All articles tagged: Medical research

World Trade Center (WTC) exposure is associated with increased DNA methylation, which may contribute to breast cancer, according to a study published in the June issue of Environmental Epidemiology.

Even when air pollutant concentrations decrease, the health risks posed by these pollutants can remain consistently high. This is the conclusion of an international study conducted under the leadership of researchers from Helmholtz Munich.

The most frequently used mpox vaccine provides partial immunity to the disease but isn't always able to prevent severe symptoms or disease transmission. A new vaccine candidate from Moderna, mRNA-1769, more effectively limits symptoms and disease duration in primates that were infected with a lethal strain of the mpox virus when compared to a currently licensed modified vaccinia Ankara (MVA) vacci

Sleep, fasting, exercise, green porridge, black coffee, a healthy social life—there is an abundance of advice out there on how to live a good, long life. Researchers are working hard to determine why some people live longer than others, and how we get the most out of our increasingly long lives.

In a recent development in Alzheimer's disease research, Auburn University scientists have studied a new drug, troriluzole, that can prevent brain changes leading to memory loss and cognitive decline in a mouse model of the disease. This study, published in the Journal of Neurochemistry, is the first to show how troriluzole can target early-stage alterations associated with Alzheimer's, providing

A new approach to manufacturing cells that secrete and deliver therapies to specific parts of the body has taken a big step toward one day repairing joints and damage after heart attacks, countering transplant rejection and healing currently untreatable lung conditions.

Artificial intelligence (AI), in various forms, has burst onto the scene in both society and medicine. Its role in medicine is still evolving, but undoubtedly, it will assist in the evaluation of images (radiographs, pathological reports, videos of colonoscopy,) as well as in preparing discharge summaries, consultative evaluations and diagnosis. It may also help in the long-awaited goal of precisi

Prostate cancer is the second most common cancer among men worldwide, following lung cancer. In the United States alone, nearly 300,000 new cases are diagnosed annually. While reducing testosterone and other male hormones can be an effective treatment for prostate cancer, this approach becomes ineffective once the disease progresses to metastatic castration-resistant prostate cancer (mCRPC). At th

Fatigue is a common and often debilitating companion for people with inflammatory bowel conditions. Now, a new Danish study provides insight into why vitamin B1—also known as thiamine—helps some patients regain their energy, while others do not experience the same effect. The findings are published in the journal Gastro Hep Advances.

A research team from the School of Engineering of the Hong Kong University of Science and Technology (HKUST) has developed an innovative magnetic actuation platform that enables the one-step formation of sperm-like "micro-robots," demonstrating excellent motility and efficient performance in precise drug delivery.

Health care is a leading contributor to the world's carbon footprint. New analysis on the environmental impact of two common heart procedures shows it is possible to make changes within cardiac care, without compromising on quality of health care.

Melbourne researchers have made a world first breakthrough in creating blood stem cells that closely resemble those in the human body. And the discovery could soon lead to personalized treatments for children with leukemia and bone marrow failure disorders.

We all know the adage, "You can't teach an old dog new tricks." As we age, our ability to learn new skills, like mastering a foreign language or picking up a musical instrument, seems to fade. The culprit? A decline in brain plasticity—the brain's capacity to rewire itself and adapt to new challenges.

Researchers from Flinders University and University of South Australia have unveiled a promising new strategy that could be used to treat the most aggressive forms of prostate cancer. Their study, published in British Journal of Cancer, explores the role of a novel drug, CDKI-73, to tackle drug-resistant prostate cancer that defies conventional therapies.

A study by an international research collaborative reports a stunning blood modification method that not only protects red blood cells for perfusion-based transplant organ cryostorage, but could make blood types cross-compatible and eventually enable blood transfusions between species. The breakthrough is reported in the Proceedings of the National Academy of Sciences, and if the study's claims ar

To the known risk factors for cardiovascular disease—high blood pressure, high cholesterol, diabetes, overweight and obesity, smoking, and physical inactivity—a new one has to be added, clonal hematopoiesis. This condition is triggered by acquired mutations in blood stem cells and was already known to be associated with an elevated cardiovascular risk.

In light of the ongoing threat posed by new viruses following the emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which led to the COVID-19 pandemic, new antiviral drugs continue to be developed to effectively block viral entry into the human body.

S6K1 is a protein involved in the regulation of aging and age-related diseases. Blocking this protein in mice makes them live longer and mimics the health benefits of reducing calorie intake, such as reduced body fat, stronger bones and resistance to diabetes, though the underlying mechanisms were not previously understood.

Sexual reproduction is protected by a sophisticated network of regulatory systems functioning in a coordinated manner. Within this framework, some of the most important molecules are kisspeptins, proteins produced mostly in the hypothalamus and that play a crucial role in the regulation of the reproductive system. Recent research coordinated by the University of Cordoba and the IMIBIC has managed

University of Iowa researchers have defined how people recognize words. In a new study with people who use cochlear implants to hear, the researchers identified three main approaches that people with or without hearing impairment use to recognize words, an essential building block for understanding spoken language. Which approach depends on the person, regardless of hearing aptitude or ability: So

In a study providing important new insights into the development of the female reproductive tract and fertility, researchers have revealed how the thickness of fluid surrounding the egg can impact the cellular structure of the fallopian tube and how well the egg or embryo travels along it.

Research presented in Frontiers of Medicine delves into the regulatory role of the long non-coding RNA (lncRNA) ZNF593-AS in cardiac hypertrophy and myocardial remodeling, processes that are pivotal in the progression of heart failure and other cardiovascular diseases.

Pain is a necessary biological signal, but a variety of conditions can cause those signals to go awry. For people with chronic pain, the root is often faulty signals emerging deep within the brain, giving false alarms about a wound that has since healed, a limb that has since been amputated, or other intricate, hard-to-explain scenarios.

New insights into the biology of kidney cancer, including those informed by scientific discoveries that earned a Nobel Prize, have led to advances in treatment and increased survival rates, according to a review by UNC Lineberger Comprehensive Cancer Center's William Kim, MD, and Tracy Rose, MD, MPH.

People who are taller are at greater risk of developing cancer. The World Cancer Research Fund reports there is strong evidence taller people have a higher chance of developing cancer of the:

Even before the coronavirus pandemic, high rates of burnout and staffing shortages plagued the nursing industry, primarily because of the stressful demands of the job. The COVID-19 pandemic only amplified these challenges, and with nearly a third of all Missouri nurses nearing retirement, improving nurse retention is key to avoiding an impending nursing workforce crisis in our state.

So-called low-intensity blood stem cell transplants, which use milder conditioning agents than standard stem cell transplants, do not appear to damage the lungs and may help improve lung function in some patients with sickle cell disease (SCD), according to a three-year study of adults who underwent the procedure at the National Institutes of Health (NIH).

A recent study investigates the role of the deubiquitinase OTUB1 in vascular smooth muscle cells (VSMCs) within the context of atherosclerosis, a disease characterized by lipid accumulation and plaque formation in arteries. Atherosclerosis is a major cause of cardiovascular and cerebrovascular diseases, with VSMCs playing a significant role in its development. The research explores the potential o

Blinding diseases lead to permanent vision loss by damaging photoreceptor cells, which humans cannot naturally regenerate. While researchers are working on new methods to replace or regenerate these cells, the crucial question is whether these regenerated photoreceptors can fully restore vision.

Austocystin D, a natural compound produced by fungi, has been recognized for its cytotoxic effects and anticancer activity in various cell types. It exhibits potent activity even in cells that express proteins associated with multidrug resistance, attracting significant global research interest.

In looking for new ways to fight breast cancer, scientists from Duke-NUS Medical School have unmasked a surprising role of a protein generally associated with cancer growth. They have discovered that in estrogen receptor-positive (ER+) breast cancer, this protein acts as a tumor suppressor instead.

A new study from The Ohio State University College of Medicine shows that the way paramedics help people breathe before they get to the hospital is changing.

A research team from University of Tsukuba has developed an innovative method to quantify stress using Integrated Information Theory. This approach comprehensively evaluates biological signals and has demonstrated a strong correlation with subjective stress reports, especially in relation to feelings of boredom. This suggests that the method may serve as a comprehensive measure of stress, encompas

Researchers at Rutgers University in New Jersey have discovered that a protein produced by parasitic worms in the gut enhances wound healing in mice. The study, appearing in the journal Life Science Alliance, reveals that applying the protein to skin wounds speeds up wound closure, improves skin regeneration, and inhibits the formation of scar tissue. Whether the protein can be harnessed to enhanc

An estimated 462 million people around the world suffer from type 2 diabetes, a chronic disease in which the body has problems using sugar as a fuel, leading to a buildup of sugar in the blood and chronic health issues.

University of Queensland researchers have discovered a mechanism in DNA that regulates how disease-causing mutations are inherited. The research paper has been published in Cell Metabolism.

A study appearing in Journal of Bioethical Inquiry explored the legal and ethical challenges expected to arise in human brain organoid research.

In the first 24 hours after a python devours its massive prey, its heart grows 25%, its cardiac tissue softens dramatically, and the organ squeezes harder and harder to more than double its pulse. Meanwhile, a vast collection of specialized genes kicks into action to help boost the snake's metabolism fortyfold. Two weeks later, after its feast has been digested, all systems return to normal—its he

A research paper recently published in eLife identifies the function of a less-understood cell protein referred to as MEMO1. Dr. Oleg Dmitriev (Ph.D.), a professor in the department of Biochemistry, Microbiology and Immunology, and oncology professor Dr. Franco Vizeacoumar (Ph.D.) in USask's College of Medicine were two of the authors of the study.

Homicide is a major reason behind lower and more variable reduction in life expectancy for Black rather than white men in recent years, according to a new study published August 21, 2024 in the open-access journal PLOS ONE by Michael Light and Karl Vachuska of the University of Wisconsin-Madison, U.S..

A small team of psychologists and public health specialists from the University of Virginia, Virginia Commonwealth University, Old Dominion University and the University of Wisconsin-Madison has found via analysis of data from several studies that most implicit bias training efforts suffer from flawed methodology and translational gaps that compromise their integrity.

A research team from Université Laval has shown the benefits of camu-camu on non-alcoholic fatty liver disease, which affects over seven million people in Canada. This exotic fruit reduces liver fat levels.

A review published in the journal Molecular Biomedicine provides a comprehensive overview of the METTL family, a group of methyltransferase-like proteins crucial for cellular function. METTL family members are widely distributed across the cell nucleus, cytoplasm, and mitochondria. They play a vital role in regulating gene expression by transferring methyl groups to DNA, RNA, and proteins, thereby

Atherosclerosis, a major cause of mortality worldwide, involves an overgrowth of vascular smooth muscle cells in the blood vessels, constraining blood flow and potentially causing cardiovascular diseases.

Scientists are finding clues on how to treat diabetes and hormone disorders in an unexpected place: a toxin from one of the most venomous animals on the planet.

A study led by investigators at the UCLA Health Jonsson Comprehensive Cancer Center found that Manuka honey could potentially be an alternative, natural option for breast cancer prevention and treatment—particularly for estrogen receptor (ER)-positive breast cancer, the most common subtype of breast cancer that accounts for about 70–80% of all breast cancer cases.

Potatoes are often considered to be less healthy compared to other vegetables. In 2000, Dr. Fedon A. Lindberg created a stir in Norway when he announced that a large proportion of the population ought not to eat so many potatoes. Many of us can gain weight and develop type 2 diabetes, he believed.

Rutgers researchers have found a new way to manage the receptors that control the sense of touch, which could lead to treating chronic pain more effectively.

This southeast Minnesota city could soon be at the forefront of efforts to use genetically modified pig organs for human transplants.

Moffitt Cancer Center researchers have developed a novel reagent that enhances the precision of drug synthesis. This innovative method, published in Nature Communications, introduces a new sulfur fluoride exchange (SuFEx) reagent that allows for highly controlled production of crucial sulfur-based molecules, including sulfinamides, sulfonimidamides and sulfoximines.

Scientists at the Icahn School of Medicine at Mount Sinai have identified a new class of RNAs packed into tiny particles known as extracellular vesicles (EVs) that could revolutionize how cancer and other diseases are diagnosed. The team found that these molecules undergo changes when cancer is present, suggesting their potential as biomarkers for detecting prostate cancer or as targets for therap

A recent study, led by Professor Wu (Wenzhou Institute University, Wenzhou Medical University) and Professor Huang (Northeastern University), explores liquid–liquid phase separation (LLPS), a phenomenon closely associated with various diseases, including cancer and neurodegenerative disorders. The research is published in the journal MedComm.

The treatment of patients with severe COVID-19 following SARS-CoV-2 infection remains difficult. Severe inflammatory reactions and thrombotic complications (blood clots) in particular can be life-threatening. Classic anticoagulants such as heparin often cannot prevent these complications.

A new review was published as the cover paper of Aging, titled "Types of cell death and their relations to host immunological pathways."

Over the past few decades, scientists have generated a pile of evidence suggesting that a diet rich in saturated fats is enough to cause heart diseases. Besides other problems like diabetes and atherosclerosis, saturated fats have also been linked to life-threatening arrhythmias.

A large, multi-institutional team of medical researchers reports that giving anorexic mice the peptide ACBP stimulated eating. In their paper published in the journal Science Translational Medicine, the group describes their study of the binding protein and its role in stimulating hunger in mice.

Over half of people with iron deficiency were found to still have low iron levels three years after diagnosis, and among patients whose condition was effectively treated within that timeframe, they faced longer-than-expected delays, pointing to substantial gaps in appropriate recognition and efficient treatment of the condition, according to a study published in Blood Advances.

A new paper finds that bone fracture rates in older women differ by race, quite significantly. While researchers have known for years that the risk of bone fracture is highest for White women, this is the first study to show the real fracture rate for Asian and Hispanic women.

An analysis of 12 years of data collected from over 500 hospitals in 25 different states shows that weather, geographic location, and urban or rural location all appear to influence hospitalizations for waterborne infectious diseases, according to a study published August 7, 2024 in the journal PLOS Water, by Victoria Lynch and Jeffrey Shaman from Columbia University.

Researchers have developed an industry-standard tool to facilitate drug development and translational research in collaboration between labs at Karolinska Institutet and the Gygi Lab at Harvard Medical School. Their results are published in Advanced Science.

In a preliminary study with a small number of humans, rabbits and mice, researchers at Johns Hopkins Children's Center say they have developed four new regimens that have the potential to treat and save the lives of people with multidrug-resistant (MDR) tuberculous (TB) meningitis.

If it's ever felt like everything in your body is breaking down at once, that might not be your imagination. A new Stanford Medicine study shows that many of our molecules and microorganisms dramatically rise or fall in number during our 40s and 60s.

With aging, collagen and elastin in the skin decrease, leading to sagging, fine lines and deep wrinkles. These changes often arise from oxidative stress, inflammation, and changes in enzyme activities.

A research team led by Prof. Li Lei and Prof. Liu Chang from the Shenzhen Institute of Advanced Technology (SIAT) of the Chinese Academy of Sciences (CAS) has revealed the significant systemic health impact of microplastic (MP) exposure, using the terrestrial model organism Drosophila melanogaster (fruit fly). The study was published in Zoological Research.

Clinical trials for treatments to prevent recurring strokes typically only include participants who have little to no disability from a prior stroke. A new Yale study finds that leaving patients with such disability out of trials may limit what can be concluded from their results.

All mammals have mammary glands that produce milk, a feature that has fascinated scientists for many years. Questions such as why mammary glands evolved in the first place, how they have adapted across different species and what unique evolutionary pressures shaped their development remain largely unanswered.

Radiation is a powerful tool for treating cancer, but prolonged exposure can damage the skin. Radiation-induced skin injuries are painful and increase a person's chances of infection and long-term inflammation. Now, researchers in ACS Biomaterials Science & Engineering report an aspirin-containing hydrogel that mimics the nutrient-rich fluid between cells and accelerates healing of skin damaged by

In a new study, researchers with the Advanced Science Research Center at the CUNY Graduate Center (CUNY ASRC) have identified a distinct histone tag in adult oligodendrocyte progenitor cells (OPCs) that may pave the way for innovative therapies targeting myelin repair, a critical target for several neurodegenerative and psychiatric disorders, including multiple sclerosis, Alzheimer's disease, and

Our skin–the body's largest organ–provides the first line of defense against infections and many other threats to our health. Decades of research has shown that a wide range of diseases can occur, or become worse, when the skin cannot form an effective barrier.

A research group at the University of Bologna has identified, for the first time, the specific location and genomic context where DNA breaks occur due to the inhibition of the topoisomerase I, a protein crucial for many biological processes in cells. The results, published in the journal Science Advances, could lead to significant advances in the development of new cancer treatments.

Substance use disorder is a major concern with few therapeutic options. In 2019, close to 20.4 million people were diagnosed with substance use disorder, and nearly 71,000 people died of an overdose, with cocaine and methamphetamine (meth) responsible for approximately 15,000 deaths that year.

A multi-institutional team of biochemical engineers has developed an exosome-based delivery system that can carry beneficial proteins into cells to allow new kinds of medical treatments. Their paper is published in the journal Science Translational Medicine.

Science Translational Medicine has published a study by researchers from the Institute of Biology Leiden (IBL) on a potent new antibiotic that can overcome resistance. "The idea was to tweak the original antibiotic and create a next-generation drug," says Nathaniel Martin, professor of Biological Chemistry. He is already considering ways to bring the new antibiotic to market.

The amino acid taurine, a common ingredient in energy drinks, is one of the most abundant amino acids in humans, where it plays key roles in our muscles, our brains, and in the mitochondria that power all our cells. Research suggests that taurine may play a beneficial role in human health, but the mechanisms have long been murky.

Data from a new investigational drug that could alter the standard treatment for a rare blood disease suggests it has the potential to delay or prevent anemia and the need for intrauterine blood transfusions in babies who are at high risk for the condition, known as Hemolytic Disease of the Fetus and Newborn (HDFN). Results of the Phase 2 clinical trial of the drug nipocalimab were published today

Columbia University's Division of Ethics Chief Sandra Soo-Jin Lee, Ph.D., is lead author of a new target article in The American Journal of Bioethics, titled "Racial Equity, Diversity and Inclusion in Bioethics: Recommendations from the Association of Bioethics Program Directors Presidential Task Force." This pivotal work responds to urgent calls for addressing racism within bioethics, highlightin

Researchers at the Center for Genomic Regulation (CRG) have discovered a treatment which accelerates the production and quality of pluripotent stem cells in mice. The discovery has the potential to improve disease modeling and drug testing for individuals with two X chromosomes; women, transgender men or men with an extra X chromosome in Klinefelter Syndrome.

Increasing ventilation in child-care settings may not always be effective at preventing flu virus spread, according to a new study published by a team of researchers at Emory University, University of Pittsburgh School of Medicine, and Virginia Tech.

Everyone wants to live to a ripe old age, but no one wants to be decrepit. Now, University of Connecticut researchers have demonstrated a treatment that could lengthen life—and vigor—up to the very end.

Researchers have identified variants in a gene that influences the likelihood of smokers developing abnormal dreams while taking a medication to help them quit.

The Australian National Health and Medical Research Council (NHMRC) has just released its much-anticipated landmark statement advocating for sex, gender, variations of sex characteristics and sexual orientation to be routinely considered in health and medical research.

Alzheimer's disease, a debilitating brain disorder with limited treatment options, has long challenged researchers. Specifically, researchers have struggled with slowing the buildup of amyloid beta plaques, harmful clumps of proteins that exacerbate the disease by damaging brain cells and causing memory loss.

Scientists at Sanford Burnham Prebys and Salk Institute for Biological Studies have uncovered a new role for a protein known for its role in the brain helping control feelings of hunger or satiety, as well as in the liver to aid the body in maintaining a balance of energy during fasting. The new study shows that this protein also supports the maintenance of heart structure and function, but when i

Emory researcher David Weiss has spent years studying a baffling phenomenon called heteroresistance, in which a tiny fraction of bacteria remain resistant to antibiotics, while the remainder succumb. Recently, he brought his scientific acumen to the equally deadly threat of fungal bloodstream infections in patients receiving bone marrow transplants. Bloodstream infections can be lethal in these pa

Injuries, infection and inflammatory diseases that damage the spinal cord can lead to intractable pain and disability. Some degree of recovery may be possible. The question is, how best to stimulate the regrowth and healing of damaged nerves.

A research group led by Associate Professor Katsuya Sakai, Researcher Nichole Marcela Rojas-Chaverra, and Professor Kunio Matsumoto of the Cancer Research Institute and Nano-Life Science (WPI-NanoLSI) at Kanazawa University has developed a long-acting, subcutaneously injectable artificial hepatocyte growth factor (HGF) mimetic molecule using a fusion technology of cyclic peptides and protein engin

Researchers constantly seek innovative approaches to tackle cancer. One concept gaining traction is antifragility, a property where systems not only withstand stress but improve because of it. In cancer research, this concept is particularly relevant for tumors that adapt and evolve in response to treatment. Understanding antifragility could lead to more effective therapies.

A clinical trial at Oregon Health & Science University suggests that a subset of older adults with a genetic predisposition to Alzheimer's disease may benefit from fish oil supplements.

A study published in Nature reveals the functional relevance of tumor-neuron interactions that regulate the growth of ependymoma brain tumors. The study, conducted by researchers at Baylor College of Medicine and St. Jude Children's Research Hospital, highlights how neuronal signaling, modifications in DNA-associated proteins and developmental programs are intertwined to drive malignancy in brain

The general anesthetic propofol may hold the keys to developing new treatment strategies for epilepsy and other neurological disorders, according to a study led by researchers at Weill Cornell Medicine and Sweden's Linköping University.

The connections between the nervous system and muscles develop differently across the kingdom of life. It takes newborn humans roughly a year to develop the proper muscular systems that support the ability to walk, while cows can walk mere minutes after birth and run not long after.

Healthy blood vessels matter for more than just heart health. Vascular well-being is critical for brain health and potentially in addressing age-related cognitive decline and neurodegenerative disorders, like Alzheimer's disease, according to a new study led by Penn State researchers. The findings point to an understudied but possible key role the brain's vascular network—or energy infrastructure—

An AI model developed by scientists at King's College London, in close collaboration with University College London, has produced three-dimensional, synthetic images of the human brain that are realistic and accurate enough to use in medical research.

Underrepresentation of racial and ethnic minority populations in cancer clinical trials persists partly because translation and interpretation services and resources are unavailable or inadequate in the United States, according to a Children's Oncology Group (COG) study led by Columbia University School of Nursing. The updated study was published online in JNCI Cancer Spectrum on July 25, 2024 and

Eating a vegan diet for eight weeks is associated with reductions in biological age estimations based on levels of DNA methylation—a type of chemical modification of DNA (known as an epigenetic modification) that alters gene expression but not DNA itself.

A study from China has reported that Cordyceps sinensis (CS), a traditional Chinese medicinal fungus, can ameliorate idiopathic pulmonary fibrosis (IPF) in mice by inhibiting mitochondrion-mediated oxidative stress.

A combination of two drugs was capable of suppressing tumors in a non-conventional manner. Instead of inhibiting tumor cell division, as the most widely used medications do, the strategy consisted of hyperactivating oncogenic signaling by these cells to the point where they became stressed. The other drug then attacked the stressed cells. The approach will be tested in colorectal cancer patients i

Doctors and others who take care of hospitalized patients may want to sit down for this piece of news. A new study suggests that getting at a patient's eye level when talking with them about their diagnosis or care can really make a difference. Sitting or crouching at a hospitalized patient's bedside was associated with more trust, satisfaction and even better clinical outcomes than standing, acco

Scientists in America have developed a nasal spray that can remove proteins in the brain associated with Alzheimer's disease—at least, in mice.

In a rigorous medical records study covering tens of thousands of patients, Johns Hopkins Medicine researchers conclude that some patients with preoperative anemia have better outcomes if they get iron infusions before surgery rather than standard red blood cell transfusions.

mRNA vaccines contain instruction codes for making parts of pathogenic viruses. Can so-called self-amplifying types of such vaccines form unwanted and dangerous connections with other viruses? Yes, say Wageningen virologists Tessy Hick and Gorben Pijlman after experimental research. But the practical dangers are negligible.

There are many important reasons for keeping cuts and sores clean, but new research from the Perelman School of Medicine at the University of Pennsylvania shows that a certain bacterium, Alcaligenes faecalis (A. faecalis), can facilitate healing of hard-to-treat wounds among people with diabetes. While there are many studies done on potentially harmful bacteria in wounds, the researchers discovere

A study on live tissue cells is the first to reveal how channels that allow sodium to enter into breast cancer cells enable tumors to grow and spread.

Researchers from the University of Otago, Christchurch, have spearheaded the discovery of a protein function which has the potential to guide the development of novel cancer treatment options and improve the diagnosis of various cancers.

Probably everyone has heard the conventional wisdom that a glass of wine a day is good for you—or you've heard some variation of it. The problem is that it's based on flawed scientific research, according to a new report in the Journal of Studies on Alcohol and Drugs.

Ultrafine particles, UFPs, the smallest contributors to air pollution, hinder the function of mitochondria in human olfactory mucosa cells, a new study shows. Led by the University of Eastern Finland, the research showed that traffic-related UFPs impair mitochondrial functions in primary human olfactory mucosa cells by hampering oxidative phosphorylation and redox balance.

University of Calgary librarian Kathryn Ruddock had read about the lack of diversity in anatomy illustrations. As a visible minority librarian with a medical sciences background, the revelation struck a chord.

Receptor protein tyrosine phosphatases are cell membrane-localized proteins. They are regulators of cell-cell contacts and are also considered likely to be tumor suppressors, but the specifics of how they function are unknown. A member of this family, PTPRK, is implicated as a tumor suppressor in several cancer types, particularly colorectal cancer, and mutations and genetic events inactivating PT

Mice don't get Alzheimer's—and while that's good news for mice, it's a big problem for biomedical researchers seeking to understand the disease and test new treatments. Now, researchers at The Jackson Laboratory are working to create the first strain of mice that's genetically susceptible to late-onset Alzheimer's, with potentially transformative implications for dementia research.

Acute myeloid leukemia (AML) is the most common blood and bone marrow cancer in adults. Caused by an increase in immature cells that rapidly destroy and replace healthy blood cells (red and white blood cells and platelets), AML is lethal in half of those affected under the age of 60, and in 85% of those over that age.

The American College of Chest Physicians (CHEST) recently released a new clinical guideline on central airway obstruction (CAO). Published in the journal CHEST, the guideline contains 12 evidence-based recommendations to guide the management of both malignant and nonmalignant CAO.

Deaths from injection-related infections like endocarditis have increased among young people, likely due to the growth of injection drug use and stronger, shorter-acting fentanyl. While medications for opioid use disorder reduce the risk of death, initiating and retaining patients on these life-saving treatments is difficult.

A public health approach is necessary to address the legal, medical, and social complexities of cannabis use, says the American College of Physicians (ACP) in a new policy paper released today.

Data from the Anti-Amyloid Treatment in Asymptomatic Alzheimer's (A4) study, the first and largest clinical trial of pre-symptomatic Alzheimer's disease, is now widely available to researchers studying the condition. The comprehensive dataset has already yielded key insights about Alzheimer's disease, which affects nearly seven million people in the United States, and sharing the data opens avenue

Monoclonal antibodies (mAbs) have revolutionized cancer therapy due to their ability to specifically target tumor cells while sparing healthy ones. These biologics have become indispensable in treating various cancers, offering improved specificity and fewer side effects compared to traditional chemotherapy.

A research group led by Dr. Keisuke Obara, Dr. Kento Yoshioka, and Professor Yoshio Tanaka of the Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toho University, has found that docosahexaenoic acid (DHA), which is abundant in fish oil, suppresses gastric fundus smooth muscle contractions induced by physiologically active substances such as bradykinin.

A position paper published by the International Osteoporosis Foundation (IOF) Working Group on Epidemiology and Quality of Life addresses the ongoing debate about the necessity and impact of incorporating race and ethnicity adjustments in clinical algorithms. It responds specifically to the recent American Society of Bone and Mineral Research (ASBMR) Task Force report on Clinical Algorithms for Fr

Antibiotics are essential tools in modern medicine, regularly used to treat bacterial infections and prevent infections during surgery. However, the widespread use of antibiotics has led to many bacteria developing resistance, posing a significant threat to public health.

Neuromuscular training reduces the onset of chemotherapy-induced peripheral neuropathy (CIPN), according to a study published online July 1 in JAMA Internal Medicine.

A new compound developed by researchers at MUSC Hollings Cancer Center shows promise in overcoming chemotherapy resistance in triple-negative breast cancer—and could potentially be applied to fibrotic conditions like liver fibrosis or pulmonary fibrosis.

Large language models may pass medical exams with flying colors but using them for diagnoses would currently be grossly negligent. Medical chatbots make hasty diagnoses, do not adhere to guidelines, and would put patients' lives at risk.

Some people who develop a weird and terrifying allergy to red meat after a bite from a lone star tick can still eat pork from a surprising source: Genetically modified pigs created for organ transplant research.

A paper published in MedComm presented a Chinese EncephalApp diagnosis model (Stroop-CN) based on healthy controls distributed throughout the country and covering different demographic information.

The human body hosts a diverse array of microorganisms that maintain a delicate balance crucial for overall health. This microbial harmony can be disrupted by factors such as infections, aging, and hormonal changes, leading to dysbiosis—a condition where microbial communities become imbalanced and harmful to health.

Outdated and inflexible medical information systems are harmful to transgender and gender diverse (TGD) people, according to a literature review published in the Journal of Medical Radiation Sciences (JMRS). It found patient record options available to medical practices and hospitals frequently merge sex and gender as a single, binary concept.

Cancer cells salvage purine nucleotides to fuel tumor growth, including purines in foods we eat, an important discovery with implications for cancer therapies from research by Children's Medical Center Research Institute at UT Southwestern published in Cell.

Temperature extremes, becoming increasingly frequent due to growing global climate change, are associated with higher rates of missed primary care appointments, according to a recently published study by Drexel University researchers in the American Journal of Preventive Medicine.

Researchers from Drexel's College of Medicine have identified new drugs that show early success in shrinking breast cancer tumors that have metastasized in the brain. The discovery marks the first time that targeting a key metabolic enzyme in cancer cells in the brain has shrunk tumors in a mouse model. The findings, which could develop into more effective therapies for breast cancer brain metasta

Thin lips are not only a common cosmetic concern in patients with scleroderma, a condition that involves tightening and hardening of the skin among other effects on internal organs, but also can impact a person's ability to chew, swallow, and sleep.

A federal regulation called the Common Rule previously requested the public posting of participant consent forms to trials listed in the national clinical study database clinicaltrials.gov, among other human research protections, since 1991. However, the forms were often not posted in a timely manner or at all.

An international consortium of experts led by Translational Research Professor Oliver A. Cornely of the University of Cologne has created a white paper on innovative approaches for clinical vaccine research in order to be better prepared for future pandemics. The contributing scientists see the future of vaccine research in the field of adaptive platform trials (APTs), a new type of clinical trial

Scientists at the Medical Research Council Laboratory of Medical Science and Imperial College London have discovered that 'switching off' a protein called IL-11 can significantly increase the healthy lifespan of mice by almost 25%.

The number of retractions issued for scientific research articles in 2023 exceeded 10,000—smashing annual records. To date, publishers have struggled to clean up a slew of papers with serious integrity concerns.

Metabolic dysfunction-associated steatohepatitis (MASH) is one of the most common chronic liver diseases, primarily caused by metabolic disorders and systemic inflammatory responses. Although the incidence of MASH is gradually increasing, there is a lack of effective drugs and methods for its treatment, thus limiting therapeutic options for MASH.

A new research paper titled "Roles of pigment epithelium-derived factor in exercise-induced suppression of senescence and its impact on lung pathology in mice" has been published in Aging.

A treatment for metastatic cancer—researchers at Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), the University of Innsbruck, the Massachusetts Institute of Technology (MIT) and Universität Würzburg have now come a major step closer to this ambitious goal. Their approach for attacking the migrating cancer cells is to use ferroptosis—a cell death mechanism only discovered in 2012.

Preeclampsia (PE) is a significant contributor to the increase in maternal morbidity and mortality worldwide, with particularly alarming numbers in the United States, where it affects about 2–8% of pregnancies, resulting in premature birth with associated morbidities for their infants as well. A new study by researchers at UCLA Health finds that early detection of specific microRNAs (miRNAs) packa

Research assessed the effects of the nonverbal behavior of health care providers on pain reports and placebo effects in 51 males and 53 females randomly divided into four groups. The results revealed no differences between the groups in the reduced pain and showed that healthy males and females may differ in underlying mechanisms of placebo effects.

Liquid-liquid phase separation is not a precursor to formation of amyloid fibrils, a pathological hallmark of Parkinson's disease, shows a recent study. Rather, the formation of protein into liquid droplets may help to dissolve aggregated protein. The study, published in the journal Advanced Science, deepens our understanding of neurodegenerative diseases linked to protein aggregation and could he

Funding agencies in Canada need to review their policies for evaluating research proposals to ensure that South Asian research is conducted by South Asians, write authors in a commentary, titled "A call to stop extractive health research on South Asian diaspora communities in Canada," in the Canadian Medical Association Journal.

A group of scientists at UCL have successfully created mechanical force sensors directly in the developing brains and spinal cords of chicken embryos, which they hope will improve understanding and prevention of birth malformations such as spina bifida.

Researchers from University of California San Diego have found that two of the most frequently administered stem cell therapies, which are often used interchangeably, actually contain completely different types of cells. The results challenge the current "one-cell-cures-all" paradigm in orthopedic stem cell therapeutics and highlight the need for more informed and rigorous characterization of inje

In biomedical research involving human subjects, research ethics committees around the world have traditionally emphasized individual rights and protections for participants, including informed consent. The emerging field of translational bioethics maintains that the social, economic and psychological implications of pioneering health research—such as gene therapy, xenotransplants and artificial i

In the military trauma setting, prehospital transfusion (PHT) is a firmly evidenced means to reduce preventable death. It stands to reason that the same would be true in the civilian emergency medical service (EMS) setting, but investigators from Beth Israel Deaconess Medical Center (BIDMC) found it would not be wise to jump to that conclusion.

A multicenter safety study at UC Davis Health tested a protein drug (INBRX-101), developed to improve care for people with alpha-1 antitrypsin deficiency (AATD), and showed the therapy is quite safe.

Chronic pain affects approximately 20% of the United States population and 30% of the global population. Along with sensory manifestations, chronic pain conditions also are associated with high rates of comorbid depression and substance abuse. Unfortunately, the complex and variable clinical presentations of chronic pain and affective comorbidities, as well as the multifaceted regional and molecul

Today, the American Journal of Human Genetics published a perspective piece on the need for an equitable and inclusive future for DNA and ancient DNA (aDNA) research in Africa. The paper, coauthored by an international team of 36 scientists from Africa, North America, Asia, Australia, and Europe, was led by Dr. Elizabeth (Ebeth) Sawchuk of the Cleveland Museum of Natural History and Dr. Kendra Sir

Switching from a diet high in saturated animal fats to one rich in plant-based unsaturated fats affects the fat composition in the blood, which in turn influences long-term disease risk. A recent study published in Nature Medicine, conducted by a team of researchers from Chalmers University of Technology, Sweden, the German Institute of Human Nutrition, Germany and several other universities, show

In preclinical studies, a team of researchers from Mount Sinai Health System in New York City and City of Hope in Los Angeles report new findings on a therapeutic combination that regenerated human insulin-producing beta cells, providing a possible new treatment for diabetes. The findings were published in Science Translational Medicine.

Sweating is a vital process in a normally functioning body. Generally, sweating occurs to regulate body temperature or as a response to stimuli such as stress. Most sweat glands are of the eccrine type. These eccrine sweat glands are distributed all over the body, but their density is greatest in the armpit and on the palms of the hands and the soles of the feet.

In order to find previously unknown substances for the treatment of chlamydial infections, the scientific team led by Georg Stary (Department of Dermatology at MedUni Vienna, CeMM of the Austrian Academy of Sciences) screened a comprehensive compilation of 2,200 active substances. While 28 of these significantly reduced the growth of chlamydia, one of the substances was even able to prevent infect

A newly developed molecule, LK-2, could inform new therapies for stroke-related brain injury, find scientists at The Hospital for Sick Children (SickKids).

Researchers from the Department of Biochemistry and NUS Centre for Cancer Research (N2CR), at the Yong Loo Lin School of Medicine, National University of Singapore (NUS Medicine), have been pioneering a treatment using stem cell precision engineering technology, to deliver drugs directly to tumor sites in dogs and cats with late-stage cancer and no treatment options available.

For patients with degenerative lumbar spinal stenosis (DLSS) and predominantly neurogenic claudication pain symptoms, acupuncture may relieve pain-specific disability, according to a study published online July 2 in the Annals of Internal Medicine.

In a new study, Yale researchers identify the targets in the human body to which pathogens transmitted by mosquitoes, ticks, and other vectors bind. Their findings, they say, could help address the rising threat of vector-borne diseases, a leading cause of death worldwide.

A molecule called nidogen-2 may be a key driver of pancreatic cancer progression and metastasis, offering a promising new treatment approach for this aggressive cancer, according to a Garvan Institute study.

Pulmonary hypertension is a very serious disease that leads to heart failure and death in many patients. Searching for new treatment options, a team headed by Professor Daniela Wenzel and Dr. Alexander Seidinger from the Department of Systems Physiology at Ruhr University Bochum, Germany, tested the plant substance FR900359—referred to as FR by the researchers.

A new study recently published in The EMBO Journal by researchers from the Department of Medical Biochemistry and Biophysics at Karolinska Institutet (Sweden) in collaboration with several other research groups has brought the enzyme TRP14 (also called TXNDC17) into the spotlight, discovering its fundamental role in reduction of cystine to form cysteine, which is an essential process for various l

Stem cells are like the emergency tool kit of the human body. They have the unique ability to form into other types of specialized cells—from immune cells to brain cells. They can divide and regenerate indefinitely to repair and replenish our system on command.

Neurological disorders, such as trauma, stroke, epilepsy, and various neurodegenerative diseases, often lead to the permanent loss of neurons, causing significant impairments in brain function. Current treatment options are limited, primarily due to the challenge of replacing lost neurons.

Stem cell-based embryo models (SCBEMs) are three-dimensional biological structures that mimic aspects of early human embryo development. They can be created in the lab from stem cells, and can provide new insights into critical stages of early human development that are normally inaccessible to researchers.

A novel approach for early cancer treatment known as radioligand therapy (RLT) has been shown to significantly reduce the risk of advanced neuroendocrine tumor progression and death, according to research led by scientists at Sunnybrook Health Sciences Centre and the University of Toronto.

University of Houston, associate professor of electrical and computer engineering Bhavin R. Sheth and former student Adam Jones, have introduced a groundbreaking approach to sleep stage classification that could replace the current gold standard in sleep testing, the cumbersome polysomnography, which uses a myriad of wires and is performed in a clinic.

Randomized controlled trials, or RCTs, are believed to be the best way to study the safety and efficacy of new treatments in clinical research. However, a recent study from Michigan State University found that people of color and white women are significantly underrepresented in RCTs due to systematic biases.

Doctors in virtual online health care contacts are no more likely to prescribe antibiotics for infections than doctors in regular health centers, quite the opposite. This is shown by a new study of doctor's visits in Sörmland during 2020–2021 led from Umeå University, Sweden.

Northwestern investigators have identified a novel transcription factor that regulates a signaling mechanism utilized by a fertilized embryo to protect its mother from cellular and environmental stress, according to a study to published in the journal Genes & Development.

Our bodies are inhabited by trillions of microorganisms, with specific microbes unique to each individual. Through experimentation, scientists have pinpointed certain factors that account for variation in the gut: diet, living conditions, exercise and maternal line.

A loss of salt and body fluid can stimulate kidney regeneration and repair in mice, according to a new study led by USC Stem Cell scientist Janos Peti-Peterdi and published in the Journal of Clinical Investigation.

While chemotherapy can stimulate antitumor immunity, it may also impair immune cell function and induce lymphodepletion, reducing the effectiveness of subsequent immunotherapy. Thus, nanoparticle-based drug delivery systems have been developed for their improved drug biodistribution and reduced toxicity, striking a delicate balance between efficacy and safety.

Potassium channels are openings that allow charged potassium atoms to cross the cell membrane. Voltage-gated potassium channels—which open only when a specific voltage is reached across the cell membrane—are essential for the electrical impulses that nerve cells or neurons use to communicate. Dysfunction of these channels is implicated in diseases like epilepsy, autism and schizophrenia.

Despite significant improvements in data sharing for cancer clinical trials over the last 10 years, further changes are still needed to ensure patient-centered care, medical advancements, and trust in the pharmaceutical industry, say Flinders University researchers.

A research team led by Prof. Chen Yan and Prof. Yang Lifeng from the Shanghai Institute of Nutrition and Health of the Chinese Academy of Sciences revealed a physiological function of monocarboxylate transporter 1 (MCT1) in mediating the intracellular and extracellular lactate transport in skeletal muscle.

AL (immunoglobulin light chain) amyloidosis is a rare disease that often results in progressive organ dysfunction, organ failure and eventual death.

Whether it's a first-time visit to a zoo or when we learned to ride a bicycle, we have memories from our childhoods kept well into adult years. But what explains how these memories last nearly an entire lifetime?

A large analysis of data from nearly 400,000 healthy U.S. adults followed for more than 20 years has found no association between regular multivitamin use and lower risk of death. The study, "Multivitamin Use and Mortality Risk in 3 Prospective US Cohorts" led by researchers at the National Institutes of Health's National Cancer Institute, was published June 26, 2024, in JAMA Network Open.

Years after questions were raised about their integrity, two of the University of Minnesota's highest-profile scientific discoveries have been retracted in one week—one that offered hope over the therapeutic potential of stem cells and the other that offered a promising path toward treating Alzheimer's disease.

Why do some people live for longer than others? The genes in our DNA sequence are important, helping avoid disease or maintain general health, but differences in our genome sequence alone explain less than 30% of the natural variance of human life expectancy.

Chronic pain affects millions worldwide, and current treatments often rely on opioids, which carry risks of addiction and overdose. Non-addictive alternatives could revolutionize pain management, and new research targeting the human protein which regulates cold sensations, brings scientists closer to developing pain medications that don't affect body temperature and don't carry the risks of addict

The quest for rejuvenation treatments often targets senescent cells, despite them having a positive physiological role in health in many recent cases, a leading researcher has warned.

Researchers at Purdue University's College of Science have developed a patent-pending compound called HSN748 to treat drug-resistant acute myeloid leukemia (AML). AML is a cancer that begins in bone marrow and sometimes metastasizes to the central nervous system, liver, lymph nodes, spleen and testicles.

A study led by the Institute for Bioengineering of Catalonia (IBEC) describes a new approach to producing mini-kidneys in the laboratory that mimic a complex vasculature, similar in some characteristics to those of the human kidneys. These "asembloids" are created by combining 3D kidney organoids with endothelial organoids.

Binge drinking significantly increases the risk of alcohol addiction. In a study published in Microbiome on June 17, a team led by University of Connecticut School of Medicine researchers reports that valeric acid, a substance made by gut bacteria, reduces binge drinking in mice. Their findings open a new avenue in the search for treatments for alcohol abuse.

Researchers at the National Institutes of Health (NIH) have developed a non-chemotherapy treatment regimen that is achieving full remissions for some people with aggressive B-cell lymphoma that has come back or is no longer responding to standard treatments. The five-drug combination targets multiple molecular pathways that diffuse large B-cell lymphoma (DLBCL) tumors use to survive.

Each second of our lives, cells in our body grow and divide to ensure we stay healthy. However, this process has a dark side: if cell growth and divisions become excessive, that may cause cancer. To keep a safe balance, our cells are equipped with several molecular mechanisms to limit their own growth and division.

A new study led by Dr. Shir Atzil and her team from the Department of Psychology at the Hebrew University unveils intriguing insights into the mechanisms of romantic bonding, focusing particularly on physiological synchrony—the alignment of physiological responses between individuals—and its impact on perceived romantic attraction.

The over-the-counter supplement nicotinamide riboside, a form of vitamin B3, increased the walking endurance of patients with peripheral artery disease, a chronic leg condition for which there are few effective treatments.

Alzheimer's disease (AD) remains one of the most challenging and prevalent neurodegenerative disorders, affecting millions worldwide. In two recent studies, researchers led by Prof. Lucía Chávez Gutiérrez (VIB-KU Leuven), Prof. William Mobley (UCSD, U.S.), and Prof. Carsten Hopf (CeMOS, Mannheim, Germany) shed light on the role of toxic protein fragments and plaque composition in AD, offering valu

A new research paper was published on the cover of Aging, titled, "Mitophagy and cancer: role of BNIP3/BNIP3L as energetic drivers of stemness features, ATP production, proliferation, and cell migration."

The sites where our bodies come into contact with the outside world—via skin, the surface of the eye, inside the mouth, the lining of the intestine and the urinary tract, for example—are known as barrier tissues.

A study led by Nagoya University Graduate School of Medicine in Japan has revealed a link between gut microbiota and Parkinson's disease (PD). The researchers found a reduction in the gut bacteria of genes responsible for synthesizing the essential B vitamins B2 and B7.

A study by the University of Southampton has revealed a surprising link between breast size and the amount of sweat produced by the breast during exercise.

A team of researchers led by Monash University and the Baker Heart and Diabetes Institute have published the first compelling evidence of the therapeutic potential of a new therapy to treat hypertension-induced organ damage. The paper appears in the journal Cardiovascular Research.

A research team, led by Professors Tae-Hyuk Kwon and Duyoung Min from the Department of Chemistry at UNIST, has achieved a significant breakthrough in the battle against cancer through the utilization of reactive oxygen species (ROS) generated via water oxidation.

Eczema, a skin inflammatory disease that causes dry, itchy and inflamed skin, affects millions worldwide. Eczema is associated with an altered skin microbiome and higher colonization by Staphylococcus aureus.

Researchers have presented the latest findings from a clinical trial aimed at discovering a cure for sickle cell disease, a painful genetic blood disorder with limited treatment options.

The innate immune system is responsible for protecting the human body from threats that could cause disease or infection. The system relies on innate immune sensors to detect and transmit signals about these threats. One of the key innate immune strategies to respond to threats is through cell death. New research from St. Jude Children's Research Hospital discovered that NLRC5 plays a previously u

The European Alliance of Associations for Rheumatology has long recognized the pivotal role of patients in the development of recommendations, and the role of patients in research is also evolving. But collaboration with patients in this way is relatively new, and trials or effectiveness studies are not yet available.

Some people seem to be more resilient to developing Alzheimer's disease, despite having the biological hallmarks of the devastating disease. For obvious reasons, scientists are very interested in studying this special group of people.

While health data is essential for scientific research, that data also needs to be protected. In her doctoral thesis, Irith Kist found a balance between protecting the individual and exchanging health data.

Select patients with progressive multiple sclerosis (MS) may benefit from mesenchymal stem cell-neural progenitors (MSC-NPs), according to a study published May 23 in Stem Cell Research & Therapy.

An analysis of reviews of translational biomedical research reveals that just 5% of therapies tested in animals reach regulatory approval for human use. The study, an umbrella review, published June 13 in the open access journal PLOS Biology, summarizes other systematic reviews and provides high level evidence that while the rate of translation to human studies is 50%, there is a steep drop off be

Increased use of blood transfusions after major traumatic brain injury could help people hospitalized in intensive care units regain greater functional independence and a better quality of life.

A team of neurologists at Third Military Medical University, in China, has found that transplanting stem cells from the bone marrow of young mice into older mice led to a slowdown of the development of Alzheimer's disease.

Herbal medicines have been an integral part of traditional health care systems worldwide, dating back thousands of years. These natural remedies, rooted in cultural traditions, are now experiencing a resurgence in popularity as the demand for holistic and personalized health care grows. This review explores the convergence of traditional wisdom and modern science in the realm of herbal medicines,

As a new space race revs up, propelling humans back to the moon and toward a Mars landing for the first time, mysteries remain about the unique pressures of space flight on humans—especially for those blasting off through new commercial space travel operations.

Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive lung disease marked by the thickening and scarring of lung tissue with unclear etiology. Affecting around five million people worldwide, IPF causes severe respiratory problems and greatly diminishes the quality of life.

Women live longer than men. This isn't unique to humans, either; we see this trend in a wide range of other animals. Biologists have theorized that the discrepancy in life expectancy between sexes might be partly related to reproduction, but how?

An international research team, coordinated by academics from the University of Bologna and the IRCCS—Policlinico Sant'Orsola Hospital, has identified a key growth factor capable of exerting a proliferative and regenerative effect on cardiac muscle cells. The research, published in the journal Cell Reports, paves the way for potential new therapies to regenerate damaged hearts.

There are various types of widow spiders, including black, red, and brown varieties in North and South America, the Australian redback spider, and several button spider species that inhabit South Africa. In Europe, Latrodectus tredecimguttatus—the European black widow—inhabits the Mediterranean region, but recently and due to the changing climate, the widows have been expanding their habitat.

The proportion of patient harms associated with medical procedures, treatment, and contact with health care systems rose by 59%, from 11 million to 18 million globally, between 1990 and 2019, finds a data analysis published online in the journal BMJ Quality & Safety.

Sepsis—the leading cause of mortality in children around the world—can present with a wide range of signs and symptoms, making a one-size-fits-all treatment strategy ineffective. Pursuing a precision medicine approach for pediatric sepsis, researchers used artificial intelligence to analyze a large set of clinical data and find a distinct group of patients who might respond better to targeted trea