All articles tagged: Oncology & Cancer

A new study from researchers at The University of Texas MD Anderson Cancer Center finds that, in healthy women, some breast cells that otherwise appear normal may contain chromosome abnormalities typically associated with invasive breast cancer. The findings question conventional thinking on the genetic origins of breast cancer, which could influence early cancer detection methods.

A new pathology tool created at Yale harnesses barcode technology and shows potential for use in cancer diagnoses. The technology, Patho-DBiT (pathology-compatible deterministic barcoding in tissue), was discussed in a new study published in the journal Cell.

Researchers at Karolinska Institutet have found a molecule that can both help the intestines to heal after damage and suppress tumor growth in colorectal cancer. The discovery could lead to new treatments for inflammatory bowel disease (IBD) and cancer.

Immunotherapy is a promising treatment that recruits the immune system to help fight cancer, but it has had limited success in gastrointestinal cancers. Now, researchers at Washington University School of Medicine in St. Louis have engineered a probiotic that delivers immunotherapy directly to the gut to shrink tumors in mice, offering a potentially promising oral drug for hard-to-reach cancers.

Researchers at the University of British Columbia (UBC), BC Cancer, Harvard Medical School and Memorial Sloan Kettering Cancer Center (MSK) have pinpointed what could be the early genetic origins of breast cancer—cancer-like mutations appearing in the cells of healthy women.

Cancer researchers at the University of Chicago and the University of California, San Francisco (UCSF) have discovered that mutations in certain genes can lead to the accumulation of DNA errors, resulting in a specific type of genetic change known as large tandem duplications (TDs) that can arise from the collision of two critical cellular processes: transcription and DNA replication.

A type of immunotherapy appears to be effective in treating a deadly subset of thyroid cancer, according to the results of a clinical trial published in JAMA Oncology.

Experts have been concerned by rising rates of pancreatic cancer in young adults, but new research reveals the jump in cases has not been accompanied by any increase in deaths from the disease.

A new study led by scientists from the Northwestern Medicine Canning Thoracic Institute and published in the Journal of Clinical Investigation has revealed a connection between COVID-19 infection and cancer regression. The team's discovery could pave the way for novel cancer treatments.

More people with lung cancer are living longer, but it remains America's deadliest cancer, a new state-by-state report shows.

Results from a randomized, phase 2 clinical trial show that adding high-dose, intravenous (IV) vitamin C to chemotherapy doubles the overall survival of patients with late-stage metastatic pancreatic cancer from eight months to 16 months.

Norway ranks third in the world when it comes to the incidence of melanoma (formerly called mole cancer) and has the highest mortality from this disease in Europe.

Cases of mouth cancer have reached a record high in England and Scotland, a new report shows. Last year, there were more than 10,000 new cases.

One-third of HER2-positive (HER2+) tumors express the P95HER2 protein, which associates with an aggressive form of breast cancer with a poorer prognosis. Investigators of the Vall d'Hebron Institute of Oncology's (VHIO) Growth Factors Group, in collaboration with researchers of the Cancer Research Program of Hospital del Mar Research Institute (HMRI), Barcelona, have developed a novel chimeric ant

Each cell in our body experiences up to tens of thousands of DNA-damaging events per day, primarily from routine cellular maintenance or exposure to toxins in our environment. Despite the high frequency of wear-and-tear, cells have efficient repair mechanisms that work tirelessly, allowing our bodies to maintain our DNA in each one of our cells throughout our lifetimes.

Researchers at Karolinska Institutet have investigated how well different AI models can predict the prognosis of triple-negative breast cancer by analyzing certain immune cells inside the tumor. The study, published in the journal eClinicalMedicine, is an important step toward using AI in cancer care to improve patient health.

Gastric cancer (GC) is a lethal malignancy with worldwide occurrence, and is considered endemic in eastern Asian, eastern European and South American countries. Indeed, in my home country, Chile, GC is the leading cause of cancer death in men.

An experimental vaccine could offer fresh hope to women diagnosed with an aggressive and hard-to-treat form of breast cancer, new research suggests.

Researchers at the University of Toronto's Faculty of Applied Science & Engineering have designed a new microfluidic platform that allows for unprecedented control and manipulation of tumor shapes—a largely unexplored area with great potential to advance cancer research.

A study published inClinical Cancer Research found that in patients with unresectable, locally advanced esophageal cancer, the triple combination of radiation, chemotherapy, and immunotherapy made tumors more amenable to surgery, which was associated with significantly improved outcomes.

Former winner of TV show Alone Australia Gina Chick was diagnosed with breast cancer just days after finding out she was pregnant. She describes in her recent book her experience with chemotherapy and what followed.

Dr. Cornelia Peterson is dedicated to finding treatments for cancer by researching tumors that develop in Meibomian glands, the specialized oil-secreting glands of the eyelid. She joined Cummings School of Veterinary Medicine at Tufts University's faculty a year and a half ago as an assistant professor of anatomic pathology in the Department of Comparative Pathobiology, establishing her own lab at

Immunotherapy, which enhances the immune system's T cell response to eliminate cancer cells, has emerged as a key approach in cancer treatment. However, in the case of glioblastoma, an aggressive and treatment-resistant brain tumor, numerous clinical trials have failed to confirm its efficacy.

Researchers at Helmholtz Munich, in collaboration with colleagues at Tohoku University, have identified a specific redox protein as a critical regulator of ferroptosis—a form of regulated oxidative cell death. Ferroptosis has garnered strong interest due to its therapeutic potential in addressing therapy-resistant and metastasizing cancers, and its involvement in neurodegenerative diseases.

To determine the type and severity of a cancer, pathologists typically analyze thin slices of a tumor biopsy under a microscope. But to figure out what genomic changes are driving the tumor's growth—information that can guide how it is treated—scientists must perform genetic sequencing of the RNA isolated from the tumor, a process that can take weeks and costs thousands of dollars.

Breast cancer is a major health concern worldwide, and early detection is crucial for effective treatment. Traditional imaging methods, such as mammography, have limitations, especially for women with dense breast tissue. Photoacoustic imaging, which combines light and sound to create detailed images of breast tissue, offers a promising alternative. However, recent research has highlighted a signi

An international, multidisciplinary team of leading neuro-oncology researchers and clinicians has released new recommendations for good clinical practice—a set of guidelines that helps ensure clinical trial results are reliable, and patients are protected—regarding the use of artificial intelligence methods to more accurately diagnose, monitor and treat brain cancer patients.

It's well documented that firefighters have significantly higher rates of cancer than the general population, and these elevated rates have been associated with exposures to toxic chemicals on the job. However, most research on cancer in firefighters has been done in men and less is known about the risks in women.

A team led by Dr. Yuri Tolkach at the University of Cologne's Faculty of Medicine and University Hospital Cologne has investigated prostate tumors and developed an advanced, realistic, three-dimensional model of prostate cancer with the help of mathematical modeling.

By exploiting the genetic variation in cancer cells, an already approved cancer drug demonstrated enhanced effects against cancer cells in specific patient groups. This is shown in a study by Uppsala University, published in the journal eBiomedicine. The findings suggest a potential for more individually tailored and more effective cancer therapies.

Hepatocellular carcinoma, a type of liver cancer, is the sixth most common cancer worldwide and the third leading cause of cancer-related deaths. Screening efforts for this cancer focus on individuals diagnosed with viral hepatitis or those known to have irreversible liver scarring, or cirrhosis.

Most cancer treatments—from chemotherapies to engineered immune cells—have a host of side effects, in large part because they affect healthy cells in the body at the same time as targeting tumor cells. For the same reason, designing new cancer drugs can be challenging due to the molecular similarities between tumor cells and healthy cells.

Researchers at the LKS Faculty of Medicine of the University of Hong Kong (HKUMed) have discovered a significant association between specific Epstein-Barr virus (EBV) variants and nasopharyngeal carcinoma (NPC). NPC is a cancer notably prevalent in southern China, where it is 20 times more common than in non-endemic regions of the world.

Regular, self-reported symptom screening was associated with reduced symptom burden when compared with usual care for pediatric patients with cancer, according to new research led by scientists at the University of Toronto and The Hospital for Sick Children (SickKids).

Researchers from the Walter and Eliza Hall Institute (WEHI)in Australia have found a new way to predict a subset of patients who are likely to become resistant to PARP inhibitors (PARPi), a key therapy used to treat ovarian and breast cancers in Australia.

Multiple myeloma (MM) is an incurable blood cancer, leading to weakened immunity, bone damage, and other serious health issues. The high relapse rates following initial treatments make the search for novel immunotherapies urgent. However, the effectiveness of these therapies often depends on a functional immune microenvironment in MM patients.

After a comprehensive two-year follow-up, researchers at the UCLA Health Jonsson Comprehensive Cancer Center found that MRI-guided stereotactic body radiotherapy (SBRT) for prostate cancer significantly reduced long-term side effects and improved quality of life, particularly in bowel and sexual health, compared to conventional CT-guided treatment.

Ongoing fundamental research on cancer cells could be used to create new drugs and therapies that fight the spread of cancer cells. The work of Dr. Tanmay Lele, joint faculty in chemical engineering, and chemical engineering Ph.D candidate Ting-Ching Wang proves that the mechanical stiffness of tissue can alter the fate of tumor cell populations.

November is National Pancreatic Cancer Awareness Month. Approximately 66,000 people in the U.S. will be diagnosed with pancreatic cancer this year, according to the National Cancer Institute.

An immune-cell therapy shrank children's brain tumors, restored neurologic function and—for one participant in a Stanford Medicine clinical trial—erased all detectable traces of a brain cancer typically considered incurable.

Researchers have developed an AI-powered model that—in 10 seconds—can determine during surgery if any part of a cancerous brain tumor that could be removed remains, a study published in Nature suggests.

Scientists have identified new gene faults and evolutionary patterns contributing to testicular cancer. Their findings offer profound insights into the development of the disease and into potential treatment strategies.

Addition of the immunotherapy drug pembrolizumab to standard of care for patients with advanced soft tissue sarcoma of the limb significantly improved disease-free survival, according to the results of the SU2C-SARC032 clinical trial led by researchers from the University of Pittsburgh, UPMC, Duke University and Princess Margaret Cancer Center, University Health Network.

Only half of people with early-onset cancers reported discussing fertility preservation options prior to their oncology treatments, according to results of a cross-sectional study published Nov. 12 in JAMA Network Open.

A recent study published in the journal Scientific Reports correlates higher levels of pollutant particulate matter to higher occurrences of head and neck aerodigestive cancer.

A team of researchers have applied a novel blood test that can detect early signs of potentially fatal lung damage in cancer patients taking antibody–drug conjugates (ADCs). This breakthrough method aims to offer a safer, simpler way to monitor patients for drug-induced lung disease, potentially reducing the need for frequent scans. The study is published in ESMO Open.

Blocking the METTL3 protein can increase sensitivity to chemotherapy in neuroblastoma, according to research from the University of Gothenburg. The study shows how specific RNA modifications affect gene expression in the early development of neuroblastoma.

As many as 81% of cancer cures touted by content creators on TikTok are fake, according to new research from City St George's, University of London.

Researchers from the Data Science and Artificial Intelligence Institute (DATAI) at the University of Navarra have developed artificial intelligence (AI) models to personalize immune therapies for oncology patients.

Glioblastoma is the most common kind of malignant brain tumor in adults. So far, no treatment has been able to make this aggressive tumor permanently disappear. The tumor cells are too varied, and the microenvironment is too tumor-friendly. Researchers at the University of Basel and University Hospital Basel have now developed an immunotherapy that not only attacks the tumor—it also turns its micr

Researchers have identified a key weakness in acute myeloid leukemia, offering a promising new strategy to delay the progression of this aggressive blood cancer. The discovery focuses on disrupting the function of a certain protein complex that cancer cells, including leukemia cells, rely on to maintain their abnormal growth.

A research team led by UCLA Health Jonsson Comprehensive Cancer Center investigators has shown that combining pembrolizumab, an immunotherapy drug, with standard chemotherapy can improve treatment outcomes for patients with small cell bladder cancer and small cell/neuroendocrine prostate cancer.

Continuous enrollment in Medicaid was associated with a lower rate of a late-stage lymphoma diagnosis in children and adolescents/young adults (AYAs). However, fewer than half of Medicaid-insured patients in these age ranges were continuously enrolled before diagnosis, according to a study published in Blood Advances.

Researchers at the Center for Genomic Regulation (CRG) reveal that metabolic enzymes known for their roles in energy production and nucleotide synthesis are taking on unexpected "second jobs" within the nucleus, orchestrating critical functions like cell division and DNA repair.

Medical physicists at the Australian Radiation Protection and Nuclear Safety Agency (ARPANSA) have worked with the International Atomic Energy Agency (IAEA) to develop a global radiotherapy audit method.

In drug discovery, targeted protein degradation is a method that selectively eliminates disease-causing proteins. A University of California, Riverside team of scientists has used a novel approach to identify protein degraders that target Pin1, a protein involved in pancreatic cancer development.

The largest ever clinical trial of T cell therapy for solid tumors has ended, heralding a new era for precision T cell therapy. Led by a Singapore clinician-scientist, the multinational, Phase III VANCE trial demonstrates that Singapore has the expertise and capabilities to run a large-scale global cell therapy trial. Results were published in Annals on Oncology, in October 2024.

Researchers at Uppsala University and KTH Royal Institute of Technology have developed a new form of precision medicine, an antibody, with the potential to treat several types of cancer. Researchers have managed to combine three different functions in the antibody, which together strongly amplify the effect of T cells on the cancer tumor. The study has been published in Nature Communications.

People inherit two copies of each gene—one from each parent—an evolutionary fail-safe to ensure survival even when one of them doesn't function.

Increasing percentages of some older U.S. men with intermediate-risk and high-risk prostate cancers are undergoing treatments that carry risks of side effects that can significantly reduce the quality of life without extending life, according to a new study led by Cedars-Sinai. This trend is problematic because these men may not have life expectancies that would allow them to receive the benefits

Fructose, the most common food sweetener, is widely used in processed sugary beverages, candies, and baked goods. Excessive fructose intake is closely associated with metabolic diseases like obesity, diabetes, and fatty liver.

In a study published in Nature, researchers led by Prof. Hu Zheng from the Shenzhen Institutes of Advanced Technology (SIAT) of the Chinese Academy of Sciences, along with their collaborators, demonstrated a new model of early evolution in the transition of tumors from polyclonal to monoclonal, and elucidated the mechanisms of intercellular communication and the interaction underlying the polyclon

Researchers from the Tumor Profiler consortium have combined single-cell multi-omics and functional profiling for 21 AML patients to reveal resistance mechanisms to the Bcl-2 inhibitor venetoclax and identify emerging treatment vulnerabilities.

Researchers at the National Institutes of Health (NIH) and their collaborators have discovered a new way in which RAS genes, which are commonly mutated in cancer, may drive tumor growth beyond their well-known role in signaling at the cell surface.

A Michigan State University researcher's new model for studying breast cancer could help scientists better understand why and where cancer metastasizes.

A new randomized controlled trial out of the Baker Heart and Diabetes Institute has found that combining structured exercise training with reductions in sitting time protects against heart damage and declines in cardiovascular fitness in adults receiving stem cell transplantation for blood cancers.

In recent research published in eGastroenterology, Dr. J-Matthias Löhr and colleagues provide an in-depth review of diagnostic methods for pancreatic incidentaloma—incidental findings often detected during imaging scans intended for other conditions.

The process of identifying promising small molecule drug candidates that target cancer checkpoints may become faster and smarter through virtual screening, according to Weill Cornell Medicine researchers.

The most comprehensive study ever conducted of lung cancer diagnosis in England has revealed significant disparities between ethnic groups and striking evidence that people living in the most deprived areas were diagnosed with lung cancer at twice the rate of those in affluent areas.

University of Kentucky Markey Cancer Center researchers identified a protein that could be key to developing new treatments for triple-negative breast cancer.

Prostate cancer is the second most common cancer in men worldwide. Despite medical advances in recent years, this type of tumor is still responsible for one in eight male cancer deaths in Austria alone.

"Those who cope best with cancer treatment are often those who had an active lifestyle before diagnosis. It reduces the risk of delayed injury and complications," says Benedikte Western.

A new study led by Oxford University and involving Swansea University has found that the treatment of cancer in twelve former Soviet Union countries is being impacted by shortages and inconsistencies in equipment and staff.

Cleveland Clinic researchers are presenting updated findings from their novel study of a vaccine aimed at preventing triple-negative breast cancer, the most aggressive and lethal form of the disease.

Researchers from Queen Mary University of London, the Chinese Academy of Sciences and Capital Medical University in Beijing have tested a virus treatment in eight patients with glioblastoma. The treatment was safe and effective below a maximum dose, with complete remission achieved in one patient, supporting progression to phase II clinical trials.

QUT scientists have uncovered functionality of a genetic variant in the prostate specific antigen (PSA) gene to improve the current diagnostic test to help distinguish aggressive from non-aggressive prostate cancers and the level of treatment the patient needs.

Across the world, one in five people are diagnosed with cancer during their lifetime. By age 85, almost one in two Australians will be diagnosed with cancer.

There is a negative association between travel time to tanning facilities and county-level melanoma incidence rates, according to a study published online Nov. 7 in the Journal of Investigative Dermatology.

As cancer cells grow, they pump out metabolic byproducts such as lactic acid into the tumor microenvironment. Exhausted T cells—which have lost their cancer-fighting oomph—consume this lactic acid, which further saps their energy, according to new research from the University of Pittsburgh and UPMC Hillman Cancer Center.

Scientists from Duke-NUS Medical School and their collaborators have identified an inherited genetic variation prevalent among East Asians that contributes to drug resistance, driving the aggressive growth of cancer cells in patients with chronic myeloid leukemia.

A new study from the USC Norris Comprehensive Cancer Center has found evidence that targeting CD47, a protein that is part of the innate immune system, could be a key step in fighting colorectal cancer.

In operable non-small cell lung cancer (NSCLC), molecular residual disease (MRD) detection via circulating tumor DNA (ctDNA) has emerged as a promising approach to identify individuals at high risk of disease recurrence and potentially guide adjuvant therapy decisions.

UC San Francisco treated its first brain cancer patient with an experimental new CAR-T therapy discovered and manufactured at the university earlier this year. The treatment, known as E-SYNC, is a form of "switchable" CAR-T therapy that can be turned on and off to better target cancer and reduce side effects.

Researchers at the University of Virginia have discovered a new mechanism driving drug resistance in pancreatic ductal adenocarcinoma, one of the deadliest cancers. Their findings could lead to more effective treatments, providing hope for patients facing this aggressive disease.

Even treated with the most advanced therapies, patients with glioblastoma—an aggressive brain cancer—typically survive less than two years after diagnosis. Efforts to treat this cancer with the latest immunotherapies have been unsuccessful, likely because glioblastoma cells have few—if any—natural targets for the immune system to attack.

Mitochondria have long been known as the tiny organelles that act as the battery packs inside our cells while also serving as internal sensors and communicators. But relatively little is understood about how their energy-producing activities in soupy cellular interiors impacts metastatic cancer, which occurs when cancerous cells spread in the body.

The immune system is a major target for cancer treatments. Immune checkpoint inhibitors and CAR-T cell therapy can dramatically improve outcomes for many cancers. But for about 70% of patients, these therapies don't work.

In 1937, President Franklin Roosevelt signed the National Cancer Act, launching a nationwide effort to combat the disease. Eighty-seven years later, despite significant progress, cancer treatment often falls short, with 50% to 80% of patients not responding to treatment and more than 600,000 cancer deaths annually in the United States.

The risks of adverse effects and complications from treatment for prostate cancer are substantial and continue for years after treatment ends. The largest comprehensive analysis reporting long-term risks from such treatment relative to the risks faced by a control group of untreated men has just been published in the journal JAMA Oncology.

An international research effort led by Charles Sturt University, Australia, is projecting a significant rise in global cancer cases and deaths by 2050. They identify widening disparities between low Human Development Index (HDI) and very high HDI countries, sounding the alarm for urgent action in cancer prevention and care worldwide.

Maintaining good health and well-being is crucial for how well patients respond to cancer treatments. Unfortunately, cachexia, or involuntary weight loss, is a major concern for many individuals with advanced cancer. A new study from Japan has revealed that lower cachexia rates, particularly with prevalence less than 40–50%, are linked to shorter overall survival (OS) rates. The study also showed

A recent prospective cross-sectional study in Thailand demonstrates that multitarget stool DNA testing is highly sensitive and specific for detecting colorectal cancer (CRC) among Thai individuals. Researchers believe that this testing method could serve as a viable non-invasive alternative to colonoscopy, especially in settings where colonoscopy is less accessible or less accepted by patients.

An international team led by Goethe University Frankfurt has identified an intracellular sensor that monitors the quality of so-called MHC-I molecules, which help the immune system recognize and kill harmful cells, including tumor cells. The sensor ensures that defective MHC-I molecules remain inside the cell, where they are eventually degraded. Surprisingly, a lack of this quality assurance can l

A research team from Memorial Sloan Kettering Cancer Center (MSK) is demonstrating that cancer outcome predictions can be improved by breaking down hospitals' traditional data silos and analyzing the information—including physicians' clinical notes—with the help of artificial intelligence (AI).

A novel discovery in the field of pancreatic cancer treatment has been unveiled, revealing the epigenetic silencing of BEND4 as a potential synthetic lethal marker for enhancing the efficacy of ATM inhibitors in pancreatic cancer treatment.

Artificial intelligence (AI)-based risk classification improves prognostication with localized prostate cancer, according to a study published online Oct. 24 in JCO Precision Oncology.

Scientists have uncovered how certain E. coli bacteria in the gut promote colon cancer by binding to intestinal cells and releasing a DNA-damaging toxin. The study, published in Nature, sheds light on a new approach to potentially reduce cancer risk. The study was performed by the teams of Prof. Lars Vereecke (VIB-UGent Center for Inflammation Research) and Prof. Han Remaut (VIB-VUB Center for Str

A trio of research papers from Stanford Medicine researchers and their international collaborators transforms scientists' understanding of how small DNA circles—until recently dismissed as inconsequential—are major drivers of many types of human cancers.

Many of us remember from high school biology class that mitochondria are the cell's "power plants." These small kidney-bean-shaped structures are what convert nutrients from food into ATP—the cell's "energy currency." Cells spend that currency every time they perform basic cellular activities, whether that's encoding memories in nerve cells or detoxifying chemicals in liver cells.

A tightly tied waist cord of the underskirt (petticoat) traditionally worn under a saree, particularly in rural parts of India, may lead to what has been dubbed "petticoat cancer," warn doctors in the journal BMJ Case Reports after treating two women with this type of malignancy.

For patients facing a pancreatic cancer diagnosis, a compassionate approach to care can be transformative. Yet, a new study published in Healthcare reveals that palliative care, a service focused on enhancing the quality of life for those with serious illnesses, remains significantly underutilized among pancreatic cancer patients in the United States.

Canada's current national screening guidelines for breast cancer are less appropriate for women of certain race and ethnicity groups since they are diagnosed at younger ages with more advanced stages of the disease. The new findings from a University of Ottawa research team underscore the urgent need to reevaluate screening guidelines to account for racial and ethnic differences and ensure equitab

A recent study offering a comprehensive view of the genome and transcriptome of gastrointestinal stromal tumors (GISTs) has introduced a new, multi-omics-based molecular classification of these tumors.

Scientists at the Johns Hopkins Kimmel Cancer Center have identified 16 genes that breast cancer cells use to survive in the bloodstream after they've escaped the low-oxygen regions of a tumor. Each is a potential therapeutic target to stop cancer recurrence, and one—MUC1—is already in clinical trials.

In the quest to enhance the efficacy of chimeric antigen receptor T (CAR-T) cell therapy against hepatocellular carcinoma (HCC), a study in Frontiers of Medicine has identified a pivotal role for CD39 expression in modulating the function of CAR-T cells.

A research team at Lund University in Sweden has discovered a certain type of cell—foam cells—in patients with the aggressive brain tumor glioblastoma. It has been shown how these cells accelerate the cancer's growth and that this can be successfully inhibited using a drug developed for arteriosclerosis. The study is published in the journal Science Translational Medicine.

Led by forensic pathologist Andreas G. Nerlich of Ludwig-Maximilians-University in Munich, a team of international experts propose that Michelangelo's fresco "The Flood" in the Sistine Chapel portrays a young woman exhibiting signs consistent with breast cancer.

In addition to lowering your cholesterol, keeping your brain healthy and improving mental health, new research from the University of Georgia suggests omega-3 and omega-6 fatty acids may help ward off a variety of cancers.

Glioblastoma is the most common and deadliest form of brain cancer. Patients face a bleak prognosis—the average survival after diagnosis is between 12 and 15 months. And just 6.9% of patients survive beyond five years, making it one of the most poorly survived cancers.

Neuroblastoma (NB), the most prevalent extracranial solid tumor in children, poses a significant therapeutic challenge due to its metastasis and high heterogeneity. A recent study leveraging single-cell RNA sequencing (scRNA-seq) has uncovered vital molecular mechanisms underlying NB's progression and metastasis, shedding light on potential therapeutic targets.

A team led by researchers at the University of Toronto has uncovered new targets that could be the key to effectively treating glioblastoma, a lethal type of brain cancer. These targets were identified through a screen for genetic vulnerabilities in patient-derived cancer stem cells that represent the variability found in tumors.

There is a lung cancer screening test that is saving lives—and yet most people who could be getting the test have never heard of it or never talked about it with a doctor.

University of Alberta-led researchers, including the developers and promoters of the Fracture Risk Assessment Tool (FRAX), have found that FRAX combined with bone mineral density can reliably predict future fractures in a mixed group of people with certain types of cancer.

When facing colorectal liver metastases or colorectal cancer that has spread to the liver, finding effective treatment options can be challenging. Dr. Katherine Poruk, a surgical oncologist at Mayo Clinic, says a specialized therapy known as hepatic artery infusion pump (HAIP) chemotherapy is an option for some.

A new collaborative study from Karolinska Institutet published in Science Advances shows that the levels of mitochondrial DNA (mtDNA) directly influence lung adenocarcinoma (LUAD) progression in mice.

Researchers have identified 22 pesticides consistently associated with the incidence of prostate cancer in the United States, with four of the pesticides also linked with prostate cancer mortality. The findings are published in Cancer.

About 1 in 3 patients diagnosed with cancer in Ontario visited an emergency department (ED) in the 90 days before diagnosis, found a new study published in the Canadian Medical Association Journal.

Breast cancer rates rose by 1% a year from 2012–2021 for all American women combined, but steeper increases were seen for women under 50 and Asian American and Pacific Islander women, according to the American Cancer Society, which released its biennial report in October 2024 on the state of the disease in the nation.

Treatment for breast cancer can come in many forms. In addition to surgery to remove cancerous tissue and radiation therapy, breast cancer is also commonly treated with drugs that are taken orally or intravenously, as an infusion into a vein.

Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) can decrease the risk for developing early-onset colorectal cancer (EO-CRC) in patients with diabetes regardless of weight, according to a study presented at the annual meeting of the American College of Gastroenterology, held from Oct. 25 to 30 in Philadelphia.

Nationwide, fewer people smoke than did a decade ago, but the proportion who smoke menthol-flavored cigarettes is on the rise.

Pre-surgery treatment with the novel drug vidutolimod and the PD-1 checkpoint inhibitor nivolumab led to tumor control in 55% of patients with stage 3 cutaneous melanoma, according to the results of a single-arm phase 2 clinical trial led by the University of Pittsburgh, UPMC Hillman Cancer Center and the National Cancer Institute (NCI).

At UC Davis Comprehensive Cancer Center, one scientist's sleepless nights are driven by the mysteries of virus-host interactions. Researcher Yoshihiro Izumiya is delving into the complex world of herpesviruses. These viruses often lie dormant for years, then wake up to wreak havoc on their hosts, causing severe diseases and complications.

October is Breast Cancer Awareness Month, and fittingly, University of New Mexico Comprehensive Cancer Center biologist Curt Hines, Ph.D., has published a pair of papers that comprehensively describe the 12 major types of cells in the human breast.

A team of AI and medical researchers at startup Ataraxis AI, who are also affiliated with a host of institutions across the U.S., has announced the development of an AI model that they claim is more accurate at predicting the progression rate of breast cancer than standard tests now administered in hospitals.

Fear of cancer recurrence (FCR) is defined as the "fear, worry, or concern relating to the possibility that cancer will come back or progress." This is increasingly recognized as a significant survivorship concern, and while the vast majority of research aims to examine the experience of FCR among cancer survivors, far fewer studies consider their partners or informal caregivers. A recent study lo

A recent study has developed a novel method to analyze genetic variations in families with a high incidence of breast cancer. By examining 1,218 genetic variants in 12 families, the research identified 80 genes linked to an increased risk of the disease. It also highlighted the significant—yet previously overlooked—roles of peroxisomal and mitochondrial pathways in breast cancer predisposition and

A new study has found a surprising link between high levels of methylmalonic acid and the weakening of CD8+ T cells, shedding light on potential pathways through which aging may promote lung cancer progression.

Each year, more than 3 million people are diagnosed with cancers driven by mutations in three RAS-family genes: KRAS, NRAS, and HRAS. RAS-family mutations are associated with numerous types of cancer.

Although much rarer than either breast or prostate cancers, testicular cancer is the most common solid tumor in males between the ages of 15 and 35, with approximately 10,000 young men diagnosed annually in the United States.

In a major leap toward more effective cancer treatments, researchers at the University of Oulu have developed an innovative pipeline designed to directly analyze drug responses in primary patient tumor samples.

Smokers who are diagnosed with cancer now have more incentive to quit, as researchers from The University of Texas MD Anderson Cancer Center have found survival outcomes were optimized when patients quit smoking within six months of their diagnosis.

Cancers are diseases of abnormal cellular growth, and although many are treatable or even curable, their origins are not necessarily clear. Understanding the precise timing of cellular events—as cells transition from normal to cancerous conditions—is key to uncovering new treatments or diagnostic opportunities.

Metastasis remains the primary challenge to reducing cancer deaths worldwide, says Memorial Sloan Kettering Cancer Center (MSK) gastrointestinal oncologist Karuna Ganesh, MD, Ph.D.. That's when a primary tumor—colorectal cancer, for example—spreads to a new part of the body, such as the brain, liver, or bones.

A single biopsy from a metastatic breast cancer tumor contains hundreds of thousands of cells—some cancerous and others part of the complex web of immune cells, blood vessels, and supportive tissue that surround a tumor. Researchers have typically analyzed these cells as a mixed-together group, but this approach can miss rare cell types, and makes it difficult to draw conclusions about how cells i

New research into the long-term dynamics of transplanted stem cells in a patient's body explains how age affects stem cell survival and immune diversity, offering insights that could make transplants safer and more successful.

A new research paper titled "Initiation of tumor dormancy by the lymphovascular embolus" has been published in Oncotarget

A growing cancer is shaped by more than just the tumor cells it contains; the tissue around a tumor also alters its biology. Now, researchers at The Jackson Laboratory (JAX) have combined advanced imaging techniques with a new computational method to probe how immune cells interact with each other in never-before-seen detail, revealing that the interactions between immune cells in the vicinity of

A technological breakthrough by medical researchers at Tel Aviv University enabled the discovery of a cancer mechanism that prevents the immune system from attacking tumors. The researchers were surprised to find that reversing this mechanism stimulates the immune system to fight the cancer cells, even in types of cancer considered resistant to prevailing forms of immunotherapy.

Men could benefit from fewer unnecessary treatments and reduced anxiety if their doctors stopped calling certain changes in the prostate "cancer," according to prominent UC San Francisco prostate cancer expert Matthew Cooperberg, MD, MPH. In fact, the changes are a low-grade, extremely common condition among older men that won't metastasize or kill, but should be actively monitored, he says.

A new analysis led by researchers at Washington University School of Medicine in St. Louis has revealed detailed 3D maps of the internal structures of multiple tumor types. These cancer atlases reveal how different tumor cells—and the cells of a tumor's surrounding environment—are organized, in 3D, and how that organization changes when a tumor spreads to other organs.

Researchers at the Icahn School of Medicine at Mount Sinai have discovered a way that ovarian cancer tumors manipulate their environment to resist immunotherapy and identified a drug target that could overcome that resistance.

While pancreatic cancer rates are rising in people under age 50, a new survey conducted by The Ohio State University Comprehensive Cancer Center—Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC—James) shows most people continue to believe that pancreatic disease affects only the elderly—and that there is nothing they can do to reduce their risk.

Using computational tools, researchers from the Johns Hopkins Kimmel Cancer Center and the Johns Hopkins University School of Medicine have developed a method to assess which patients with metastatic triple-negative breast cancer could benefit from immunotherapy. The work by computational scientists and clinicians was published Oct. 28 in the Proceedings of the National Academy of Sciences.

Yale Cancer Center researchers at Yale School of Medicine have taken a significant step towards understanding the unique experiences of women of color living flat without breast reconstruction after a mastectomy (surgery). Their new study titled, "Living Flat: Stories from Women of Color After Mastectomy," published in Annals of Surgical Oncology on October 15, explains how cultural factors, spiri

Scientists at deCODE genetics/Amgen, and their collaborators have discovered six novel genes with rare germline variants that associate with cancer risk. The findings are published today in Nature Genetics under the title "Gene-based burden tests of rare germline variants identify six cancer susceptibility genes."

Newly available blood tests to screen for colorectal cancer sound far more appealing than a standard colonoscopy. Instead of clearing your bowels and undergoing an invasive procedure, the tests require only a simple blood draw. But are the tests effective?

For children with vesicoureteral reflux, recurrent urinary tract infections (UTIs) are associated with a decrease in estimated glomerular filtration rate (eGFR), according to a research letter published online Oct. 24 in JAMA Pediatrics to coincide with Kidney Week, the annual meeting of the American Society of Nephrology, held from Oct. 23 to 27 in San Diego.

Researchers utilized specialized genomic technology at the University of Calgary to enhance our understanding of Marjolin's ulcer (MU), a rare, highly aggressive skin cancer that affects chronic wounds that can often arise from established scars like those caused by severe burns.

Head and neck cancers have increased significantly over the last 30 years. In Germany, there are about 18,000 to 20,000 new cases of head and neck tumors every year. In particular, the incidence of carcinomas of the middle pharynx has increased, which is associated with the increase in human papillomavirus (HPV) infections.

Language can give people the power to take an active part in their own health care, or it can create barriers.

Enrollment in Medicaid was associated with higher risk of death from a central nervous system (CNS) tumor, with an almost two-fold higher risk for young CNS tumor patients enrolled at diagnosis, finds a study from the Brown School at Washington University in St. Louis.

A new study has found that cancer diagnosis can be less accurate when AI is used to help, with people over relying on AI rather than their own opinion.

Research has shown that eating a plant-based diet may provide a healthier alternative to the standard American diet, which is typically high calorie, loaded with red meat, high-fat dairy products, heavily processed foods, fast foods, refined carbohydrates, added sugars and salt. The American Institute for Cancer Research promotes a plant-based diet.

A scientist whose discoveries about prostate cancer have led to lifesaving treatments is now shedding light on an emerging and deadlier form of the disease: neuroendocrine prostate cancer (NEPC).

Prostate cancer is Australia's most commonly diagnosed cancer. One in six men will be diagnosed by the time they turn 85.

A new lung cancer screening initiative has made significant strides in overcoming barriers to care for low-income, uninsured and minority populations in Central Texas—a critical step toward reducing disparities in lung cancer outcomes.

A new study has uncovered molecular markers in blood at birth that are linked to later development of acute lymphoblastic leukemia (ALL), the most common cancer type that affects children.

A new study led by The University of Texas Health Science Center at San Antonio (UT Health San Antonio) is shedding light on a novel role of breast cancer gene 1 (BRCA1) in tumor suppression.

Researchers at Winship Cancer Institute of Emory University have identified a novel type of immune cell, called the stem-like CD4 T cell, that plays a pivotal role in anti-tumor immunity. The pre-clinical findings, published in Nature, highlight the potential to activate these cells to fight tumors more effectively, offering new hope for broader treatment success, particularly in patients with can

Cancer, a disease with global impact, is intricately linked to dysregulated gene expression, which is influenced by both genetic mutations and epigenetic changes, including RNA modifications. A comprehensive review published in Frontiers of Medicine reveals the significant role of various RNA modifications in cancer development and progression. The review particularly focuses on N6-methyladenosine

A newly described stage of a lymph node-like structure seen in liver tumors after presurgical immunotherapy may be vital to successfully treating patients with hepatocellular carcinoma, according to a study by researchers from the Johns Hopkins Kimmel Cancer Center.

Researchers have shown for the first time that it is possible for a specially designed 'mini-protein' to deliver a radiation dose directly to tumor cells expressing a protein on their cell surfaces called Nectin-4, which is often found in a number of different cancers.

Researchers have discovered key mutations in certain cancer cells that make them resistant to WRN inhibitors, a new class of anti-cancer drugs. The yet-to-be-published findings are presented on Friday at the 36th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics in Barcelona, Spain.

Researchers have shown that they can accurately recreate clinical trials of new treatments using "digital twins" of real cancer patients. The technology, called FarrSight-Twin, which is based on algorithms used by astrophysicists to discover black holes, was presented at the 36th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics in Barcelona, Spain.

Researchers at The University of Texas at El Paso have created a portable device that can detect colorectal and prostate cancer more cheaply and quickly than prevailing methods. The team believes the device may be especially helpful in developing countries, which experience higher cancer mortality rates due in part to barriers to medical diagnosis.

Researchers at Baylor College of Medicine and Washington University School of Medicine, St. Louis have identified clinical and genetic predictors of multiple recurrent meningiomas (MRMs), the most aggressive form of this common brain tumor. Published in Science Advances, the study opens new opportunities for future development of potential biomarkers and therapeutic agents for these challenging tu

For millions of American women, hormone replacement therapy (HRT) has provided relief from side effects of menopause. As the ovaries stop releasing eggs, a woman's body also stops producing the hormones progesterone and estrogen. This change often affects quality of life due to hot flashes, mood swings, vaginal dryness, and a loss of bone density. HRT replenishes the hormones lost during this proc

New research published online-ahead-of-print in Journal of the National Comprehensive Cancer Network found that people with newly-diagnosed hormone receptor (HR)-negative, human epidermal growth factor receptor 2 (HER2)-positive breast cancer were more likely to receive timely, guideline-concordant treatment and have longer survival in states that participate in Medicaid expansion under the Afford

People with grandparents from a remote Scottish island are more likely than the rest of the U.K. population to have a version of a gene that increases cancer risk.

In 1893, the American Journal of the Medical Sciences reported on 10 patients whose large and hitherto incurable cancers had been injected with bacteria taken from skin infections. In every case, striking improvement was seen, marking the birth of "cancer immunotherapy"—using the power of the immune system to attack cancer.

A new study from researchers at Sylvester Comprehensive Cancer Center, part of the University of Miami Miller School of Medicine, suggests that higher breast cancer rates among Caribbean women may be linked to shifting patterns in their reproductive health.

Radiation therapy is a common component of breast cancer treatment for patients. The high-powered beams of intense energy kill cancer cells and reduce the risk of the cancer recurring.

Using a gene signature technique to tailor chemotherapy for patients with early triple negative breast cancer shows promise as a way to improve disease-free survival, finds a clinical trial published by The BMJ today.

Scientists have created a 3D-printed model to mimic the specific conditions that spur the spread of cancer cells. The model, published in the journal Life Science Alliance, allows researchers to study a process previously hidden from view and may open the door to new screening and treatment options for cancers at risk of spreading.

Scientists at the Agency for Science, Technology and Research (A*STAR) along with collaborators from the National Cancer Centre Singapore (NCCS) have uncovered a critical link between the overconsumption of red meat and an increased risk of colorectal cancer. Their findings pave the way for new therapeutic approaches targeting telomerase, an enzyme implicated in cancer progression.

Weill Cornell Medicine researchers have discovered a mechanism that ovarian tumors use to cripple immune cells and impede their attack—blocking the energy supply T cells depend on. The work, published Oct. 23 in Nature, points toward a promising new immunotherapy approach for ovarian cancer, which is notoriously aggressive and hard to treat.

Investigators from Weill Cornell Medicine have discovered a defense mechanism that protects skin cancer cells from oxidative stress and helps them spread. The findings suggest a new drug target that could lead to therapies for deadly metastatic skin cancer.

A preclinical study is revealing new insights into the molecular machinery that drives the aggressiveness of pancreatic cancer.

A new drug called WNTinib can delay the growth of tumors and improve survival in hepatoblastoma, a type of liver cancer that occurs in young children. This effect was seen in cancer cells taken from patients and implanted into mice.

A study of patients with metastatic lung cancer by researchers based in Brazil and the United States has found that their performance in simple physical tests such as sitting down, standing and walking can help physicians arrive at a prognosis and approach to treatment.

Dermatofibrosarcoma protuberans (DFSP) is a rare skin sarcoma known for its high recurrence rates, making treatment particularly challenging. While surgery remains the standard option, it often leads to scarring and other complications.

Cutting off cancer cells' access to fat may help a specific type of cancer treatment work more effectively, reports a study by Van Andel Institute scientists. The findings, published in Cell Chemical Biology, lay the groundwork for developing tailored dietary strategies to help anti-cancer medications better kill malignant cells.

Overall, cancer detection in the United States recovered meaningfully in 2021 following substantial disruptions in 2020, according to a study published online Oct. 14 in JAMA Network Open.

A new report has revealed a concerning rise in the number of people diagnosed with head and neck cancers in England.

Breast cancer is the number one cancer among women: more than 2 million cases were diagnosed worldwide in 2022. It is also particularly challenging to treat. Physiologist Anna-Mart Engelbrecht, who heads the Cancer Research Group at Stellenbosch University, explains why this is so and how precision medicine could help.

Magnetic resonance imaging (MRI) can spare many patients with rectal cancer from invasive surgery that can carry lifelong side effects, new research indicates.

Sir Chris Hoy, an inspiration to so many of us, has just revealed he has terminal prostate cancer aged just 48 years old.

For some proteins, a single mutation, or change in its DNA instructions, is all it takes to tip the balance between functioning normally and causing cancer. But despite causing major disease, these slightly mutated proteins can resemble their normal versions so closely that treatments designed to target mutants could also harm healthy cells.

Ludwig Cancer Research scientists have devised new types of chimeric antigen-receptor (CAR) T cells—a type of cancer immunotherapy—that can be switched on to varying degrees of intensity and then switched off on demand with existing drugs. The design and preclinical evaluation of the CAR-T cells, led by Melita Irving and Greta Maria Paola Giordano Attianese of the Lausanne Branch of the Ludwig Ins

The updated national colorectal cancer screening guidelines that recommend screening begin at age 45—rather than 50—can benefit younger adults, a new Kaiser Permanente study found.

Immunotherapies that mobilize a patient's own immune system to fight cancer have become a treatment pillar. These therapies, including CAR T-cell therapy, have performed well in cancers like leukemias and lymphomas, but the results have been less promising in solid tumors.

Pembrolizumab plus chemotherapy improves disease-free survival (DFS) in patients with high-risk endometrial cancer after surgery with curative intent, according to a study published online Oct. 16 in the Journal of Clinical Oncology.

A combination of two drugs that can block the growth of cancer cells has shown promising results in women with a form of ovarian cancer that rarely responds to chemotherapy or hormone therapy.

An immune protein could hold the key to developing new drugs to help fight bowel cancer, according to new research from The Australian National University (ANU).

Recent research from the University of Helsinki sheds new light on the behavior of the KRAS gene in two of the deadliest cancers—pancreatic and colorectal cancer. These findings suggest potential pathways for targeted therapies in KRAS-driven cancers.

More than 400 people, 80% of them being children under 14 years old, will be diagnosed with B-cell Acute Lymphoblastic Leukemia (B-ALL) next year in Spain, according to the latest projections from the Spanish network of cancer registries (REDECAN). Survival rates for this rapidly growing and aggressive type of blood cancer are high in youth, but fall rapidly with age, especially after 40. New ther

Polyploidy is a state where a cell contains more copies of the genetic material than the usual "diploid" cell, which contains two copies. Polyploidy often occurs in human diseases and cancers, and its effect on cell fate has been unclear. Now, researchers from Japan have shown that polyploidy can be a double-edged sword when it comes to cancer and its treatment.

The protein factories of our cells are much more diverse than we thought they were. Scientists from the Netherlands Cancer Institute have now shown that cancer cells can use these ribosomes to boost their invisibility cloak, helping them hide from the immune system.

Proton beam therapy, a type of radiation therapy, possesses a physical property known as the Bragg peak, which causes the beam to exert its strongest effect at a specific depth, with no effect beyond that point. This characteristic allows for a higher concentration of the dose on tumors located deep within the body, making it a promising cancer treatment method.

Many women who receive chemotherapy experience a decreased ability to remember, concentrate, and/or think—commonly referred to as "chemo-brain" or "brain fog"—both short- and long-term.

A new study has found a link between hormonal intrauterine devices (IUDs) and breast cancer.

Immunotherapy has become the most promising strategy for treating cancer, but its effectiveness is still very uneven. In the month of breast cancer, the most common tumor in women—almost 2.5 million cases are diagnosed worldwide each year—three researchers present the main advances and challenges in the application of immunotherapy to this tumor at the Spanish National Cancer Research Center (CNIO

Researchers from Tampere University, Finland, and Izmir Institute of Technology, Turkey, have developed an in vitro cancer model to investigate why breast cancer spreads to bone. Their findings hold promise for advancing the development of preclinical tools to predict breast cancer bone metastasis.

Intrauterine devices (IUDs) may raise the chances of a breast cancer diagnosis for women who use the hormonal birth control method, but that risk remains low, new research finds.

Imagine that you have a history of breast cancer in your family, and you want a better idea of what your personal risk is. You consult your physician, and they recommend that you test to see if you have a genetic variant that would increase your chances of developing breast cancer. After weeks of nervously waiting, the results come in and you learn that your variants of BRCA 1 and 2, the genes ass

Although breast cancer is the most common non-skin cancer diagnosed in women, finding support during treatment and through survivorship can be incredibly challenging. An analysis of posts from breast cancer patients on the popular online forum Reddit found that many breast cancer patients often struggle with several unmet emotional and financial concerns during treatment and long after.

A diagnosis of cancer can take a toll on more than a person's health. Researchers at Beth Israel Deaconess Medical Center and Harvard Medical School in Boston found that financial fallout can follow patients with cancer and their families in the form of bankruptcy, lower credit scores, and other forms of financial challenges years after a cancer diagnosis.

Younger adults with colon cancer tend to be diagnosed at a later stage and have more aggressive types of tumors. Additionally, young patients living with colorectal cancer have long-term, adverse consequences on their lives, which are different from the impact the disease has on older adults, according to two studies presented at the American College of Surgeons (ACS) Clinical Congress 2024 in San

Breast cancer is the most diagnosed cancer in U.S. women with about one in eight women diagnosed over the course of their lifetime. In about 35% of cases, a mastectomy is part of a woman's treatment plan and involves removing all tissue in one or both breasts, sometimes including the nipples and areolas. While it is considered a lifesaving procedure for women with breast cancer, it can take an emo

All cancer mutations that cause drug resistance fall into one of four categories. New research has detailed each type, helping to uncover targets for drug development and identify potential effective second-line therapies.