All articles tagged: Oncology & Cancer

A systematic review into the potential health effects from radio wave exposure has shown mobile phones are not linked to brain cancer. The review was commissioned by the World Health Organization and is published today in the journal Environment International.

A study presented today at the International Association for the Study of Lung Cancer 2024 World Conference on Lung Cancer demonstrates a promising pathway toward developing predictive biomarkers for immune checkpoint inhibitors.

Despite significant improvements in the perception of biomarker testing compared to a 2018 survey, substantial barriers to implementation persist globally, according to results of the 2024 IASLC Global Survey on Biomarker Testing released today at the International Association for the Study of Lung Cancer (IASLC) World Conference on Lung Cancer 2024.

Research presented today suggests an artificial intelligence tool called DeepGEM may provide an advancement in genomic testing that offers an accurate, cost-effective, and timely method for gene mutation prediction from histopathology slides.

Research over the years has suggested intermittent fasting has the potential to improve our health and reduce the likelihood of developing cancer.

Researchers at Korea University College of Medicine have identified a new candidate marker for determining the severity and metastasis of sarcoma and developed a molecular sensor that enables fluorescence imaging targeting this marker.

Experts from the University's School of Medicine have revealed that the Cancer Aging Research Group (CARG) score—a tool used to estimate the risk of severe chemotherapy-related side effects for patients—is not robust when used in an older U.K. population.

When it comes to cancer metastasis, it takes two to tango. That was one of the key findings of a new study led by researchers at Memorial Sloan Kettering Cancer Center (MSK): The TGF-beta and RAS signaling pathways work together to spur the spread of cancer in lung adenocarcinoma, a leading cause of cancer deaths around the world.

In a study published in Cell Chemical Biology, a research team led by Prof. Tan Weihong and Prof. Wu Qin from the Hangzhou Institute of Medical of the Chinese Academy of Sciences has identified protein arginine methyltransferases (PRMTs), crucial regulators of RNA splicing and chromatin stability, as a new therapeutic target for overcoming paclitaxel resistance in triple-negative breast cancer (TN

Scientists at Huntsman Cancer Institute at the University of Utah (the U), the National Cancer Institute-designated cancer center for the Mountain West, have made a significant breakthrough in predicting the prognosis of triple-negative breast cancer (TNBC), a particularly aggressive disease.

About 8 to 10 million Americans over age 40 have an overabundance of cloned white blood cells, or lymphocytes, that hamper their immune systems. Although many who have this condition—called monoclonal B-cell lymphocytosis (MBL)—do not experience any symptoms, a new study shows they may have an elevated risk for several health complications, including melanoma, a form of skin cancer.

Age-related changes in the fibroblasts, cells that create the skin's structure, contribute to the development of aggressive, treatment-resistant melanoma in males, according to research in mice by the Johns Hopkins Kimmel Cancer Center.

For patients with metastatic or surgically unresectable leiomyosarcoma, combination therapy with doxorubicin and trabectedin is associated with improved overall and progression-free survival compared with doxorubicin alone, according to a study published online Sept. 4 in the New England Journal of Medicine.

Researchers at Weill Cornell Medicine have used artificial intelligence to identify drug targets based on mapping regulatory networks in patient tumors. The study, published in Cell Systems, experimentally identified and validated four drug candidates for neuroendocrine, liver and renal cancers, which have a dismal prognosis with current therapeutic options.

Assistant Professor Keiko Hatanaka of Toho University, a Ph.D. student of Tokyo Medical and Dental University (TMDU), in collaboration with Professors Yoshiko Sasaki and Makoto Tanaka of Tokyo Medical and Dental University (TMDU), revealed the process of adjusting to living with chronic liver disease (CLD) among patients who continued regular health care visits for hepatocellular carcinoma (HCC) s

A novel study by researchers at the Icahn School of Medicine at Mount Sinai addresses a critical yet under-explored question in cancer research: Why is aging the biggest risk factor for cancer? The study reveals how an aging immune system spurs tumor growth, offering new insights into cancer prevention and treatment, especially for older adults.

An estimated one in eight men at some point will get prostate cancer. Those statistics are expected to surge in the next 15 years partly due to the Baby Boomer generation reaching the age when prostate cancer is most common. Millennials won't be far behind, so prostate cancer cases could continue to rise.

Staging of patients with early pancreatic cancer is inaccurate as much as 80% of the time, according to a new Cedars-Sinai Cancer study published in JAMA. The finding underscores the urgent need for advancements in diagnostic technology and staging, which could significantly alter early pancreatic cancer treatment and research.

A cancer study has found that certain gut bacteria may influence whether or not a patient's immune system is successful in fighting mesothelioma, an aggressive form of cancer.

Researchers at Baylor College of Medicine and the Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital have uncovered a new cell type in the human brain.

In contrast to other commonly-diagnosed cancers like colorectal and lung cancer, the five-year survival rate after diagnosis for pancreatic cancer is alarmingly low, at 8.5% in Japan.

Research published online by the Journal of the National Comprehensive Cancer Network (JNCCN) finds that for many commonly-used treatment regimens targeting metastatic gastrointestinal (GI) cancers, such as FOLFOX, FOLFIRI, or FOLFIRINOX, it is possible to administer 5-FU solely through continuous infusion, minus the bolus (quick-delivery via intravenous push) component, without negatively affecti

Rates of prostate cancer across Europe since 1980 are "indicative of overdiagnosis," say researchers in a study published by The BMJ.

A study led by researchers at UT Southwestern Medical Center reveals significant disparities across the country in the use of immunotherapy for patients with advanced kidney and bladder cancers. The findings, published in Urologic Oncology: Seminars and Original Investigations, suggest that factors such as race, socioeconomic status, and the type of health care facility influence whether patients

Immune checkpoint inhibitors are a type of cancer treatment that helps the immune system attack cancer cells more effectively. One of the key proteins involved in this process is lymphocyte activation gene-3 (LAG3), which suppresses the antitumor immune response. Moffitt Cancer Center researchers have made an important discovery about LAG3, revealing how it interacts with other proteins to control

A new review was published in Oncotarget on August 2, 2024, entitled, "Targeting WNT5B and WNT10B in osteosarcoma."

A treatment paradox has recently come to light in prostate cancer: Blocking testosterone production halts tumor growth in early disease, while elevating the hormone can delay disease progression in patients whose disease has advanced.

CDK4/6 inhibitors, which are already FDA approved for the treatment of other forms of cancer, show early signs of promise in the treatment of a subtype of pediatric high-grade glioma, according to new research from Dana-Farber Cancer Institute and the Institute of Cancer Research in London. Treatment of a patient with a second relapse of this glioma subtype and no other treatment options resulted

Two recent scientific papers about optimal treatment of older patients with cancer not only improve clinical care but also demonstrate Wilmot Cancer Institute's international leadership in this growing field.

While immune checkpoint inhibitors (ICIs) can provide lifesaving treatment for patients with cancer, they have also been found to cause immune-related adverse events (irAEs)—side effects that can impact almost every organ in the body to varying degrees. The frequency and severity of irAEs in real-world datasets are not well understood, making it difficult to combine cases effectively across instit

A team of researchers at the VIB-KU Leuven Center for Cancer Biology, the Netherlands Cancer Institute and Oncode Institute and the University of Cambridge have discovered that a defensive mechanism connected to the menstrual cycle plays a role in spreading mutant cells within mammary tissue.

Scientists at Harvard Medical School have designed a versatile, ChatGPT-like AI model capable of performing an array of diagnostic tasks across multiple forms of cancers.

Rare diseases affect fewer than 1 in 2,000 people individually. However, with over 7,000 different types identified, their global impact is significant. In the Asia-Pacific region, approximately 258 million people have a rare disease, the highest number globally, with over 45 million in Southeast Asia alone. This vast number highlights significant challenges in treatment, as the diversity of this

Researchers from the University of Alabama at Birmingham have identified a promising new combination therapy for metastatic colorectal cancer that enhances the effectiveness of existing treatment while reducing harmful side effects.

In news that should reassure folks glued to their cellphones all day, a new international review finds no link between cellphone use and brain cancer.

A new study from researchers with the Advanced Science Research Center at the CUNY Graduate Center (CUNY ASRC) sheds light on why certain oligodendrocyte progenitor cells (OPCs) in the adult brain transform into gliomas, the most common and incurable type of adult brain tumors. Previous work identified OPCs—dividing cells in the adult brain that play a crucial role in the brain's maintenance—as on

Led by investigators of the Vall d'Hebron Institute of Oncology's (VHIO) Experimental Therapeutics Group, in collaboration with VHIO's Hereditary Cancer Genetics Group and the Medical Oncology Department at the Vall d'Hebron University Hospital (HUVH), results of a study published in Genome Medicine show that the PARP1 selective inhibitor saruparib (AZD5305) elicited superior and durable antitumor

For many doctors and researchers, immunotherapy that uses someone's own immune system to target and attack cancer cells is the next and best frontier of cancer treatment. Chimeric antigen receptor T-cell therapy, or CAR-T cell therapy, is one type of immunotherapy. Sometimes likened to a "smart drug" or "living drug," CAR-T cell therapy relies on genetically modified immune cells to recognize and

In a study using human breast cancer cells, scientists say they have potentially identified immune system white blood cells that appear to be the closest neighbors of breast cancer cells that are likely to spread. The researchers say the finding, focused on a white blood cell called a macrophage, may provide a new biological target for immunotherapies designed to destroy spreading cancer cells tha

In patients with newly diagnosed type 2 diabetes, baseline interleukin-6 (IL-6) levels may enhance prediction of new-onset obesity-related cancers, according to a study scheduled to be presented at the annual meeting of the European Association for the Study of Diabetes, being held from Sept. 9 to 13 in Madrid.

Leiden researchers have developed a model to advance cancer immunotherapy. Using a 3D printer, they create mini-tumors within an environment that closely mimics human tissue. They have also developed a method to monitor real-time interactions of these mini-tumors with immune cells during tests.

A University of Alberta research team has found a potential new treatment target for ovarian cancer. Their new research is the first to comprehensively investigate the elevated expression of a gene called ZIC2 in ovarian cancer cells, finding that it is associated with poor survival rates of ovarian cancer patients and testing ways to inactivate the gene.

Researchers at WEHI have identified a promising new two-in-one treatment that not only targets and destroys an aggressive form of brain cancer, but also helps the immune system develop a lasting defense against it.

An Aston University researcher has used light to develop the first step towards a quicker, cheaper and less painful technique to detect cancer.

Women residing in persistently impoverished neighborhoods have worse breast cancer outcomes, according to a study published online Aug. 29 in JAMA Network Open.

A new editorial was published in Oncotarget, titled "Beyond pixels: Graph filtration learning unveils new dimensions in hepatocellular carcinoma imaging."

An editorial was published in the journal Oncoscience on July 19, 2024, titled "Functional information offers individualized adaptive cancer therapies."

During recent decades, the incidence of colorectal cancer (CRC) has been rising globally and its prevalence in Singapore is no exception.

A new study from researchers at Brighton and Sussex Medical School (BSMS) reveals that patients living with certain long-term health conditions may face delays in being diagnosed with lung cancer. This is particularly concerning as lung cancer remains the leading cause of cancer-related deaths in the UK for both men and women, with high mortality rates largely due to late-stage diagnosis.

Ribociclib—a drug already used to treat breast cancer—may help slow the growth of diffuse hemispheric glioma (DHG), new research has found.

Pediatric hepatocellular carcinoma (HCC) and fibrolamellar carcinoma are rare, aggressive forms of liver cancer that typically affect adolescents and young adults. Although some immunotherapy drugs are approved by the Food and Drug Administration as first-line treatments for HCC in adults, less is known about their effectiveness in treating pediatric liver carcinomas.

Scientists at Van Andel Institute and Icahn School of Medicine at Mount Sinai have developed a potent anti-cancer compound that inhibits cancer cell growth in a tough-to-treat type of infant leukemia. The findings are published in the journal Science Advances.

F. nucleatum, an oral anaerobe, is frequently associated with colorectal cancer and is linked to increased cancer cell proliferation, metastasis, and poor treatment outcomes.

A new tool for monitoring immune health patterns over time has revealed how a pair of checkpoint inhibitor therapies works together to recruit new cancer-fighting T cells with every infusion.

Scientists are on the verge of a cancer breakthrough after working out how the body's immune system targets cells devastated by the disease.

A team of scientists led by Dr. Björn von Eyss has discovered an additional control mechanism that prevents the growth of liver cancer.

Investigators have discovered that aberrant activation of a specific oncoprotein drives key tumor-promoting changes in the prostate tissue microenvironment during cancer progression, according to a Northwestern Medicine study published in Nature Communications.

Researchers at the Medical College of Georgia at Augusta University are searching for a better way to understand why many men with prostate cancer end up with Alzheimer's disease, and whether it's the standard hormone therapy treatment or an overactive immune response that actually contributes to the problem.

An innovative software tool could advance cancer pathology by providing diagnostic insights from tissue biopsies. The tool, called METI (Morphology-Enhanced Spatial Transcriptome Analysis Integrator), was developed by researchers at MD Anderson and Emory.

A new research paper was published in Oncotarget, titled "Inhibition of miR-10b treats metastatic breast cancer by targeting stem cell-like properties."

A new paper published in the journal Nature Communications explores programmed cell death (PD-1) in melanoma cells and the immune system's response.

Researchers at the University of Massachusetts Amherst and UMass Chan Medical School have demonstrated in mice a new method to combat pancreatic cancer. The study, published in Science Translational Medicine, outlines the synergistic effects of a novel nanoparticle drug-delivery system to activate an immune pathway in combination with tumor-targeting agents.

Half of cancer survivors experience cancer-related financial hardship, according to a research letter published online Aug. 20 in JAMA Network Open.

A deadly liver cancer that mainly affects children and young adults rewires its cellular metabolism in order to thrive, according to a new study that opens the door to exploring new targets for therapies.

Cancer cells have voracious appetites. And there are certain nutrients they can't live without. Scientists have long hoped they might stop tumors in their tracks by cutting off an essential part of cancer cells' diet. But these cells are crafty and often find a new way to get what they need. How? By reprogramming their metabolism and switching to backup food supplies.

Salt could help to boost the immune defense against cancer. This is suggested by the research findings of a team led by Prof. Dr. Christina Zielinski, who holds the Chair of Infection Immunology at the Friedrich Schiller University in Jena. The group presents its findings in Nature Immunology.

Individuals with type 2 diabetes who are at higher risk of certain cancers could be identified by a simple blood test, this year's Annual Meeting of the European Association for the Study of Diabetes (EASD) (Madrid, 9–13 September) will hear.

Researchers at the University of Notre Dame have developed a novel, automated device capable of diagnosing glioblastoma, a fast-growing and incurable brain cancer, in less than an hour. The average glioblastoma patient survives 12–18 months after diagnosis.

Reduced salivary flow, or hyposalivation, can cause an increased risk for tooth decay and other mouth conditions. Measuring salivary flow is important to guide risk assessment and management strategies when treating patients with oral health diseases. Typically, the same standard normal values are used for both females and males in interpreting results of salivary flow testing.

Researchers at Peter Mac are using their knowledge of an ancient signaling pathway to find new treatments for mesothelioma, a devastating cancer that has few effective treatments and a very poor prognosis.

Oregon Health & Science University researchers have identified a combination of treatments that show promise in slowing the progression of cancer and reducing tumor growth. Their research lays the groundwork for developing more effective treatments for triple negative breast cancers and mesotheliomas—both aggressive forms of cancer that are difficult to treat.

A new editorial was published in Oncotarget, titled "Artificial intelligence: A transformative tool in precision oncology."

The most common form of colorectal cancer, microsatellite-stable colorectal cancer (MSS CRC), can currently only be treated to a limited extent with modern immunotherapies. A research team led by MedUni Vienna has now identified the possible cause of treatment failure and thus found a way to improve treatment for patients. The study was recently published in Nature Communications.

Researchers have developed an artificial intelligence which can differentiate cancer cells from normal cells, as well as detect the very early stages of viral infection inside cells. The findings, published today in a study in the journal Nature Machine Intelligence, pave the way for improved diagnostic techniques and new monitoring strategies for disease. The researchers are from the Centre for G

Just 28% of U.S. women are aware that a healthful diet can lower the risk of developing breast cancer, according to a just-released Physicians Committee for Responsible Medicine/Morning Consult survey.

A recent editorial was published in Oncotarget, titled "Genotype matters: Personalized screening recommendations for germline CHEK2 variants."

Cancer Council WA has welcomed a new study showing its SunSmart program is saving money as well as lives. Published in Health Promotion International, the research confirms the SunSmart program is expected to prevent 300,000 skin cancers, save 1,000 lives and return $8.70 to the public purse for every dollar spent over the next 20 years.

Women diagnosed with breast cancer who had regular screening mammograms every year were less likely to have late-stage cancer and had higher overall survival than those who received screening every other year or less often, according to new research from the University of Pittsburgh and UPMC published in the Journal of Clinical Oncology.

When it comes to cancer disparities, community may count. A study published Aug. 21 in the Journal of the National Cancer Institute showed that although Hispanic non-small cell lung cancer patients tend to be diagnosed at later stages than white patients, that disadvantage disappears in South Florida.

Small cell lung cancer (SCLC) is a fast-growing and highly malignant subtype of lung cancer. One of the biggest challenges doctors face is the cancer's resistance to platinum-based chemotherapy, the standard treatment for SCLC patients.

The fight against cancer is an arms race, and one of the most effective weapons in clinicians' arsenals is immunotherapy. Immune checkpoint therapy has become the standard for treating several types of cancer. However, the Nobel Prize-winning strategy is ineffective for most pancreatic ductal adenocarcinoma (PDAC) patients.

High levels of traffic-related air pollutants have been linked with elevated risks of developing cancer and other diseases. New research indicates that multiple aspects of structural racism—the ways in which societal laws, policies, and practices systematically disadvantage certain racial or ethnic groups—may contribute to increased exposure to carcinogenic traffic-related air pollution. The findi

The lotus leaf is a pioneer of self-cleaning, water-repellant engineering. Water droplets all but hover on its surface, whose unique texture traps air in its nanosized ridges and folds.

A recent study shines light on the treatment and survival outcomes for women with breast cancer in Gaza before the current conflict. While over half of reported diagnoses were made at advanced stages, a high short-term survival rate was discovered, highlighting the positive impact of international investment and collaboration in recent years before the conflict.

Recent research highlights the importance of targeted therapies for treating advanced colorectal cancer (CRC) with rare genetic variants. These mutations, often linked to poor prognosis and limited response to conventional treatments, are being addressed through advanced sequencing technologies and new targeted drugs. This study explores the clinical diagnosis and treatment strategies tailored to

In a recent comprehensive review published in Cyborg Bionic Systems, researchers detail significant advances in the identification and application of biomarkers for prostate cancer (PCa). This critical insight is pivotal as prostate cancer remains one of the most common malignancies among men globally, emphasizing the urgent need for effective diagnostic and therapeutic strategies. The team was le

A new research paper was published inGenes & Cancer on August 9, 2024, titled "Dialyl-sulfide with trans-chalcone prevent breast cancer prohibiting SULT1E1 malregulations and oxidant-stress induced HIF1a-MMPs induction."

Return to work two years after a breast cancer diagnosis is associated with higher cognitive speed performance before and after treatment, according to a study published online Aug. 19 in JAMA Network Open.

Prostate cancer is often treated by a robotic keyhole surgery called a robotic-assisted radical prostatectomy. Accompanying this surgery is an MRI scan that tells the surgeon where the cancer is within the prostate.

Researchers discovered an alternative way to classify distinct types of colon cancer, making the information more valuable to patients and their doctors as they consider treatment.

Belzutifan, a hypoxia-inducible factor 2α (HIF-2α) inhibitor, improves progression-free survival and objective responses over everolimus among patients with advanced clear-cell renal cell carcinoma, according to a study published in the Aug. 22 issue of the New England Journal of Medicine.

How effective medications are depends on various factors, including the time of day when they are administered. Why? Because our bodies don't always function exactly the same. Instead, they follow the cycle set by their internal clock, otherwise known as circadian rhythm. But since each person's circadian rhythm is different and depends on a number of different factors, it is difficult to tailor m

Obesity-related cancer rates in China were rising at an alarming 3.6% every year between 2007 and 2021 while non-obesity-related cancers remained stable, according to the first comprehensive study published August 22 in the journal Med.

A team of researchers from the University of Cologne's Faculty of Medicine and University Hospital Cologne, led by Dr. Yuri Tolkach and Professor Dr. Reinhard Büttner, has created a digital pathology platform based on artificial intelligence. The platform uses new algorithms developed by the team and enables fully automated analysis of tissue sections from lung cancer patients.

What are the characteristics of a cancer cell that are recognized by the immune system? Knowledge of the potential target structures for the immune cells is a basic prerequisite for the development of personalized cancer immunotherapies.

Men who work offshore and have been in contact with asbestos in their working environment have a higher risk of developing pleural cancer.

Elevated salivary levels of CD44 and total protein (TP) can identify head and neck cancer patients with an increased risk for cancer recurrence, according to a study published online Aug. 15 in JAMA Otolaryngology-Head and Neck Surgery.

A new report describes a promising approach to studying neurofibromatosis type 1 (NF1), a genetic condition with limited treatment options. The condition causes a number of different cancerous and non-cancerous tumors to form throughout the body. Among these tumors are cutaneous neurofibromas, benign tumors that grow from nerve terminals in the skin.

The growth of healthy tissues in the body depends on the development of new blood vessels, a process called angiogenesis, that enables proper blood flow, meaning nutrients and oxygen are delivered while toxic metabolic products are removed.

A new treatment for locally advanced rectal cancer shows favorable results in that surgery can sometimes be avoided completely. It also reduces the risk of recurrence. The method has been confirmed as effective in a comprehensive study conducted at Uppsala University and published in eClinicalMedicine.

Scientists have discovered how interactions between RNA and the TOP1 essential enzyme, which is overexpressed in many human cancers, regulate DNA during transcription and may inform the creation of new cancer therapies, according to a Northwestern Medicine study published in Molecular Cell.

Immunotherapy has revolutionized cancer treatment, with immune checkpoint inhibitors (ICIs) playing a pivotal role. However, current ICIs, primarily monoclonal antibodies, face significant challenges like poor tissue penetration, high production costs, and off-target effects. These limitations hinder their efficacy and accessibility. Due to these issues, there is an urgent need to explore alternat

Children who survive a brain tumor often experience effects from both the cancer and its treatment long after therapy concludes. Scientists at St. Jude Children's Research Hospital found very young children treated for brain tumors were less prepared for school (represented by lower academic readiness scores) compared to their peers.

There may be a way to slow the growth of endometrial cancer through targeted cancer cell therapy, according to new research from the University of Missouri School of Medicine.

Researchers from BGI Genomics and Fudan University have published new findings on ovarian cancer (OV) among Chinese patients in JCO Global Oncology.

A new molecular imaging technique that pairs a novel tracer with a next-generation PET/CT scanner can identify neuroblastoma in children with high sensitivity, requiring a scan time of only minutes and no sedation or anesthesia. With its ability to accurately diagnose neuroblastoma, this technique, known as 18F-MFBG LAFOV PET/CT, has the potential to impact therapeutic decision-making for children

A new editorial titled "Strategies to disrupt NKG2A:HLA-E interactions for improved anti-cancer immunity" has been published in Oncotarget.

Dose-dense adjuvant chemotherapy can improve survival for patients with high-risk breast cancer, according to a team of researchers that includes the Karolinska Institutet. The international PANTHER trial, which studied more than 2,000 patients where 97% had metastasis to the lymph nodes in the armpit, compared two different chemotherapy regimens and found that the dose-intensive treatment reduced

Spouses of patients with cancer have an increased risk for suicide attempt and suicide death, especially during the first year after diagnosis, according to a study published online Aug. 15 in JAMA Oncology.

An international team of scientists has uncovered a mechanism by which acute myeloid leukemia (AML) cells sustain their growth.

A recent analysis of all relevant published studies reveals clear benefits of cognitive behavioral therapy (CBT) for improving mental health and quality of life in cancer survivors. The findings, which are published in Cancer Medicine, extend CBT's effects beyond what has long been known in the general population.

Twenty minutes of mindful breathing, which focuses a person's attention on their breath, can rapidly reduce the intensity and unpleasantness of cancer pain and relieve the associated anxiety, suggest the findings of a small comparative study, published online in the journal BMJ Supportive & Palliative Care.

Researchers are discovering new genes linked to breast cancer and refining evaluation of risk to help spare women from life-changing surgery.

Multiple myeloma (MM) is a complex hematological malignancy with significant unmet needs. While conventional therapies have significantly improved patient survival, the disease remains incurable. A review, led by Qizhong Lu, Donghui Yang, Ting Niu, and Aiping Tong, explores the multifaceted nature of MM and the promising potential of targeted therapies.

Esophageal cancer, a highly aggressive malignancy originating in the esophageal epithelium, poses significant public health challenges in China, where it ranks sixth in incidence and fifth in mortality among cancers. The country's large population contributes to over half of the global cases and deaths from esophageal cancer. This cancer's poor prognosis is often due to late diagnosis, as early-st

Researchers from University of Queensland's Frazer Institute have discovered the mechanism that bladder cancer uses to suppress the immune system's natural killer (NK) cells.

Researchers from Brigham and Women's Hospital have used artificial intelligence tools to accelerate the understanding of the risk of specific cardiac arrhythmias when various parts of the heart are exposed to different thresholds of radiation as part of a treatment plan for lung cancer.

Men with metastatic castration-resistant prostate cancer should be treated primarily with second-generation hormone drugs, which offer better treatment response and longer life expectancy than chemotherapy. However, the effect depends on which mutations the patient's tumor carries. These findings are a result of the ProBio study, led by researchers at Karolinska Institutet in Sweden. The study is

Researchers at the University of Reading have contributed to a study that could lead to new treatments for a deadly cancer caused by a herpesvirus.

An unprecedented effort to sequence the genome, exome and RNA in tumors from patients with multiple myeloma defines distinct subtypes of the disease, according to an international team of scientists led by researchers from the Translational Genomics Research Institute (TGen), part of the City of Hope.

Pancreatic cancer is an aggressive disease with few available treatments. Thankfully, researchers are hard at work to improve treatment options, and researchers from Japan have now unveiled something promising.

Simple alternative criteria for lung cancer screening (LCS) can identify high-benefit groups, especially among certain racial and ethnic-minority groups, according to a study published online Aug. 20 in the Annals of Internal Medicine.

The saga of cancer treatment is marked by a relentless pursuit of effectiveness against a disease characterized by complexity and adaptability. While immunotherapy has opened new frontiers, the challenges posed by tumor diversity and immune evasion call for innovative solutions. The drive to achieve precision in targeting cancer's Achilles heel without harming healthy tissue is propelling the expl

A new review titled "The gut barrier as a gatekeeper in colorectal cancer treatment" has been published in Oncotarget.

Older patients with acute myeloid leukemia (AML) have high health care utilization and poor survival outcomes, according to a study published online Aug. 13 in Hematological Oncology.

For patients with hepatocellular carcinoma (HCC), immune checkpoint inhibitor (ICI) use prior to liver transplant (LT) does not worsen outcomes, according to research published online July 10 in the Journal of Hepatology.

The first few years of your child's life are a time of major growth and development in which the foundation for social, emotional and learning skills is laid. A cancer diagnosis and cancer treatment can disrupt the safe environment and routines that foster childhood development. This can cause distress, affect behavior, and temporarily delay or revert milestone progress.

Ovarian cancers are often found when they are already advanced and hard to treat.

A recent study of the psychological outcomes of over 57,470 patients with rare cancers showed that they have higher risk of developing mental health issues compared to patients with common cancers.

Personalized medicine is transforming cancer treatment by tailoring therapies to the genomic profile of each tumor. Next-generation sequencing (NGS) is key to this approach, but its complexity and inconsistent reporting have been hurdles. A recent paper in Annals of Oncology introduces new guidelines to standardize NGS reports, aiding clinicians in making informed decisions and improving patient o

Socioeconomic status, provider-patient relationships and rural living environments have been found to affect cancer screening behaviors for people LBGTQIA+ individuals, according to a recent study from Callie Kluitenberg Harris, a Ph.D. candidate at the Michigan State University College of Nursing.

A novel test developed by Johns Hopkins Kimmel Cancer Center investigators could give gastroenterologists insight into which patients with Barrett's esophagus—a premalignant condition in which parts of the esophagus become damaged by chronic acid reflux—are likely to progress to esophageal cancer or an abnormal collection of cells called high-grade dysplasia. This information could help physicians

A new research paper was published in Oncotarget titled, "A nanobody against the V-ATPase c subunit inhibits metastasis of 4T1-12B breast tumor cells to lung in mice."

PARP inhibitors have improved survival of breast cancer patients with BRCA1/2 mutations, but the drugs eventually stop working and the cancer returns.

Patients with liver cancer who received immune checkpoint inhibitors (ICIs) before surgery—including those who would not have been eligible for surgery by conventional criteria—had similar outcomes to patients who received surgery upfront, according to results from a retrospective study published in Cancer Research Communications.

New international guidelines developed by QIMR Berghofer researchers are expected to improve the accuracy of genetic tests that determine a person's cancer risk.

Cancer is no longer a death sentence. Across Europe, around 20 million people are now living beyond their disease. But their efforts to return to normal life are severely hampered by a particularly unjust form of financial discrimination.

A special type of MRI scan where patients inhale 100% oxygen could result in lower radiotherapy doses for some cancer patients.

For years, mouthwash has been marketed as an essential hygiene item to prevent bad breath, even though it offers minimal if any health benefits.

St. Jude Children's Research Hospital scientists report the first successful treatment of a pediatric patient with high-risk refractory neuroblastoma using a targeted therapy guided by clinical genomics.

Offering self-sampling kits to women overdue for cervical cancer (CC) or colorectal cancer (CRC) screening when they attend breast cancer (BC) screening can result in increased screening participation, according to a study published online Aug. 13 in PLOS Medicine.

A new Cleveland Clinic study has identified diet-derived molecules called metabolites as main drivers of young-onset colorectal cancer risk, especially those associated with red and processed meat. The npj Precision Oncology report, which analyzed metabolite and microbiome datasets, highlighted that one of the best ways a younger (

Researchers at Children's Hospital of Philadelphia (CHOP), St. Jude Children's Research Hospital (St. Jude) and the Children's Oncology Group (COG) today announced a significant paradigm shift in the understanding of T-lineage acute lymphoblastic leukemia (T-ALL), an aggressive and high-risk form of cancer, to one frequently driven by genetic changes in non-coding portions of our DNA.

Researchers at the University of Glasgow have found that adults with learning disabilities are more likely to die from cancer compared to the general population.

Researchers at Children's Hospital of Philadelphia (CHOP) announced a significant breakthrough in understanding chemotherapy resistance in high-risk neuroblastoma, a common and potentially deadly childhood cancer arising within the peripheral nervous system.

Scientists at UC San Francisco have discovered a way to get rid of pancreatic cancer in mice by putting them on a high fat, or ketogenic, diet and giving them cancer therapy.

For rural patients, getting cancer treatment close to home has always been difficult. But in recent years, chemotherapy deserts have expanded across the United States, with 382 rural hospitals halting services from 2014 to 2022, according to a report published this year by Chartis, a health analytics and consulting firm.

A study published in the International Journal of Gynecological Cancer found that the UK's protocol for picking up early-stage disease in women with high grade serous ovarian cancer—the most common, aggressive, and lethal form of the disease—is an effective way to diagnose even early-stage ovarian cancer.

A recent study uncovers the molecular signatures of mammographic calcifications in hormone receptor-positive, HER2-negative breast cancer. The research identifies distinct molecular traits associated with calcification status, suggesting that tumors with probably benign calcifications are linked to higher hormone receptor expression and endocrine therapy sensitivity, while tumors with calcificatio

In the past two decades, immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment, showing promising results against various solid tumors. A recent study reviews recent developments in ICIs, focusing on new targets like T cell immunoreceptor with Ig and ITIM domains (TIGIT), T cell immunoglobulin and mucin domain-containing protein 3 (TIM-3), and lymphocyte activation gene-3 (LAG-3

Two studies published in the latest issue of the journal Cell by University of Pittsburgh researchers uncover how immunotherapies targeting the immune checkpoints PD1 and LAG3 work together to activate immune responses. The findings shed light on why combination therapies targeting both checkpoints can improve outcomes for melanoma patients compared to monotherapies targeting only PD1.

Hodgkin's lymphoma (HL), impacting the lymph nodes and lymphatic system, has experienced a gradual increase in survival rates thanks to contemporary chemotherapy. However, challenges persist for patients who exhibit resistance to initial treatments or suffer relapses, highlighting an urgent demand for more potent therapeutic solutions. The intricacies of early-stage versus advanced disease managem

Researchers at the Leibniz Institute for Immunotherapy (LIT) studied hundreds of patients with acute myeloid leukemia (AML). They discovered that specific mutations in the STAG2 protein cause altered DNA folding in the cell nucleus, thereby contributing to the development of AML.

A new study of more than 10,000 non-smoking adults found that solid lung nodules were present in a considerable portion of study participants. Non-smokers are traditionally thought to be at low risk for lung nodules and lung cancer. The results of the study were published in Radiology.

An experimental drug based on ancient Chinese herbal medicine can help ease the toxic side effects of chemotherapy and radiation therapy in cancer patients, the results of a small new trial results suggest.

Ovarian cancer is one of the most common malignancies in women worldwide. Unlike breast cancer, ovarian cancer lacks early diagnostic markers and does not show noticeable symptoms until cancer metastases, leading to a low survival rate for ovarian cancer patients. Traditional cancer treatments include surgery, radiation therapy, chemotherapy and interventional therapy. However, the distribution of

Florida State University researchers are giving oncologists another tool in their fight against pediatric brain cancer.

A new research perspective titled "Targeting the multifaceted BRAF in cancer: New directions" has been published in Oncotarget.

Researchers at the Indiana University Melvin and Bren Simon Comprehensive Cancer Center have completed the most extensive mapping of healthy breast cells to date. These findings offer an important tool for researchers at IU and beyond to understand how breast cancer develops and the differences in breast tissue among genetic ancestries.

For years, the treatment of early-stage prostate cancers that haven't spread beyond the organ has often included the removal of nearby lymph nodes in the pelvis. It's done as a precaution and as a means of "staging" the disease.

Natural killer (NK) cells engineered to express interleukin-21 (IL-21) demonstrated sustained antitumor activity against glioblastoma stem cell-like cells (GSCs) both in vitro and in vivo, according to new research from The University of Texas MD Anderson Cancer Center.

The body has a veritable army constantly on guard to keep us safe from microscopic threats from infections to cancer. Chief among these forces is the macrophage, a white blood cell that surveils tissues and consumes pathogens, debris, dead cells, and cancer. Macrophages have a delicate task. It's crucial that they ignore healthy cells while on patrol, otherwise they could trigger an autoimmune res

Pancreatic neuroendocrine tumors (PanNETs) are a rare form of pancreatic cancer for which predicting patient clinical outcomes and providing appropriate patient management remain challenging.

Scientists from St. Jude Children's Research Hospital, Seattle Children's and the Children's Oncology Group (COG) have identified novel genetic variations that influence relapse risk in children with standard risk B-cell acute lymphoblastic leukemia (SR B-ALL), the most common childhood cancer.

Rheumatoid arthritis (RA) is associated with a significantly increased risk for lung cancer, according to a study published online July 28 in Arthritis & Rheumatology.

In an analysis of 30 cancer types among men, investigators uncover substantial disparities in cancer cases and deaths by age and countries' economic status—disparities that are projected to widen by 2050. The study is published in the journal Cancer.

A worrying new study by the American Cancer Society has revealed that generation X and millennials are at more risk of developing many types of cancer than their predecessors. This is in line with a growing body of evidence which shows that some cancers, like those of the bowel, breast and pancreas, are becoming more common in young people.

The complex interplay between extracellular genetic material and the tumor's genetic landscape presents a significant challenge in grasping cancer evolution, tumor genetic heterogeneity, and treatment response. Earlier research has revealed the role of circulating tumor DNA (ctDNA) in mediating the gene expression among cancer cells, offering new insights into a previously under-explored aspect of

Dr. Sabine Mai, Canada Research Chair in Genomic Instability and Nuclear Architecture of Cancer with the Rady Faculty of Health Sciences recently co-authored an article published in the American Journal of Hematology. The groundbreaking study shows early risk stratification of smoldering multiple myeloma, a precursor state to multiple myeloma, a deadly form of blood cancer.

A research team co-led by investigators at Vanderbilt University Medical Center and the University of Virginia has identified associations between DNA methylation and cancer risk. DNA methylation is an epigenetic change—the addition of "methyl groups" to DNA—that can affect gene expression without changing the DNA sequence. Most DNA methylation occurs on CpG sites in the genome.

Investigators from the laboratory of Marc Mendillo, Ph.D., associate professor of Biochemistry and Molecular Genetics, have discovered new cellular regulators of a cancer cell transcription factor linked to cancer resilience and tumor progression, according to findings published in the Proceedings of the National Academy of Sciences.

T cell therapies, which use genetically-engineered T cells of the human immune system as therapeutics, are revolutionizing medical oncology by effectively treating previously incurable blood cancers. However, their success against solid tumors has been limited.

Progenitor exhausted CD8+ T (Tpex) cells have emerged as a pivotal component in tumor immunotherapy due to their unique ability to self-renew and rapidly proliferate. These cells have shown promise in expanding and differentiating into functional exhausted CD8+ T cells, significantly enhancing clinical outcomes. Understanding and leveraging Tpex cells can revolutionize immunotherapeutic strategies

A new research paper titled "Chemical complementarity of tumor resident, T-cell receptor CDR3s and renalase-1 correlates with increased melanoma survival" has been published in Oncotarget.

In a pioneering venture, researchers have harnessed AI and multi-omics to shed light on the intricate pathways of gastric inflammation-induced tumorigenesis. This study heralds a new era in early detection and personalized medicine, identifying key biological triggers of tumorigenesis and laying down a robust framework for innovative gastric cancer therapies.

A new study reviews how cancer-associated fibroblasts (CAFs) influence lymph node metastasis. Researchers identified various CAF subsets that interact with the tumor microenvironment, promoting cancer spread.

A study from the USC Head and Neck Center, part of Keck Medicine of USC and the USC Caruso Department of Otolaryngology—Head and Neck Surgery, suggests that cannabis, the most commonly used illicit substance worldwide, is associated with an increased occurrence of head and neck cancer.

Using a combination of computer simulations and experimental studies, a team of researchers is uncovering vital clues into how breast cancer cells invade breast tissue.

For decades, researchers have worked to develop therapies that can prime the immune system to recognize and attack proteins on the surface of tumor cells. However, success has been limited due to the technological challenge of engineering therapies that provide specific enough "training" to the immune system to identify a given patient's neoantigens.

An activity pattern in certain genes responsible for building proteins known as spleen tyrosine kinases can predict which melanoma patients are likely to have severe side effects from immunotherapy designed to treat the most deadly skin cancer, a study, publishing in the journal Clinical Cancer Research online Aug. 8, shows.

QIMR Berghofer researchers have developed super-charged immune cells that could potentially improve glioblastoma survival by fighting the deadly brain cancer and preventing its recurrence.

A pioneering study, has provided the most comprehensive analysis to date of the genetic makeup of colorectal cancer (CRC).

Using zebrafish "avatars," an animal model developed by the Cancer Development and Innate Immune Evasion lab at the Champalimaud Foundation (CF), led by Rita Fior, Mayra Martínez-López—a former Ph.D. student at the lab now working at the Universidad de las Américas in Quito, Ecuador—and colleagues studied the initial steps of the Bacillus Calmette-Guérin (BCG) vaccine's action on bladder cancer ce

New evidence published by The BMJ today casts doubt on a much-hyped blood test for the NHS that promises to detect more than 50 types of cancer.

Providing radiotherapy after surgery could prevent breast cancer from returning in the same place for up to 10 years, a long-term study suggests.

A new editorial paper titled "How to deal with runaway metastatic disease?" has been published in Oncotarget.

For pediatric patients with acute myeloid leukemia (AML), a pharmacogenomics-based 10 single nucleotide polymorphism cytarabine (Ara-C) score (ACS10) can be used to tailor induction regimens, yielding improved outcomes, according to a study published online July 30 in Clinical Cancer Research.

Using a unique collection of genetic and clinical data for colorectal cancer, researchers at Uppsala University have revealed genetic new alterations and developed of a new molecular classifier of tumor variants. The finding could lead to improved possibilities for individualized therapies. This is shown in study recently published in the journal Nature.

Cancer doesn't grow in a vacuum—each tumor grows in a particular microenvironment within the body and spreads through a tangled web of vasculature and nerves. Scientists have come to understand that the most potent therapies address cancer in context—accounting for both the tumor and the support structure that forms around it.

New Corewell Health research suggests an MRI scan can help predict whether patients with intermediate-risk prostate cancer (cancer confined to the entire prostate) may have more aggressive cancer in five years. Knowing this could potentially help doctors determine if treatment is needed up front vs. using a method called active surveillance where the disease is closely monitored over time. The stu

Vorasidenib has been approved by the U.S. Food and Drug Administration (FDA) for patients with Grade 2 gliomas with IDH1 or IDH2 mutations.

The complex dynamics between liver cancer stem cells (CSCs) and immune cells within the tumor microenvironment (TME) are central to the progression of liver cancer. These interactions are critical in creating an immunosuppressive setting that significantly impacts the response to immunotherapy.

Glioblastoma multiforme (GBM) stands as a formidable adversary in oncology, characterized by its molecular complexity and relentless progression. Despite advancements, the high degree of tumor heterogeneity and its tendency to evade conventional therapies pose significant clinical challenges.

Cytotoxic T-lymphocyte antigen 4 (CTLA-4) is a protein receptor on T immune cells that prevents the cells from killing other cells, such as cancer cells. Blocking CTLA-4 with a specific antibody is an effective treatment for some cancers, but it can damage the heart. New research published in The FASEB Journal reveals the mechanisms involved in this side effect—a finding that could be used to help

Women who develop gestational diabetes are not more likely to go on to be diagnosed with breast cancer, according to a study of almost three-quarters of a million mothers to be presented at this year's Annual Meeting of the European Association for the Study of Diabetes (EASD; Madrid, 9-13 September).

By recruiting the immune system to combat tumor cells, immunotherapy has improved survival rates, offering hope to millions of cancer patients. However, only about one in five people responds favorably to these treatments.

Yu-Hwa Huang, Ph.D. and Charles Yoon, MD, of the Department of Medicine and Department of Surgery at Brigham and Women's Hospital respectively, are co-lead authors of a paper titled "High-dimensional mapping of human CEACAM1 expression on immune cells and association with melanoma drug resistance," published in Communications Medicine. In this article, they discuss their findings.

A protein called Meteorin-like (METRNL) in the tumor microenvironment saps energy from T cells, thereby severely limiting their ability to fight cancer, according to new research directed by investigators at the Johns Hopkins University School of Medicine and the Johns Hopkins Kimmel Cancer Center and its Bloomberg~Kimmel Institute for Cancer Immunotherapy.

The financial burden of health care in Australia can be high, particularly for people diagnosed with cancer. A new study from the Daffodil Centre has shown one in ten people with cancer in NSW spends more than $10,000 on health care in the first year following diagnosis.

Screening for cancer saves lives, but a new report shows it comes with a hefty price tag: The United States spends at least $43 billion annually on tests that check for five major cancers.

Researchers from The University of Texas MD Anderson Cancer Center have demonstrated that adding metastasis-directed radiation therapy to standard-of-care chemotherapy improved progression-free survival (PFS) in patients with oligometastatic pancreatic cancer. Findings from the multicenter EXTEND trial, published today in the Journal of Clinical Oncology, were first presented at the 2024 American

For individuals younger than 25 years, the incidence of cervical intraepithelial neoplasia (CIN) decreased continuously from 2007 through 2020, according to a research letter published online July 25 in JAMA Oncology.

Since the first immunotherapy drug to boost the body's immune response against advanced lung cancer was introduced in the United States in 2015, survival rates of patients with the disease have improved significantly. That's the conclusion of a recent real-world study published in the journal Cancer.

Chimeric antigen receptor (CAR) T–cell immunotherapy re-engineers a patient's immune cells to target cancer cells. While successful in some types of leukemia, the approach has yet to realize its potential against pediatric solid tumors.

Axicabtagene ciloleucel, commonly known as axi-cel, is an innovative immunotherapy that uses modified T cells to target and destroy cancer cells. Approved for patients who have not responded to at least two prior lines of therapy, axicabtagene ciloleucel has been a game-changer in treating large B-cell lymphoma.

As novel cancer treatments continually emerge, it is essential to collect data on patients' quality of life along with how the treatment is working to extend survival. This is particularly true in young people with cancer who may be more prone to health complications later, according to a nationwide study involving children and teenagers led by AnnaLynn Williams, Ph.D., at the Wilmot Cancer Instit

Lung cancer remains the leading cause of cancer-related deaths worldwide. Detecting this disease in its early stages significantly improves survival rates, making low-dose CT screening an essential component in the fight against lung cancer.

Cervical cancer is a highly prevalent cancer, with approximately 500,000 new cases diagnosed each year. Shockingly, the number of individuals diagnosed with precursor lesions in the cervix—also known as cervical intraepithelial neoplasia (CIN)—is 20 times higher.

Early detection of lung cancer through low-dose computed tomography screening is one of the most promising strategies to reduce lung cancer mortality among high-risk individuals.

Mental health screenings must be incorporated into routine prostate cancer diagnoses say University of South Australia researchers. The call follows new research in Psycho-Oncology that shows men need more support both during and immediately after a diagnosis of prostate cancer.

A new form of immunotherapy using innovative nanoparticles can delay resistance to hormone therapy and help men with prostate cancer live longer.