Gene-edited pig kidney keeps monkey alive for 2 years, trial finds, a step toward longer-lasting human transplants

Researchers achieved a breakthrough by transplanting kidneys from genetically modified pigs into monkeys, extending their lifespans. This solution addresses the severe shortage of human kidneys, with modifications reducing organ rejection risks.

The transplants' success hinged on three gene alterations in the pigs, eliminating rejection-causing antigens and adding human genes to control rejection pathways. These changes, coupled with immunosuppressive drugs, led to longer survival times for the monkeys.

The team, alongside eGenesis, seeks FDA approval for human trials, a significant advancement in xenotransplantation. Despite the promise, experts warn of potential risks and the complexity of ensuring the safety of these gene edits.