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HealthDay 30 November at 09.59 PM

Psychiatric Comorbidity Increases Risk for Schizophrenia With ADHD


THURSDAY, Nov. 30, 2023 (HealthDay News) -- The presence of psychiatric comorbidity in young patients with attention-deficit/hyperactivity disorder (ADHD) is associated with a higher risk for being diagnosed with schizophrenia, according to a study published online Nov. 30 in JAMA Network Open.

Soo Min Jeon, Pharm.D., Ph.D., from Jeju National University in South Korea, and colleagues assessed the risk for being diagnosed with schizophrenia among children and adolescents with ADHD. The analysis included 211,705 children and adolescents (ages 5 to 19 years) who received an ADHD diagnosis in 2010 through 2018.

The researchers found that patients with psychiatric comorbidity had a significantly higher risk for being diagnosed with schizophrenia than those without (adjusted hazard ratio, 2.14) in a dose-response manner. Several individual psychiatric disorders were associated with incident schizophrenia, including autism spectrum disorder, intellectual disability, tic disorder, depression, and bipolar disorder. Three-fourths of patients (73.8 percent) without psychiatric comorbidities experienced the emergence of other psychiatric disorders before developing schizophrenia.

"These findings highlighted the significance of carefully monitoring psychiatric comorbidities in patients with ADHD to effectively mitigate the burden of schizophrenia," the authors write.

Abstract/Full Text

#Psychiatry #Attention-deficit hyperactivity disorder, unspecified type (F90.9) #Attention-deficit hyperactivity disorder, other type (F90.8) #Attention-deficit hyperactivity disorder, predominantly hyperactive type (F90.1) #Attention-deficit hyperactivity disorders (F90) #Attention-deficit hyperactivity disorder, predominantly inattentive type (F90.0) #Schizophrenia, unspecified (F20.9) #Schizophrenia (F20) #Paranoid schizophrenia (F20.0) #Other schizophrenia (F20.89) #Schizoaffective disorder, unspecified (F25.9) #Disorganized schizophrenia (F20.1) #Mental disorder, not otherwise specified (F99) #Unspecified psychosis not due to a substance or known physiological condition (F29) #Autistic disorder (F84.0) #Unspecified intellectual disabilities (F79) #Moderate intellectual disabilities (F71) #Mild intellectual disabilities (F70) #Other intellectual disabilities (F78) #Severe intellectual disabilities (F72) #Tic disorder, unspecified (F95.9) #Depression, unspecified (F32.A) #Bipolar disorder, unspecified (F31.9) #Bipolar disorder, current episode manic severe with psychotic features (F31.2)
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