All articles tagged: Pathology

Air pollution is associated with a higher risk for an infertility diagnosis in men, while road traffic noise pollution is associated with a higher risk for an infertility diagnosis in women aged 35 years and older, according to a study published online Sept. 4 in The BMJ.Mette Sørensen, Ph.D., from the Danish Cancer Institute in Co

The risk for lung cancer is high in patients with rheumatoid arthritis (RA) and pulmonary complications, according to a study published online Sept. 3 in Modern Rheumatology.Shunsuke Mori, M.D., Ph.D., from the Kumamoto Saishun Medical Center in Koshi, Japan, and colleagues assessed the incidence and predictive factors of lung canc

As mpox continues to spread in Africa, Congolese authorities said Thursday that the first batch of vaccines have arrived in that country's capital.The shipment comes three weeks after the World Health Organization declared mpox outbreaks in 12 African countries a&nbsp;<a href="https://www.who.int/news/item/14-08-2024-who-director-general-de

World Trade Center (WTC) exposure is associated with increased DNA methylation, which may contribute to breast cancer, according to a study published in the June issue of Environmental Epidemiology.Stephanie Tuminello, Ph.D., M.P.H., from the NYU Grossman School of Medicine in New York City, and colleagues examined the DNA methylation

Genetic predisposition to high ferritin and serum iron status is associated with a lower risk for developing rheumatoid arthritis (RA), according to a study published online Aug. 29 in Global Medical Genetics.Boyuan Wu, from the School of Global Public Health at New York University in New York City, used genetic data from a large gen

The association of prenatal ω-3 long-chain polyunsaturated fatty acid (n-3 LCPUFA) with the risk for childhood atopic dermatitis (AD) varies based on the maternal cyclooxygenase-1 (COX1) genotype, according to a study published online Aug. 28 in JAMA Dermatology.Liang Chen, from Herlev and Gentofte Hospital in Copenhagen, Denmark, an

In patients with newly diagnosed type 2 diabetes, baseline interleukin-6 (IL-6) levels may enhance prediction of new-onset obesity-related cancers, according to a study scheduled to be presented at the annual meeting of the European Association for the Study of Diabetes, being held from Sept. 9 to 13 in Madrid.Mathilde Dahlin Bennetsen, from th

A number of U.S. travelers returning from Cuba have been diagnosed with Oropouche virus, according to research published in the Aug. 27 early-release issue of the U.S. Centers for Disease Control and Prevention Morbidity and Mortality Weekly Report.Noting that there have been reports of two deaths in patients with Oropouche virus infec

A single combined measure of high-sensitivity C-reactive protein (CRP), low-density lipoprotein (LDL) cholesterol, and lipoprotein(a) levels predict the 30-year risk for incident cardiovascular events in healthy U.S. women, according to a study published online Aug. 31 in the&nbsp;New England Journal of Medicine&nbsp;to coincide with the Euro

Fecal immunochemical tests (FITs) have variable sensitivity and specificity for detecting advanced colorectal neoplasia (ACN), according to a study published online Sept. 3 in the Annals of Internal Medicine.Barcey T. Levy, M.D., Ph.D., from the University of Iowa Carver College of Medicine in Iowa City, and colleagues compared the per

Multiple sclerosis (MS) is associated with a lower risk for Alzheimer disease, according to a study published in the September issue of the Annals of Neurology.Noting that development of typical Alzheimer disease dementia syndrome is uncommon in people with MS, Matthew R. Brier, M.D., Ph.D., from Washington University in St. Louis, and

In middle-aged individuals with Down syndrome (DS), lecanemab-labeled amyloid plaques are seen in postmortem brain tissue analysis, in addition to extensive binding to brain blood vessels, according to a study published online Aug. 19 in JAMA Neurology.Lei Liu, M.D., Ph.D., from Brigham and Women's Hospital in Boston, and colleagues ex

Comprehensive human papillomavirus (HPV) screening, including genotyping, is important in urology and fertility clinics, according to a study published online Aug. 23 in Frontiers in Cellular and Infection Microbiology.Carolina Olivera, Ph.D., from the FOCIS Center of Excellence Centro de Inmunología Clínica de Córdoba in Argentina, and

Low-grade systemic inflammation across childhood and adolescence is associated with the subsequent onset of mental health disorders, according to a study published online Aug. 21 in JAMA Psychiatry.Edward R. Palmer, M.B.B.S., from the University of Birmingham in the United Kingdom, and colleagues examined trajectories of inflammation, a

Elevated salivary levels of CD44 and total protein (TP) can identify head and neck cancer patients with an increased risk for cancer recurrence, according to a study published online Aug. 15 in JAMA Otolaryngology-Head and Neck Surgery.Elizabeth J. Franzmann, M.D., from the University of Miami Health System and Jackson Memorial Hospit

Childhood maltreatment is associated with later cognitive difficulties, according to a study published in the September issue of&nbsp;The Lancet Psychiatry.Andrea Danese, M.D., Ph.D., from King's College London, and Cathy Spatz Widom, Ph.D., from the John Jay College City University of New York in New York City, evaluated association

From 2020 to 2021, life expectancy at birth declined for 39 U.S. states and increased for 11 states, according to the Aug. 21 National Vital Statistics Reports, a publication from the National Center for Health Statistics.Elizabeth Arias, Ph.D., from the National Center for Health Statistics in Hyattsville, Maryland, and colleagues p

Artificial intelligence (AI) is able to distinguish Marfan from non-Marfan facial images using ordinary online photographs with an extremely high degree of accuracy, according to a study published in the July 15 issue of Heliyon.Danny Saksenberg, from the Yale University School of Medicine in New Haven, Connecticut, and colleagues ex

Increased activity of the insect-borne Oropouche virus has prompted warnings from the U.S. Centers for Disease Control and Prevention for travelers to South America and the Caribbean.Oropouche virus has caused two deaths and five cases of fetal death or birth defects a

An artificial intelligence (AI) tool can exclude pathology, with an equal or lower rate of critical misses on radiographs than radiologists, according to a study published online Aug. 20 in Radiology.Louis Lind Plesner, M.D., from Herlev and Gentofte Hospital in Denmark, and colleagues estimated the proportion of unremarkable chest rad

Low levels of magnesium with or without high homocysteine (Hcy), are associated with increased DNA damage, according to a study recently published in the European Journal of Nutrition.Varinderpal S. Dhillon, Ph.D., from the University of South Australia in Adelaide, and colleagues examined whether magnesium deficiency alone or in conjun

As syphilis cases surge throughout the United States, the U.S. Food and Drug Administration on Friday approved the first diagnostic at-home test to spot the bacterial disease."This is the first at-home, over-the-counter test to detect Treponema pallidum [syphilis] antibodies in human blood," the FDA said in a <a href="https://www.fda.go

Symptom-triggered testing can identify women with high-grade serous ovarian cancer with low disease burden, according to a study published online Aug. 13 in the International Journal of Gynecological Cancer.Fong Lien Audrey Kwong, from The Pan-Birmingham Gynaecological Cancer Centre at the Sandwell and West Birmingham NHS Trust in the U

For children with recurrent respiratory tract infections (rRTIs), serum antibody levels are not associated with respiratory disease severity, but salivary polyreactive immunoglobulin (Ig)A and Haemophilus influenzae are associated with severity, according to a study published online Aug. 8 in the European Respiratory Journal.Mi

As an outbreak of a new strain of mpox continues in Africa, Sweden announced Thursday that it has confirmed the first case in that country.Known as the clade I strain, this latest iteration of mpox appears to be spread more easily and cause more severe disease, experts say."A person who sought care at Region Stockholm has been diagnosed w

The World Health Organization on Wednesday made the rare move of declaring an ongoing African outbreak of mpox a global health emergency.A new clade (strain) of the virus, plus its troubling spread throughout the Democratic Republic of Congo (DRC) and nearby countries in central Africa, drove the declaration, said WHO director general <a href=

In a health alert issued by the U.S. Centers for Disease Control and Prevention, the agency said it has received reports of higher test positivity rates for parvovirus B19 in recent months: The proportion of people with antibodies indicating recent infection, which fell below 3 percent from 2022 to 2024, spiked to 10 percent in June.But child

Gastroesophageal reflux disease (GERD) increases the risk for rheumatoid arthritis (RA), according to a study published online Aug. 1 in&nbsp;Scientific Reports.Quan Yuan, from the First Hospital of Jilin University in Changchun, China, and colleagues used Mendelian randomization (MR) to assess the causal relationship between GERD an

Most clinicians show positive attitudes toward education in climate change, according to a study published online Aug. 8 in&nbsp;JAMA Network Open.Wynne Armand, M.D., from the Center for the Environment and Health at Massachusetts General Hospital in Boston, and colleagues evaluated whether a quality incentive program measure for cli

Routine clinical laboratory values do not serve as biomarkers for postacute sequelae of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (PASC), according to a study published online Aug. 13 in the Annals of Internal Medicine.Kristine M. Erlandson, M.D., from the University of Colorado Anschutz Medical Campus in A

Elevated metal levels in plasma and urine are associated with amyotrophic lateral sclerosis (ALS) risk and survival, according to a study published online Aug. 6 in the Journal of Neurology, Neurosurgery &amp; Psychiatry.Dae-Gyu Jang, Ph.D., from the University of Michigan in Ann Arbor, and colleagues examined associations of metal measu

There are racial differences in the frequency of skin biopsy for psoriasis, indicating diagnostic uncertainty, according to a research letter published online Aug. 7 in JAMA Dermatology.Fahad Ahmed, from the Perelman School of Medicine at the University of Pennsylvania in Philadelphia, and colleagues conducted a cross-sectional study inv

The assessment of cancer risk based on symptoms, age, and sex can be enhanced by considering information from common blood test results among patients presenting with nonspecific abdominal symptoms, according to a study published online July 30 in PLOS Medicine.Meena Rafiq, M.D., Ph.D., from University College London, and colleagues quan

In 2023, there was a provisional total of 3,090,582 deaths in the United States, according to research published in the Aug. 8 issue of the U.S. Centers for Disease Control and Prevention Morbidity and Mortality Weekly Report.Farid B. Ahmad, M.P.H., from the National Center for Health Statistics in Hyattsville, Maryland, and colleagues

U.S. doctors should be on the lookout for a more severe strain of mpox that is spreading widely in parts of Africa, federal health officials warned Wednesday.The&nbsp;alert,&nbsp;issued by the U.S. Centers for Disease Control and Prevention, came just hours after the World Health Org

In 2021, the estimated total health care costs for initial cancer screening were $43 billion in the United States, according to a study published online Aug. 6 in the Annals of Internal Medicine.Michael T. Halpern, M.D., Ph.D., from the National Cancer Institute in Bethesda, Maryland, and colleagues estimated the annual cost of initial c

Stringent state-level COVID-19 restrictions were associated with substantial decreases in pandemic mortality, according to a study published online July 26 in JAMA Health Forum.Christopher J. Ruhm, Ph.D., from the Frank Batten School of Leadership and Public Policy at the University of Virginia in Charlottesville, examined how state rest

Mpox cases have soared by 160% in Africa this year, as a lack of both vaccines and treatments hamper efforts to slow the spread of the virus.In a report released by the Africa Centers for Disease Control and Prevention on Wednesday, officials said that mpox has now been detec

For patients with Gleason Grade Group (GGG) 1 prostate cancer (PC), those with percentage positive biopsies (PPB) &gt;50 percent or prostate-specific antigen (PSA) &gt;20 ng/mL have a significantly increased risk for adverse outcomes, according to a study published online July 2 in European Urology Oncology.Derya Tilki, M.D., from Univ

Plasma biomarkers of Alzheimer disease (AD) neuropathy increase with age and are associated with known dementia risk factors, according to a study published online July 28 in the Journal of the American Medical Association to coincide with the Alzheimer's Association International Conference, held from July 28 to Aug. 1 in Philadelphia.<p

The amyloid probability score 2 (APS2) has high diagnostic accuracy for identifying Alzheimer disease (AD) among individuals with cognitive symptoms in primary and secondary care, according to a study published online July 28 in the Journal of the American Medical Association to coincide with the Alzheimer's Association International Confer

Measures of familial loss experienced from childhood to adulthood are associated with biological aging, according to a study published online July 29 in JAMA Network Open.Allison E. Aiello, Ph.D., from the Mailman School of Public Health at Columbia University in New York City, and colleagues examined the associations of losing a paren

Pesticide usage is associated with an increased incidence of cancer, according to a study published online July 25 in Frontiers in Cancer Control and Society.Jacob Gerken, D.O., from the Rocky Vista University College of Osteopathic Medicine in Englewood, Colorado, and colleagues examined the relationship between pesticides and cancer

The U.S. Food and Drug Administration on Monday approved a new blood test that can spot colon cancer.In late May, an FDA advisory panel had voted 7-2 that the benefits outweigh the risks when using the Guardant Health's Shield test for&n

Hematopoietic cell transplantation (HCT) donors' socioeconomic status (SES) affects recipients' health outcomes, according to a study published online July 15 in PNAS.Lucie M. Turcotte, M.D., M.P.H., from the University of Minnesota Medical School in Minneapolis, and colleagues examined the cellular transplantability of SES-associated

For girls and young women with sickle cell disease (SCD), exposure to hydroxyurea does not reduce ovarian reserve, according to a study published online July 18 in Blood Advances.Tamara Diesch-Furlanetto, Ph.D., from the University of Basel Children's Hospital in Switzerland, and colleagues counted follicles and categorized them based

Alterations in the proportion of T cell subpopulations are associated with brain structural abnormalities in patents with schizophrenia with tardive dyskinesia (TD), according to a study published in the July issue of Schizophrenia Research.Na Li, from the Peking University HuiLongGuan Clinical Medical School in Beijing, and colleague

Specific body composition patterns are associated with neurodegenerative diseases and brain aging, according to a study published online July 24 in Neurology.Shishi Xu, M.D., Ph.D., from the West China Hospital of Sichuan University in Chengdu, and colleagues conducted a retrospective analysis using data from the U.K. Biobank to exam

Hospitals and clinical laboratories across the United States are facing a critical shortage of bottles used to culture blood samples, federal health officials report.Without the ability to culture blood, patients might receive the wrong antibiotics to treat conditions like <a href="https://my.clevelandclinic.org/health/diseases/16957-endocard

Arizona health officials are reporting an increase in hantavirus infections, which are spread by rodents and can cause severe respiratory illness.In a recent health alert, the Arizona Department of Health Service

Many breast cancer survivors with indications for genetic counseling and testing do not receive it, according to a study published online July 15 in the&nbsp;Journal of Clinical Oncology.Steven J. Katz, M.D., from the University of Michigan in Ann Arbor, and colleagues examined receipt of genetic testing and communication with relative

Screening with fecal immunochemical tests (FITs) lowers the risk of dying from colorectal cancer (CRC), according to a study published online July 19 in&nbsp;JAMA Network Open.Chyke A. Doubeni, M.D., from The Ohio State University College of Medicine in Columbus, and colleagues evaluated whether FIT screening is associated with a lower

A joint artificial intelligence (AI)-assisted model integrating clinical information and endoscopic ultrasonographic (EUS) images improves diagnosis of solid lesions in the pancreas, according to a study published online July 19 in JAMA Network Open.Haochen Cui, M.D., from Tongji Hospital in Wuhan, China, and colleagues developed a mult

At least 28 people have been hospitalized and two have died in a multi-state outbreak of listeria linked to deli meat, U.S. health officials warned.In an&nbsp;investigation notice posted Friday, the U.S. Centers for Disease Control and Prevention said the true number

Expression of several stress-related genes in prostate tumors is elevated among men residing in disadvantaged neighborhoods, according to a study published online July 12 in JAMA Network Open.Joseph Boyle, Ph.D., from Virginia Commonwealth University in Richmond, and colleagues examined whether several neighborhood disadvantage metrics

A German man has become the seventh person to apparently be cured of HIV, researchers report.The 60-year-old man, referred to as the “next Berlin Patient,” was treated with a stem cell transplant in October 2015 for acute myeloid leukemia, researchers said.He stopped taking the antiretroviral drugs needed to suppress HIV in September 2018

Multiple substantia nigra (SN) pathologies are associated with parkinsonism, according to a study published online July 15 in JAMA Neurology.Jason W. Adams, Ph.D., from the Boston University Alzheimer's Disease and CTE Center, and colleagues examined the frequency of parkinsonism in individuals with chronic traumatic encephalopathy (CT

An estimated 40.0 percent of all incident cancer cases and 44.0 percent of cancer deaths are attributable to potentially modifiable risk factors among U.S. adults aged 30 years and older, according to a study published online July 11 in CA: A Cancer Journal for Clinicians.Farhad Islami, M.D., Ph.D., from the American Cancer Society in A

For patients with private insurance undergoing diagnostic testing after prostate-specific antigen (PSA)-based screening, out-of-pocket costs are considerable and increased from 2010 to 2020, according to a study published online July 15 in Cancer.Arnav Srivastava, M.D., M.P.H., from the University of Michigan in Ann Arbor, and colleague

Five poultry workers in Colorado have been diagnosed with bird flu, state health officials reported Sunday."In coordination with the Colorado Department of Agriculture, the State Emergency Operations Center and Centers for Disease Control and Prevention, the Colorado Department of Public Health and Environment [CDPHE] is now reporting a total of

Women in the health care workforce are more likely to experience verbal abuse, sexual harassment, and bullying, while men are more likely to experience physical violence, according to a study published online July 2 in PLOS Global Public Health.Sioban Nelson, R.N., Ph.D., from the University of Toronto, and colleagues conducted a scopin

Tampon use is a potential source of metal exposure, according to a study published in the August issue of Environmental International.Jenni A. Shearston, Ph.D., from the School of Public Health at the University of California Berkeley, and colleagues compared the concentrations of 16 metal(loid)s (arsenic, barium, calcium, cadmium, co

Lupus is caused by a specific defect in the immune system that can be reversed, potentially curing the autoimmune disorder, a new study claims.The disease appears to be caused by malfunctions in an immune system pathway that regulates cells’ response to environmental pollutants, bacteria and toxins.Insufficient activation of this pathwa

Anorexia nervosa could be caused by lack of a specific brain chemical, reports a research team that has developed a possible cure for the eating disorder.Mouse studies have revealed that a deficit in acetylcholine, a neurotra

Colorado health officials on Tuesday confirmed a case of human plague in that state.The infection -- which occurred in Pueblo County, in the southern part of the state -- was&nbsp;first reported&nbsp;Friday ba

Few Americans understand the health risks of drinking raw milk, a new survey shows, so experts are redoubling efforts to get the word out on its dangers.The push dovetails with the discovery this spring of bird flu virus in milk from infected cows. The H5N1 virus is widespread in wild birds worldwide and is causing outbreaks in poultry and U.

During 2023, there were increases in the incidences of certain foodborne disease, which may reflect changes in diagnostic practices, according to research published in the July 4 issue of the U.S. Centers for Disease Control and Prevention Morbidity and Mortality Weekly Report.Hazel J. Shah, M.P.H., from the CDC in Atlanta, and colleague

In a trial involving patients with therapy-refractory cancer treated with approved targeted or immunotherapies, matched to their tumor molecular profile but outside their registered indications, those for whom a waiver was granted had similar serious adverse event rates and clinical benefit rates as those who did not receive a waiver, according to a stu

Pandemic-associated physician revenue recovery in 2021 and 2022 varied by specialty and practice type, according to a study published in the July issue of&nbsp;Health Affairs.Ravi B. Parikh, M.D., from the University of Pennsylvania in Philadelphia, and colleagues assessed pandemic-related impact on physician revenue (2020 to 2022) and h

Amid an ongoing outbreak of bird flu in dairy cows, a fourth case of H5N1 avian flu has been confirmed in another dairy worker, U.S. health officials reported Wednesday.The latest case was reported in Colorado, the U.S. Centers for Disease Control and Prevention said in a news release."As with previous cases, the person is a worker on a

U.S. health officials announced Tuesday that the federal government will pay Moderna $176 million to speed development of a pandemic flu vaccine based on mRNA technology.Such a vaccine could be used to treat bird flu in people, as concern grows about&nbsp;H5N1 cases spreading in dairy cows&nbsp;across the country, the U.S. Department of Health a

The mean cost of developing a new drug for the U.S. market is estimated to be $879.3 million when both drug development failure and capital costs are considered, according to a study published online June 28 in&nbsp;JAMA Network Open.Aylin Sertkaya, Ph.D., from Eastern Research Group Inc., in Lexington, Massachusetts, and colleagues ass

For individuals with Alzheimer disease (AD), the emergence of psychosis is associated with elevations in levels of plasma tau phosphorylated at threonine 181 (p-tau181), according to a study published online June 26 in JAMA Psychiatry.Jesus J. Gomar, Ph.D., and Jeremy Koppel, M.D., from the Feinstein Institutes for Medical Research in Ma

As bird flu continues to spread among U.S. dairy cows, reassuring new government research finds the pasteurization process widely used in the industry effectively kills all bird flu virus in milk.In a health update&nbsp;poste

The spread of H5N1 avian flu to dairy cows has health experts and many Americans on edge, and now a new study finds the virus stays viable on milking equipment for at least an hour.“Dairy cows have to be milked even if they are sick, and it has not been clear for how long the virus contained in residual milk from the milking process remains stab

Rare predicted loss-of-function (pLOF) variants and a polygenic risk score (PRS) are associated with increased atrial fibrillation (AF) risk, according to a study published online June 26 in JAMA Cardiology.Oliver B. Vad, M.D., from Copenhagen University Hospital–Rigshospitalet in Denmark, and colleagues examined rare pLOF variants as

The gut microbiome has a potential functional role in the pathogenesis of type 2 diabetes (T2D), according to a study published online June 25 in Nature Medicine.Zhendong Mei, Ph.D., from Brigham and Women's Hospital in Boston, and colleagues analyzed 8,117 shotgun metagenomes from 10 cohorts of individuals with T2D, prediabetes, and

The cumulative risk for advanced gastric cancer varies from 6.5 to 10.3 percent for carriers of germline CDH1 pathogenic/likely pathogenic (P/LP) variants, according to a study published online June 14 in the Journal of the American Medical Association to coincide with presentation at the International Gastric Cancer Linkage Consortiu

Cognitive impairment is delayed among persons who are heterozygous for the apolipoprotein E3 Christchurch variant (APOE3Ch), according to a study published in the June 20 issue of the New England Journal of Medicine.Yakeel T. Quiroz, Ph.D., from Massachusetts General Hospital in Boston, and colleagues analyzed data

A deadly bacterial infection known as streptococcal toxic shock syndrome (STSS) is spreading across Japan, officials in that country report.In March, Japan's National Institute of Infectious Diseases issued its first warning&nbs

In 2023, 7.6 percent of the U.S. civilian noninstitutionalized population was uninsured, according to early estimates from the National Health Interview Survey, 2023, released by the National Center for Health Statistics.Robin A. Cohen, Ph.D., from the National Center for Health Statistics in Hyattsville, Maryland, and colleagues used data from

In a success story for Americans seeking affordable healthcare coverage, tax credits put in place during the pandemic helped millions gain health insurance, a new report found.Trouble is, the credits are set to expire at the end of 2025, noted a research team from the nonprofit Robert Wood Johnson Foundation (RWJ).According to RWJ's <a h

Past-year Papanicolaou testing rates were lower in 2022 than in 2019, overall, and lower rates were seen in rural versus urban women, according to a study published in online June 14 in JAMA Network Open.Tyrone F. Borders, Ph.D., and Amanda Thaxton Wiggins, Ph.D., from the University of Kentucky in Lexington, examined receipt of a Papan

Second tumors are rarely seen after chimeric antigen receptor (CAR) T-cell therapy, according to a study published in the June 13 issue of the New England Journal of Medicine.Mark P. Hamilton, M.D., Ph.D., from Stanford University in California, and colleagues examined the occurrence of second tumors after CAR T-cell therapy since 2016.

Health care spending growth is projected to outpace that of the gross domestic product (GDP) during the coming decade, according to a study published online June 12 in Health Affairs.Jacqueline A. Fiore, Ph.D., from the Centers for Medicare &amp; Medicaid Services in Baltimore, and colleagues projected growth in national health expend

Select patients with progressive multiple sclerosis (MS) may benefit from mesenchymal stem cell-neural progenitors (MSC-NPs), according to a study published online May 23 in Stem Cell Research &amp; Therapy.Violaine K. Harris, Ph.D., from the Tisch Multiple Sclerosis Research Center of New York in New York City, and colleagues conduct

Generation X is experiencing larger per-capita increases in the incidence of cancers than Baby Boomers, according to a study published online June 10 in JAMA Network Open.Philip S. Rosenberg, Ph.D., and Adalberto Miranda-Filho, Ph.D., from the National Cancer Institute in Bethesda, Maryland, estimated invasive cancer incidence trends

A U.S. Food and Drug Administration advisory panel voted unanimously on Monday to recommend that the benefits of a new drug for Alzheimer's outweigh its harms, which can include brain swelling and bleeding.Eli Lilly's donanemab did slow declines in thinking skills in patients with early-stage Alzheimer's: <a href="https://www.fda.gov/media/1791

A novel blood-based lung cancer screening test has been developed and validated using genome-wide sequencing to analyze cell-free DNA (cfDNA) fragmentation profiles, according to a study published online June 3 in Cancer Discovery.Noting that changes in genome-wide cfDNA fragmentation profiles (fragmentomes) in peripheral blood reflect

Higher county-level prevalence of prostate-specific antigen (PSA) screening is associated with lower odds of advanced disease, all-cause mortality, and prostate cancer-specific mortality, according to a study published online June 4 in&nbsp;JAMA Network Open.Hari S. Iyer, Sc.D., from Rutgers Cancer Institute of New Jersey in New Brunswic

The U.S. Food and Drug Administration on Thursday asked states to work harder to protect the public from the risks of raw milk as a bird flu outbreak continues to spread among dairy cows.In an open letter to state and local officials,&nbsp;the agency urged more testing of&nbsp;her

Anthrax disease in humans is rare and when it does occur, it's usually during hot, dry summers.That's why the case of a Texas rancher who developed anthrax in January of this year piqued the interest of investigators at the U.S. Centers for Disease Control and Prevention.The rancher, who survived his ordeal, caught the anthrax germ after b

Lowering the fecal immunochemical test (FIT) positive threshold yields levels of sensitivity and specificity that are comparable to those reported for multitarget stool RNA (mt-sRNA) testing without the additional testing, according to a research letter published online June 1 in the Journal of the American Medical Association.Tobias

Excess mortality persisted in 2020 through 2022 in the Western world, according to a study published online June 3 in BMJ Public Health.Saskia Mostert, M.D., from Amsterdam UMC, and colleagues explored excess mortality in the Western world from 2020 to 2022 using all-cause mortality reports abstracted from the "Our World in Data" databa

As the H5N1 avian flu continues to spread among dairy cows in the United States, nearly 5 million doses of flu vaccine are now being prepared for possible use in humans.Since the outbreak in livestock began this spring, bird flu has been confirmed in three humans who worked on dairy farms in Texas and Michigan, and health experts are concerned th

Amid an ongoing outbreak of bird flu in dairy cows, there's been a third case of H5N1 avian flu confirmed in a dairy worker, U.S. health officials reported Thursday.The previous two human cases -- the first in Texas, the second in Michigan, where this latest case also occurred -- involved only a brief discomfort of the eyes, linked to conjuncti

From 2007 to 2019, there was an increase in inflation-adjusted health care spending, largely due to increasing contributions to premiums, according to a research letter published online May 28 in JAMA Internal Medicine.Sukruth A. Shashikumar, M.D., from the Beth Israel Deaconess Medical Center in Boston, and colleagues conducted a cro

Bird flu has been detected for the first time in alpacas, the U.S. Department of Agriculture (USDA) announced Tuesday.The animals that tested positive were on a farm in Idaho where poultry that had tested positive for the H5N1 virus were culled in May.&nbsp;The alpacas tested positive on May 16, the USDA's National Veterinary Services Laborato

A novel natural language understanding (NLU) pipeline can identify the rates of lymphedema and node positivity among women with estrogen receptor-positive (ER+), clinically node-negative (cN0) breast cancer, according to a study published online May 22 in JCO Clinical Cancer Informatics.Neil Carleton, from the UPMC Hillman Cancer Center

Primary human papillomavirus (HPV) screening intervals could be extended, with the risk for cervical precancer or worse (CIN2+) eight years after negative HPV screening comparable to risk after three years in cytology cohorts, according to a study published online May 22 in Cancer Epidemiology, Biomarkers &amp; Prevention.Anna Gottschlic

A U.S. Food and Drug Administration advisory panel on Thursday recommended the approval of a new blood test that can spot colon cancer.The panel voted 7-2 that the benefits outweigh the risks when using the Guardant Health's Shield test for&nbsp;colon cancer</a

Variation is seen in preparedness and response to highly pathogenic avian influenza (HPAI) A(H5N1) viruses, according to a research letter published online May 21 in the Journal of the American Medical Association.Noting that HPAI A(H5N1) clade 2.3.4.4b viruses pose pandemic potential, Noah Kojima, M.D., from the U.S. Centers for Diseas

In a systematically screened population, there is no association between autoimmune disease and monoclonal gammopathy of undetermined significance (MGUS), according to a study published online May 21 in the Annals of Internal Medicine.Ingigerdur Sverrisdottir, M.D., from the University of Iceland in Reykjavik, and colleagues conducted a

Individuals with BRCA1-associated protein (BAP1) have a high rate of nail abnormalities consistent with onychopapillomas, according to a study published online May 17 in JAMA Dermatology to coincide the annual meeting of the Society for Investigative Dermatology, held from May 15 to 18 in Dallas.Alexandra Lebensohn, from the Nat

There is a high level of approval for use of polygenic embryo screening, according to a study published online May 14 in JAMA Network Open.Rémy A. Furrer, Ph.D., from the Center for Bioethics at Harvard Medical School in Boston, and colleagues surveyed U.S. adults to examine general attitudes, interests, and concerns relating to use of P

Male and female V1421 carriers face a similar and substantial risk for heart failure hospitalization, according to a study published online May 12 in the Journal of the American Medical Association to coincide with the European Society of Cardiology Heart Failure 2024, held from May 11 to 14 in Lisbon, Portugal.Noting that individual s

Non-Hispanic Black (NHB) melanoma patients have distinct tumor characteristics, presenting with more advanced disease and exhibiting worse outcomes, according to a study published in the May issue of the Journal of Surgical Oncology.Jessica A. Steadman, M.B.B.S., from the Mayo Clinic in Rochester, Minnesota, and colleagues examined fe

In its biennial Cancer Disparities Progress Report published today, the American Association for Cancer Research presents the latest statistics on disparities in cancer progress experienced by ethnic-minority groups and other medically underserved populations in the United States.Robert A. Winn, M.D., from the Virginia Commonwealth Un

The U.S. Food and Drug Administration has approved a kit that will allow women to collect their own vaginal sample for HPV screening, a move that could increase early detection in those at risk for cervical cancer.Women will be able to swab thems

San Francisco is on the verge of passing a ban on "forever chemicals" in the protective clothing firefighters wear while battling blazes.City lawmakers are expected to pass an ordinance on Tuesday&nbsp

Physicians with disabilities (PWDs) are significantly more likely to experience depersonalization but not emotional exhaustion when compared with their peers without disabilities, according to a research letter published online May 9 in&nbsp;JAMA Network Open.Lisa M. Meeks, Ph.D., from the University of Michigan Medical School in Ann Arb

The U.S. Department of Agriculture and U.S. Department of Health &amp; Human Services have jointly announced a myriad of initiatives aimed at preventing the H5N1 avian flu virus, currently infecting U.S. dairy cows, from mutating and spreading in humans.The illness is typically not fatal in bovines, but monitoring and prevention on the nation's f

Ascension, a major U.S. health care system with 140 hospitals in 19 states, announced late Thursday that a cyberattack has caused disruptions at some of its hospitals."Systems that are currently unavailable include our electronic health records system, MyChart (which enables patients to view their medical records and communicate with their provid

A total of 113 novel genetic loci have been identified in the largest single-stage common variant genome-wide association study of blood pressure (BP) reported to date, according to a study published online April 30 in Nature Genetics.Jacob M. Keaton, Ph.D., from the National Institutes of Health in Bethesda, Maryland, and colleagues exa

Hematopoietic cell transplantation (HCT) use has increased among all racial/ethnic groups and has increased faster among non-Hispanic African Americans (NHAAs) and Hispanics than non-Hispanic Whites (NHWs), according to a study published online April 25 in Blood Advances.Nandita Khera, M.D., from the Mayo Clinic in Phoenix, and colleagues

CD7 expression is associated with poorer outcomes in patients with newly diagnosed acute myeloid leukemia (AML), according to a study published online April 11 in the British Journal of Haematology.Wei-Ying Jen, B.M., B.Ch., from the University of Texas MD Anderson Cancer Center in Houston, and colleagues collected flow cytometry data on

Doctors in Texas are describing the only known human case of H5N1 avian flu connected to the ongoing outbreak of the disease in dairy cows.Bird flu in humans remains extremely rare, but in the hundreds of cases documented worldwide over the past few years, about half proved fatal -- upping scientists' concerns about the possibility that an easily

A genome-wide association study meta-analysis, published online April 26 in Nature Genetics, has identified 63 susceptibility regions containing 108 independent risk loci for kidney cancer.Mark P. Purdue, Ph.D., from the National Cancer Institute in Rockville, Maryland, and colleagues conducted a multi-ancestry genome-wide association s

Adherence to healthy lifestyles can largely overcome the genetic risk for a shorter lifespan, according to a study published online April 29 in BMJ Evidence Based Medicine.Zilong Bian, from the Zhejiang University&nbsp;School of Medicine in&nbsp;Hangzhou, China, and colleagues investigated associations of genetic and lifestyle factors

A random-forest, machine-learning classifier, artificial intelligence-Model organism Aggregated Resources for Rare Variant ExpLoration (AI-MARRVEL), achieves superior accuracy compared with existing methods for genetic diagnosis, according to a study published online in the May issue of NEJM AI.Dongxue Mao, Ph.D., from the Baylor Colle

On Monday, the U.S. Department of Agriculture announced that it is now testing ground beef for any presence of the H5N1 virus that continues to spread among dairy cows.The agency said it is sampling ground beef bought in grocery stores in states where dairy cattle have tested positive for the virus, also known as H5N1, CNN reported. O

H5N1 avian "bird" flu is making headlines this week, with new reports finding inactive virus detected in 1 in 5 U.S. milk samples. That means the virus is infecting mammals such as dairy cows, and now res

Laboratory tests used by millions of Americans are soon to be classified as medical devices, and as such be regulated by the U.S. Food and Drug Administration, the agency announced Monday.The new rule does not apply to tests and kits made by big medical device manufacturers -- those already face FDA review. Instead, the agency is widenin

Bits of bird flu virus have been discovered in roughly 20% of retail milk samples tested in a national survey, the U.S. Food and Drug Administration said Thursday.The finding suggests that bird flu has spread far more widel

The spatial distribution, timing, and magnitude of tau burden differs for people with Down syndrome and those with autosomal-dominant Alzheimer disease, according to a study published in the May issue of The Lancet Neurology.Julie K. Wisch, Ph.D., from Washington University in St. Louis, and colleagues conducted a cross-sectional obs

For almost all patients with sickle cell disease, treatment with exagamglogene autotemcel (exa-cel) eliminates vaso-occlusive crises, according to a study published in the April 24 issue of the New England Journal of Medicine.Haydar Frangoul, M.D., from the Sarah Cannon Research Institute at the Children's Hospital at TriStar Centenn

As bird flu continues to spread among dairy cows in the United States, the U.S. Department of Agriculture said Wednesday it will start requiring testing of the animals if they are moved across state lines. The "USDA has identified [bird flu] spread between cows within the same herd, spread from cows to poultry, spread between dairies associat

Bits of inactive bird flu virus have been discovered in samples of pasteurized milk from across the United States, health officials said Tuesday, although they stressed the viral fragments don't threaten humans.However, the U.S. Food and Drug Administration did note that testing suggests that bird flu has likely infected far more dairy cows

A new prostate cancer test has higher diagnostic accuracy for high-grade disease than current guideline-endorsed biomarkers, according to a study published online April 18 in JAMA Oncology.Jeffrey J. Tosoian, M.D., M.P.H., from Vanderbilt University Medical Center in Nashville, Tennessee, and colleagues developed a multiplex urinary pa

The H5N1 avian flu virus that's infecting U.S. cattle is increasingly showing up in mammals -- a dangerous sign that it could someday easily infect people.That's the warning issued late last week by World Health Organization chief scientist Dr. Jeremy Farrar, CNN reported.“We have to watch, more than watch, we have to make sure

Two common PFAS "forever chemicals" have been deemed hazardous substances by the Environmental Protection Agency.The new designation, enacted under the country's <a href="https://www.epa.gov/laws-regulations/summary-comprehensive-environmental-response-compensation-and-liability-act#:~:text=The%20Comprehensive%20Environmental%20Response%2C%20Co

For patients with early-stage triple-negative breast cancer (TNBC) who undergo surgery without chemotherapy, tumor-infiltrating lymphocyte (TIL) abundance is associated with improved survival, according to a study published online April 2 in the Journal of the American Medical Association.Roberto A. Leon-Ferre, M.D., from the Mayo Cl

Heritability for autism spectrum disorder (ASD) varies for males and females, with higher heritability seen for males than females, according to a study published online April 17 in JAMA Psychiatry.Sven Sandin, Ph.D., from the Karolinska Institutet in Stockholm, and colleagues estimated the sex-specific heritability of ASD in a popu

Certain demographic, clinical, and genetic factors heighten the risk for extraintestinal manifestations (EIMs) with inflammatory bowel disease (IBD), according to a study published online March 13 in&nbsp;Gastroenterology.Michelle Khrom, from Cedars-Sinai Medical Center in Los Angeles, and colleagues investigated the clinical, serol

Subclassification of individuals at high risk for pancreatic adenocarcinoma (PC) can enable the development of surveillance approaches better tailored to risk, according to a study published online April 16 in the Journal of the National Comprehensive Cancer Network.George Zogopoulos, M.D., Ph.D., from McGill University Health Cente

The Biden Administration announced Tuesday that it will work with 50 nations worldwide to try to prevent global pandemics such as COVID-19, which brought the world to a standstill four years ago."Today, I am proud to announce that my Administra

Working-age adults in the United States are dying at higher rates than their peers in high-income countries, according to a study published online March 21 in the&nbsp;International Journal of Epidemiology.Jennifer Beam Dowd, Ph.D., from the University of Oxford in the United Kingdom, and colleagues synthesized cause-specific mortalit

Mailed at-home self-sampling for&nbsp;human papillomavirus&nbsp;(HPV) testing&nbsp;increases cervical cancer screening participation in underscreened populations by almost threefold, according to a study presented at the annual meeting of the American Association for Cancer Research, held from April 5 to 10 in San Diego.Jane R. Montealegre, Ph.

The Environmental Protection Agency announced Wednesday that it has finalized a first-ever rule that will drastically lower the amount of PFAS, also known as "forever chemicals," in the nation's drinking water.“Drinking water contaminated with PFAS has plagued communities across this country for too long,”&nbsp;EPA Administrator <a href="htt

The novel viral-based personalized cancer vaccine, TG4050, which encodes up to 30 patient- and tumor-specific sequences is feasible and safe for patients with resected head and neck squamous cell carcinoma, according to a study presented at the annual meeting of the American Association for Cancer Research, held from April 5 to 10 in San Diego.

Accelerated aging (AA) is increasing and is associated with an increased incidence of early-onset solid tumors, according to a study presented at the annual meeting of the American Association for Cancer Research, held from April 5 to 10 in San Diego.Ruiyi Tian, M.P.H., from the Washington University School of Medicine in St. Louis, and colleag

An exosome-based liquid biopsy assay can distinguish patients with pancreatic ductal adenocarcinoma (PDAC) from healthy donors (HDs), according to a study presented at the annual meeting of the American Association for Cancer Research, held from April 5 to 10 in San Diego.Caiming Xu, M.D., Ph.D., from the Beckman Research Institute of The City o

A single invitation for prostate-specific antigen (PSA) screening is associated with reduced prostate cancer deaths, although the absolute reduction is small, according to a study published online April 6 in the Journal of the American Medical Association to coincide with the 39th Annual European Association of Urology Congress, held from Apri

For patients with clinically node-negative breast cancer with sentinel-node macrometastases, the omission of completion axillary-lymph-node dissection is noninferior to more extensive surgery, according to a study published in the April 4 issue of the New England Journal of Medicine.Jana de Boniface, M.D., Ph.D., from the Karolinska I

When a soldier is rushed to medical care following a blast or other injury to the head, time is crucial in deciding just how extensive that injury is.Now, the U.S. Army has announced that the U.S. Food and Drug Administration has cleared a bedside whole blood test that can answer that question in about 15 minutes.Prior tests relied on

High levels of glucose and triglycerides are associated with future risk for depression, anxiety, and stress-related disorders, according to a study published online April 2 in JAMA Network Open.Charilaos Chourpiliadis, M.D., from the Karolinska Institutet in Stockholm, and colleagues conducted a population-based cohort study with long

A recently developed multivariable model can accurately predict smoldering multiple myeloma (SMM) or worse in persons with presumed monoclonal gammopathy of undetermined significance (MGUS), according to a study published online April 2 in the Annals of Internal Medicine.Elias Eythorsson, M.D., Ph.D., from the University of Iceland in R

A regional collaborative involving universal decolonization in long-term care facilities and targeted decolonization among hospital patients in contact precautions is associated with better multidrug-resistant organism (MDRO)-related outcomes, according to a study published online April 1 in the&nbsp;Journal of the American Medical Association

There has been a rise in invasive meningococcal disease, mainly attributable to Neisseria meningitidis serogroup Y, according to an alert issued by the U.S. Centers for Disease Control and Prevention.There were 422 cases of invasive meningococcal disease in 2023, the most seen since 2014. So far this year, 143 cases have already been r

U.S. physicians received $12.13 billion from industry from 2013 to 2022, according to a research letter published online March 28 in the Journal of the American Medical Association.Ahmed Sayed, M.B.B.S., from Ain Shams University in Cairo, and colleagues examined the distribution of payments within and across specialties and the medica

The daily step count needed to reduce the risk for obesity varies based on an individual's genetic risk for higher body mass index (BMI), according to a study published online March 27 in JAMA Network Open.Evan L. Brittain, M.D., from the Vanderbilt University Medical Center in Nashville, Tennessee, and colleagues conducted a retrospec

For older patients with acute myeloid leukemia (AML) undergoing allogeneic hematopoietic cell transplantation (allo-HCT), posttransplant outcomes have improved over time, according to a study published online March 22 in Clinical Cancer Research.Ali Bazarbachi, Ph.D., M.P.H., from the American University of Beirut Medical Center in L

Fewer than half of adults have a follow-up colonoscopy within six months following an abnormal stool-based screening test (SBT) for colorectal cancer (CRC), according to a study published online March 25 in JAMA Network Open.Elizabeth L. Ciemins, Ph.D., M.P.H., from the American Medical Group Association in Alexandria, Virginia, and

Male and female p.C282Y homozygotes, including those undiagnosed with hemochromatosis, have increased morbidity risks, according to a study published in the March issue of BMJ Open.Mitchell R. Lucas, from the University of Exeter in the United Kingdom, and colleagues conducted a prospective cohort study in the U.K. Biobank (2006 to

Global adult mortality rates increased during the COVID-19 pandemic, reversing previous decreasing trends, according to a study published online March 11 in The Lancet.Austin E. Schumacher, Ph.D., from the Institute for Health Metrics and Evaluation in Seattle, and colleagues examined changes in mortality and life expectancy from 1950

Intrathecal gene transfer with scAAV9/JeT-GAN may result in some benefit for children with giant axonal neuropathy, according to a study published in the March 21 issue of the New England Journal of Medicine.Diana X. Bharucha-Goebel, M.D., from the National Institutes of Health in Bethesda, Maryland, and colleagues conducted an intrath

A high proportion of individuals with synucleinopathies has positivity for cutaneous phosphorylated α-synuclein, according to a study published online March 20 in the Journal of the American Medical Association.Christopher H. Gibbons, M.D., from Harvard Medical School in Boston, and colleagues examined the positivity rate of cutaneous

Up-to-date cervical cancer screening is lower in rural than urban community health centers (CHCs), with the differences mainly due to CHC-level characteristics, according to a study published online March 25 in Cancer.Hyunjung Lee, Ph.D., from the American Cancer Society in Atlanta, and colleagues examined rural-urban differences in ce

FRIDAY, March 22, 2024 (HealthDay News) --&nbsp;ChatGPT accurately answers questions about genetic syndromes, genetic testing, and counseling, according to a study presented at the Society of Gynecologic Oncology Annual Meeting on Women's Cancer, held from March 16 to 18 in San Diego.Jharna M. Patel, M.D., from New York University Langone Health in New York City, and colleagues examined

Systemic inflammation is associated with an elevated risk for chronic kidney disease, according to a study published online Feb. 20 in&nbsp;Frontiers in Immunology.Xiaoxin Liu, from Tongji Medical College at the Huazhong University of Science and Technology in Wuhan, China, and colleagues investigated the relationship between the syste

Life expectancy increased to 77.5 years in 2022, while the age-adjusted rate of drug overdose deaths increased from 2002 to 2022 but did not change from 2021 to 2022, according to two March data briefs published by the National Center for Health Statistics.Kenneth D. Kochanek, from the National Center for Health Statistics in Hyattsville, Mar

Neutralizing anti-interleukin-23 is associated with severe, persistent, opportunistic infections, according to a study published in the March 21 issue of the New England Journal of Medicine.Noting that interleukin-12 shares a common subunit with interleukin-23, Aristine Cheng, M.D., from the National Institute of Allergy and Infectio

Some U.S. government personnel have reported dizziness, pain, visual problems, and cognitive dysfunction after experiencing intrusive sounds and head pressure, termed anomalous health incidents (AHIs), but no differences are seen in terms of clinical, research, and biomarker assessments or in magnetic resonance imaging (MRI) modalities compared with c

Polygenic risk scores (PRSs) derived from the general population are associated with a subsequent risk for certain cancers among survivors of childhood cancer, with an additive risk for PRS and radiotherapy, according to a study published online March 7 in Nature Medicine.Todd M. Gibson, Ph.D., from the National Cancer Institute in Bet

A cell-free DNA (cfDNA) blood-based test has sensitivity of 83.1 percent for detection of colorectal cancer and specificity of 89.6 percent for any advanced neoplasia, according to a study published in the March 14 issue of the New England Journal of Medicine.Daniel C. Chung, M.D., from Massachusetts General Hospital and Harvard Medica

A next-generation multitarget stool DNA test has higher sensitivity for colorectal cancer and advanced precancerous lesions than fecal immunochemical testing (FIT), according to a study published in the March 14 issue of the New England Journal of Medicine.Thomas F. Imperiale, M.D., from the Indiana University School of Medicine in I

Middle-aged veterans with blast-related mild traumatic brain injury (mTBI) have reduced levels of cerebrospinal fluid (CSF) β-amyloid (Aβ), according to a study published online March 13 in Neurology.Ge Li, M.D., Ph.D., from the Veterans Affairs Northwest Mental Illness Research, Education, and Clinical Center in Seattle, and colleag

Following a cyberattack on one of the nation's largest health insurers that's thrown health care payments into disarray and likely exposed reams of private patient data, the U.S. Department of Health and Human Services said Wednesday it has begun an investigation into the incident.In a&nbsp;<a href="https://www.hhs.gov/about/news/2024/03/13/h

Lower, stable maternal mortality rates are seen on identification of maternal deaths by requiring mention of pregnancy among multiple causes of death, according to a study published online March 12 in the American Journal of Obstetrics &amp; Gynecology.K.S. Joseph, M.D., Ph.D., from the University of British Columbia in Vancouver, C

Following a cyberattack on the largest health insurer in the United States last month, health care providers continue to scramble as insurance payments and prescription orders continue to be disrupted and physicians lose an estimated $100 million a day.That <a href="https://www.ama-assn.org/press-center/press-releases/cyberattack-jeopardizes

Three pesticides (lindane, simazine, and atrazine) are associated with Parkinson disease (PD) in the Rocky Mountains/Great Plains region of the United States, according to a study scheduled for presentation at the annual meeting of the American Academy of Neurology, to be held from April 13 to 18 in Denver.Alexia Lapadat, Ph.D., from Amherst Co

There are notable concerns relating to the use of currently available artificial intelligence (AI) dermatology mobile applications (apps), according to a study published online March 7 in JAMA Dermatology to coincide with the annual meeting of the American Academy of Dermatology, held from March 8 to 10 in San Diego.Shannon Wongvibulsin

More Americans exposed to radiation caused by the government would be compensated under a bill that passed the U.S. Senate Thursday.The bipartisan legislation, which would cost an estimated $50 billion, would expand the <a href="https://www.justice.gov/civil/common/reca"

The perpetrator of a mass shooting in Maine last fall had extensive brain damage from "thousands of low-level blasts" tied to his work at an Army Reserve hand grenade training range, a new report shows.On Oct. 25, Robert Card, 40, killed 18 and injured another 13 in a deadly rampage in the town of Lewiston after opening fire in a bowling alley