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HealthDay 11 July at 03.25 PM

Proteomics Panel Not Useful for Predicting Hypertensive Disorders of Pregnancy


THURSDAY, July 11, 2024 (HealthDay News) -- Large-scale proteomics in early pregnancy is not clinically useful for risk prediction of hypertensive disorders of pregnancy (HDP), according to a study published online July 3 in JAMA Cardiology.

Philip Greenland, M.D., from the Feinberg School of Medicine at Northwestern University in Chicago, and colleagues conducted a nested case-control study to examine the predictive ability of large-scale proteomics for prediction of HDP in early pregnancy. Nulliparous individuals during first-trimester clinical visits were included; cases were those with HDP, while controls were selected from those who delivered at or after 37 weeks without any HDP, preterm birth, or small-for-gestational-age infants. Data were included for 753 HDP cases and 1,097 controls. An aptamer-based assay that included 6,481 unique human proteins was performed on stored plasma.

The elastic net model was used to adjust protein-based models for clinical and demographic variables. Using this approach, the researchers found no proteins were selected for augmenting the clinical and demographic covariates. Modest predictive performance was seen for the resulting model, with areas under the curve of 0.64 and 0.62 for the training and test sets, respectively. Only minimal changes were yielded with further adjustment for study site.

"In this case-control study with detailed clinical data and stored plasma samples available in the first trimester, an aptamer-based proteomics panel did not meaningfully add to predictive utility over and above clinical and demographic factors that are routinely available," the authors write.

Several authors disclosed ties to the pharmaceutical industry.

Abstract/Full Text (subscription or payment may be required)

#Cardiology #Family Practice #OBGYN & Women's Health #Less than 8 weeks gestation of pregnancy (Z3A.01) #Pregnant state, incidental (Z33.1) #Supervision of high risk pregnancy, unspecified, third trimester (O09.93) #Supervision of high risk pregnancy, unspecified, unspecified trimester (O09.90) #Gestational [pregnancy-induced] hypertension without significant proteinuria, unspecified trimester (O13.9) #Gestational [pregnancy-induced] hypertension without significant proteinuria (O13) #Gestational [pregnancy-induced] hypertension without significant proteinuria, third trimester (O13.3) #Unspecified pre-existing hypertension complicating pregnancy, second trimester (O10.912) #Gestational [pregnancy-induced] hypertension without significant proteinuria, second trimester (O13.2) #Encounter for supervision of normal pregnancy, unspecified, first trimester (Z34.91) #Encounter for supervision of normal first pregnancy, unspecified trimester (Z34.00) #Encounter for full-term uncomplicated delivery (O80) #Onset (spontaneous) of labor after 37 completed weeks of gestation but before 39 completed weeks gestation, with delivery by (planned) cesarean section (O75.82) #Single liveborn infant, delivered vaginally (Z38.00) #Preterm labor with preterm delivery, unspecified trimester, not applicable or unspecified (O60.10X0) #Preterm newborn, unspecified weeks of gestation (P07.30) #Preterm newborn, gestational age 35 completed weeks (P07.38) #Preterm labor without delivery (O60.0) #Term delivery with preterm labor, unspecified trimester, not applicable or unspecified (O60.20X0) #Newborn small for gestational age (P05.1) #Newborn small for gestational age, unspecified weight (P05.10)
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