All articles tagged: Medications

Hair loss significantly impacts patients' quality of life, and it may be nonscarring or scarring. Etiologically, hair loss may be hereditary (androgenetic alopecia [AGA]); related to age; congenital (hair shaft disorders); traction-induced; inflammatory (primary scarring alopecia); autoimmune (alopecia areata); or secondary to medical, surgical, or emotional stressors (telogen effluvium), infectio

Trendy weight-loss drugs making headlines for shrinking waistlines may also be shrinking the human heart and other muscles, according to a new University of Alberta study in JACC: Basic to Translational Science. The authors say the research should serve as a "cautionary tale" about possible long-term health effects of these drugs.

Drug-drug interaction (DDI) is a phenomenon in which the efficacy of a drug is weakened or enhanced when multiple drugs are combined. The DI can cause serious health risks to patients.

For patients with chronic kidney disease (CKD), the risk for emergently treated hypocalcemia with denosumab increases with worsening CKD stage, according to a study published online Nov. 19 in the Annals of Internal Medicine.

Antiviral treatment is underutilized among children and adolescents hospitalized with influenza, according to research published in the Nov. 14 issue of the U.S. Centers for Disease Control and Prevention Morbidity and Mortality Weekly Report.

For the first time since 2021, a pill used to help people quit smoking—varenicline—will again be available from the NHS.

Eradivir, a preclinical biotech company, has developed a patent-pending antiviral therapeutic that reduces lung viral loads of advanced-stage influenza in preclinical studies quicker and more effectively than currently available therapies.

Common cardiovascular drugs are linked to a lower risk of dementia in older age, according to a new study from Karolinska Institute, published in Alzheimer's & Dementia.

Commonly prescribed drugs used to treat high blood pressure have been shown to, over time, wreck the kidneys' ability to filter and purify blood, but exactly how that dangerous side effect unfolded has been a riddle. University of Virginia School of Medicine researchers say they've solved the mystery.

Doctors may soon use an AI-driven solution to swiftly prescribe a personalized antibiotic regimen for patients with just a few mouse clicks instead of giving general treatment. The antibiotic regimen can then be adjusted, if necessary, when bacterial culture and other investigation test results become available.

More than half of all American adults, almost 137 million people, could be candidates for the blockbuster GLP-1 drug semaglutide, a new analysis finds.

Drugs already taken by millions of diabetes patients appear to also help slash asthma attacks by up to 70%, new British research shows.

A new study highlights the recent but fluctuating growth in global human antibiotic consumption, one of the main drivers of growing antimicrobial resistance (AMR). AMR results in infections that no longer respond to antibiotics (and other antimicrobial medicines) and often leads to longer hospital stays, higher treatment costs, and higher mortality rates. AMR is estimated to be associated with nea

In his recent doctoral thesis, defended at the University of Helsinki, Matej Zore investigated two drugs, fingolimod and etrasimod—initially developed to treat autoimmune diseases—for their potential to fight drug-resistant bacterial infections. Both drugs showed notable antibacterial effects, including against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcu

A clinical trial testing muvalaplin, a novel oral medication, was able to safely and effectively lower high levels of lipoprotein (a), according to late-breaking science presented today at the American Heart Association's Scientific Sessions 2024. The study is simultaneously published today in JAMA, the Journal of the American Medical Association.

A new nasal spray form of the medication bumetanide may reduce the tissue swelling caused by heart failure as effectively as the standard oral and intravenous formulations of the medication, according to late-breaking science presented Nov. 18 at the American Heart Association's Scientific Sessions 2024. The meeting, held Nov. 16–18, in Chicago, is a premier global exchange of the latest scientifi

A mother says years of painful headaches and speech issues from brain tumors were caused by prolonged use of a Pfizer birth control shot, according to a lawsuit filed Nov. 14 in Nevada Federal District Court.

Prescribing anti-clotting medications to adults younger than age 65 who have atrial fibrillation (AFib) but no other risk factors for stroke did not reduce the risk of cognitive decline, stroke or transient ischemic attack (TIA), according to late-breaking science presented Nov. 16 at the American Heart Association's Scientific Sessions 2024.

Patients living in linguistically discordant long-term care homes in Ontario are at higher odds of being inappropriately prescribed psychosis medication, says a new University of Ottawa study highlighting the importance of delivering care in the patient's preferred language.

Children born to mothers who take antiseizure medications to manage seizures and psychiatric conditions during pregnancy may face increased risks of neurodevelopmental conditions, according to new data from researchers at Drexel's Dornsife School of Public Health.

New research, led by experts at the University of Nottingham, has found that certain types of medication used to treat diabetes may be effective in reducing alcohol use.

The U.S. Food and Drug Administration has approved Bristol Myers Squibb's Cobenfy (xanomeline and trospium chloride), a first-in-class muscarinic agonist, for the treatment of schizophrenia in adults.

Europe's medicines watchdog on Thursday partially approved a marketing request for a long-awaited new treatment for Alzheimer's disease, reversing an earlier decision not to give it the green light.

In a new study, researchers at McMaster University have identified a potential treatment for Sandhoff and Tay-Sachs diseases—two rare, often fatal lysosomal storage disorders that cause progressive damage to nerve cells in the brain and spinal cord.

A new study by Monash University medicine safety experts found the use of gabapentinoids—medicines widely used to treat neuropathic pain—increased the risk of hip fractures, especially in older patients who were frail or had kidney disease.

A new joint study by the University of Eastern Finland and Karolinska Institutet in Sweden found that the GLP-1 agonists semaglutide and liraglutide, which are used for treating diabetes and obesity, were associated with fewer hospitalizations among individuals with alcohol use disorder, AUD.

In the wake of Donald Trump's victory in the presidential election, retailers report that online sales of emergency contraceptives have soared. The spike in purchases of what is also known as the morning-after pill or Plan B suggests women worry the incoming administration might soon limit their access to emergency contraception, Monica Cepak, CEO of the sexual and reproductive telehealth company

Over the past few decades, the opioid epidemic has gripped the United States, fueled in large part by the over-prescription of pain-relieving drugs like oxycodone. As those pharmaceuticals were made more difficult to obtain, opioids such as heroin and fentanyl began new waves of the epidemic and more deaths from overdose.

Acupuncture. Ketamine infusions. "Electroshock" or electroconvulsive therapy. The existing treatment options for those diagnosed with major depressive disorder (MDD) and treatment-resistant depression (TRD), may sometimes feel daunting or expensive alternatives to medication. However, a groundbreaking study from Emory University demonstrates how psilocybin-assisted therapy could impact more than 5

The treatment landscape for patients with prostate cancer, especially individuals with advanced disease, has dramatically changed in recent years. However, aside from drug or hormonal therapies, other targets to treat prostate cancer are still necessary to prolong life and slow the progression of this potentially lethal disease.

All patients who have had a heart attack are typically treated using beta blockers. According to a Swedish study conducted earlier in 2024, this drug is unlikely to be needed for those heart patients who have normal pumping ability. Now a sub-study at Uppsala University shows that there is also a risk that these patients will become depressed by the treatment.

A multi-institutional study made up of 26 researchers led by the University of Melbourne has discovered that iron-reducing deferiprone accelerates cognitive decline in patients with early Alzheimer's disease. This unexpected finding shows that reducing brain iron levels with deferiprone is detrimental for individuals with Alzheimer's.

The weight-loss drug Ozempic can help reduce stroke patients' risk of a heart attack or death, a new study says.

The head of the company that makes the diabetes and obesity drugs Ozempic and Wegovy has warned that compounded versions of the active ingredient in those medications have now been linked to at least 100 hospitalizations and 10 deaths.

A global investigation led by Monash University into antimicrobial knowledge in medicine, pharmacy, nursing, dentistry and veterinary undergraduate students has uncovered a need for better education across all five disciplines to curb the growing threat of antimicrobial resistance and its impact on planetary health.

Concerns about COVID-19 have significantly diminished, but researchers continue to analyze its high transmission rate, aiming to prepare for future infectious diseases. A research team has newly identified the mechanism behind the rapid proliferation of the COVID-19 virus.

Researchers from the George Washington University and the Washington DC Veterans Affairs Medical Center have published a case report that signifies a potential breakthrough in the treatment of an aggressive type of prostate cancer.

As the hunt for effective cancer therapies intensifies, some scientists are turning back to look at old drugs in a new light. The anti-malarial hydroxychloroquine is one such drug that has been "repurposed" to fight cancer. Despite its effectiveness at blocking the resupply of needed resources to cancer cells, clinical trial results have been disappointing, in part because cancer cells eventually

A new study, out today in the Journal of the American Medical Association, has found that pharmacy closures in communities around Colorado significantly impact patient access to anticonvulsant medications, typically used to treat epilepsy, neuropathic pain and psychiatric disorders. Missing doses of this class of medication can result in increased mortality, pain and emergency room visits.

At least a quarter of children in the United States who died from opioid poisoning between 2004 and 2020 were victims of prior abuse or neglect, a new Yale study finds, and more than two-thirds of 10- to 17-year-olds who suffered fatal poisonings had a history of substance use.

Recent studies have shown that pharmacological treatment with GLP-1-RA and dual GLP-1/glucose-dependent insulinotropic polypeptide receptor agonists (GIP-RA) causes almost as much weight loss as gastric surgery.

Fentanyl kills. Make that: Fentanyls kill. The threat is plural and potent, as illicit laboratories continually concoct new forms of the drug that sidestep today's best detection techniques and protect drug dealers from prosecution. It's a loophole that drug dealers are quick to step through—creating new drugs faster than the law and health care providers can keep track of them.

Most women use medication during pregnancy. Yet, selecting appropriate drugs and doses is challenging. In an article in The Lancet, physicians and researchers from the Radboud university medical center, Maastricht UMC+, Imperial College London, and the University of Liverpool introduce a shared decision-making approach combining ethical principles and a pregnant woman's values with existing eviden

Ochsner Health physicians Dr. Richard Zweifler and Dr. Joseph Tarsia are co-authors on a post hoc analysis carried out in the ARCADIA randomized clinical trial, comparing the effectiveness of apixaban versus aspirin in preventing adverse clinical outcomes in patients with a history of cancer and cryptogenic stroke. The research found no significant difference in the risk of major ischemic and hemo

Colin Xu, assistant professor in the Department of Psychology and Communication at University of Idaho, has co-authored a new study that challenges popular beliefs about the progression of side effects in patients undergoing antidepressant treatment.

Peking University-led researchers have modified an existing treatment for liver disease that does not cause itchiness, a common side effect of existing treatments.

A powerful, three-drug therapy for aggressive advanced breast cancer doubles the length of time before the cancer progresses, compared with a drug combination currently available on the NHS, new research has shown.

Reports of drug-related supply-chain issues were 40% less likely to result in drug shortages in Canada versus the United States, according to a study from University of Pittsburgh researchers and published in JAMA.

Polypharmacy, commonly defined as taking five or more medications daily, is a significant health care concern impacting over 30% of older adults. It is associated with poor health outcomes like falls, medication interactions, hospitalizations and even death.

A new study from University of Western Ontario researchers in collaboration with the Office of the Chief Coroner of Ontario highlights the scope of opioid-related deaths in young children in Ontario, while providing a clearer picture of the risk factors.

The largest trial to examine the impact of colchicine in acute myocardial infarction (MI) found that both acute and long-term colchicine use did not reduce cardiovascular death, myocardial infarction, stroke, or ischemia-driven revascularization.

A study published in JAMA reveals text message reminders for patients who delay refilling their medications didn't help improve how regularly they refilled medications over a year.

A 14-day course of the oral anti-inflammatory drug montelukast didn't shorten symptom duration in nonhospitalized US adults with mild or moderate COVID-19, finds a randomized controlled clinical trial published today in JAMA Network Open.

People with atrial fibrillation (AF) who have a stroke could benefit from blood thinning treatments, known as anticoagulants, at an earlier stage than is currently recommended, finds a new study led by UCL researchers.

A collaboration of researchers led by Emory University Rollins School of Public Health, Atlanta, is urging caution when prescribing off-label glucose-lowering drugs to individuals with type 1 diabetes (T1D).

Glucagon-like peptide-1-receptor agonists (GLP-1RA) are medications that are increasingly prescribed for patients with type 2 diabetes and congestive heart failure. Reports of GLP-1RA–associated acute kidney injury (AKI) have emerged, but the risk of GLP-1RA–associated AKI among patients on anti-cancer drugs is unclear.

The diabetes drug semaglutide, also known as Ozempic, has a positive effect on patients with chronic kidney disease and obesity. The amount of protein in their urine decreased, as did the degree of inflammation of their kidneys and their blood pressure.

Patients with advanced bladder cancer that has spread to other parts of the body (metastasized) have responded well in a phase I clinical trial of an investigational drug, TYRA-300. The drug targets changes in the FGFR3 gene that drive tumor growth in about 10%-20% of these patients.

New research from biologists at the USC Dornsife College of Letters, Arts and Sciences reveals that mifepristone, a drug best known for its use for ending early pregnancies, might also extend lifespan. The findings could pave the way for anti-aging treatments.

Consensus is growing around the idea that for some patients higher doses of a gold-standard opioid addiction treatment drug may be better than lower doses at keeping patients healthy and in treatment, especially for those who use fentanyl.

A new study has found that an antibiotic for liver disease patients could expose them to greater risk of a dangerous superbug.

Researchers at the Case Western Reserve School of Medicine have found that when compared to seven other anti-diabetic drugs, semaglutide, a popular diabetes and weight-loss drug, may lower the risk of Alzheimer's disease in people with type 2 diabetes (T2D).

Drugs designed to target HER2-postive breast cancer could also benefit some patients with bile duct cancer, according to results of a patient trial to be presented on Thursday at the 36th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics in Barcelona, Spain. Bile duct cancer is rare, treatment options are limited, and the survival rates are low.

The U.S. Food and Drug Administration has approved Vyloy (zolbetuximab-clzb) in combination with fluoropyrimidine- and platinum-containing chemotherapy for the first-line treatment of adults with locally advanced unresectable or metastatic human epidermal growth factor receptor 2-negative gastric or gastroesophageal junction (GEJ) adenocarcinoma whose tumors are claudin (CLDN) 18.2-positive as det

A team of Lawrence Livermore National Laboratory (LLNL) researchers has discovered a promising new treatment to counteract the effects of fentanyl and related opioids. The new treatment could, over time, be a boon to doctors and medical professionals dealing with the crisis of fentanyl, a drug whose lethal effects has killed more than 210,000 Americans during the past three years.

Britain's drug regulator approved the Alzheimer's drug Kisunla on Wednesday, but the government won't be paying for it after an independent watchdog agency said the treatment isn't worth the cost to taxpayers.

Opioid use disorder affects more than 2 million people in the U.S. and contributes to the public health crisis of opioid addiction and overdoses. While previous studies have focused on how prevalent prescription opioid use is, researchers from Mayo Clinic and the National Center for Complementary and Integrative Health looked into who is choosing to use prescription opioids for the first time.

The U.S. Food and Drug Administration has approved AbbVie's Vyalev (foscarbidopa and foslevodopa) for adults living with advanced Parkinson's disease (PD).

A University of Alberta pharmacology researcher has discovered that a new experimental anti-obesity drug improves diastolic heart function in mice with type 2 diabetes independent of its weight loss effects, suggesting the drug may work as a treatment to prevent the most prevalent form of heart failure in people with diabetes.

A team of researchers says it has developed the first wearable camera system that, with the help of artificial intelligence, detects potential errors in medication delivery.

Treating hospitalized patients with bloodstream infections with antibiotics for seven days is noninferior to treating for 14 days, according to a study presented at the annual meeting of the Infectious Diseases Society of America (IDWeek), held from Oct. 16 to 19 in Los Angeles.

Preexposure prophylaxis (PrEP) use increased between 2013 and 2023, according to a research letter published online Oct. 14 in the Journal of the American Medical Association.

The high price and side effects of Ozempic, the blockbuster diabetes drug also used off label for weight loss, has led people to stretch out their supply by taking the medication in smaller, micro doses.

Brigham researchers reviewed the benefits and limitations of seven strategies that clinicians can use to help their patients navigate high-prescription drugs. These include co-payment cards, patient assistance programs, pharmacy coupons, direct-to-consumer pharmacies, public assistance programs, international online pharmacies, and real-time prescription benefit tools.

Non-steroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen, may help reduce patients' risk of postoperative delirium, according to a study presented at the ANESTHESIOLOGY 2024 annual meeting.

A systematic review and network meta-analysis of 68 studies has found no clear evidence that any specific antipsychotic significantly improves cognitive function in patients with schizophrenia spectrum disorders compared to placebo.

There are no significant differences in all-cause or cardiovascular mortality with the prescription of dialysate calcium 1.50 versus 1.25 mmol/L for patients undergoing hemodialysis, according to a study published online Oct. 4 in the Clinical Kidney Journal.

Expanding access to new, highly effective weight-loss medications could prevent more than 40,000 deaths a year in the United States, according to a new study led by researchers at Yale School of Public Health and the University of Florida.

A study published in the journal Addiction has found that people with opioid or alcohol use disorder (OUD, AUD) who take Ozempic or similar medications to treat diabetic/weight-related conditions appear to have a 40% lower rate of opioid overdose and a 50% lower rate of alcohol intoxication than people with OUD and AUD who do not take Ozempic or similar medications.

Glioblastomas are aggressive brain tumors with a median survival time of less than 22 months despite standard therapy including surgery, irradiation, and chemotherapy. It has become clear in recent years that not all cells within the brain tumor have an equal potential to divide and drive tumor growth.

Potential fathers with type 2 diabetes can be reassured that taking the drug metformin is not associated with birth defects in their offspring, concludes a large study of more than 3 million pregnancies published by The BMJ.

The U.S. Food and Drug Administration has approved Itovebi (inavolisib), in combination with palbociclib (Ibrance) and fulvestrant, for the treatment of adults with endocrine-resistant, PIK3CA-mutated, hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative, locally advanced or metastatic breast cancer.

For people with ischemic stroke, treatment with the clot-busting drug tenecteplase is associated with a slightly higher likelihood of an excellent recovery and reduced disability three months later than the drug alteplase, according to a meta-analysis published in the October 16, 2024, online issue of Neurology. Researchers found that the likelihood of good recovery was similar between the two tre

The increasing incidence of sexually transmitted bacterial infections (STIs) is a major public health problem worldwide. Currently, among the therapies being studied is the use of the antibiotic doxycycline as a method of post-exposure prophylaxis after unprotected sex—known as DoxyPEP.

,A weight-loss drug more effective than Ozempic and Wegovy has recently been approved in Australia.

New data shows that the number of children suffering a seizure after swallowing medications or illegal substances has doubled between 2009 and 2023 in the US. The findings were presented at the European Emergency Medicine Congress.

The U.S. Food and Drug Administration (FDA) approved Hympavzi (marstacimab-hncq) for routine prophylaxis to prevent or reduce the frequency of bleeding episodes in adult and pediatric patients aged 12 years and older with hemophilia A without factor VIII inhibitors or hemophilia B without factor IX inhibitors.

Pharmacists may continue making compounded versions of the weight-loss medication tirzepatide while the U.S. Food and Drug Administration revisits its Oct. 2 decision to remove the medicine from a national drug shortage list.

The desire to have our own biological children is hard-wired into many of us. And the desire is often felt more keenly in those struggling with infertility. So the promise of a simple solution is hard to ignore—which may be why "the Mucinex method" is trending on social media.

Researchers led by the University Hospital Zurich have identified cases of sterile intraocular inflammation, including severe retinal vasculitis, associated with faricimab injections used to treat eye conditions including age-related macular degeneration and diabetic macular edema.

Long-term treatment with finerenone is estimated to extend event-free survival among people with heart failure with mildly reduced or preserved ejection fraction, according to a brief report published online Sept. 27 in JAMA Cardiology to coincide with the annual meeting of the Heart Failure Society of America, held virtually from Sept. 27 to 30.

The NRG Oncology NRG-HN005 phase II/III clinical trial has not met the non-inferiority criteria to proceed to the phase III portion of the study. The phase II portion of the NRG-HN005 evaluated two experimental treatment arms against a control arm for patients with p16-positive (p16+, accepted as a surrogate for HPV+ status), locoregionally advanced oropharyngeal cancer. The interim futility resul

The addition of the cancer immunotherapy drug atezolizumab to the standard of care concurrent chemoradiation (cCRT) did not improve overall survival for patients with limited-stage small cell lung cancer (LS-SCLC) in the second planned interim analysis of the NRG Oncology/Alliance NRG-LU005 clinical trial. These results were recently reported during the Plenary Session of the American Society for

On Tuesday, Louisiana will become the first state in the U.S. to categorize two widely used abortion pills as "controlled dangerous substances."

The American Academy of Pediatrics has published its first clinical guideline for pediatricians on prescribing opioids, including explicit instructions on how and when to prescribe these medications for pain while reducing the long-term risk of addiction.

Experts expressed enthusiasm Friday after US health regulators approved the first new form of treatment for schizophrenia in decades.

For infants and young children hospitalized with respiratory syncytial virus (RSV) infection, ziresovir reduces signs and symptoms of bronchiolitis, according to a study published in the Sept. 26 issue of the New England Journal of Medicine.

Two studies have found that the virus that causes COVID-19 is becoming resistant to two drugs used to treat patients with infections.

Houston Methodist researchers have developed an advanced mathematical model that predicts how novel treatment combinations could significantly extend progression-free survival for patients with non-small-cell lung cancer (NSCLC), the most common type of lung cancer.

Lamotrigine, a drug commonly used to treat epilepsy and certain mood disorders, has been shown to be an excellent treatment option for a rare genetic neuromuscular disease known as non-dystrophic myotonia, in a world-first trial led by University College London researchers.

An estimated one-third of patients with major depressive disorder have treatment-resistant depression (TRD), characterized by an inadequate response to two or more oral antidepressants (OADs).

Children born to greater socioeconomic backgrounds are significantly more likely to be prescribed opioids, according to research presented during the American Academy of Pediatrics 2024 National Conference & Exhibition at the Orange County Convention Center from Sept. 27–Oct. 1.

The U.S. Food and Drug Administration has approved Ocrevus Zunovo (ocrelizumab and hyaluronidase-ocsq) as the first and only twice-a-year, 10-minute subcutaneous injection for people with relapsing and progressive multiple sclerosis (MS).

The U.S. Food and Drug Administration has approved Bimzelx (bimekizumab-bkzx) for the treatment of adults with active psoriatic arthritis (PsA), adults with active nonradiographic axial spondyloarthritis (nr-axSpA) with objective signs of inflammation, and adults with active ankylosing spondylitis (AS).

In 2022, nearly 619,000 global deaths due to malaria were caused by Plasmodium falciparum, the most virulent, prevalent, and deadly human malaria parasite. For decades, the parasite's resistance to all antimalarial drugs has posed a big challenge for researchers working to stop the spread of the disease.

The EU's drug watchdog Thursday called for the suspension of approval for Pfizer's medicine to treat sickle cell disease, saying doctors should stop using the drug.

The arrival of GLP-1 analog drugs (such as Wegovy) marked a huge shift in the weight-loss drug market. These drugs have been shown to lead to significant weight loss in users—as much as 15% or more of their body weight in clinical trials. For this reason, demand for weight-loss drugs has skyrocketed worldwide.

Buprenorphine, an evidence-based treatment for opioid use disorder, is currently underprescribed because of concerns that it can cause "precipitated withdrawal," in which the first dose causes sudden, intense pain and anxiety that resolves within a few hours. A new review of the best available evidence has found that the rate of buprenorphine-precipitated withdrawal in adults with opioid use disor

In people with primary progressive multiple sclerosis (MS), a new study has found no difference in the amount of time before disability worsened between people taking certain medications and those not receiving treatment. The study is published in the September 25, 2024, online issue of Neurology.

Adults with opioid use disorder who receive a higher daily dose of the opioid addiction treatment medication buprenorphine may have a lower risk of subsequent emergency department visits or use of inpatient services related to behavioral health (such as for mental health and substance use disorders) than adults receiving the recommended dose, according to an analysis published in JAMA Network Open

Since being deemed a public health emergency in 2017, opioids are responsible for 72% of drug overdose deaths in the United States, according to the National Center for Drug Abuse Statistics.

The boss of the Danish pharmaceutical giant behind the blockbuster diabetes and weight-loss drugs Ozempic and Wegovy promised Tuesday to examine lowering their prices in the United States, after coming under pressure from Congress.

Pharmacists now have more guidance for combating the opioid crisis and providing treatment to patients, thanks to new national guidelines developed at the University of Houston College of Pharmacy. The Pharmacy Access to Resources and Medication for Opioid Use Disorder Guideline, released today, addresses critical barriers in the treatment of Opioid Use Disorder across the nation's community pharm

In a study published in Brain Medicine, UCI researchers have uncovered a striking correlation between internet searches for ADHD medications and actual prescription rates during the COVID-19 pandemic. This finding opens up new possibilities for using online search data to predict and prevent prescription drug shortages.

For patients with recurrent or refractory graft-versus-host disease (GVHD), the colony-stimulating factor 1 receptor (CSF1R)-blocking antibody axatilimab results in a high incidence of overall response, according to a study published in the New England Journal of Medicine.

A direct comparison between the experimental psychedelic drug psilocybin and a standard SSRI antidepressant shows similar improvement of depressive symptoms, but that psilocybin offers additional longer-term benefits.

New, more expensive migraine drugs are no more effective against the throbbing headaches than traditional painkillers, and even performed worse than an older range of treatments called triptans, said a massive global analysis Thursday.

Two new drugs, the first capable of slowing down the debilitating progression of Alzheimer's disease, have become embroiled in one of the biggest medical controversies in recent years.

Lycium barbarum is a traditional and valuable medicinal herb in China. It has the effects of "strengthening muscles and bones with prolonged use, promoting longevity, and resisting cold and heat," according to "Ben Cao Gang Mu" ("Compendium of Materia Medica"), an encyclopedic work on traditional Chinese medicine.

Half a century of advancements in biomedical science paved the way for today's powerful weight-loss drugs like Ozempic—so what was that journey like for the scientists involved?

The U.S. Food and Drug Administration has approved Eli Lilly's Ebglyss (lebrikizumab-lbkz) for adults and children aged 12 years and older with moderate-to-severe atopic dermatitis.

Some triptans are a more effective treatment for acute migraines than newer, more expensive drugs, finds an analysis of the latest evidence published in The BMJ.

About one-third of patients with schizophrenia do not respond to conventional medications, leaving them with one effective treatment option: clozapine. Clozapine's most serious side effect, a life-threatening drop in white blood cell levels, has been effectively controlled through strict monitoring.

In the fight against fatty liver disease, researchers are looking for any and all possible solutions. But to combat the disease, which is also known as metabolic dysfunction-associated steatotic liver disease, or MASLD, scientists must first understand how the liver metabolizes fat. MASLD is on the rise in the U.S., now affecting nearly 40% of adults. The condition occurs when the body deposits ex

Women with early stage breast cancer may now take Kisqali, a medication already approved for advanced disease, following the U.S. Food and Drug Administration's expanded approval of the treatment, drug maker Novartis announced Tuesday.

Would-be dads taking drugs to stop their epilepsy seizures—and valproate in particular—should be largely reassured that the available evidence on the developmental risks to their offspring doesn't justify any major concerns, concludes a systematic review of relevant studies published online in the Journal of Neurology Neurosurgery & Psychiatry.

Drug overdose is the leading cause of injury deaths in young adults in the United States, with fentanyl causing over 70,000 deaths annually.

Around 75% of Australians have experienced a bad reaction to a medication, but fewer than half have reported it to a doctor or the Therapeutic Goods Administration (TGA), a new survey has found.

Nobody wants to see another Thalidomide tragedy.

Injectable weight loss drugs are popular right now but can be hard to get because they are in short supply or too expensive without insurance. The result is that some people are skipping the doctor's office and reaching out to potentially unreliable sources such as unlicensed online pharmacies or telehealth sites, which could expose patients to risks.

Fatty liver disease linked to diabetes and obesity can easily progress to liver cirrhosis, but new research suggests that GLP-1 medicines like Ozempic can help stop that.

The Alliance for Clinical Trials in Oncology today announced that final results will be presented at ESMO 2024 from CABINET (A021602), a phase III trial evaluating cabozantinib compared with placebo in two cohorts of patients with previously treated neuroendocrine tumors: one cohort of patients with advanced pancreatic neuroendocrine tumors (pNET) and a second cohort of patients with advanced extr

Professors Tom Powles and Peter Schmid recently delivered results from their phase three clinical trials during Sunday's Presidential Symposium to over 30,000 attendees at the European Society for Medical Oncology (ESMO) Congress 2024.

A targeted radioactive infusion that is a game-changer in late-stage prostate cancer can also dramatically improve outcomes for patients in earlier stages of this disease, a Peter Mac-led study has shown.

A study from Mass General Brigham researchers provides evidence that large language models (LLMs), used for generative artificial intelligence (AI), ChatGPT-4 and Google's Gemini, demonstrated no differences in suggested opioid treatment regimens for different races or sexes. Results are published in Pain.

Pfizer Inc.'s experimental drug for cancer weight loss was shown to help patients regain weight in a mid-stage study, offering fresh promise for treating the dangerous muscle-wasting condition.

Every time you are prescribed medicine in hospital, a computer will prompt your doctor about the appropriateness of the medicine and its dose.

University of Sydney research has found people over 65 are being prescribed antidepressants as pain treatment based on international guidelines that use limited evidence. The paper is published in the British Journal of Clinical Pharmacology.

A Cleveland Clinic study identified key factors that can impact the long-term weight loss of patients with obesity who were prescribed injectable semaglutide or liraglutide for the treatment of type 2 diabetes or obesity. The study was published in JAMA Network Open.

From 2017 to 2022, there was an increase in naloxone prescribing among adolescents, with pediatricians accounting for an increasing proportion of prescriptions dispensed, according to a study published online Sept. 12 in Pediatrics.

Common medicines used to treat conditions including heartburn, reflux, indigestion and stomach ulcers may be the subject of a class action lawsuit in Australia.

All doses of tirzepatide, a medication approved in the EU to treat type 2 diabetes and obesity, consistently reduced body weight in women and men, but women experienced greater weight loss, according to new post hoc research to be presented at this year's Annual Meeting of the European Association for the Study of Diabetes (EASD), Madrid (9-13 Sept.).

As more people with type 2 diabetes (T2D) are taking medications to help manage blood sugar levels and weight loss, concerns about whether these drugs are safe have emerged. Now real-world evidence from the FDA Adverse Event Reporting System (FAERS) database reveals a reassuring safety profile for tirzepatide (TZP).

The anti-obesity medication semaglutide may help to prevent heart attacks, strokes, and other major adverse cardiovascular events (MACE) as well as death in adults with overweight or obesity who don't have diabetes, whether or not they also have impaired kidney function, according to new research to be presented at this year's Annual Meeting of the European Association for the Study of Diabetes (E

The phase 3 SURPASS-4 trial published in 2021 established that tirzepatide lowers blood sugar and supports weight loss better than insulin glargine (a long-acting insulin) for type 2 diabetes (T2D). Now new research examining a broad range of potential predictors of sustaining blood sugar control and weight loss indicates that greater weight loss, better β-cell function, and a greater decrease in

You don't often see a "science day" in a Philadelphia courtroom. But that's exactly what happened last week in a potentially ground-shifting legal fight brought by patients against the manufacturers of blockbuster drugs for diabetes and weight loss.

Individuals who received a once-a-day oral weight loss drug lost up to 13% of their body weight over three months, according to a presentation at the annual meeting of the European Association for the Study of Diabetes (EASD), held in Madrid, Spain (9–13 September).

Have you ever been instructed to take your medicine with food and wondered why? Perhaps you've wondered if you really need to?

A new study from King's College London shows that off-label prescriptions of a common antidepressant doesn't help breathlessness in patients with respiratory disease—and may cause side effects.

Sickle cell disease is a common genetic disorder characterized by periodic occurrences of pain that occur repeatedly throughout life. These episodes, referred to as vaso-occlusive episodes, happen when sickled cells obstruct blood vessels. The degree of pain may range from a mild discomfort to a severe disabling pain for which the person needs treatment in hospital.

Erik Almazan, MD, of the Department of Medicine at Brigham and Women's Hospital and Raymond T. Chung, MD, of the Liver Center at Massachusetts General Hospital, are the authors of a paper titled "Association of Statin, Metformin, and Aspirin Use with Hepatocellular Carcinoma in the All of Us Research Program, published in Gastro Hep Advances.

Ronald Rodriguez, MD, Ph.D., professor of medical education and urology at Joe R. and Teresa Lozano Long School of Medicine at The University of Texas Health Science Center at San Antonio (UT Health San Antonio), has discovered that the combination of valproic acid and docosahexaenoic acid (DHA) may reduce the risk of contracting COVID-19 and lessen its severity, according to a study published in

Laboratory mice with cognitive issues including Alzheimer's disease showed improved memory skills within a couple of weeks of treatment with a new medicine tested at Colorado State University.

The HER2-specific tyrosine kinase inhibitor zongertinib was well tolerated and demonstrated promising efficacy in patients with HER2 mutation-positive non-small cell lung cancer, meeting the primary endpoint of the Beamion LUNG-1 Phase Ib Cohort 1 study, according to research presented at the International Association for the Study of Lung Cancer 2024 World Conference on Lung Cancer.

Treatment with BAY 2927088 led to rapid, substantial, and durable responses in patients with heavily pretreated HER2-mutant non-small cell lung cancer (NSCLC), according to research presented at the International Association for the Study of Lung Cancer 2024 World Conference on Lung Cancer.

Phase 2 results from the NeoCOAST-2 study have demonstrated that the combination of durvalumab with Dato-DXd yielded the highest pathological complete response rates among the tested regimens.

Data from a Phase 3 study has revealed that ivonescimab demonstrates a statistically significant and clinically meaningful improvement in progression-free survival compared to pembrolizumab for patients with PD-L1-positive advanced non-small cell lung cancer. The results were presented today at the International Association for the Study of Lung Cancer (IASLC) 2024 World Conference on Lung Cancer.

New data from landmark analysis presented today reports a decreased risk of disease recurrence or death in patients with resectable NSCLC who received adjuvant nivolumab following neoadjuvant nivolumab plus chemotherapy and surgery compared to those who received only neoadjuvant nivolumab plus chemotherapy.

French researchers have developed a new drug delivery system that could cut the dosing schedule for type 2 diabetes and weight control drug semaglutide to just once a month, according to new research to be presented at this year's annual meeting of the European Association for the Study of Diabetes (EASD), Madrid (9-13 Sept).

The antibody–drug conjugate ifinatamab deruxtecan (I-DXd) has shown clinically meaningful responses in pretreated patients with extensive-stage small cell lung cancer (ES-SCLC), according to an interim analysis of the Phase 2 IDeate-Lung01 study. The data was presented today at the International Association for the Study of Lung Cancer (IASLC) 2024 World Conference on Lung Cancer.

Psychological distress is the most common negative outcome experienced by health care professionals after making medication errors, according to a new study from the University of Eastern Finland. After such events, turnover intentions and absenteeism were more common among those experiencing inadequate organizational support and so-called second victim distress.

The growing legal use of recreational and medical cannabis has generated an increased concern for potential side effects from long-term use, particularly regarding problems with memory and sleep. Until now, the effect of cannabis use on sleep and on memory have only been studied separately. Research led by Francesca Filbey, Ph.D., from the Laboratory of Neuroimaging of Reward Dynamics at The Unive

A new study reveals that young patients treated with psychiatric medications receive potentially dangerous combinations with concerning frequency.

Mineralocorticoid receptor antagonists (MRAs) reduced the risk of cardiovascular death or heart failure (HF) hospitalization in patients with HF and reduced ejection fraction (HFrEF) and also in those with mildly reduced or preserved ejection fraction (HFmrEF/HFpEF), according to late-breaking research presented in a Hot Line session at ESC Congress 2024.

For researchers, projects can sometimes feel like babies, and there is nothing more satisfying than seeing your baby grow up. For William Tansey, professor of cell and developmental biology, this baby started 10 years ago when he and Stephen Fesik, Orrin H. Ingram II, Professor of Cancer Research and professor of biochemistry, discovered that a protein called WDR5 is a "partner in crime" to MYC, a

People with chronic diabetic foot ulcers could soon have a new way to treat their wounds for faster healing and fewer hospital stays. Researchers from Michigan State University and South Shore Hospital have uncovered that the combination of two common diabetes drugs—injectable insulin and orally-administered metformin—increases the amount of metformin at the wound site. As metformin can accelerate

Stroke patients who survive a blood clot in the brain's blood vessels are prone to developing new blockages during their recovery periods, even if they receive vessel-clearing interventions. In an effort to avoid further clots, doctors at 57 sites around the U.S. have tested a possible solution: the addition of anti-coagulant drugs to medicine that dissolves blood clots.

The American Journal of Gastroenterology has published a new guideline on the treatment of Helicobacter pylori (H. pylori) infection.

Despite decades of advancement in treatment, cancer spreading to multiple parts of the body remains one of the biggest challenges facing patients and their health-care teams.

More hospitals and clinics now offer patients ketamine therapy for severe depression, post-traumatic stress disorder and other mental health conditions that haven't responded to other treatments.

There was no apparent benefit to continuing oral anticoagulants compared with interruption in patients undergoing transcatheter aortic valve implantation (TAVI), according to late-breaking research presented in a Hot Line session today at ESC Congress 2024. The study is published in the New England Journal of Medicine.

Folks taking weight-loss drugs like Wegovy or Zepbound might think they've found a shortcut to better health.

A low-dose triple single-pill combination was effective at lowering blood pressure (BP) in two trials presented in a Hot Line session today at ESC Congress 2024.

Long-term use of beta-blockers in patients with myocardial infarction and preserved heart function does not significantly change quality of life or well-being compared to no beta-blockers. This is according to a study from Karolinska Institutet and Uppsala University, presented at the European Society of Cardiology's annual congress in London and simultaneously published in the European Heart Jour

Asundexian 50 mg daily was inferior to apixaban for stroke and systemic embolism prevention in high-risk patients with atrial fibrillation (AF), according to late-breaking research presented in a Hot Line session Sept. 1 at ESC Congress 2024.

In two trials, one in frail elderly patients, evening administration of BP-lowering medications had no clinical benefits over morning administration, according to late-breaking research presented in a Hot Line session August 31 at ESC Congress 2024.

Among patients undergoing non-cardiac surgery more than one year after coronary drug-eluting stent (DES) implantation, there was no difference with respect to ischemic outcomes or major bleeding between perioperative aspirin monotherapy and receiving no antiplatelet therapy, according to late-breaking research presented in a Hot Line session August 31 at ESC Congress 2024.

A single-pill combination of four BP-lowering medications was significantly more effective than a combination of three medications, according to late-breaking research presented in a Hot Line session August 31 at ESC Congress 2024.

Edoxaban monotherapy reduced net adverse clinical events compared with edoxaban plus a single antiplatelet agent, when used as long-term antithrombotic therapy, in patients with high-risk atrial fibrillation (AF) and stable coronary artery disease (CAD), according to late-breaking research presented in a Hot Line session Sept. 1 at ESC Congress 2024.

New research shows that a treatment plan based on a novel combination of low doses of three anti-hypertensive drugs in a single pill—known as GMRx2—was superior to a high-quality standard care treatment plan at lowering blood pressure in patients with uncontrolled hypertension.

Patients with heart failure, a condition affecting more than 60 million worldwide, are four times more likely to receive the optimal combination of medications after 12 weeks of digital consultations. Researchers from five Dutch hospitals, coordinated by Amsterdam UMC, found that the use of digital consults improved care while maintaining patient satisfaction. These results are published today in

Vutrisiran significantly improved mortality, cardiovascular events and markers of disease progression in patients with transthyretin amyloidosis with cardiomyopathy (ATTR-CM), according to late-breaking research presented in a Hot Line session held today, August 30, at ESC Congress 2024.

The cardiovascular safety of an interrupting beta-blocker could not be shown in comparison to continuation in patients with a history of myocardial infarction (MI) and there was no benefit to the patients' quality of life, according to late-breaking research presented in a Hot Line session today at ESC Congress 2024.

A randomized controlled trial of 435 women having a medical abortion after 12 weeks of pregnancy found 71% of patients who took the first dose of misoprostol at home spent fewer than 9 hours in hospital, compared to 46% of patients who took the first dose of misoprostol at hospital. There was no difference in safety outcomes observed between the two groups. However, of the women who took the first

Expanding access to naloxone is a key component of the national strategy to end the opioid crisis in America, and community pharmacies play a central role in distributing this overdose-reversing medication.

Delirium is a sudden onset and temporary state of disturbed consciousness or cognition, occurring due to underlying medical issues like fever or alcohol withdrawal. It is most common among older hospitalized adults aged 75 years or above, leading to increased risk of falls, dementia, low life expectancy, and high health care expenses.

Karolinska Institutet has discovered that an already registered antidepressant, duloxetine, may also have positive effects on memory and cognitive functions in the elderly.

When taken at the first signs of a migraine, before headache pain begins, a drug called ubrogepant may be effective in helping people with migraine go about their daily lives with little or no symptoms, according to a study published in the August 28, 2024, online issue of Neurology.

The weight-loss drug Wegovy is now available in Australia.

Nearly half of counties in the United States have at least one 'pharmacy desert' where there is no retail pharmacy within 10 miles, according to a study published in JAMA Network Open by researchers at The Ohio State University Comprehensive Cancer Center—Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC—James).

In the late 1960s, three Weizmann Institute of Science researchers developed several protein-like molecules, called copolymers, that they believed would produce a disease similar to multiple sclerosis in laboratory animals. The scientists—Prof. Michael Sela, Prof. Ruth Arnon and Dr. Dvora Teitelbaum—were surprised to discover that, instead of causing the disease, the copolymers cured it; one of th

Artificial intelligence (AI) and traditional medicine may seem like strange bedfellows but African researchers are harnessing both to advance drug discovery on the continent.

Australia currently finds itself in the unusual position of being both in an opioid epidemic and experiencing a shortage of these critical medicines.

Dementia with Lewy bodies is a type of dementia that is similar to both Alzheimer's disease and Parkinson's disease, but studies on long-term treatments are lacking. A new study from Karolinska Institutet in Sweden, published in Alzheimer's & Dementia, highlights the potential cognitive benefits of cholinesterase inhibitor treatment.

The investigational drug elinzanetant significantly reduces the frequency and severity of hot flashes associated with menopause while improving women's quality of life, according to new UVA Health research published in the Journal of the American Medical Association (JAMA) shows.

Chronic cough, with symptoms lasting more than eight weeks, affects approximately one in 10 adults. Cough is among the most common reasons for seeking medical care in the United States, yet chronic cough is difficult to treat.

A type of drug developed for treating cancer holds promise as a new treatment for neurodegenerative diseases such as Alzheimer's, according to a study by researchers at Penn State, Stanford University and an international team of collaborators.

A wildly popular class of drugs called GLP-1 agonists—which includes Ozempic, Wegovy, Mounjaro, and Zepbound—are revolutionizing the treatment of obesity.

The anti-cancer drug olaparib may be effective in treating biochemically recurrent prostate cancer without accompanying hormone therapy for men who have mutations in genes such as BRCA2, according to results of a Phase II clinical trial of 51 patients conducted at the Johns Hopkins Kimmel Cancer Center and three other sites.

Higher thiazide doses are associated with greater reductions in urine calcium, which in turn correlate with fewer symptomatic kidney stone events, according to a Vanderbilt University Medical Center (VUMC) study published in JAMA Network Open.

A newly developed compound that reduces harmful inflammation caused by overactive neutrophils in rats shows great potential as a safer treatment for various inflammatory diseases in humans.

A study carried out in St Vincent's University Hospital (SVUH) Dublin challenges the belief that weight-loss medications such as Ozempic, Wegovy or Monjaro work just by promoting satiety and making you eat less.

When UC San Francisco research showed that routinely treating children in Sub-Saharan Africa with a common antibiotic could reduce deaths in children under five, the World Health Organization (WHO) moved quickly to recommend the treatment—but only for infants between 1 and 11 months old.

Drugs like Ozempic and Wegovy, known as GLP-1 receptor agonists, have surged in popularity as a treatment for weight loss and management. The increase involves not only adults but also adolescents, along with bariatric surgery patients.

Drugs such as Ozempic, Rybelsus and Wegovy have made news for their abilities to treat diabetes and encourage weight loss.

Researchers at the University of Liverpool have found that the weight-loss drug tirzepatide is associated with a significantly reduced risk of developing type 2 diabetes (T2D).

UVA Health scientists seeking drugs that can trigger the regeneration of heart tissue after a heart attack say their efforts show promise and may lead to future treatment options.

People with Down syndrome are likely to develop Alzheimer's disease at a young age, with autopsy studies showing that by age 40 years, the brains of individuals with Down syndrome have amyloid plaques. Yet people with Down syndrome have been excluded from or underrepresented in clinical trials of new therapies for treating AD. Lecanemab, which has been shown to target and remove beta-amyloid plaqu

The investigation into the death of "Friends" star Matthew Perry has led to a sweeping indictment that pulled in five people who prosecutors say contributed to his ketamine overdose in October, including two doctors and a street dealer involved in providing Perry large amounts of the powerful anesthetic.

Millions of Americans who have allergies have really had only one option when it comes to emergency treatment for a severe reaction: using an autoinjector like the EpiPen.

The U.S. Food and Drug Administration has approved Galderma's Nemluvio (nemolizumab) for adult patients living with prurigo nodularis.