All articles tagged: Neurology & Neurosurgery

Early data support the concept that targeting pituitary adenylate cyclase–activating polypeptide signaling could be an effective new approach for migraine prevention.

A new national study showed the association between AD risk and nighttime light pollution was seen across subgroups, with younger people particularly vulnerable.

General practitioners found use of the Montreal Cognitive Assessment to be easy and fast, and the test had a high yield.

A new cohort study found no association between a history of migraine and increased risk for Parkinson's disease in women.

Athira Pharma said on Tuesday its drug failed to meet the main goal in a mid-to-late stage trial in patients with mild-to-moderate Alzheimer's disease.

A recent study has built on emerging evidence that intense training can be safe and beneficial for patients recovering from stroke.

Patient voices have been welcomed at federal agencies and on Capitol Hill, but some question whether better-funded organizations have an outsize influence.

COVID-19 vaccination was not associated with increased risk for multiple sclerosis relapse, except in those with high MS activity.

Managing hypertension in older adults may reduce the risk for Alzheimer's disease, a meta-analysis suggested.

Alzheimer's patients in Britain's state-run health service are unlikely to get access to Eisai and Biogen's new Leqembi drug, after it was approved on Thursday by the...

Genetic variants associated with Parkinson's disease are far more common than previously thought, occurring in 13% of those with the disease.

Personalized, adaptive deep brain stimulation can offer better control of motor symptoms of Parkinson's disease than standard DBS, a new pilot study showed.

A recent Lancet report claims nearly half of dementia cases could be prevented by addressing 14 risk factors, including vision loss. But is this recommendation backed by evidence? Let's explore

A man with severely impaired speech due to ALS was able to communicate with loved ones with 97% word accuracy using a new brain-computer interface.

Women's parity and genetic susceptibility to the disease modified the association between pill use and risk.

At least 25% of unresponsive patients with a disorder of consciousness may retain some awareness, an estimate that is higher than previous research suggests.

Patients with chronic pain receiving opioid analgesics more likely develop opioid dependence, opioid use disorder, and aberrant behaviour, a new study showed.

The CONVINCE trial of the anti-inflammatory drug colchicine missed its primary endpoint, but secondary analyses suggested benefit.

A new consensus statement outlines best practices for assessing and managing spasticity across a range of conditions.

Tenecteplase improved functional outcome in patients with LVO presenting beyond 4.5 hours who had salvageable brain tissue but no access to endovascular therapy.

Estimating the risk for unprovoked seizures in the year following an ischemic stroke using a novel prognostic model may help guide decisions about driving, new research suggested.

Although the prevalence of migraine has remained largely unchanged for the past 30 years, migraine-associated disability nearly doubled during that time.

Personalized repetitive transcranial magnetic stimulation targeting the hippocampal network improves cognitive and functional performance in early Alzheimer's.

Consuming highly processed foods may be harmful to the aging brain, independent of risk factors for adverse neurologic outcomes and adherence to recommended dietary patterns.

Decompressive craniectomy appears to benefit patients with severe deep intracerebral hemorrhage, new research showed.

Antiplatelet therapies increased the risk for intracranial hemorrhage in patients with stroke receiving thrombolysis, but the absolute increased risk was small.

Physicians are more than twice as likely to die by suicide, and surgeons are at particularly high risk due at least in part to the US neurosurgeon shortage.

A new study challenges guideline recommendations to rapidly reduce BP in acute ischemic stroke patients to allow for swift thrombolysis.

Minor ischemic stroke patients with intracranial occlusion should not be treated with IV thrombolysis, a new trial has concluded.

A novel 'drip and ship' program that significantly increased thrombectomy access in stroke patients at rural hospitals in Australia can be easily applied to other countries.

Preliminary findings suggest lateral thalamotomy results in improved outcomes for patients with refractory trigeminal neuralgia.

An external spinal stimulation device improves upper-extremity strength and function in 72% of patients with a spinal cord injury.

Some patients with severe TBI who died because life support was withdrawn may have survived and recovered at least partial independence, new data suggest.

The INTERACT4 trial showed that early reduction of blood pressure is beneficial in patients with hemorrhagic stroke but detrimental in those with ischemic stroke.

The economic cost to individuals with traumatic brain injury continues for years post injury, results of a national cohort study showed.

Early results from a trial of DBS as a potential treatment for chronic low back pain suggest the procedure was effective with no serious adverse events or complications.

The TASTE trial adds to a string of previous trials showing noninferiority of tenecteplase to alteplase. In addition, an updated meta-analysis suggests tenecteplase is superior.

New expert guidance to help clinicians manage the treatment of patients with epilepsy during pregnancy has been released.

Full results of the ANNEXA-I trial, showing better control of hematoma expansion but an increase in thrombotic events with andexanet vs usual care, are now published in NEJM.

Meningitis was among three strong clinical risk factors identified in a nationwide, population-based study.

Two new drugs are headed toward pivotal trials after making their endpoints in phase 2 treatment-resistant epilepsy studies.

The diabetes/weight loss drug semaglutide is associated with a significantly greater risk for repeat operations in patients with diabetes who require lumbar surgery.

A first-in-human trial suggests that neural stem cell transplant is safe, improves motor function, and provides hope for patients with chronic ischemic stroke.

There is no link between the SARS-CoV-2 vaccine and increased risk for new-onset seizure activity, results from a new meta-analysis showed.

New evidence-based practice guidelines related to peripheral neuropathy related to Sjogren disease have been developed by a multidisciplinary panel of physicians from across medicine.

Two copies of APOE4 may be more than just a risk factor for AD; the pair may cause the disease in 15%-20% of cases.

Proton pump inhibitors, which are used to control acid reflux, are associated with an increased risk for migraine and other severe headache types, new research showed.

For Black Americans, racial discrimination in midlife is associated with an increased risk of developing Alzheimer's disease later in life, new findings show.

For Black Americans, racial discrimination in midlife is associated with an increased risk of developing Alzheimer's disease later in life, new findings show.

A global increase in stroke-related death and disability has been linked to extreme temperatures related to climate change, data from a 30-year global study showed.

Researchers have discovered a genetic variant that reduces the risk for Alzheimer's disease by up to 70%.

Real-world US claims-based data show major gaps in the care and management of three major neurologic diseases – Alzheimer's, Parkinson's, and multiple sclerosis.

A unique autoantibody signature of multiple sclerosis may predict the disease years before individuals become symptomatic.

Some companies claimed that engaging in "brain games" can improve cognition or stave off cognitive decline. What's the evidence and do crosswords and Sudoku count?

After years of disappointing ALS clinical trial results, this year's Sheila Essey Award recipient for significant contributions in ALS research is shifting to prevention.

Studies suggest that lower stroke risk associated with newer antidiabetic therapies is not due to the drugs' tighter glycemic control. So, what is the mechanism?

The lecanemab open-label extension trial for AD showed no new safety signals, but the placebo roll-over group failed to show the gains seen in the experimental arm.

A program that teaches internal medicine residents, medical students, and other trainees how to assess neurologic conditions could help address neurologist shortage.

New evidence suggested that a section of the Latin American population may have increased sensitivity to pain, which heightens the problem of inadequate healthcare access.

Airborne exposure to a common industrial solvent was linked to a 24% increased risk of Parkinson’s disease in urban areas.

Nearly 70% of patients showed improvement after treatment with efgartigimod plus rHuPH20 in phase 2 of the largest randomized controlled trial for CIDP to date.

Many clinicians delay CD20 treatment until vaccine schedules are complete. A study suggests that this precaution may not be necessary.

Alerting neurologists via telemedicine that a patient with suspected acute stroke is en route to the hospital significantly speeds thrombolytic treatment.

AXS-05, a combination of dextromethorphan and bupropion, led to a rapid and sustained improvement in agitation related to Alzheimer's disease in the phase 3 ACCORD trial.

Lidocaine injections into the greater occipital nerve relieve severe, refractory migraine attacks in children, results of a randomized controlled trial showed.

There is no increased relapse risk in patients with multiple sclerosis and comorbid cancer who are taking checkpoint inhibitor therapy, results of a small study suggest.

Lidocaine injections into the greater occipital nerve relieve severe, refractory migraine attacks in children, results of a randomized controlled trial show.

A new test appears to be better than current options for diagnosing pathogens that cause meningitis, encephalitis, and other neurologic infections.

In the first randomized controlled trial, vaporized cannabis containing a THC-CBD mix led to rapid and sustained relief of acute migraine.

Headache, including tension-type, migraine, and posttraumatic, are robustly associated with both attempted and completed suicide, a large study shows.

Infusions of ketamine are an effective, safe, and well tolerated option for severe, refractory headache in children, researchers report.

Interim data from an ongoing open-label extension study support the long-term safety and efficacy of atogepant for prevention of chronic and episodic migraine.

Higher seizure burden, defined by an AI algorithm applied to point-of-care EEG recordings, correlates with poorer functional outcomes, new research shows.

Analyzing temporal changes in people's speech could be a simple way to detect mild cognitive impairment for further assessment of dementia risk.

The benefit in functional outcome is a welcome finding for these deadly strokes but was restricted to a select patient population, one expert suggests.

The consequences of chronic musculoskeletal pain (CMP) may extend well beyond physical discomfort, potentially leading to more rapid brain aging, new research shows.

Using whole-genome sequencing, Canadian researchers found a high prevalence of genetic abnormalities in children with cerebral palsy.

MS has three distinct subtypes, each based on different blood-based "immune signatures," which may help predict disease course and lead to more personalized treatment decisions.

The prevalence of dementia among homeless people is almost double that in the general, housed population, according to a new comparative analysis from Canadian researchers.

After disappointing phase 3 trial results in ALS, Amylyx will pull Relyvrio from the market but provide it free to patients who want to stay on the medication.

Clinicians need to pay more attention to nontraditional stroke risk factors, especially in adults under 35 years, new research suggests.

Cognitive assessments administered via a smartphone app proved accurate and reliable in detecting frontotemporal dementia in high-risk individuals.

Early initiation of HET in pediatric-onset MS was linked to slower progression to disability compared to treatment with low-efficacy therapy or no treatment.

Research suggested that EBV is the primary cause of MS. What are the clinical implications, and could this transform treatment and prevention of this neurodegenerative condition?

Over time, exercising at least twice a week is associated with significantly fewer insomnia symptoms and better sleep duration, new research showed.

Erenumab was more effective than oral preventive medications in reducing migraine days with better patient adherence and satisfaction.

In older patients with nonactive MS, there is a significant increased risk for relapse after discontinuing natalizumab and fingolimod, new research showed.

There is no increased risk for stroke during the 6 weeks following receipt of either brand of the COVID-19 bivalent vaccine, new research shows.

Absolute stroke rates have increased in recent years, with hemorrhagic stroke showing the most striking increase in mortality, new data show.

A skin biopsy that can detect an abnormal protein in cutaneous nerve fibers holds promise for early detection of Parkinson's and other neurodegenerative disorders.

The new indication in adults with AQP4 Ab+ NMOSD is based on positive results from a phase 3 trial that showed the long-acting C5 complement inhibitor protects against relapse.

Givinostat (Duvyzat), a histone deacetylase inhibitor, is the first nonsteroidal drug approved to treat patients aged 6 years or older with all genetic variants of DMD.

Hospitalization for influenza raises the risk for future neurologic conditions more than hospitalization for COVID-19, the results of a large study showed.

Very low LDL cholesterol levels may increase the risk of bleeding in patients with stroke who are receiving dual antiplatelet therapy.

Statins have historically been discouraged in elderly nursing home residents with dementia, but new findings suggest their use can reduce mortality risk in this population.

Treatment with the investigational agent givinostat has the potential to delay disease progression when added to corticosteroid treatment in ambulatory boys with Duchenne muscular dystrophy.

Atidarsagene autotemcel (Lenmeldy) is approved for presymptomatic late infantile, presymptomatic early juvenile, or early symptomatic early juvenile MLD.

Investigators found significant Black patients are significantly less likely than their White counterparts to receive genetic testing for neurologic disorders, new research shows.

Over 7 years, the US health care system spent more than $3 billion on DMD treatments eteplirsen, golodirsen, and casimersen, despite a lack of confirmatory trial data.

Epilepsy was linked to a significantly increased the risk for hospitalization and death from COVID-19 early in the pandemic, while healthcare utilization rates declined.

MS that develops after age 50 tends to progress more rapidly than younger-onset MS and is less apt to respond to disease-modifying therapy, Swedish registry data show.

Neurological conditions are now the leading cause of illness and disability, affecting more than 3 billion people around the world, a comprehensive new analysis showed.

Skipping meals, mood and anxiety disorders, as well as vaping and substance use, all raise the risk for frequent recurrent headaches in children and adolescents.

Worsening symptoms among several patients with MS taking the OTC antihistamine clemastine prompted investigators to halt that arm of a multidrug trial.

Aspirin and acetaminophen may offer an effective and inexpensive solution to exercise-induced heat sensitivity in relapsing-remitting multiple sclerosis, phase 3 data suggested.

Dementia is three times more common among people with essential tremor, results from a longitudinal study showed.

Obstructive sleep apnea is linked to a higher risk of incident stroke regardless of CPAP use – but only in White individuals.

Treatment with batoclimab resulted in a nearly 60% sustained improvement in daily activities in adult patients with generalized myasthenia gravis.

The watchdog group Public Citizen is calling for the prompt removal of the ALS drug Relyvrio after it failed to meet primary and secondary endpoints in top-line results from a phase 3 trial.

Infant exposure to monoclonal antibodies used to treat MS via breast milk does not negatively affect health or development out to 3 years, a new study shows.

Investigative sleuths say the rewards are high while consequences are almost nonexistent, all while investigations take years to complete.

Working with a trained service dog is associated with fewer seizures in patients with treatment-resistant epilepsy, new research shows.

Real-world patient data show a 30%-54% reduced prevalence of Alzheimer's disease in patients using the erectile dysfunction drug sildenafil (Viagra).

Patients treated with tenecteplase at up to 24 hours had a threefold higher rate of reperfusion without intracranial hemorrhage than those receiving best medical treatment.

Common symptoms expressed in an intense or complicated way, or the presence of many symptoms in the same patient, should raise suspicion of rare disease, said one clinician.

Topline results for the ALS drug Relyvrio show that it failed to meet primary or secondary endpoints. The company says it may voluntarily pull the drug from the market.

In an unexpected move, the FDA has decided to hold an advisory meeting of outside experts to discuss the efficacy and safety of donanemab for Alzheimer's disease.

Results of the ELEVATE trial demonstrating the safety and efficacy of oral atogepant for the prevention of treatment-resistant episodic migraine prevention have now been published.

Black, male, and older ischemic stroke patients are less likely than other populations to antithrombolytic therapy.

Patient-reported outcomes in multiple sclerosis matter but remain underused due to multiple barriers.

ASCLEPIOS sub-studies show high sNfL levels at 3 and 12 months predictive of future CNS activity in patients with multiple sclerosis.

At interim analysis, a stem cell extension study showed favorable clinical and biomarker effects for progressive MS.

The phase 3 MS trial of the BTK inhibitor evobrutinib was not superior to teriflunomide for any endpoint.

Symptoms of sleep apneas are associated with a 50% increased risk for cognitive and memory problems, results from a large study showed.

The risk for seizure is almost twofold higher in patients with multiple sclerosis than in those without MS and higher still among those taking an S1PR modulator.

A common comorbidity in multiple sclerosis migraine is not part of the 3- to 5-year disease prodrome, new research suggested.

Iron accumulation in the brain may be a biomarker of concussion and posttraumatic headache, new research suggests.

Nearly 70% of patients with relapsing forms of MS were relapse-free at 5 years, but hematologists disagree over where the drug fits in the treatment plan.

Maternal use of antiseizure medications during pregnancy did not increase children's epilepsy risk beyond that associated with maternal epilepsy itself.

Traffic-related air pollution is linked to high levels of amyloid plaques in the brains, results of a new postmortem study showed.

The novel investigational second-generation anti–CD40 ligand monoclonal antibody frexalimab significantly reduced disease activity in relapsing MS in a phase 2 study.

A new study confirms earlier reports of increased risks for psychiatric and neurologic disorders after severe COVID but found no association between risk and mild illness.

Herpes simplex virus (HSV) is associated with an increased risk for dementia but cytomegalovirus (CMV) is not, new observational data suggested.

New data on the timing of CSF biomarker changes leading to a diagnosis of Alzheimer's disease could provide useful starting points for prevention and therapeutic strategies.

COVID-19–related cognitive deficits in severe cases were equivalent to a 9-point drop in IQ, new data show, with most deficits in memory, reasoning, and executive function.

COVID-19–related cognitive deficits in severe cases were equivalent to a 9-point drop in IQ, new data show, with most deficits in memory, reasoning, and executive function.

Moderate/severe traumatic brain injury (TBI) is associated with an increased risk for brain cancer, new research showed.

New research supports the use of highly effective therapies as first-line treatment in children with relapsing-remitting pediatric-onset multiple sclerosis.

A large longitudinal study suggests that older adults who regularly use the Internet for less than 2 hours per day have a decreased risk for dementia.

Incidence of stroke was significantly higher among Indigenous people in affluent countries than their non-Indigenous counterparts.

Clinicians have often advised patients with migraine to avoid caffeine, which is seen as a potential headache trigger. This study found no such association.

Sarepta Therapeutics said on Friday that the US FDA would review an application seeking traditional approval for its gene therapy to treat a muscle-wasting disorder by June...

Playing a musical instrument or singing in a musical group was associated with better working memory and executive function, new study results showed.

Flavonoids have been proposed as an approach to reducing Parkinson's disease risk, but new data showed no association of flavonoid intake with protective benefit.

The STOP-CAD study signaled a short course of an antithrombotic regimen might lower ischemic stroke risk in some patients without significantly increasing major bleeding.

Results from a mouse model could lead to the development of therapies to prevent neurologic damage caused by viruses such as Zika.

Biogen said on Monday its drug for treating a rare genetic disorder that causes progressive damage to the nervous system has won European health regulator's approval for use...

Argatroban and eptifibatide were ineffective as adjunctive therapies to thrombolysis in patients with ischemic stroke in the MOST trial.

It's well known that radon increases lung cancer risk. This study found that being exposed to radon may also increase the risk for stroke.

Leading a healthy lifestyle that includes a healthy diet, moderate exercise, and minimum alcohol consumption is linked to better cognition in later life, new data showed.

Men with newly diagnosed erectile dysfunction who were prescribed drugs like sildenafil or tadalafil were 18% less likely to develop AD at 5-years follow-up, new research shows.

About 25% of all ADSC participants have dementia, and the prevalence of dementia in ADSCs that specialize in the disorder is more than 40%.

The US prevalence of idiopathic intracranial hypertension increased significantly between 2015 and 2022. Black and Hispanic women experienced the greatest increases, new research revealed.

For comatose patients with suspected acute poisoning, a conservative strategy aiming to avoid intubation is associated with superior clinical benefits, data suggest.

Updated recommendations outline key healthcare services that dedicated epilepsy centers should provide to deliver the highest quality of care.

More than 2 years after its controversial accelerated FDA approval, Biogen says it will halt development and commercialization of aducanumab and focus on lecanemab.

Patients who received contaminated growth hormone developed AD decades later. The study suggests AD is transmissible, but researchers stress it cannot be transmitted through routine medical care.

Combining electrical and optical methods with AI, researchers developed a new brain implant that can read deep-brain activity without penetrating tissue.

About 80% of patients hospitalized with a first ischemic stroke require a second hospitalization, new data shows. Cardiovascular and cerebrovascular diagnoses at readmission were most common.

The favorable effect of deep brain stimulation on overall quality of life in patients with advanced Parkinson's disease was primarily because of improved mobility.

Newly approved updated labeling allows patients to receive full-body MRI scans while implanted with the Abbott dorsal root ganglion (DRG) neurostimulation system.

A new robotic garment may stop freezing episodes, one of the most disabling features of Parkinson's disease.

HyQvia, which combines immunoglobulin with hyaluronidase, is administered subcutaneously by a healthcare professional or the patient or caregiver, after appropriate training.

Less than 30% of patients who received ECMO support had favorable neurologic outcomes a year after treatment, results of a new meta-analysis showed.

Transcranial alternating current stimulation reduces insomnia severity, increases total sleep time, and alleviates daily disturbances such as fatigue.

While stroke incidence had declined among both Black and White people over the last two decades, racial disparities persisted.

NM-101, from Terran Biosciences, is a cloud-based software platform to analyze neuromelanin-sensitive MRI scans, which could aid in the diagnosis of neurodegenerative diseases.

Social isolation, alcohol use disorder, and vitamin D deficiency are among the modifiable risk factors linked to young-onset dementia.

Intravenous nipocalimab provides clinical benefits for patients with generalized myasthenia gravis, an IgG autoantibody-mediated disease characterized by muscle weakness.

Attention to oral health may be a promising target for early interventions focused on improving brain health, a new study suggests.

Zolpidem and behavior therapy each reduce daytime symptoms of insomnia such as fatigue, functional impairments, and depressive symptoms, data suggested.

Poststroke depression is one of the most common complications of stroke. Two new studies shed light on its mechanisms, paving the way for future treatment targets.

Data suggested that clinically apparent Helicobacter pylori infection is associated with an 11% increase in risk, but an expert urges caution in interpreting the findings.

Transcranial direct current stimulation significantly improved cognitive function in a sham-controlled trial of patients with Alzheimer's disease.

Helicobacter pylori infection is associated with a moderately increased risk for Alzheimer's disease, new research suggests.

Extracranial surgery performed soon after traumatic brain injury is linked to poorer functional recovery and neurocognition, new research shows.

Selecting a treatment plan to deal with acute migraine attacks is like putting together a toolkit of possible therapies which can be individualized for each patient, one expert said.

Adverse experiences early in life, especially including physical and sexual abuse, increase risk for chronic pain in adulthood.

The FDA has rejected Clene Nanomedicine's application for accelerated approval for the experimental drug ALS drug, CNM-Au8, citing insufficient evidence.

Biogen Inc said on Tuesday the European Commission has revoked the marketing authorization for generic versions of its multiple sclerosis drug Tecfidera held by the firms...

Placebo-controlled trials are insufficient for decisions that affect medication availability in EU member states.

The Lancet Public Health has retracted a study published last spring suggesting that untreated hearing loss increases dementia risk after the researchers identified a coding error in the analysis.

Restarting a CGRP monoclonal antibody (mAb) after a gap in treatment may lower response rate, a new study suggests. However, switching to a different mAb may counter this effect.

A mindfulness-based treatment has shown multiple benefits in patients with chronic migraine and medication-overuse headaches, results of a new randomized trial show.

Shift work is tied to a plethora of sleep disorders, including insomnia and sleep-related breathing disorders. These problems are worse in individuals who work night shifts.

Depression, constipation, cystitis, urinary tract infections, and sexual dysfunction may precede a diagnosis of multiple sclerosis by 5 years, new research shows.

With many medications to choose from, doctors need to weigh the pros and cons of each drug to decide on the best approach for the patient.

The number of TBI-related deaths in the US increased 22% between 2010 and 2020, with the largest rise in individuals aged 75 and older, a new study shows.

Migraine is often thought of as a female disorder, but multiple factors make it difficult to determine its true prevalence in women and men.

Migraine is often thought of as a female disorder, but multiple factors make it difficult to determine its true prevalence in women and men.

Following recent FDA approval of two renal denervation systems for the treatment of hypertension, experts speculate on which patients will be prioritized for the procedure.

Older patients with epilepsy who are resistant to antiseizure medication might benefit from adding this diet to their treatment regimen.

Co-prescription of enzyme-inducing antiseizure medications is not associated with alteration in direct-acting oral anticoagulant efficacy or safety.

For the first time, new research shows that taking a specific class of migraine medication during the prodromal phase reduces the development and severity of the subsequent headache.

Some personality traits may increase the risk for dementia whereas others may lower it, results of a new meta-analysis show.

Patients with migraine are less likely to respond to the new CGRP monoclonal antibody preventive treatments, if they have certain psychiatric disorders, new research shows.

Triptans, ergots, and antiemetics were ranked as the top three most effective acute migraine medications in an analysis of 10.8 million users' self-reported records.

Imaging and other tools that take advantage of developing understanding of migraine pathophysiology could eventually address difficulties in diagnosing and treating the condition.

Medication overuse headache is a common secondary order condition whose treatment requires behavioral intervention and education.

Medication overuse headache is a common secondary order condition whose treatment requires behavioral intervention and education.

People with epilepsy convert from normal cognition to mild cognitive impairment and from mild cognitive impairment to dementia faster than did those without epilepsy

Early life adversity is associated with greater amygdala reactivity and diminished prefrontal cortex reactivity, according to the results of a meta-analysis of 83 neuroimaging studies.

Benefits of genetic testing in adults with unexplained epilepsy include enrollment in a clinical trial of a relevant gene therapy, connection to families with a similar diagnosis, and peace of mind.

Sleep disorders in people with epilepsy are linked to a significantly increased risk for sudden unexplained death in epilepsy and all-cause mortality, new research shows.

Mounting research links poverty and other elements of neighborhood deprivation to worse cognition in people with epilepsy.

In a first-in-humans trial, deep brain stimulation restored executive function in five individuals with moderate to severe traumatic brain injury 3-18 years after injury.

Secondhand smoke exposure is associated with migraine or severe headache, results of a large population-based study show, prompting the researchers to call for increased regulation of tobacco use.