All articles tagged: Medications

A new drug to treat Alzheimer's disease was approved by the U.S. Food and Drug Administration on Tuesday.

Benzodiazepines do not appear to increase dementia risk, but could have subtle long-term effects on brain structure, a new study reports.

A study lead by the Economic Evaluation of Chronic Diseases group of Biogipuzkoa Health Research Institute has revealed the relationship between the use of antipsychotics in dementia and socioeconomic status. This work have been authored by Javier Mar, Uxue Zubiagirre, Igor Larrañaga, Myriam Soto-Gordoa, Lorea Mar-Barrutia, Ana González-Pinto and Oliver Ibarrondo from Biogipuzkoa HRI, Bioaraba HRI

Researchers looked at over 100 cases of misconduct involving the overprescription of opioid drugs in an anonymized US state. The study investigated professional bodies composed predominantly of doctors tasked with assessing and disciplining physician misconduct.

US President Joe Biden on Tuesday called on pharmaceutical giants Novo Nordisk and Eli Lilly to lower prices for diabetes and weight loss drugs such as Ozempic, saying firms must stop "ripping off the American people."

Drugs for serious or life-threatening diseases can receive expedited U.S. Food and Drug Administration (FDA) review, allowing patients to receive faster access to promising new treatments. Under the expedited review pathway of accelerated approval, drugs can be FDA-approved based on surrogate markers or proxy measures such as changes in imaging or lab tests that are "reasonably likely" to predict

New evidence comparing weight gain under eight different first-line antidepressants finds that bupropion users are 15–20% less likely to gain a clinically significant amount of weight than users of sertraline, the most common medication.

A total of 135 batches of potassium chloride capsules have been recalled because the extended release capsules might not release.

A new pill that slowly releases ketamine could treat people with severe depression without giving them the psychedelic side effects of the often-misused drug, early trial results suggested on Monday.

A small number of surgical procedures, including orthopedic procedures and cesarean delivery, account for a large proportion of opioid prescriptions dispensed after surgery, according to a study published online June 26 in JAMA Network Open.

Older GPs are more likely to prescribe antibiotics than their younger colleagues. A more cautious approach will not degrade treatment—and it can help fight antibiotic resistance that could soon kill millions of people annually. The discovery was made in a new study from the Department of Economics at the University of Copenhagen.

A team of biomedical researchers from the U.S. and the U.K. has identified two groups of neurons that take part in the process of feeling full—one before eating and one after. In their study, published in the journal Science, the group conducted experiments with mice to learn more about factors in the brain that lead to feelings of fullness after eating.

Doctors are prescribing antibiotics to most kids and teens who have pink eye, despite guidelines that discourage their use, researchers reported Thursday.

Just 25% of people battling opioid use disorder are getting medications aimed at helping them quit and potentially avoid an overdose, new data shows.

In a far-reaching effort to understand the factors contributing to HIV transmission among sexual and gender minority (SGM) individuals and improve HIV prevention strategies, a team of scientists at the CUNY Graduate School of Public Health and Health Policy (CUNY SPH) and the CUNY Institute for Implementation Science in Population Health (CUNY ISPH) led a four-year national cohort study of 6,059 c

A drug used to prevent migraine may also be effective in people with migraine who experience rebound headaches, according to a new study published in Neurology.

Underrepresented populations have been historically excluded from clinical trials including women, racial and ethnic minority groups, and pregnant, lactating, pediatric and geriatric populations. While the importance of including these groups in clinical trials is slowly being recognized and remedied, there are still questions about how currently prescribed drugs affect these populations, includin

NIAID research has led to the availability of a new over-the-counter topical eczema probiotic. The probiotic is based on the discovery by scientists at the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, that bacteria present on healthy skin called Roseomonas mucosa can safely relieve eczema symptoms in adults and children.

Novo Nordisk's flagship weight-loss drug Wegovy has been approved for use in China, the Danish pharmaceutical giant said.

Studies of mouse models of Fragile X syndrome and Phelan-McDermid syndrome show that treatment with cannabidiol (CBD) and the diabetes drug metformin can alleviate behavioral difficulties, according to research presented today (Wednesday) at the Federation of European Neuroscience Societies (FENS) Forum 2024.

The use of the active ingredient 3,4-methylenedioxy-N-methylamphetamine (MDMA), commonly known as "ecstasy," to support psychotherapy for mental illnesses such as post-traumatic stress disorder is being discussed worldwide.

A survey representing about 150 million adults annually suggests that aspirin use for primary prevention of cardiovascular disease (CVD) remains prevalent among older adults, contrary to recommendations from the American College of Cardiology and the American Heart Association. According to the study authors, these findings highlight the urgent need for physicians to inquire about aspirin use and

For patients with resected stage III melanoma, adjuvant therapy with dabrafenib plus trametinib is associated with a nonsignificant benefit in terms of overall survival, according to a study published in the New England Journal of Medicine.

For patients with acute myeloid leukemia (AML) undergoing allogeneic stem cell transplantation, posttransplant cyclophosphamide (PTCy) graft-versus-host-disease (GVHD) prophylaxis yields comparable relapse incidence (RI) and significantly lower incidence of GVHD than conventional prophylaxis, according to a study published online June 10 in the American Journal of Hematology.

For those suffering from treatment-resistant depression, the anesthetic drug ketamine offers hope, but it has side effects and can be costly to access—a University of Otago-led clinical trial may change that.

The current method for assessing medication-related liver injury is not providing an accurate picture of some medications' toxicity—or lack thereof—to the liver, according to a new study led by researchers from the Perelman School of Medicine at the University of Pennsylvania.

Researchers compared patients who received care remotely to those who got ultrasounds and found no differences in outcomes. Medication abortion patients who receive pills by mail without first getting an ultrasound do just as well as those who are examined and given the drugs in person, new research from UC San Francisco has found.

New research from the Indiana University Kelley School of Business explains how pharmaceutical companies were able to saturate the country with massive quantities of opioids, despite efforts by the Drug Enforcement Administration to regulate their supply.

Chocolate-flavored pills for children who hate taking medicine. Several drugs combined into one daily pill for seniors who have trouble remembering to take their medications. Drugs printed at your local pharmacy at personalized dosages that best suit your health needs.

Just two injections a year of a new HIV drug protected young women in Africa from infection with the sexually transmitted disease, new trial results show.

The U.S. Food and Drug Administration has approved Merck's Keytruda (pembrolizumab) plus chemotherapy as treatment for adult patients with primary advanced or recurrent endometrial carcinoma. This is the third FDA-approved indication for Keytruda in endometrial carcinoma.

Semaglutide, a medication initially developed for type 2 diabetes and obesity, significantly improves symptoms in men and women with a common type of heart failure that has had few therapeutic options.

The manufacturers of the most popular weight loss drugs are being challenged in court.

Researchers at University of California San Diego School of Medicine and international collaborators have led a worldwide, advanced study demonstrating the potential of tirzepatide, known to manage type 2 diabetes, as the first effective drug therapy for obstructive sleep apnea (OSA), a sleep-related disorder characterized by repeated episodes of irregular breathing due to complete or partial bloc

People with type 2 diabetes who are treated with GLP-1 agonists have a decreased risk of developing dementia, according to a new study from Karolinska Institutet published in the journal eClinicalMedicine.

People with an irregular heart rhythm taking a common blood pressure drug may be at greater risk of serious bleeding, according to a study recently published in JAMA.

Last year, Oregon became the first state in the nation to provide state-regulated access to supervised services involving mind-altering magic mushrooms—raising the likelihood of introducing psilocybin to many Oregonians who have never experienced psychedelics before.

Heart attacks have been the leading cause of death in the U.S. for a century. While most treatments for cardiac events target breaking down blood clots, Georgia Tech researchers have found a way to prevent blood clots from even forming. Dramatically, their drug is shown to completely knock out the formation of blood clots without increasing the risks of bleeds in vivo.

A class of drugs already on the market to lower blood pressure appears to reduce adults' risk of developing epilepsy, Stanford Medicine researchers and their colleagues have discovered. The finding comes out of an analysis of the medical records of more than 2 million Americans taking blood pressure medications.

An analysis of data from a randomized clinical trial for patients with stage 3 colon cancer found that those with PIK3CA mutations who took celecoxib, an anti-inflammatory drug, after surgery lived significantly longer and had longer disease-free survival compared to those without the mutation. The study, highlighting a potential breakthrough in personalized cancer treatment, was led by clinical i

Combining antiobesity medications enhances preoperative weight loss in individuals with high body mass index (BMI) preparing for metabolic surgery, according to a study presented at the annual meeting of the American Society for Metabolic and Bariatric Surgery, held from June 9 to 13 in San Diego.

Seventy-nine-year-old Genevieve Lane volunteered to take the Alzheimer's drug Leqembi in a clinical trial because she was forgetting words and misplacing her keys.

Only a third of outpatient community mental health treatment facilities in 20 states with the highest opioid related overdose deaths report offering medication treatment for opioid use disorders, suggesting efforts may be needed to strengthen such services, according to a new RAND study.

Therapists have discovered a variety of effective treatments for patients with post-traumatic stress disorder: Talk therapy, narrative writing, medication and a system that involves discussing painful experiences while focusing on blinking lights and vibrations.

In studies with genetically engineered mice, Johns Hopkins Medicine researchers say they have identified a potentially new biological target involving Aplp1, a cell surface protein that drives the spread of Parkinson's disease-causing alpha-synuclein.

The U.S. Food and Drug Administration has approved the first generic version of Emflaza (deflazacort) oral suspension for Duchenne muscular dystrophy (DMD). Approval of the generic version of Emflaza oral suspension was granted to Cranbury Pharmaceuticals (Tris Pharma).

Around one in seven Australians take antidepressants. The decision to start is often made in a time of crisis, with the thought that they might help for a period and then be stopped. Most people don't start antidepressants thinking they will take them for life.

As temperatures rise, so do chances for migraine attacks, according to a new study from a team of researchers at the University of Cincinnati College of Medicine, Icahn School of Medicine at Mount Sinai, Errex Inc. and Teva Pharmaceuticals U.S. Inc.

A widely available drug helps prevent upper gastrointestinal bleeding in critically ill adults on a breathing machine, according to the results of a global study and meta-analysis led by researchers at McMaster University.

A team of metabolic specialists and molecular biologists at Fudan University's Zhongshan Hospital, working with colleagues from other institutions in China, has found that some antimalarial drugs show promise in treating polycystic ovarian syndrome (PCOS) in women.

Early therapeutic interventions in inflammatory rheumatic diseases have proven successful in inducing drug-free remission, and EULAR—The European Alliance of Associations for Rheumatology—recommends early intervention in arthritis, since conventional synthetic disease-modifying antirheumatic drugs (csDMARD) have been shown to slow disease progression in both rheumatoid and psoriatic arthritis.

Glucocorticoids are a mainstay of treatment for systemic lupus erythematosus (SLE). But due to long-term adverse effects, dose reduction is becoming a crucial part of treat-to-target management goals. However, data regarding the optimum dose target is conflicting. Recommendations from EULAR—The European Alliance of Associations for Rheumatology—advise a glucocorticoid dose of no more than 5 mg/day

The U.S. Supreme Court on Thursday threw out a case that aimed to curb access to the controversial abortion drug mifepristone, saying the plaintiffs who brought the case to the court had no legal standing to do so.

Changing the way antibiotics are given to adult patients with sepsis will save thousands of lives a year globally, according to research by The University of Queensland and The George Institute for Global Health.

New University of Pittsburgh research points to a potential approach to reducing the risk of diabetes associated with widely-prescribed antipsychotic medications.

Alzheimer's disease is the world's most common neurodegenerative disease, affecting more than 50 million people globally. Alzheimer's disease is also among the most fatal, landing as one of the top five causes of death worldwide. However, most currently available treatments are limited to alleviating the disease's symptoms.

Glioblastoma multiforme (GBM) is among the most aggressive forms of brain tumors, with few effective treatment options and a bleak prognosis. The current standard of care (SOC), known as the STUPP regimen, includes surgical resection, radiotherapy, and temozolomide chemotherapy. Despite this rigorous approach, median progression-free survival (PFS) and overall survival (OS) are typically low.

Few people in the UK with early stage Alzheimer's disease are likely to be suitable for the latest drugs that aim to halt progress of the condition, yet many are nevertheless likely to be referred for these treatments, finds research published online in the Journal of Neurology Neurosurgery & Psychiatry.

A team of Vanderbilt researchers has created a new series of drug candidates against a hard-to-target receptor involved in the formation of blood clots. The research, spearheaded by the labs of Jens Meiler, research professor of chemistry, Craig Lindsley, Executive Director of Warren Center for Neuroscience Drug Discovery and professor of pharmacology, and Heidi Hamm, the Aileen M. Lange and Annie

Flinders University researchers have analyzed how an antidiabetic treatment could help control the growth of tumors, potentially paving the way for the design of better cancer treatments.

An independent panel of US medical experts voted Monday to recommend Eli Lilly's experimental Alzheimer's drug, meaning there could soon be another treatment option available to patients with the devastating brain disorder.

The combination of bulevirtide plus peginterferon alfa-2a is superior to bulevirtide monotherapy for achieving undetectable hepatitis D virus (HDV) RNA level at 24 weeks after the end of treatment in patients with chronic hepatitis D, according to a study published online June 6 in the New England Journal of Medicine to coincide with the annual congress of the European Association for the Study of

"Don't wake the bear that sleeps" is one of the central conclusions of a dissertation on medication for children before anesthesia and surgery. The effect of anti-anxiety, calming and sleep-inducing drugs can quickly wear off if the child is unintentionally woken up during the anesthesia preparation.

By super cooling a molecule on the surface of brain cells down to about minus 180 degrees Celsius—nearly twice as cold as the coldest places in Antarctica—scientists at Johns Hopkins Medicine say they have determined how a widely-used epilepsy drug works to dampen the excitability of brain cells and help to control, although not cure, seizures.

Individuals treated with anti-obesity medications generally experience reduced appetite, which typically leads to reduced food intake. As a result, dietary quality becomes more important because nutritional needs must be met within the context of eating less. To improve this process, medical experts have developed a list of evidence-based nutritional recommendations to assist clinicians treating p

Facing ongoing concerns about rural hospital closures, Capitol Hill lawmakers have introduced a spate of proposals to fix a federal program created to keep lifesaving services in small towns nationwide.

If national guidelines are revised to incorporate a new risk equation, about 40% fewer people could meet criteria for cholesterol-lowering statins to prevent heart disease, according to a study by researchers at the University of Pittsburgh, Beth Israel Deaconess Medical Center and University of Michigan.

In a clinical trial conducted by Stanford Medicine investigators and their colleagues, a 15-day course of Paxlovid—an antiviral drug combination targeting SARS-CoV-2, the virus that causes COVID-19—proved safe as an extended-duration treatment but didn't lessen select symptoms of the syndrome known as long COVID: the persistence, or reappearance, of COVID-related symptoms three months or more afte

A new trial conducted by the University of Oxford reveals that sildenafil, commonly known as Viagra, enhances blood flow to the brain and improves the function of brain blood vessels in patients at a heightened risk of vascular dementia.

For patients with non-small cell lung cancer with the epidermal growth factor receptor (EGFR) variant, ivonescimab plus chemotherapy improves progression-free survival, according to a study published online May 31 in the Journal of the American Medical Association (JAMA) to coincide with the annual meeting of the American Society of Clinical Oncology, held from May 31 to June 4 in Chicago.

Patients with atrial fibrillation (Afib) who took low doses of blood-thinning medications known as direct oral anticoagulants (DOACs) experienced more bleeding episodes during the first three months of treatment and about one in five had high blood levels of the medications, compared with similar patients who took standard doses of the same medications, according to a study published in Blood Adva

A drug approved to treat eczema provided significant improvement in the symptoms of patients with severe itching diseases that currently have no targeted treatments, according to a study published in JAMA Dermatology.

For someone stopping taking antidepressants, the risk of experiencing one or more discontinuation symptoms (also called withdrawal symptoms), such as dizziness, headache, nausea, insomnia and irritability due directly to stopping the medication is 15% (equivalent to one in six to seven people), according to a systematic review and meta-analysis published in The Lancet Psychiatry.

A new study suggests that people who take a few common drugs may have a decreased risk of having a bleeding stroke due to a ruptured brain aneurysm. The study is published in the June 5, 2024, online issue of Neurology. The results do not prove that these drugs reduce the risk of this type of aneurysm; they only show an association.

Diabetes rates continue to rise, with 11.7 million Canadians living with diabetes or pre-diabetes. At UBC, scientists have created a pain-free drug delivery method to help people with diabetes manage the disease and maintain their health more easily.

Attention Deficit/Hyperactivity Disorder (ADHD) is one of the most prevalent neurodevelopmental disorders and can persist into adulthood in the majority of cases. ADHD is associated with deficits in cognitive functions, in particular executive functions such as motor and interference inhibition, sustained attention, working memory, timing, psychomotor speed, reaction time variability and switching

Crinecerfont results in a greater decrease from baseline in the mean daily glucocorticoid dose among patients with congenital adrenal hyperplasia (CAH), according to a study published June 2 in the New England Journal of Medicine to coincide with the annual meeting of the Endocrine Society, held from June 1 to 4 in Boston.

Human skin, hair and nails are all vulnerable to fungal infections. While these infections are usually not serious, they're difficult to fully resolve and often recur after treatment—sometimes for years. They're also often resistant to treatments, including a common class of antifungals called azoles.

A first-of-a-kind proposal to begin using the mind-altering drug MDMA as a treatment for PTSD was roundly criticized Tuesday—a potentially major setback to psychedelic advocates who hope to win a landmark federal approval and bring the banned drugs into the medical mainstream.

Researchers from the Indian Institute of Management Calcutta, University of Chicago, and Management Development Institute, Gurgaon have published a new study that examines the unintended consequences of an Indian government health care policy.

A medication to treat chronic myeloid leukemia (CML) has shown its potential to become the new frontline therapy for people living with the life-threatening blood cancer.

A team of UC Davis Health researchers has discovered that a common anti-inflammatory drug, mesalamine, can replace the work of good bacteria in fighting the nasty fungus Candida albicans in the gut.

Some people should consider taking an antibiotic as a morning-after pill to try to prevent certain sexually transmitted diseases, U.S. health officials recommended Tuesday.

Federal health advisers are weighing the first-of-a-kind approval of MDMA, the mind-altering club drug, as a treatment for PTSD—part of a decadeslong effort by psychedelic advocates to win medical acceptance for the drug's purported benefits.

A new study suggests that a course of the drug doxycycline can decrease acute seizure-related hospitalization and deaths related to nodding syndrome.

Drugs like Ozempic, Wegovy and Mounjaro have been around for years, but they've recently been making headlines due to a rise in popularity as weight loss agents. They all belong to a class of drugs known as glucagon-like peptide-1 receptor agonists (GLP-1RAs), which mimic a hormone (GLP-1) in the body that helps control insulin and blood glucose levels and promotes feelings of satiety.

The U.S. Food and Drug Administration has approved Tris Pharma's once-daily Onyda XR (clonidine hydrochloride) as the first liquid, nonstimulant treatment for attention-deficit/hyperactivity disorder (ADHD).

As social media platforms like TikTok and Instagram have risen in popularity, so have direct-to-consumer advertisements for drugs like Ozempic, whether it be pop-up advertisements or social media influencers promoting products to their followers. Now, more and more people are asking their doctors to prescribe them drugs they have seen in advertisements, prompting three chief medical residents—Lynn

Obeldesivir (GS-5245), a novel investigational small molecule oral antiviral, represents a new tool in the ongoing effort to prepare for future pandemics.

Two early-phase clinical trials presented at the 2024 American Society of Clinical Oncology (ASCO) Annual Meeting by researchers from The University of Texas MD Anderson Cancer Center demonstrate promising responses and safety profiles in heavily pretreated patients with advanced solid tumors.

A new study by researchers at the Case Western Reserve University School of Medicine reveals that the popular diabetes and weight-loss drugs Wegovy and Ozempic are linked to reduced incidence and recurrence of alcohol abuse or dependence.

Lori Tipton is among the growing number of people who say that MDMA, also known as ecstasy, saved their lives.

Most patients with thyroid eye disease treated with teprotumumab didn't require additional treatment nearly two years later, according to industry-supported research being presented Sunday at ENDO 2024, the Endocrine Society's annual meeting in Boston, and published in the journal Thyroid.

A novel male contraceptive gel combining two hormones, segesterone acetate (named Nestorone) and testosterone, suppresses sperm production faster than similar experimental hormone-based methods for male birth control, according to a new study.

Medications for type 2 diabetes and obesity known as GLP-1 receptor agonists may lower the risk of acute pancreatitis recurrence in people with obesity and those with type 2 diabetes, according to a study presented Saturday at ENDO 2024, the Endocrine Society's annual meeting in Boston, Mass.

Having medical conditions linked to obesity does not impact the total weight loss achieved with the anti-obesity medication tirzepatide, according to an industry-supported study being presented Saturday at ENDO 2024, the Endocrine Society's annual meeting in Boston, Mass.

A team of medical researchers affiliated with several institutions in the U.S. has found that a high percentage of doctors posting endorsements regarding drugs on the social media site X were paid to do so by the makers of the drugs.

The first new PTSD drug in over 20 years is up for approval. It will require U.S. regulators to do something they've never done before: greenlight the mind-altering—and illegal—party drug known as ecstasy.

A Pfizer lung cancer drug has been shown to greatly reduce tumor progression and improve survival outcomes for people in the advanced stages of a rare form of the disease, according to trial results published Friday.

An April 24 letter from Vermont Sen. Bernie Sanders to the CEO of Novo Nordisk began with heartfelt thanks to the Danish drugmaker for inventing Ozempic and Wegovy, two medications poised to improve the health of tens of millions of Americans with obesity and related diseases.

A thesis at Umeå University shows that certain non-steroidal anti-inflammatory drugs, known as NSAIDs, can help patients who have undergone surgery for colorectal cancer. These patients suffer fewer recurrences of cancer and fewer leaks at the surgical site, so-called anastomotic leakage.

Bimekizumab is well tolerated and produces clinically meaningful responses in patients with hidradenitis suppurativa, according to a study published online May 22 in The Lancet.

Researchers at George Mason University's College of Public Health have leveraged the power of artificial intelligence (AI) analytical models to match a patient's medical history to the most effective antidepressant, allowing patients to find symptom relief sooner. The free website, MeAgainMeds.com, provides evidence-based recommendations, allowing clinicians and patients to find the optimal antide

Humans have long been searching for a "magic elixir" to make us smarter, and improve our focus and memory. This includes traditional Chinese medicine used thousands of years ago to improve cognitive function.

A drug approved to treat certain autoimmune diseases and cancers successfully alleviated symptoms of a rare genetic syndrome called autoimmune polyendocrine syndrome type 1 (APS-1). Researchers identified the treatment based on their discovery that the syndrome is linked to elevated levels of interferon-gamma (IFN-gamma), a protein involved in immune system responses, providing new insights into t

A new study published in JAMA Dermatology looks at how taking the oral contraceptive pill could be linked to a form of hair loss, known as frontal fibrosing alopecia (FFA).

A new study led by investigators from Mass General Cancer Center reveals that statins—commonly used cholesterol-lowering drugs—may block a particular pathway involved in the development of cancer that results from chronic inflammation. The findings are published in Nature Communications.

More than 300 politicians, health experts and celebrities on Thursday called for US pharmaceutical giant Gilead to allow cheap, generic versions of a promising new HIV drug to be produced so it can reach people in developing countries most affected by the deadly disease.

Research recently published in Drug Resistance Updates has revealed a previously unknown biological process through which breast tumor cells develop resistance to standard treatment, which could open the door for cancer scientists around the world to further target this vulnerability in hopes of creating more effective therapies for disease.

While older drugs for epilepsy, taken while pregnant, have been shown in previous research to affect the creative thinking of children, a new study finds no effects on creativity for children born to those taking newer epilepsy drugs. This study is published in Neurology.

A large, linked data study has detailed the scale of prescription opioid use—such as oxycodone, morphine, or tramadol—after a hospital or emergency department (ED) visit, while giving insight into how often people then go onto long-term and potentially problematic use of these medicines in NSW.

Foam mixed with medications is already used to treat conditions such as varicose veins, hemorrhoids, wounds on the skin and even hair loss. Now, Fred Hutchinson Cancer Center scientists have found that foam might also be used as a vehicle to deliver expensive gene therapies.

Synesthesia, hallucinations, euphoria. The documented effects of classic psychedelic substances such as psilocybin (magic mushrooms) or lysergic acid diethylamide (LSD) are vast. With their usage common and their effects profound, a team of speech and psychology researchers explored the impact of psychedelics on people who stutter, finding evidence that users see some benefits.

A small interfering RNA (siRNA) investigational therapy that inhibits a gene involved in lipoprotein metabolism has been shown in a clinical trial led by Mount Sinai researchers to significantly reduce levels of different types of cholesterol and triglycerides in individuals with mixed hyperlipidemia, a condition in which fats build up in the blood.

For the past year and a half, Tandra Cooper Harris and her husband, Marcus, who both have diabetes, have struggled to fill their prescriptions for the medications they need to control their blood sugar.

Conjugated equine estrogen (CEE) taken alone for menopause may increase the risk for developing and dying from ovarian cancer, according to a study presented at the annual meeting of the American Society of Clinical Oncology, held from May 31 to June 4 in Chicago.

A study of adults aged 60 years and older found that the use of statin therapy as primary cardiovascular disease (CVD) prevention was effective for preventing CVD and all-cause mortality, even in adults aged 85 years and older. The study is published in Annals of Internal Medicine.

Research led by Baylor College of Medicine has shown that a new therapy significantly reduces triglyceride levels in individuals with mixed hyperlipidemia—elevations of triglycerides and cholesterol.

Thousands of Australians struggle with serious mental health conditions. But when the recommended treatment involves antipsychotic medications, the side effects are excess kilos, which only adds weight to an already complex diagnosis.

With summer around the corner, telehealth outlets and medical spas are going into hyperdrive advertising the sale of semaglutide, the active ingredient in popular weight-loss drugs Ozempic and Wegovy.

Anorexia nervosa is a severe mental health disorder where people fear weight gain. Those with the disorder have distorted body image and hold rigid beliefs their body is too big. They typically manage this through restricted eating, leading to the serious medical consequences of malnutrition.

Antibody-mediated rejection (AMR) is one of the most common causes of kidney transplant failure. To date, however, no treatment has proven effective in combating this complication in the long term.

A randomized, placebo-controlled clinical trial led by a collaboration between Duke-NUS Medical School, National Heart Center Singapore (NHCS) and Klinikum Nürnberg, Germany, has revealed surprising new insights into how SGLT2 inhibitor drugs, originally developed for diabetes, benefit patients with heart failure.

A study led by UCLA Health Jonsson Comprehensive Cancer Center researchers found that using a combination of experimental immunotherapy drugs with chemotherapy significantly improves progression-free survival and overall survival for patients with metastatic colorectal cancer who have previously undergone standard chemotherapy treatment when compared to those who received the targeted therapy rego

A pioneering study has demonstrated that semaglutide significantly reduces the risk of major kidney disease events, cardiovascular outcomes, and all-cause mortality in patients with type 2 diabetes and chronic kidney disease. The landmark trial, presented at the 61st ERA Congress, will pave the way for new treatment strategies and offer hope to millions of patients globally. The study is also publ

Access to effective antibiotics is essential to all health systems in the world. Antibiotics prolong lives, reduce disabilities, limit health care costs and enable other life-saving medical interventions such as surgery. However, antimicrobial resistance (AMR) threatens this backbone of modern medicine and is already leading to deaths and disease which would have once been prevented.

University of Oklahoma researchers have deepened their understanding of a drug's ability to prevent fat buildup in the liver, a condition that often occurs with obesity and can lead to serious fatty liver disease. Their findings—which illustrate the complexity of metabolic disorders—are published in The Proceedings of the National Academy of Sciences.

The U.S. Food and Drug Administration has approved GlaxoSmithKline's 200-mg subcutaneous route of administration of Benlysta (belimumab) for patients 5 years of age and older with active systemic lupus erythematosus (SLE) who are receiving standard therapy.

A new analysis found that the profound benefits of Novo Nordisk's obesity drug Wegovy for people at risk of heart attacks or strokes don't depend on the number of the scale—cardiovascular health improves whether people lose a lot or even very little weight.

Having an epidural during labor is associated with a marked reduction in serious complications in the first few weeks after giving birth, finds a study published by The BMJ.

A U.S. Food and Drug Administration committee voted unanimously in April to approve a new clinical endpoint, minimal residual disease (MRD), when evaluating proposed drugs to treat multiple myeloma.

About 1 in 5 people globally live with chronic pain, and it is a common reason for seeing a doctor, accounting for one in five GP appointments in the UK.

Alzheimer's disease is the most common cause of dementia, affecting more than 55 million people worldwide. Currently, the two main approaches for treatments to delay or slow its progression target the buildup of amyloid beta peptides—which form plaques in the spaces between nerve cells in the brain—and the buildup of tau protein, resulting in tangles which damage neurons.

Since cannabidiol (CBD), the non-intoxicating component of cannabis, was legalized in the United States by the 2018 Farm Bill, products containing the compound have flooded the consumer health sector.

Scientists have used breast cancer cells' weakness against themselves by linking a tumor-selective antibody with a cell-killing drug to destroy hard-to-treat tumors.

Only 14.5% of adult patients with moderate or severe asthma are prescribed the recommended SMART combination inhaler regimen and over 40% of academic pulmonary and allergy clinicians have not adopted this optimal therapy, according to research published at the ATS 2024 International Conference.

Behind the scenes, as tumors progress and gain resistance to treatment, a protein called YB-1 quietly gives directions. Now, researchers at Oregon Health & Science University have developed a first-of-its-kind drug that inhibits YB-1, effectively silencing those orders.

Many breast cancer survivors report cancer-related cognitive impairment following chemotherapy, although prevalence rates and severity vary.

Chronic obstructive pulmonary disease patients with type 2 inflammation may soon gain access to a new drug—dupilumab—that showed rapid and sustained improvements in patients in a pivotal Phase 3 clinical trial, researchers report in the New England Journal of Medicine. This monoclonal antibody is the first biologic shown to improve clinical outcomes in COPD. The data supporting the use of dupiluma

For patients with chronic obstructive pulmonary disease (COPD), bisoprolol does not reduce the number of self-reported exacerbations treated with oral corticosteroids, antibiotics, or both, according to a study published May 19 in the Journal of the American Medical Association to coincide with the American Thoracic Society 2024 International Conference, held from May 17 to 22 in San Diego.

People with seasonal allergies often turn to over-the-counter and prescription medicines to relieve symptoms like coughing, sneezing, runny nose, congestion and itchy eyes, nose or throat.

The American Pediatric Association recommends iron supplements to all healthy infants who breastfeed longer than four months, while its European counterpart, Society of Gastroenterology, Hepataology and Nutrition, does not recommend it.

A lack of detailed record-keeping in clinics and emergency departments may be getting in the way of reducing the inappropriate use of antibiotics, a pair of new studies by a pair of University of Michigan physicians and their colleagues suggests.

A researcher in the Keck School of Medicine of USC's department of surgery has discovered a potential breakthrough in delaying the onset of Alzheimer's and Parkinson's disease and treating hydrocephalus. Young-Kwon Hong, Ph.D., the chief of basic science research in the department of surgery, and his team have developed a drug that can help clear fluid and cellular debris from the brain.

A team led by investigators from Massachusetts General Hospital used a new drug to save the life of a patient with immune thrombotic thrombocytopenic purpura (iTTP), a rare disorder characterized by uncontrolled clotting throughout the small blood vessels.

People who use metformin are less likely to develop a myeloproliferative neoplasm (MPN) over time, indicating that the treatment may help prevent the development of certain types of cancers, according to a study published in Blood Advances.

The first U.S. trial of varenicline for e-cigarette cessation shows promising results and warrants larger-scale trials, the researchers say.

A recent publication in Scientific Reports unveils a promising non-opioid pain treatment developed by a team led by Dr. Hernan Bazan, the John Ochsner Endowed Professor of Cardiovascular Innovation at Ochsner Health.

Proton pump inhibitors (PPIs), a specific class of antacid drugs, are among the most widely used medications of all. They are frequently prescribed to many groups of patients, including those with rheumatism. PPIs are used to prevent the stomach problems that can arise from taking certain anti-inflammatory drugs.

In a study published in Nature, Christoffer Clemmensen and colleagues demonstrate a new use of the weight loss hormone GLP-1. GLP-1 can be used as a "Trojan Horse" to smuggle a specific molecule into the brain of mice, where it successfully affects the plasticity of the brain and results in weight loss.

Individuals taking glucagon-like peptide (GLP)-1 receptor agonists have a greater risk for subsequently being dispensed antidepressants, according to a study published online April 23 in Diabetes, Obesity, and Metabolism.

A new study led by researchers at University Hospitals Connor Whole Health has found that adults initially receiving chiropractic spinal manipulation for newly diagnosed radicular low back pain (sciatica) were significantly less likely to be prescribed tramadol over the following year compared to those receiving usual medical care.

In the international CONVINCE trial, presented today (15 May 2024) at the European Stroke Organization Conference (ESOC 2024), anti-inflammatory treatment with long-term colchicine did not reduce rates of recurrent stroke and cardiovascular events in patients with non-cardioembolic stroke in the primary intention-to-treat analysis.

Deaths from cancer or infections can occur when available treatments are ineffective. Once turned on, pregnane X receptor (PXR) activates the expression of genes encoding enzymes that metabolize external chemicals, including drugs. This causes a significant drop in the effectiveness of chemotherapy, antivirals and other pharmaceuticals.

Among slow responders to tirzepatide treatment at week 12, 90 percent went on to achieve clinically meaningful weight reduction (≥5 percent) by week 72, according to a study presented at the annual meeting of the American Association of Clinical Endocrinology, held from May 9 to 11 in New Orleans, and published in the journal Endocrine Practice.

One in eight adults (12 percent) say they have ever taken a glucagon-like peptide-1 receptor agonist (GLP-1 RA) and 6 percent say they are currently using one, according to the results of a new KFF Health Tracking Poll, released May 10.

Although medications can often help patients find a cure or respite from their condition, millions of people worldwide suffer from unpredictable drug toxicities every year. In particular, drug eruptions which manifest through symptoms such as redness, blisters, and itching on the skin, are quite common.

When a person is diagnosed with HIV, they are placed on a lifelong HIV treatment regimen, called antiretroviral therapy, to keep the virus under control. But for many people, having to take medicine every day can be a struggle for a variety of reasons, resulting in missed doses that could potentially lead to a decline in their health.

Researchers from the Cardiac Regeneration and Heart Failure Research Group (ICREC) at the Germans Trias i Pujol Research Institute (IGTP) and the Heart Institute of the Germans Trias Hospital (iCor) have found beneficial effects of the novel drug Sacubitril/Valsartan in the management of myocardial infarction (MI).

Compared to Black and Asian people, white and Hispanic people with Alzheimer's disease and related dementias were most likely to be diagnosed with symptoms like depression and agitation, according to a new study from the USC Schaeffer Center for Health Policy & Economics.

Despite national guidelines, a small proportion of children were prescribed ineffective and potentially harmful medications for acute COVID-19, according to a study published online May 8 in Pediatrics.

People with a common heart condition were able to use significantly more oxygen while exercising after taking an investigational drug in an international clinical trial, according to a study published today in the New England Journal of Medicine. The finding was also presented today at the European Society of Cardiology's Heart Failure 2024 meeting in Lisbon, Portugal.

Two studies are being presented at this year's European Congress on Obesity (ECO) in Venice, Italy (12-15 May), based on the landmark Semaglutide and Cardiovascular Outcomes (SELECT) trial from the same international author group.

In emergency rooms and intensive care units across the country, clinicians make split-second decisions about which antibiotics to give a patient when a life-threatening infection is suspected. A new U-M study reveals that these decisions may have unintended consequences for patient outcomes. The study is published in the journal JAMA Internal Medicine.

Liposomal bupivacaine was launched on the market 12 years ago to provide long-lasting local control of pain. The medication is used as a local anesthetic, particularly for orthopedic operations. A research study by MedUni Vienna has now shown the limited effectiveness of the substance.

Even though mortality and hospitalization rates have improved, the quality of life for those living with hypertrophic cardiomyopathy (HCM) can be compromised with limiting symptoms such as exertional dyspnea and decreased exercise capacity. A major cause of this in HCM patients is left ventricular outflow tract (LVOT) obstruction, which results in elevated intracardiac pressures.

The U.S. Drug Enforcement Agency announced in late April 2024 that it plans to ease federal restrictions on cannabis, reclassifying it from a Schedule I drug to the less restricted Schedule III, which includes drugs such as Tylenol with codeine, testosterone and other anabolic steroids. This historic shift signals an acknowledgment of the promising medicinal value of cannabis.

Blood pressure (BP) self-monitoring, together with self-titration of antihypertensive medications, is associated with a reduction in BP, according to a study published online May 10 in JAMA Network Open.

Dispensing abortion pills through the mail works as well as requiring patients to get them in person from a clinic or doctor's office, according to new research from UC San Francisco, which comes as the Supreme Court is considering whether to disallow the practice.

Semaglutide reduces the need for loop diuretic use and dose, and has positive effects on symptoms, physical limitations, and body weight in patients with heart failure with preserved ejection fraction (HFpEF) regardless of diuretic use, according to late breaking research presented at Heart Failure 2024, held 11–14 May in Lisbon, Portugal

Fezolinetant reduces the frequency and severity of hot flushes during menopause for 24 weeks, without serious side effects, according to research presented at the 26th European Congress of Endocrinology, held 11–14 May, in Stockholm. These findings provide further evidence of the benefits of using this non-hormonal preventative drug in women experiencing hot flushes during menopause.

Historical disparities in initiation of direct oral anticoagulants (DOACs) for atrial fibrillation have lessened for Black and Hispanic patients, according to a study published online May 6 in JAMA Network Open.

About 1 in 8 U.S. adults (12%) have tried a weight-loss drug like Wegovy, Ozempic, Zepbound or Mounjaro, a new KFF Health Tracking Poll says.

You've just been given a prescription for a new drug from your doctor. Your doctor told you why she was prescribing the medication, gave you its name and some information about common side-effects. Your pharmacist is also available to help you use the medication properly, but you want more details and general information.

A new drug could prevent sepsis-related organ failure and death by restoring the health of a patient's blood vessels. Researchers from The University of Queensland and the Queensland Children's Hospital (QCH) have successfully tested the first-in-class drug in mice.

In November 2017, days after her daughter Mallory Smith died from a drug-resistant infection at the age of 25, Diane Shader Smith typed a password into Mallory's laptop.

When doctors began using the drug sotorasib in 2021 with high expectations for its innovative approach to attacking lung cancer, retired medical technician Don Crosslin was an early beneficiary. Crosslin started the drug that July. His tumors shrank, then stabilized.

An investigation published by The BMJ today raises concerns about financial entanglements between US Food and Drug Administration (FDA) chiefs and the drug and medical device companies they are responsible for regulating.

Sodium-glucose cotransporter 2 inhibitors are a class of glucose-lowering drugs known for robust cardiovascular protective properties. However, the side effects induced by sodium-glucose cotransporter 2 inhibition limit application in cardiovascular medicine.

Systemic antibiotic exposure in the first year of life is associated with higher atopic dermatitis (AD) risk in a dose-response fashion, according to a study published online April 24 in the Journal of Allergy and Clinical Immunology.

Trifarotene plus skin care is beneficial for patients with moderate acne vulgaris (AV) and acne-induced hyperpigmentation (AIH), according to a study published online April 29 in the International Journal of Dermatology.

A team led by LDI senior fellow and Perelman School of Medicine faculty member Lauren Eberly at a Navajo Nation hospital in New Mexico has developed a simple intervention that increased the uptake of guideline-directed heart failure therapy drugs by 53%. Titled "Telephone-Based Guideline-Directed Medical Therapy Optimization in Navajo Nation: The Hózhó Randomized Clinical Trial," the study is publ

Researchers at the Icahn School of Medicine at Mount Sinai have shed valuable light on the complex mechanisms by which a class of psychedelic drugs binds to and activates serotonin receptors to produce potential therapeutic effects in patients with neuropsychiatric disorders such as depression and anxiety.

Starting people with opioid use disorder on extended-release, injectable naltrexone (XR-naltrexone) within five to seven days of seeking treatment is more effective than the standard treatment method of starting within 10–15 days, but requires closer medical supervision, according to results from a clinical trial published in JAMA Network Open.

If you're one of the millions of Americans who have a penicillin allergy listed on your medical record, research suggests it's highly likely that this label is inaccurate.

The anti-cancer drug abemaciclib (also known as Vernezio) has been added to the Australian Pharmaceutical Benefits Scheme (PBS) to treat certain types of breast cancer.

Lab tests of counterfeit oxycodone (Oxycontin) pills seized by police in Rhode Island in 2022 found 99.3% also contained dangerous fentanyl.

Newborns in Sweden are given antibiotics for suspected sepsis to an unjustified extent. This is according to a study by the University of Gothenburg in more than 1 million newborns. Despite a significant reduction in sepsis rate in the group, the use of antibiotics has not decreased.

In 2016, University of Pittsburgh researchers Dr. Farzad Esni, Ph.D., and Jing Hu, Ph.D., did an experiment in mice where they deleted one of two copies of the gene encoding an enzyme called focal adhesion kinase (FAK). They were interested in the role of FAK in pancreatic cancer, but a surprise finding took the research in a very different direction.

Researchers at HMRI and the University of Newcastle have evaluated a drug called azithromycin, a macrolide antibiotic, to test if it would put moderate to severe asthma into remission.

Eleven million U.S. adults use e-cigarettes to vape nicotine, and about half of them say that they want to stop, but many have trouble doing so because nicotine is an addictive drug.

Starving out tumor cells may be a promising therapy for treatment-resistant lung cancer, according to a new study published in Science Advances.

Patients with COVID-19 had lower viral loads if treated with metformin, according to new University of Minnesota research that argues for broader use of the cheap anti-diabetes drug and against the controversial use of ivermectin.

An analysis of 15 name-brand drugs and their "skinny label" generic counterparts found that competition from these counterparts saved Medicare Part D nearly $15 billion from 2015 to 2021. Skinny labeling allows generic drug manufacturers to exclude labeling information that remains patent-protected by the brand name manufacturer.

The Examining Quality, Use and Impact of Psychotropic (Use) in older adults with intellectual disabilities (EQUIP) study, has revealed that more than half of older adults with intellectual disability take psychotropic medicines, including antipsychotics and antidepressants used to treat mental illness.

Researchers are recommending full-scale human trials after an insomnia drug helped a man withdraw from his 16 drinks-a-day addiction.

The number of people accessing medication for attention-deficit hyperactivity disorder (ADHD) in Aotearoa New Zealand increased significantly between 2006 and 2022. But the disorder is still underdiagnosed and under-treated compared to global ADHD prevalence estimates.

A preclinical study from Karolinska Institutet offers hope for treating severe neurodegenerative diseases with an existing drug. The study suggests that the leprosy drug clofazimine may be effective in the treatment of Huntington's disease.

A drug that targets a protein known as phosphatidylserine boosted the response rate for hepatocellular carcinoma (HCC) patients receiving immunotherapy without compromising their safety, according to results of a phase two clinical trial conducted by UT Southwestern Medical Center.

Interest in psychedelics like psilocybin, mescaline, and LSD is on the rise for the first time in 50 years, as influencers, scientists, and entrepreneurs promote their therapeutic potential. Some municipalities have stopped enforcing criminal bans on their possession, and at least one state has legalized medicinal use of certain psychoactive substances.

A team of University of Minnesota researchers found that metformin, a drug commonly used to treat diabetes, can decrease the amount of COVID-19 virus in the body and lower the chances of the virus coming back strongly after initial treatment. The study was published in Clinical Infectious Diseases.

Protein imbalances that increase brain cell excitability may explain why individuals with Alzheimer's disease (AD) who also experience seizures demonstrate more rapid cognitive decline than those who do not experience seizures. These imbalances may be present in the brains of individuals before the onset of AD symptoms.

Scientists have discovered a new snakebite treatment to prevent the devastating tissue damage caused by African spitting cobra venom.

The disruption to the supply of a prescription medicine that helps people stop smoking may have led to thousands fewer people quitting each year in England, which will lead to avoidable deaths in future, suggests a new study led by UCL (University College London) researchers.

The way religious beliefs and medical treatments intersect can really affect how people use medications and stick to their treatment plans. Lately, there's been talk about "Halal pharmaceuticals," which are drugs made to fit with Islamic beliefs. But a lot of health care providers in places like the Middle East don't know much about what goes into these drugs or how they're made.

During hepatic surgery or liver transplantation, the liver is vulnerable to ischemia-reperfusion injury (IRI), especially when vessels are compressed to control bleeding or during periods of ischemia. The hallmark of IRI is mitochondrial dysfunction, which generates reactive oxygen species, and cell death through necrosis or apoptosis.

A novel oral amphotericin B (MAT2203) developed by Matinas BioPharma for treatment of invasive mucormycosis (IM) and other deadly invasive fungal infections, has demonstrated encouraging results in a series of preclinical studies. The research, led by Lundquist Institute (TLI) Investigator Ashraf Ibrahim, Ph.D., has been published in the journal Antimicrobial Agents and Chemotherapy.

California struck up a new deal with Amneal Pharmaceuticals on April 29 to bolster the state's supply of the opioid overdose-reversing medication naloxone at a much lower price for schools, police departments and others trying to ease the toll of fentanyl.

A combination of two antiviral compounds may be a promising alternative to Paxlovid when treating COVID-19 in immunocompromised patients, according to Karen S. Anderson, Ph.D., professor of pharmacology and of molecular biophysics & biochemistry at Yale School of Medicine.

Scientists at Johns Hopkins Medicine say that an experimental monoclonal antibody drug called mAb43 appears to prevent and reverse the onset of clinical type 1 diabetes in mice, and in some cases, to lengthen the animals' lifespan.

A new study examining the role of aspirin in breast cancer treatment reveals critical issues related to health equity and aging that have broad implications for cancer and other disease intervention trials, say researchers from Georgetown University's Lombardi Comprehensive Cancer Center. They outline their concerns in an editorial accompanying the study's findings published April 29 in JAMA.