professor at the Department of Genetics and Genome Sciences, and Bryan Carroll, associate professor for the Department of Dermatology, published an article titled "Limitations of the Commercially Available Gene Expression Test in Predicting Cutaneous Squamous Cell Carcinoma Metastasis and Clin

Hydroxychloroquine appears to be a safe and effective treatment option for anogenital lichen sclerosus that only has mild adverse effects, according to a study published online July 19 in the International Journal of Dermatology.

Long-term exposure to air pollution is associated with the development of new psoriasis, according to a study published online July 16 in JAMA Network Open.

Current asthma, head colds, and tonsillitis at age 7 years are associated with chronic rhinosinusitis (CRS) at midlife, according to a study published online July 10 in Allergy.

In a study in the Journal of Cosmetic Dermatology that included 60 individuals with mild to moderate acne, following the Mediterranean diet and taking omega-3 fatty acid supplements led to significant reductions in inflammatory and non-inflammatory skin lesions, as well as improved quality of life.

Psoriasis is associated with fatigue, especially among those with psoriatic arthritis (PsA), according to a study published in the July issue of the Journal of the American Academy of Dermatology.

Patients with severe asthma initiating biologics exhibit clinical responses and super-responses, but 40 to 50% do not meet response criteria, according to a study published online June 22 in Allergy.

A Mass General team has developed modified criteria that may help health care professionals more accurately identify anaphylaxis, a potentially life-threatening allergic reaction, in infants and young children.

New research led by UCLA Health confirms that both tai chi and cognitive behavioral therapy can reduce insomnia in breast cancer survivors but also may provide additional health benefits by reducing inflammation and bolstering anti-viral defenses.

Patients who have smoked with rheumatoid arthritis (RA) and an obstructive pattern may be a unique phenotype, according to a study published online June 17 in RMD Open.

A new study by investigators from Massachusetts General Hospital (MGH), a founding member of the Mass General Brigham, reveals that particular strains of gut bacteria are linked to inflammatory bowel disease (IBD), a condition that affects millions of people and is increasing in prevalence.

Fully automated diagnostic techniques, including liquid handling robots, are poised to improve the lives of millions of people living with inflammatory diseases worldwide.

Many parents have long known the link between lower air temperatures and asthma flare-ups in children who suffer from the disorder. But a lack of clear science behind the link has kept many feeling left out in the cold.

In a recent study published in the Journal of the American Geriatric Society, having high inflammation in midlife was associated with a clinically meaningful slower gait speed—an indicator of mobility—20 years later.

Researchers from Nagoya University Graduate School of Medicine in Japan have successfully treated the skin diseases epidermolytic ichthyosis (EI) and ichthyosis with confetti (IWC) by transplanting genetically healthy skin to inflamed areas. Transplanting healthy skin to inflamed areas has been used as a treatment option for severe burn injuries.

Cambridge scientists have grown 'mini-guts' in the lab to help understand Crohn's disease, showing that 'switches' that modify DNA in gut cells play an important role in the disease and how it presents in patients.

When scientists transplanted the gut microbes of aged mice into young "germ-free" mice—raised to have no gut microbes of their own—the recipient mice experienced an increase in inflammation that parallels inflammatory processes associated with aging in humans. Young germ-free mice transplanted with microbes from other young mice had no such increase.

Isotretinoin is well tolerated and effective for individuals receiving masculinizing gender-affirming hormonal therapy who have acne, according to a study published online May 29 in JAMA Dermatology.

Researchers at the Francis Crick Institute, working with UCL and Imperial College London, have discovered a new biological pathway that is a principal driver of inflammatory bowel disease (IBD) and related conditions, and which can be targeted using existing drugs.

Long-term intermittent use of ruxolitinib cream is well tolerated and provides disease control in adolescent patients with atopic dermatitis (AD), according to a study published online May 2 in the American Journal of Clinical Dermatology.

Antihypertensive drugs are associated with an increased risk for eczematous dermatitis in older adults, and the effect sizes are largest for diuretics and calcium channel blockers, according to a study published May 22 in JAMA Dermatology.

A mom or dad who vapes at home might be setting their child up for eczema, new research suggests.

A significant link between the use of electronic cigarettes and earlier age of asthma onset in U.S. adults was reported by UTHealth Houston researchers May 17, 2024 in JAMA Network Open.

The Journal of Medical Internet Research has published the results from the first phase of the validation study on the SkinNTDs mobile app, which aims to help control neglected tropical diseases and some common skin diseases, which particularly affect countries with low per capita incomes.

Miguel Divo, a lung specialist at Brigham and Women's Hospital in Boston, sits in an exam room across from Joel Rubinstein, who has asthma. Rubinstein, a retired psychiatrist, is about to get a checkup and hear a surprising pitch—for the planet, as well as his health.

Tobacco smoking is negatively associated with resolution of psoriasis symptoms, according to a study published in the April issue of Tobacco Induced Diseases.

A new study from Brigham and Women's Hospital suggests that positron emission tomography (PET) brain scans could reveal hidden inflammation in patients with multiple sclerosis (MS) who are being treated with highly-effective treatments. The findings were published in Clinical Nuclear Medicine.

In a scientific breakthrough, Mount Sinai researchers have revealed the biological mechanisms by which a family of proteins known as histone deacetylases (HDACs) activate immune system cells linked to inflammatory bowel disease (IBD) and other inflammatory diseases.

A team of researchers at the University of Missouri is uncovering how the juice from red cabbage, long used in traditional medicine, can alleviate inflammation-associated digestive health conditions such as inflammatory bowel disease (IBD) in mice, offering hope to the estimated 3 million Americans who suffer from IBD, including Crohn's disease and ulcerative colitis.

Here's a surprising statistic: Nearly 50% of people with asthma do not take their medications as prescribed. That means they risk a flare-up of symptoms or a visit to the emergency room. Asthma researchers have studied medication adherence in children and adults to improve patient education, but rarely the population that bridges those groups: young adults.

In a world-first, QIMR Berghofer scientists have discovered the mechanism that causes severe inflammation among millions of people with chronic liver disease.

Researchers at the University of Toronto and its partner hospitals have created a unique heart-on-a-chip model that is helping untangle the causes of COVID-19-induced heart inflammation and uncover strategies to reduce its impact.

Tryptophan is an essential amino acid, which means that it cannot be produced by the body but must be included as part of our diet. People with chronic bowel inflammation consume significantly more tryptophan than healthy people, as shown by previous research that involved members of the Cluster of Excellence "Precision Medicine in Chronic Inflammation" (PMI) at Kiel University.

An initial phase of multifood sublingual immunotherapy (SLIT) that bypasses oral immunotherapy (OIT) buildup is safe and effective, according to a study published online Feb. 27 in the Journal of Allergy and Clinical Immunology: In Practice.

A study by Anna Arnqvist's research group at Umeå University reveals molecular details about the gastric pathogen Helicobacter pylori's ability to bind to an inflamed stomach and how this is controlled by the stomach's pH. An increased understanding of how H. pylori bacteria can cause a persistent lifelong infection is an important piece of the puzzle in order to ultimately identify the characteri

Your skin becomes red and spots filled with pus appear, so you visit a dermatologist. When these symptoms spread to the skin throughout the body, it is difficult for the physician to distinguish whether it is generalized pustular psoriasis (GPP) or acute generalized exanthematous pustulosis (AGEP), as both have similar symptoms. The two diseases run different courses and require different treatmen

In 2023, 117 cases of multisystem inflammation syndrome in children (MIS-C) were reported, with 26 percent of patients having onset during August to October, according to research published in the March 14 issue of the U.S. Centers for Disease Control and Prevention Morbidity and Mortality Weekly Report.

The Wim Hof method may produce a beneficial anti-inflammatory response characterized by increased epinephrine levels and a reduction in pro-inflammatory cytokines, according to a systematic review published in the open-access journal PLOS ONE by Omar Almahayni and Lucy Hammond from the University of Warwick, UK.

Pediatric atopic dermatitis (AD) is associated with greater odds of reported difficulties in learning and memory, but this association is driven by children with neurodevelopmental comorbidities, according to a study published online March 6 in JAMA Dermatology.

From anxiety about the state of the world to ongoing waves of COVID-19, the stresses we face can seem relentless and even overwhelming. Worse, these stressors can cause chronic inflammation in our bodies. Chronic inflammation is linked to serious conditions such as cardiovascular disease and cancer—and may also affect our thinking and behavior.

Early-life day care attendance may be protective against allergen sensitization, according to a study presented at the annual meeting of the American Academy of Allergy, Asthma & Immunology, held from Feb. 23 to 26 in Washington, D.C.

Patients whose asthma is poorly controlled account for eight times excess greenhouse gas emissions compared with those whose condition is well controlled—equivalent to that produced by 124,000 homes each year in the U.K. This result has been published online in the journal Thorax.

A drug can make life safer for children with food allergies by preventing dangerous allergic responses to small quantities of allergy-triggering foods, according to a new study led by scientists at the Stanford School of Medicine.

An overly robust immune response to usually harmless germs has been linked to colitis, a potentially severe inflammation of the colon that afflicts millions of people worldwide. A new Yale-led study not only reveals that the presence of one class of fatty acids is the hidden villain that quietly triggers this inflammation, but also found that another group of fats—unsaturated fats such as those fo

Asthma is more common among U.S. individuals who report cannabis use in the most recent 30 days, with the odds of asthma being significantly even greater among individuals who reported cannabis use 20 to 30 days per month, according to a new study by researchers at Columbia University Mailman School of Public Health, City University of New York and Children's National Hospital at George Washington

Inflammation in the gut can trigger a doom loop of sorts. The condition messes with the sensitive relationships between food, digestive acids, microbes and the immune system in ways that can promote further inflammation and, sometimes, the eventual growth of tumors.

In an analysis of all relevant published studies that assessed atopic dermatitis (also known as eczema) associated with trends in climate-related hazards due to greenhouse gas emissions, investigators found that impacts include direct effects on eczema, like particulate matter-induced inflammation from wildfires; and indirect effects, such as stress resulting from drought-induced food insecurity.

Multisystem inflammatory syndrome in children (MIS-C) may be associated with an increased risk for future cardiovascular complications due to significant persistent vascular alterations, according to a research letter published online Jan. 16 in JAMA Pediatrics.

Lichen striatus (LS), a skin condition manifesting as linear eruptions following Blaschko's lines on the trunk or limbs of children, is often accompanied by hypopigmentation (loss of melanin or skin color). Interestingly, LS has a higher frequency of hypopigmentation compared to other skin inflammations, with up to 50% of cases that can persist for several months to even years. However, the cause

A new study, conducted by the University of Eastern Finland, the Finnish Institute for Health and Welfare, and the Finnish Institute of Occupational Health, shows that engaging in active commuting for a minimum of 45 minutes a day was associated with lower levels of C-reactive protein (CRP), a key marker of inflammation.

A new study finds that people with chronic inflammation living in poverty have more than double the risk of dying from heart disease and nearly triple the risk of dying from cancer within the next 15 years. The findings of the study, led by a University of Florida College of Public Health and Health Professions researcher, are based on data representing 95 million Americans ages 40 and over.

Some patients seen in an inflammatory bowel disease (IBD) clinic screen positive for malnutrition, according to a research letter published online Nov. 20 in Gastro Hep Advances.

Divertitulitis is a fairly common condition, especially as we get older. What to eat when plagued with this intestinal condition depends on where one is in the process. For reasons not yet completely understood, little pockets called diverticuli sometimes form in the lining of the digestive tract. The presence of these pouches is called diverticulosis.

A website that helps people with eczema to manage their symptoms could be saving the NHS hundreds of thousands of pounds, according to new research by the University of Southampton.

In a groundbreaking development in the field of anti-acne therapies, a team of researchers at University of California San Diego School of Medicine has created an acne vaccine that successfully reduces inflammation in a mouse acne model. The vaccine neutralizes a specific variant of an enzyme produced by an acne-associated bacteria, while leaving the healthy bacterial enzyme intact.

Transgender and gender-diverse individuals report experiencing acne-related stigma, according to a study published online Jan. 3 in JAMA Dermatology.

Ischemic cholecystitis is a form of gallbladder inflammation that occurs without gallstones or another form of external compression. It is caused by poor perfusion to the gallbladder tissue.

New research suggests that air pollution may contribute to the development or worsening of skin conditions.

Lower levels of vitamin D found in inflammatory bowel disease (IBD) patients are linked to inflammation, potentially playing a role in the disease's development, according to findings from a cross-sectional observational study published in the journal Medicine.

A study has shown that severe asthma can be controlled using biologic therapies, without the addition of regular high-dose inhaled steroids, which can have significant side effects.

Aging is associated with chronic, nonresolving inflammation, or "inflammaging," that can lead to tissue dysfunction. New findings reported in The American Journal of Pathology reveal insights into the cellular programs and factors that promote the resolution of inflammation during aging. These findings may lead to the development of new strategies to limit age-related organ decline.

For patients with newly diagnosed cirrhosis, markers of inflammation can predict 180-day mortality, but not liver-related admissions, according to a study published online Nov. 16 in Scientific Reports.

A recent University of Alberta study is shedding more light on how perinatal health and early life events are related to asthma control in children. "Perinatal and early life factors and asthma control among preschoolers: a population-based retrospective cohort study" was published in BMJ Open Respiratory Research.

A major systematic review of treatments for protecting the newborn brain from the negative effects of inflammation has found that earlier anti-inflammatory intervention is best, but it's better late than never.

Very few patients with psoriasis are depicted in scientific articles—only a fraction of those included in the research are represented in images. This is revealed by a study from the University of Gothenburg, Sweden, together with researchers from the University of Copenhagen, Denmark. The lack of images complicates communication with patients, according to the researchers.

High fiber diets, like those that include broccoli sprouts or other cruciferous vegetables, may reduce disease symptoms and improve quality of life in patients with inflammatory bowel disease (IBD), according to a study conducted in mice. The study was published in mSystems.

Researchers at the Francis Crick Institute and Aalborg University in Copenhagen have shown that changes can be detected in blood tests up to eight years before a diagnosis of Crohn's disease and up to three years before a diagnosis of ulcerative colitis.

The U.S. Food and Drug Administration has approved Amgen's Wezlana (ustekinumab-auub) as a biosimilar to and interchangeable with Stelara (ustekinumab) for multiple inflammatory diseases.

Imagine a skin cream that heals damage occurring throughout the day when your skin is exposed to sunlight or environmental toxins. That's the potential of a synthetic, biomimetic melanin developed by scientists at Northwestern University.

IBD is an umbrella term for chronic inflammatory bowel diseases, with a population prevalence of around 0.5%. The main types of IBD are ulcerative colitis and Crohn's disease. Unlike irritable bowel syndrome (IBS), IBD results in visible damage to the intestinal mucous membrane.

An international study involving Birmingham researchers identified for the first time how a protein found in the endothelium supports the transfer of specific immune cells, called macrophages, from the blood into the liver, causing inflammation—which can promote liver disease and liver cancer.

Inflammatory bowel diseases (IBDs), such as Crohn's disease or ulcerative colitis, arise when there is a dysregulation of the cell signaling pathways controlling the maintenance of homeostasis in the gut, leading to a chronic inflammatory response.

Itching can be uncomfortable, but it's a normal part of your skin's immune response to external threats. When you're itching from an encounter with poison ivy or mosquitoes, consider that your urge to scratch may have evolved to get you to swat away disease-carrying pests.

Almost half (42%) of patients with skin disease experience sleep disturbances, a major study presented today at the European Academy of Dermatology and Venereology (EADV) Congress 2023 has revealed.

Dr. Dawn Davis, a dermatologist at Mayo Clinic, says psoriasis is a multisystem inflammatory disorder primarily affecting the skin. She says psoriasis is inherited, and more people might have genes that make them more likely to develop the condition.

A three-year clinical trial has shown that the sublingual immunotherapy, or SLIT, is safe in peanut-allergic children ages 1 to 4, with a greater likelihood of desensitization and remission the earlier the treatment began.

Eggs, legumes including soya and peanuts, almonds and cashew nuts are now being introduced earlier in infant diets following revised advice in Sweden on the introduction of certain foods. However, there has been no change in the rate of food allergies or eczema in infants at the age of 18 months.

Some children who have a common form of eczema should also be tested for allergic reactions because they may have a second allergic-type eczema, a new study suggests.

The human gut—or gastrointestinal system—where food is broken down into nutrients for the body, is an ecosystem that harbors thousands of bacteria species. While some microorganisms are harmful, many are beneficial and help keep the human body in good health. Besides bacteria, the gut microbiota also consists of other types of microorganisms, including protists, yeasts, and viruses.

New research published in the journal Allergy has found that Basophil Activation Test (BAT) can be used to better detect allergies and predict the severity of allergic reactions than traditional predictions made via clinical criteria.

A study led by King's College London compared the safety and efficacy of ciclosporin with methotrexate in children and young people with severe atopic dermatitis, a debilitating skin condition. They also examined whether the severity of the disease changed or returned after treatment ended.

Akhil Padmanabha knows about itching. His chronic itching caused by severe eczema was so debilitating that he was hospitalized twice and had to be home-schooled during most of his high school years. Itch so impacted his life that, as an undergraduate, he contemplated becoming a psychologist so he could help chronically ill teens facing similar issues.

Eczema and psoriasis are skin conditions that can each affect a person's quality of life.

Children and adolescents who have had multisystem inflammatory syndrome in children (MIS-C) after exposure to COVID-19 are recommended to have follow-up heart function testing. A new study from Boston Children's Hospital suggests they should also be monitored for long-term neurologic and psychosocial complications.

Both children and adults with atopic dermatitis have an increased risk for inflammatory bowel disease (IBD), according to a study published online Aug. 30 in JAMA Dermatology.

Dr. Thimo Ruethers from James Cook University's Australian Institute of Tropical Health and Medicine (AITHM) and JCU's Tropical Futures Institute (TFI) in Singapore says that shellfish allergy affects up to 3% of the general population, is usually lifelong and commonly triggers anaphylaxis—a condition that leads to respiratory collapse and can be fatal. In Australia, shellfish allergy is the numbe

Fungi (molds and yeasts) in the indoor environment are not associated with an increased risk of asthma among children. This finding was made in a study conducted by the Finnish Institute for Health and Welfare (THL), which analyzed the microbiota of approximately 380 Finnish homes.

Several major childhood allergies may all stem from the community of bacteria living in our gut, according to a new study led by researchers at the University of British Columbia and BC Children's Hospital.