Damage to cell membranes causes cell aging

Cellular Senescence Discovery: The study reveals a previously unknown outcome of cell membrane damage – cellular senescence, altering the understanding of cell fate regulation.

Extent of Damage and Calcium Ion Influx: The degree of membrane damage and subsequent calcium ion influx dictate cell fate, determining whether cells repair, undergo apoptosis, or become senescent.

Impact on Cell Division: Moderate membrane damage induces senescence even after successful resealing, affecting cell division capacity and potentially contributing to aging-related processes.

Senescent Cell Functions: Senescent cells remain metabolically active and produce various secretory proteins, influencing immune responses, wound healing, cancer progression, and aging-related changes in the body.

Implications for Longevity Strategies: Understanding the role of cell membrane damage in inducing senescence offers insights for developing strategies to promote healthy longevity, potentially targeting senescent cell removal for rejuvenation.