Synaptic-like Mechanism in Neurovascular Coupling: Researchers identified a synaptic-like transmission at neural-arteriolar junctions crucial for neurovascular coupling.

NMDA Receptors in Arterioles: Functional NMDA receptors, important in neurotransmitter modulation, were found in the smooth muscle cells of arterioles across multiple species.

Dual Innervation at NsMJs: Presynaptic boutons simultaneously innervate postsynaptic dendrites and arteriolar smooth muscle cells, expressing various neuromediator receptors.

Effects of Disrupting NsMJ Transmission: Eliminating the GluN1 subunit in smooth muscle cells reduced hyperemia and brain atrophy following cerebral ischemia by preventing calcium overload.

Implications for Stroke Research: The discovery highlights a key role in neurovascular coupling and has potential implications for stroke research and treatment development.