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HealthDay 18 January at 11.04 PM

Risk for Cancer Increased for Relatives of Patients With Leukemia


THURSDAY, Jan. 18, 2024 (HealthDay News) -- Relatives of patients with myelodysplastic neoplasia (MDS), acute myeloid leukemia (AML), or acute lymphoblastic leukemia (ALL) have an increased risk for cancer, according to a study published in the February issue of Cancer Epidemiology.

Nikolaj Juul Nitschke, from Copenhagen University Hospital in Denmark, and colleagues estimated the relative risk for cancer among relatives of patients with MDS/AML/ALL using linked data from the Danish Civil Registration System and the Danish Cancer Registry, the Danish National Acute Leukemia Registry, and the Danish Myelodysplastic Syndrome Database. Standardized incidence ratios (SIRs) were calculated as a measure of relative risk.

A total of 13,010 first-degree relatives (FDRs) and 22,051 second-degree relatives (SDRs) of 8,386 patients with MDS/AML/ALL were identified. The researchers found that the relative risk for cancer overall, excluding basal cell carcinoma (BCC), was increased among FDRs and SDRs (SIRs, 1.3 and 1.5), respectively. Among FDRs, SIRs were significantly increased for malignant melanoma, BCC, and the combined group of cancers of the male genital organs, urinary tract, and MDS/AML/ALL. SIRs were significantly increased for malignant melanoma, BCC, and cancers in the digestive organs and peritoneum among SDRs.

"We speculate that to some extent the increased cancer risk reflects polygenic cancer predisposition possibly interacting with environmental factors," the authors write.

Abstract/Full Text

#Internal Medicine #Family Practice #Hematology & Oncology #Myeloid leukemia, unspecified, not having achieved remission (C92.90) #Chronic myeloid leukemia, BCR/ABL-positive, not having achieved remission (C92.10) #Acute myelomonocytic leukemia, not having achieved remission (C92.50) #Other myeloid leukemia not having achieved remission (C92.Z0) #Myeloid leukemia, unspecified in remission (C92.91) #Acute myeloblastic leukemia, not having achieved remission (C92.00) #Acute myeloblastic leukemia, in remission (C92.01) #Acute lymphoblastic leukemia not having achieved remission (C91.00) #Acute lymphoblastic leukemia [ALL] (C91.0) #Acute lymphoblastic leukemia, in remission (C91.01) #Acute lymphoblastic leukemia, in relapse (C91.02) #Leukemia, unspecified not having achieved remission (C95.90) #Acute leukemia of unspecified cell type not having achieved remission (C95.00) #Myelodysplastic syndrome, unspecified (D46.9) #Myelodysplastic disease, not classified (C94.6) #Other myelodysplastic syndromes (D46.Z) #Myelodysplastic syndromes (D46) #Myelodysplastic syndrome with isolated del(5q) chromosomal abnormality (D46.C) #Basal cell carcinoma of skin, unspecified (C44.91) #Basal cell carcinoma of skin of unspecified upper limb, including shoulder (C44.611) #Basal cell carcinoma of skin of upper limb, including shoulder (C44.61) #Basal cell carcinoma of skin of right upper limb, including shoulder (C44.612) #Basal cell carcinoma of skin of scalp and neck (C44.41) #Systemic inflammatory response syndrome (SIRS) of non-infectious origin without acute organ dysfunction (R65.10) #Malignant melanoma of skin, unspecified (C43.9) #Malignant melanoma of right lower limb, including hip (C43.71) #Malignant melanoma of right upper limb, including shoulder (C43.61) #Malignant melanoma of scalp and neck (C43.4) #Malignant melanoma of unspecified upper limb, including shoulder (C43.60) #Malignant neoplasm of male genital organ, unspecified (C63.9) #Malignant neoplasm of female genital organ, unspecified (C57.9) #Secondary malignant neoplasm of genital organs (C79.82) #Malignant neoplasm of uterus, part unspecified (C55) #Neoplasm of unspecified behavior of other genitourinary organs (D49.5) #Systemic inflammatory response syndrome (SIRS) of non-infectious origin with acute organ dysfunction (R65.11) #Malignant melanoma of left lower limb, including hip (C43.72) #Malignant melanoma of skin (C43) #Malignant neoplasm of ill-defined sites within the digestive system (C26.9) #Neoplasm of unspecified behavior of digestive system (D49.0) #Malignant neoplasm of other and ill-defined digestive organs (C26) #Secondary malignant neoplasm of other digestive organs (C78.89) #Secondary malignant neoplasm of unspecified digestive organ (C78.80)
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