Study finds RNA modification is responsible for disruption of mitochondrial protein synthesis in Alzheimer's disease

RNA Modification in Alzheimer's: Researchers found a new RNA change causing mitochondrial issues in Alzheimer's, hindering brain energy production by disrupting a key protein synthesis.

Understanding Alzheimer's Mechanisms: The study enhances understanding of Alzheimer's by emphasizing mitochondrial dysfunction alongside glucose metabolism problems and amyloid-beta buildup.

Collaborative Efforts: Multiple research groups collaborated from Johannes Gutenberg University Mainz, Mainz University Medical Center, IMB, Université de Lorraine, and the Medical University of Vienna, showcasing interdisciplinary teamwork.

TRMT10C's Role: TRMT10C enzyme was pinpointed as the catalyst for RNA modification, impairing ND5 protein production, a crucial factor in mitochondrial dysfunction in Alzheimer's.

Therapeutic Implications: Insights into this mechanism could lead to new treatments targeting TRMT10C or its effects, potentially mitigating mitochondrial dysfunction and slowing Alzheimer's progression.