All articles tagged: Alzheimer's disease, unspecified (G30.9)

A new drug to treat Alzheimer's disease was approved by the U.S. Food and Drug Administration on Tuesday.In clinical trials, donanemab (Kisunla) modestly slowed the pace of thinking declines among patients in the early stages of the m

For individuals with Alzheimer disease (AD), the emergence of psychosis is associated with elevations in levels of plasma tau phosphorylated at threonine 181 (p-tau181), according to a study published online June 26 in JAMA Psychiatry.Jesus J. Gomar, Ph.D., and Jeremy Koppel, M.D., from the Feinstein Institutes for Medical Research in Ma

For high-risk patients with hypertension, vigorous physical activity (VPA) may preserve cognitive function, according to a study published online June 6 in Alzheimer's & Dementia.Richard Kazibwe, M.D., from the Wake Forest University School of Medicine in Winston-Salem, North Carolina, and colleagues categorized the baseline self-re

Cognitive impairment is delayed among persons who are heterozygous for the apolipoprotein E3 Christchurch variant (APOE3Ch), according to a study published in the June 20 issue of the New England Journal of Medicine.Yakeel T. Quiroz, Ph.D., from Massachusetts General Hospital in Boston, and colleagues analyzed data

For patients with mild cognitive impairment (MCI) or early dementia due to Alzheimer disease (AD), comprehensive lifestyle changes may improve cognition and function, according to a study published online June 7 in Alzheimer's Research & Therapy.Dean Ornish, M.D., from Preventive Medicine Research Institute in Sausalito, Californi

A new study suggests that the APOE4 gene variant increases Alzheimer's risk more than previously thought. Individuals with two copies of the APOE4 gene are estimated to have a 60-70% chance of developing Alzheimer's by age 85. Understanding genetic risk factors can help identify those most vulnerable and inform personalized preventive measures.

Johannes Gutenberg University Mainz researchers identify a novel RNA modification causing mitochondrial dysfunction in Alzheimer's, impacting brain energy supply. This discovery, published in Molecular Psychiatry, enhances understanding of the disease's mechanisms and involves collaborative research efforts.

Cedars-Sinai researchers identified neurons in the brain responsible for coordinating focus and short-term memory, crucial for tasks like recalling a phone number. These neurons, influenced by brain waves, aid in retaining information in working memory. The study, published in Nature, sheds light on brain processes crucial for understanding and treating conditions like Alzheimer's disease and ADHD

Recent research highlights the link between the gut microbiome and neurological disorders like Alzheimer’s. Advancements in AI are aiding in the exploration of this connection, offering potential breakthroughs in treatment. This article explores how AI is used to analyze gut-brain interactions, suggesting novel avenues for therapeutic approaches in Alzheimer’s disease.

The article discusses how mentally stimulating jobs may delay cognitive decline. Complex tasks promote neuroplasticity, enhancing mental resilience. Continuing education, hobbies, and social engagement are practical ways to boost cognitive activity, offering hope for aging populations.

The Allen Institute, founded by Paul Allen in 2003, embarked on an ambitious mission to map the 86 billion neurons of the human brain. This endeavor aims to decode the intricate workings of the brain and provide insights into various neurological diseases.

The FDA is conducting further safety and effectiveness assessments of Eli Lilly's experimental Alzheimer's drug. This move follows concerns raised by its advisory panel regarding the drug's efficacy and side effects. The FDA's review aims to provide more clarity on the potential risks and benefits of the medication.

Metformin, a frontline treatment for type 2 diabetes, has long been a pharmaceutical mainstay, with over 91 million prescriptions in 2021 alone. However, recent evidence suggests that metformin's efficacy extends beyond diabetes management, encompassing various conditions such as cancer, obesity, liver disease, cardiovascular issues, neurodegenerative disorders, and renal diseases. As research exp

A study suggests a possible link between mouth herpes simplex virus and dementia. Researchers found higher levels of the virus in the brains of people with Alzheimer's disease. This association raises questions about the role of viral infections in neurodegenerative conditions.

UW-Madison scientists created 3D-printed brain tissue mimicking normal function, aiding research on disorders like Alzheimer's. They horizontally layered neurons in a soft gel, enabling communication and network formation resembling human brains, offering a precise and accessible technique for studying brain conditions and drug testing.

Biogen, maker of the Alzheimer's medicine Aduhelm, announced Wednesday that it would "discontinue the development and commercialization" of the controversial drug.Biogen will return the rights to Aduhelm to Neurimmune, the private firm that invented it, the company said in a <a href="https://in

Strategies are needed to improve the delivery of Alzheimer disease (AD) disease-modifying therapies (DMTs), according to a report published online Jan. 30 by the RAND Corporation.Jodi L. Liu, Ph.D., from the RAND Corporation in Santa Monica, California, and colleagues used a simulation model to examine how primary care capacity for early detect

Monoclonal antibodies targeting amyloid provide small benefits on cognitive and functional scales, which do not meet the minimal clinically important difference, according to a review published in the January/February issue of the Annals of Family Medicine.Mark H. Ebell, M.D., from the University of Georgia in Athens, and colleagues con

Adult day services centers (ADSCs) that provide specialized dementia care have a higher proportion of patients with dementia compared with ADSCs that do not provide specialized care, according to a study published online Jan. 25 in National Health Statistics Reports, a publication from the U.S. Centers for Disease Control and Prevention.

Ordering palliative care consultation by default increases the rate of consultation but does not reduce the length of stay for older hospitalized patients with advanced chronic illness, according to a study published in the Jan. 16 issue of the Journal of the American Medical Association.Katherine R. Courtright, M.D., from the Perelman

Known risk factors account for a considerable proportion of Alzheimer disease and related dementia (ADRD) cases, with unequal distribution across race and ethnic groups, according to a study published online Jan. 17 in Neurology.Using data from the Multiethnic Cohort Study participants, Song-Yi Park, Ph.D., from the University of Hawaii

The Montreal Cognitive Assessment (MoCA) cutpoints for identifying mild cognitive impairment (MCI) or dementia are inappropriately high in a diverse community setting, yielding a high false-positive rate, according to a study published online Jan. 10 in the&nbsp;Journal of the American Geriatrics Society.Marnina B. Stimmel, Ph.D., fr

Researchers identified five distinct subtypes of Alzheimer's disease, each with unique cerebrospinal fluid protein profiles and genetic markers, suggesting the need for tailored treatments for each subtype.

Hearing loss is associated with an increased risk for dementia, with further increased risk for those not using hearing aids, according to a study published online Jan. 4 in JAMA Otolaryngology-Head and Neck Surgery.Manuella Lech Cantuaria, Ph.D., from Odense University Hospital and the University of Southern Denmark, and colleagues exam

Racial and ethnic minority groups are underrepresented in Alzheimer disease neuroimaging literature, according to a study published online July 25 in Communications Medicine.Aaron C. Lim, Ph.D., from the Keck School of Medicine of USC in Alhambra, California, and colleagues identified median race/ethnicity composition of Alzheimer disea

Patients with Alzheimer disease and other related dementias (ADRD) are less likely to receive intensive care unit admission or procedures after transfer from an emergency department to a tertiary care hospital, according to a study recently published in&nbsp;Alzheimer's &amp; Dementia: Diagnosis, Assessment &amp; Disease Monitoring.Nan

Elevated levels of high-density lipoprotein cholesterol (HDL-C) are associated with an increased risk for all-cause dementia, according to a study published online Nov. 29 in&nbsp;The Lancet Regional Health: Western Pacific.Sultana Monira Hussain, M.B.B.S., M.P.H., Ph.D., from Monash University in Melbourne, Australia, and colleagues co

For older adults, negative wealth shock is associated with accelerated cognitive decline and increased risks for dementia, according to a study published online Dec. 26 in JAMA Network Open.Liulu Pan, from the Zhejiang University School of Medicine in Hangzhou, China, and colleagues used data from the Health and Retirement Study conduc

Exposure to residential air pollution is associated with increased use of community mental health services among people with dementia, according to a study published online Aug. 7 in BMJ Mental Health.Amy Ronaldson, Ph.D., from King's College London, and colleagues examined longitudinal associations between air pollution exposure and

The annual meeting of the Radiological Society of North America was held from Nov. 26 to 30 in Chicago, drawing nearly 25,000 participants, including radiologists, radiation oncologists, physicists in medicine, radiologic technologists, and other health care professionals. The conference featured scientific papers from a number of subspecialtie

Light therapy is associated with significant improvement in sleep and psychobehavioral symptoms in patients with Alzheimer disease, according to a review published online Dec. 6 in&nbsp;PLOS ONE.Lili Zang, from Weifang Medical University in China, and colleagues conducted a systematic literature review to identify studies evaluating the

For patients with Alzheimer disease (AD), active transcranial direct current stimulation (tDCS) may improve cognitive function, according to a study published online Dec. 5 in General Psychiatry.Xingxing Li, from the Ningbo Kangning Hospital &amp; Affiliated Mental Health Centre at Ningbo University in China, and colleagues examined th

Veterans experiencing housing instability have a substantially higher risk for receiving an Alzheimer disease or related dementia (ADRD) diagnosis versus a matched cohort of stably housed veterans, according to a study published online Dec. 6 in the&nbsp;Journal of the American Geriatrics Society.Jill S. Roncarati, Sc.D., from the Vet

Coronary heart disease (CHD) is associated with increased risks for developing all-cause dementia, Alzheimer disease, and vascular dementia, with higher risks for younger age at CHD onset, according to a study published online Nov. 29 in the Journal of the American Heart Association.Jie Liang, from the Chinese Academy of Medical Scie

Recent research suggests that visceral fat, fat around the organs, could heighten the risk of Alzheimer's disease. This risk is present regardless of overall body weight and is linked to early brain changes related to Alzheimer's, emphasizing the importance of managing this type of fat.

Higher consumption of whole grains is associated with a slower rate of global cognitive decline, according to a study published online Nov. 22 in Neurology.Xiaoran Liu, Ph.D., from Rush University Medical Center in Chicago, and colleagues examined the association of whole-grain consumption with longitudinal change in global cognition

The use of gantenerumab leads to lower amyloid plaque burden at 116 weeks, but is not associated with slower clinical decline among patients with early Alzheimer disease, according to a study published in the Nov. 16 issue of the New England Journal of Medicine.Randall J. Bateman, M.D., from the Washington University School of Medicin

Cardiac 18F-dopamine positron emission tomography (PET) can identify at-risk individuals who are subsequently diagnosed with a central Lewy body disease (LBD), according to a study published online Oct. 26 in the Journal of Clinical Investigation.David S. Goldstein, M.D., Ph.D., from the National Institutes of Health in Be

From 2010 to 2021, the gender life expectancy gap increased, with COVID-19 the leading contributor from 2019 to 2021, according to a research letter published online Nov. 13 in JAMA Internal Medicine.Brandon W. Yan, M.D., M.P.H., from the University of California in San Francisco, and colleagues systematically examined the contribution

For older adults, lower neighborhood income and lower greenspace may be a risk factor for worsening white matter grade, according to a study published online Oct. 25 in Alzheimer's &amp; Dementia: Diagnosis, Assessment &amp; Disease Monitoring.Lilah M. Besser, Ph.D., M.S.P.H., from the University of Miami Miller School of Medicine in B

Lower retinal capillary perfusion is associated with cerebral small vessel disease, according to a study published online Oct. 6 in&nbsp;Alzheimer’s &amp; Dementia.Farzan Abdolahi, M.D., from University of Southern California in Los Angeles, and colleagues investigated whether retinal capillary perfusion, measured using optical cohere