All articles tagged: Gastroenterology

Metabolic surgery is associated with significantly lower risk of major adverse cardiovascular events (MACE) compared with nonsurgical management among patients with moderate-to-severe obstructive sleep apnea (OSA) and obesity, according to a study published online June 21 in the Journal of the American College of Cardiology.Ali Aminian,

Remarkable new research by a University of Virginia undergraduate may help explain recurrent Crohn's disease in children and open the door to new ways to treat or even cure the devastating condition. The work is published in the journal Scientific Reports.

For children with eosinophilic esophagitis, dupilumab results in a significantly higher percentage of histologic remission, according to a study published in the June 27 issue of the New England Journal of Medicine.Mirna Chehade, M.D., M.P.H., from Icahn School of Medicine at Mount Sinai in New York City, and colleagues randomly assig

PIK3CA mutational status may be beneficial for predicting response to addition of the cyclooxygenase 2 (COX-2) inhibitor celecoxib to standard adjuvant chemotherapy in stage III resected colon cancer, according to a study published online June 18 in the Journal of Clinical Oncology.Jonathan A. Nowak, M.D., Ph.D., from Brigham

A new study led by researchers at UCL and the University of Sheffield, has demonstrated the potential of stem cell therapy to treat those with Hirschsprung disease.

A new study has illuminated the connection between inflammatory bowel disease (IBD) and lipid profile. IBD is a chronic condition that causes inflammation in the intestines. Abnormal lipid factor levels such as cholesterol in IBD patients have been observed in previous studies, but whether this association is causal remained unclear.

Benralizumab yields a greater histologic response than placebo for patients with eosinophilic esophagitis, but does not affect dysphagia symptoms, according to a study published in the June 27 issue of the New England Journal of Medicine.Marc E. Rothenberg, M.D., Ph.D., from the Leiden University Medical Center in the Netherlands, an

An international team of researchers has identified specific bacteria in the gut that are associated with both mice and humans developing an addiction to food that can lead to obesity. They have also identified bacteria that play a beneficial role in preventing food addiction.

Nutritionists generally advise everyone to eat more dietary fiber, but a new Cornell University study suggests that its effects on health can vary from person to person. The findings indicate that recommendations should be tailored to each individual's gut microbiome.

As industrialization and urbanization accelerate, noise-induced hearing loss (NIHL) has become an increasingly prevalent sensorineural hearing disorder. Despite the widespread use of hearing aids and cochlear implants to alleviate some of the challenges posed by hearing loss, these devices offer limited treatment efficacy and cannot reverse or cure damage to the auditory nerves and inner ear struc

Using just a single image taken by a capsule endoscopy camera, scientists have succeeded in creating a three-dimensional model of the colon. This new method provides much better images and can help specialists detect disease more rapidly.

The U.S. Food and Drug Administration has expanded the approval of Elevidys (delandistrogene moxeparvovec-rokl), a gene therapy for the treatment of Duchenne muscular dystrophy (DMD) in individuals ≥4 years with DMD with a confirmed mutation in the DMD gene.Elevidys is a single-dose, intravenous recombinant gene therapy designed to prod

Short-chain fatty acids (SCFAs) are beneficial molecules created by the bacteria residing in our gut that are closely tied to improved host metabolism, lower systemic inflammation, better cardiovascular health, lower cancer risk, and more. However, SCFA profiles can vary widely between individuals consuming the same exact diet and we currently lack tools for predicting this inter-individual variat

The cumulative risk for advanced gastric cancer varies from 6.5 to 10.3 percent for carriers of germline CDH1 pathogenic/likely pathogenic (P/LP) variants, according to a study published online June 14 in the Journal of the American Medical Association to coincide with presentation at the International Gastric Cancer Linkage Consortiu

In a study published in Science Translational Medicine, researchers at Imperial have found that a higher-fiber diet stimulates the release of a key appetite-reducing hormone, in the ileum, part of the small intestine.

Increasing physical activity during childhood may independently lower the risk for liver disease in young adulthood, according to a study published online May 29 in npj Gut and Liver.Andrew O. Agbaje, M.D., M.P.H., Ph.D., from the University of Eastern Finland in Kuopio, used data from 2,684 children (aged 11 years) participatin

Roux-en-Y gastric bypass (RYGB) is successful in achieving long-term sustained weight loss and diabetes remission, according to a study presented at the annual meeting of the American Society for Metabolic and Bariatric Surgery, held from June 9 to 13 in San Diego.John Nguyen-Lee, M.D., from the Geisinger Medical Center in Danville, Pennsylva

The number of people severely sickened after consuming mushroom edibles sold as Diamond Shruumz-brand chocolate bars, cones or gummies has risen, the U.S. Food and Drug Administration said Tuesday."As of June 17, 2024, a total of 26 illnesses have been reported from 16 states," the FDA noted in an <a href="https://www.fda.gov/food/outbreaks-f

In 2023, 7.6 percent of the U.S. civilian noninstitutionalized population was uninsured, according to early estimates from the National Health Interview Survey, 2023, released by the National Center for Health Statistics.Robin A. Cohen, Ph.D., from the National Center for Health Statistics in Hyattsville, Maryland, and colleagues used data from

Combining antiobesity medications enhances preoperative weight loss in individuals with high body mass index (BMI) preparing for metabolic surgery, according to a study presented at the annual meeting of the American Society for Metabolic and Bariatric Surgery, held from June 9 to 13 in San Diego.Michael Kachmar, D.O., from the Pennington Biome

Artificial intelligence (AI) has permeated many aspects of medicine, with promises of accurate diagnoses, better management decisions, and improved outcomes for both patients and the health care system. However, to successfully implement AI technology in clinical practice, trust and acceptance among health care providers to use such tools is crucial.

In a success story for Americans seeking affordable healthcare coverage, tax credits put in place during the pandemic helped millions gain health insurance, a new report found.Trouble is, the credits are set to expire at the end of 2025, noted a research team from the nonprofit Robert Wood Johnson Foundation (RWJ).According to RWJ's <a h

Most patients taking survodutide, a dual agonist of glucagon receptor and glucagon-like peptide-1 (GLP-1) receptor, experience significant improvement in metabolic dysfunction-associated steatohepatitis (MASH) without worsening of fibrosis, according to a phase 2 study published online June 7 in the&nbsp;New England Journal of Medicine&nbsp;to

Pantoprazole results in a significantly lower risk for clinically important upper gastrointestinal bleeding than placebo, with no increase in mortality, among patients undergoing invasive ventilation, according to a study published online June 14 in the New England Journal of Medicine to coincide with the annual Critical Care Reviews Meeting,

Bariatric surgery significantly decreases the conversion from prediabetes to type 2 diabetes, according to a study presented at the annual meeting of the American Society for Metabolic and Bariatric Surgery, held from June 9 to 13 in San Diego.John Nguyen-Lee, M.D., from the Geisinger Medical Center in Danville, Pennsylvania, and colleagues eval

A medication used for psoriasis and psoriatic arthritis is proving to be an effective treatment for moderate to severe ulcerative colitis in the findings of a global study led by University of Chicago Medicine's David T. Rubin, MD, Professor of Medicine and Chief of the Section of Gastroenterology, Hepatology and Nutrition.

Recent technological advancements have enabled the development of new cutting-edge medical devices, including surgical robots, sensors that can monitor physiological processes and VR platforms to train doctors. A long-standing goal for medical technology engineers is to also create devices that can be ingested or otherwise inserted within the human body to observe or track the activity of specific

New research has shed light on the effects of protein-rich diets on the gut microbiome and overall health. Despite the increasing protein intake in Western diets, especially among athletes and individuals with obesity, the fate of undigested protein and its impact on human health remains largely unknown.

There is no evidence to suggest that administration of live vaccines to patients receiving dupilumab is unsafe, and vaccine efficacy is not affected by dupilumab, according to a position paper published online June 5 in the Annals of Allergy, Asthma &amp; Immunology.Noting that dupilumab targets the interleukin (IL)-4 receptor alpha sub

A new study, led by Professors Mashaghi and Clevers from Leiden University and Hubrecht Institute in the Netherlands, has introduced a novel approach using intestinal organoids to uncover the mechanism of gastrointestinal motility. The study presented the first single-cell mechanical characterization of human Enteroendocrine cells (EECs) isolated from healthy intestinal organoids.

Health care spending growth is projected to outpace that of the gross domestic product (GDP) during the coming decade, according to a study published online June 12 in Health Affairs.Jacqueline A. Fiore, Ph.D., from the Centers for Medicare &amp; Medicaid Services in Baltimore, and colleagues projected growth in national health expend

The use of glucagon-like peptide 1 receptor agonists (GLP-1 RAs) for diabetes or obesity is associated with a lower quality of bowel preparation among patients undergoing colonoscopy, according to a study published online in the June issue of the American Journal of Gastroenterology.Rebecca Yao, M.D., M.P.H., from the Mayo Clinic in R

For patients with metabolic dysfunction-associated steatohepatitis (MASH) and moderate-to-severe fibrosis, 52 weeks of tirzepatide is more effective than placebo for resolution of MASH, according to a study published online June 8 in the New England Journal of Medicine to coincide with the annual congress of the European Association for the

The use of glucagon-like peptide 1 receptor agonists (GLP-1 RAs) for diabetes or obesity is associated with a lower quality of bowel preparation among patients undergoing colonoscopy, according to a study published in the June issue of the American Journal of Gastroenterology.

For patients with metabolic dysfunction-associated steatohepatitis (MASH) and moderate-to-severe fibrosis, 52 weeks of tirzepatide is more effective than placebo for resolution of MASH, according to a study published online June 8 in the New England Journal of Medicine to coincide with the annual congress of the European Association for the Study of the Liver, held from June 5 to 8 in Milan.

The burden of adverse effects of medical treatment (AEMT) is increasing, with the proportion of all cases accounted for by the increasing rates seen in older adults, according to a study published online June 11 in BMJ Quality &amp; Safety.Liangquan Lin, from the Chinese Academy of Medical Sciences &amp; Peking University Medical Col

Glucagon-like peptide-1 receptor agonist (GLP-1 RA) medications do slow gastric emptying but not by enough to warrant discontinuing medications before surgery, according to a review published in the June issue of the&nbsp;American Journal of Gastroenterology.Brent Hiramoto, M.D., from Brigham and Women's Hospital in Boston, and colle

Generation X is experiencing larger per-capita increases in the incidence of cancers than Baby Boomers, according to a study published online June 10 in JAMA Network Open.Philip S. Rosenberg, Ph.D., and Adalberto Miranda-Filho, Ph.D., from the National Cancer Institute in Bethesda, Maryland, estimated invasive cancer incidence trends

Significant progress has been made at Tufts University School of Engineering in the development of a small device, about the size of a vitamin pill, that can be swallowed and passed through the gastrointestinal tract to sample the full inventory of microorganisms in an individual's gastro-intestinal tract.

Scientists at the University of Southern California have developed an artificial intelligence (AI)-powered system to track tiny devices that monitor markers of disease in the gut. Devices using the novel system may help at-risk individuals monitor their gastrointestinal (GI) tract health at home, without the need for invasive tests in hospital settings. This work appears June 12 in the journal Cel

As described in research published in the Biotechnology Journal, investigators have developed a novel patch that can help liver tissue regenerate.

There is no significant association between exposure to immunosuppressive therapies and development of incident cancers among patients with inflammatory bowel disease (IBD) and a history of cancer, according to a study published online May 18 in Clinical Gastroenterology and Hepatology.Steven H. Itzkowitz, M.D., from the Icahn School o

A new proposed definition for Long COVID could help patients get the help they need, a new report from the National Academies of Sciences, Engineering and Medicine says.Long COVID is a chronic condition that occurs after COVID-19 infection and is present f

Bariatric metabolic surgery (BMS) is associated with a greater reduction in mortality than glucagon-like peptide-1 receptor agonist (GLP-1 RA) treatment among adults with a diabetes duration of 10 years or less, according to a study published online June 7 in JAMA Network Open.Dror Dicker, M.D., from Rabin Medical Center in Petah Tikva,

The combination of bulevirtide plus peginterferon alfa-2a is superior to bulevirtide monotherapy for achieving undetectable hepatitis D virus (HDV) RNA level at 24 weeks after the end of treatment in patients with chronic hepatitis D, according to a study published online June 6 in the&nbsp;New England Journal of Medicine to coincide with the

For adults with type 2 diabetes (T2D) and metabolic dysfunction-associated steatotic liver disease (MASLD), glucagon-like peptide 1 receptor agonists (GLP-1 RA) and sodium-glucose cotransporter 2 inhibitors (SGLT-2i) are associated with reduced risk of cardiovascular (CV) events compared with dipeptidyl peptidase 4 inhibitors (DPP-4i), according to a st

A team of Vanderbilt researchers has developed a wirelessly activated device that mimics the wavelike muscular function in the esophagus and small intestine responsible for transporting food and viscous fluids for digestion.

Bile acids are essential molecules the liver produces that play a critical role in digestion. They help us absorb fat-soluble vitamins and cholesterol from our food. However, bile acids can become a double-edged sword. While they are necessary for proper digestion, high concentrations can also be toxic to the liver.

Neoadjuvant nivolumab plus ipilimumab has an acceptable safety profile in patients with locally advanced mismatch repair-deficient (dMMR) colon cancer, according to a study published in the June 6 issue of the New England Journal of Medicine.Myriam Chalabi, M.D., Ph.D., from the Netherlands Cancer Institute in Amsterdam, and colleague

Lowering the fecal immunochemical test (FIT) positive threshold yields levels of sensitivity and specificity that are comparable to those reported for multitarget stool RNA (mt-sRNA) testing without the additional testing, according to a research letter published online June 1 in the Journal of the American Medical Association.Tobias

Patients with gastric cancer who undergo gastrectomy have a lower risk for cardiovascular events than the general population, according to a study published online March 28 in the&nbsp;International Journal of Surgery.Yeongkeun Kwon, M.D., Ph.D.,&nbsp;from the Korea University College of Medicine in Seoul, and colleagues used data from

The popular prebiotic sodas known as Poppi may not be quite as good for the gut as the company claims.In a class-action lawsuit filed last week in U.S. District Court in San Francisco, Kristin Cobbs said she bought Poppi drinks because

Digestive Disease Week, the annual meeting sponsored by the American Association for the Study of Liver Diseases, American Gastroenterological Association, American Society for Gastrointestinal Endoscopy, and Society for Surgery of the Alimentary Tract, was held from May 18 to 21 in Washington, D.C., drawing more than 13,000 participants from around the world, including researchers and academics i

In 2021, 9.6 percent of medical visits took place via telehealth, with a higher percentage seen for mental health visits, according to a research letter published online June 4 in the Annals of Internal Medicine.Sandra L. Decker, Ph.D., from the Agency for Healthcare Research and Quality in Rockville, Maryland, and colleagues describe te

Ulcerative colitis (UC) is an inflammatory bowel disease (IBD) that causes inflammation and ulcers (sores) in the digestive tract. Ulcerative colitis affects the innermost lining of the large intestine, also called the colon and rectum. At least 40,000 people are living with IBD in Ireland, and over 5 million globally.

Digestive Disease Week, the annual meeting sponsored by the American Association for the Study of Liver Diseases, American Gastroenterological Association, American Society for Gastrointestinal Endoscopy, and Society for Surgery of the Alimentary Tract, was held from May 18 to 21 in Washington, D.C., drawing more than 13,000 participants from around the world, in

For patients undergoing inguinal hernia surgery, emergency surgery rates increase from high- to low-income countries, according to a study published online May 23 in The Lancet Global Health.Maria Picciochi, Ph.D., from the University of Birmingham in the United Kingdom, and colleagues conducted a prospective, international, cohort study

Statin use may contribute to a significant reduction in the risk for new primary sclerosing cholangitis among patients with inflammatory bowel disease.

From 2007 to 2019, there was an increase in inflation-adjusted health care spending, largely due to increasing contributions to premiums, according to a research letter published online May 28 in JAMA Internal Medicine.Sukruth A. Shashikumar, M.D., from the Beth Israel Deaconess Medical Center in Boston, and colleagues conducted a cro

Nearly half of individuals diagnosed with early-onset colorectal cancer (EOCRC) present with hematochezia and abdominal pain and one-quarter present with altered bowel habits, according to a review published online May 24 in&nbsp;JAMA Network Open.Joshua Demb, Ph.D., from the University of California, San Diego, and colleagues examine

A new study by researchers from Arizona State University and their colleagues highlights a dietary strategy for significant health improvement and weight management.

Continued weight loss with bariatric surgery was paralleled by favourable changes in eating behaviour and food reward and preferences.

For patients with chronic pancreatitis and intraductal stones, combined extracorporeal shock-wave lithotripsy (ESWL) and endoscopic retrograde pancreatography (ERP) provides pain relief at 12 weeks, according to a study published online May 28 in the Annals of Internal Medicine.Rupjyoti Talukdar, M.D., from the Asian Institute of Gastro

There are systemic disparities in definitive cancer treatment delivery at minority-serving hospitals (MSHs) versus non-MSHs, according to a study published online May 27 in Cancer.Edoardo Beatrici, M.D., from Brigham and Women's Hospital in Boston, and colleagues used data from the National Cancer Database for 2010 to 2019 to examine pa

It turns out flatulence can serve a purpose beyond being uncomfortable or funny: Gas released by some gut bacteria stimulates other gut bacteria to produce a hormone involved in pregnancy and in an FDA-approved treatment for postpartum depression, according to new research led by Harvard Medical School scientists.

Semaglutide was equally effective for obesity in patients with or without IBD, with a more than 5% mean weight loss and no increased risk for disease-specific adverse events.

Some are concerned that population screening could change symptomless people into patients, but a diagnosis could help prevent future complications.

Nonalcoholic fatty liver disease (NAFLD) has become the most prevalent chronic liver condition worldwide, affecting about 25% of the global population due to the increasing rates of obesity and metabolic syndrome. NAFLD encompasses a spectrum of liver conditions ranging from simple hepatic steatosis to nonalcoholic steatohepatitis (NASH), which can progress to fibrosis, cirrhosis, and hepatocellul

Hepatocellular carcinoma (HCC) represents a significant global health burden as one of the most common malignancies in individuals with chronic liver disease or cirrhosis. This malignancy evolves through a multistep process, beginning with dysplastic nodules (DNs) and early HCC, progressing to overt HCC.

A U.S. Food and Drug Administration advisory panel on Thursday recommended the approval of a new blood test that can spot colon cancer.The panel voted 7-2 that the benefits outweigh the risks when using the Guardant Health's Shield test for&nbsp;colon cancer</a

Researchers looked at the interplay among sleep behaviors, genetic risks, and the development of 16 digestive diseases.

The researchers plan to do human clinical studies "as soon as possible."

In a clinical practice guideline issued by the American Gastroenterological Association and published online in the June issue of Gastroenterology, updated evidence-based recommendations are presented for the use of endoscopic eradication therapy (EET) in patients with Barrett esophagus (BE) and related neoplasia.Joel H. Rubenstein, M.

Patients with fibromyalgia and irritable bowel syndrome (IBS) have increased rates of severe multiple drug intolerance syndrome (MDIS), according to a study published in the May issue of the Journal of Allergy and Clinical Immunology: In Practice.Alicia A. Alvarez, M.D., from Sarasota Memorial Hospital in Florida, and colleagues conduc

In the realm of gastrointestinal (GI) endoscopy, artificial intelligence (AI) is becoming an essential tool, especially in the computer-aided detection of precancerous colon polyps during screening colonoscopy. This integration marks a significant advancement in gastroenterology care. However, the inevitability of errors persists, and in some cases, AI algorithms themselves could contribute to med

Sleeve gastrectomy leads to significant weight loss and improves eligibility for kidney transplant in adults with obesity and severe kidney disease.

An AI-based assessment before colonoscopy successfully identified individuals at high risk for missed adenomas due to inadequate bowel preparation.

After a 2023 study linked GLP-1s to an increased risk for pancreatitis, gastroparesis, and bowel obstruction, other researchers did a retrospective study to reexamine the association.

A study of 316,443 patients shows that 7.4% of these patients repeated fecal testing rather than proceeding directly to colonoscopy as guidelines recommend, and of those who repeated home tests, over half did not have a colonoscopy within 1 year.

Life expectancy and age-standardized disease burden are expected to continue improving between 2022 and 2050, according to the Global Burden of Disease (GBD) study, published in the May 18 issue of The Lancet.Stein Emil Vollset, M.D., M.P.H., and colleagues from the GBD 2021 Forecasting Collaborators provide a reference forecast and a

The monoclonal antibody in development as maintenance therapy for people with moderately to severely active ulcerative colitis was more effective than placebo.

Meaningful weight loss was seen with the use of semaglutide, regardless of whether people had previous weight loss surgery, a first-of-its-kind study revealed.

For adults who are not up to date with colorectal cancer screening, offering a choice of colonoscopy or fecal immunochemical testing (FIT) increases screening completion rates, according to a study published online April 30 in Clinical Gastroenterology and Hepatology.Shivan J. Mehta, M.D., from the Perelman School of Medicine at the Uni

With an assist from machine learning, investigators find a genetic test that can identify obesity phenotypes and predict who will benefit most from semaglutide for weight loss.

Dietary interventions could be considered as an initial treatment for patients with IBS, although more research is needed for personalized treatment plans.

Patients with complicated diverticulitis or who aren't current with colorectal cancer screening are at higher risk and should have follow-up colonoscopy to rule it out.

GI endoscopy generates 85,000 metric tons of carbon dioxide waste annually. That waste stems from high case volumes, patient travel, the decontamination process, and single-use devices.

Already approved for ulcerative colitis, the monoclonal antibody mirikizumab met study endpoints for Crohn's disease response and remission.

The addictive behavior underlying many cases of ALD often goes unaddressed. Experts offer their advice on how gastroenterologists can begin to change this in their practices.

The AGA has released updated evidence-based recommendations on the EET of Barrett's esophagus and related neoplasms, in which experts call for an individualized approach.

Patients seen by a female gastroenterologist for an initial consultation are less likely to use medical care in the emergency department, hospital or primary care office for two years after their visit when compared to patients initially seen by male gastroenterologists, according to a study presented at Digestive Disease Week (DDW) 2024, held May 18–21, in Washington, D.C.

The American Gastroenterological Association's (AGA) new evidence-based Clinical Practice Guideline on Endoscopic Eradication Therapy of Barrett's Esophagus and Related Neoplasia, published today in Gastroenterology, establishes updated guidance for Barrett's esophagus patients.

Due to a potential risk for Salmonella, the supermarket chains ALDI and Hy-Vee are recalling brands of cream cheese.No actual illnesses linked to the products have yet been reported, but Hy-Vee said it is announcing the recall of Hy-Vee Cream Cheese Spread "out of an abundance of caution due to the potential for contamination with

The rate of colorectal cancer screenings more than doubled when patients were given a choice between which type of screening they wanted—a take-home kit or colonoscopy—compared to those who were only offered the colonoscopy, according to new research led by the Perelman School of Medicine at the University of Pennsylvania.

For women with obesity, the risk for breast cancer is reduced after bariatric surgery, according to a study published online May 15 in JAMA Surgery.Felipe M. Kristensson, M.D., from the Sahlgrenska Academy at the University of Gothenburg in Sweden, and colleagues examined whether bariatric surgery is associated with breast cancer incid

Once swallowed, strong magnets entail risks for intestinal obstruction and the death of the intestinal wall.

In its biennial Cancer Disparities Progress Report published today, the American Association for Cancer Research presents the latest statistics on disparities in cancer progress experienced by ethnic-minority groups and other medically underserved populations in the United States.Robert A. Winn, M.D., from the Virginia Commonwealth Un

Both acute hepatitis C (AHC) and hepatitis C virus (HCV)-related cirrhosis incidence were up substantially globally from 1990 to 2019 in reproductive-aged women, according to a study published online April 19 in the&nbsp;Journal of Global Health.Yanzheng Zou, from the School of Public Health at Nanjing Medical University in China, and

Despite encouraging drops in overall colorectal cancer rates, it has increased 333% among 15- to 19-year-olds and 185% among 20- to 24-year-olds from 1999 to 2020, according to new research.

Hepatocellular carcinoma screening was associated with earlier detection and improved survival, even after accounting for lead-time and length-time biases in a cohort of at-risk adults.

The delay of celiac disease diagnosis among children is generally low in Italy, regardless of region.

Higher endoscopist polyp detection rates were significantly associated with fewer negative colonoscopies after positive stool tests.

For individuals aged younger than 45 years, the incidence of colorectal cancer increased considerably from 1999 to 2020, with a 333 percent increase among those aged 15 to 19 years, according to a study presented at the 2024 Digestive Disease Week, held from May 18 to 21 in Washington, D.C.Islam Mohamed, M.D., from the University of Missouri-Kans

Physicians with disabilities (PWDs) are significantly more likely to experience depersonalization but not emotional exhaustion when compared with their peers without disabilities, according to a research letter published online May 9 in&nbsp;JAMA Network Open.Lisa M. Meeks, Ph.D., from the University of Michigan Medical School in Ann Arb

An oral rinse shows distinct differences in the microbiomes of people with pre-gastric or gastric cancer compared with controls, suggesting the possibility of a new tool for early detection.

For kidney transplant (KT) candidates with obesity, sleeve gastrectomy (SG) is effective, and a considerable proportion of patients undergo KT within 20.9 months, according to a study published in the May issue of the Mayo Clinic Proceedings.Aleksandra Kukla, M.D., from Mayo Clinic in Rochester, Minnesota, and colleagues conducted a retr

When substituting meat for a nonmeat alternative, lower ammoniagenesis and altered serum metabolomics are seen for patients with cirrhosis, regardless of hepatic encephalopathy (HE), according to a study published online May 2 in Clinical and Translational Gastroenterology.Bryan D. Badal, M.D., from Richmond Veterans Affairs Medical Cent

Ascension, a major U.S. health care system with 140 hospitals in 19 states, announced late Thursday that a cyberattack has caused disruptions at some of its hospitals."Systems that are currently unavailable include our electronic health records system, MyChart (which enables patients to view their medical records and communicate with their provid

Common conditions such as indigestion and heartburn as well as peptic ulcers, autoimmune gastritis and stomach and esophageal cancers have one thing in common—they involve disruptions of the normal activity of parietal cells (PCs) in the stomach, the only cells in the body that produce acid. Despite their medical importance, little is known about the molecular and genetic pathways that direct the

Now the dominant source of calories in our diets, ultraprocessed foods have been targeted as a key driver behind increasing rates of several gastrointestinal diseases.

In the short term, bariatric surgery is associated with a greater risk for venous thromboembolism (VTE), but in the long-term, it is associated with lower risk, according to a study published online April 30 in&nbsp;Obesity Surgery.Laura B. Harrington, Ph.D., M.P.H., from Kaiser Permanente Washington Health Research Institute in Seattle

Reducing the release of the "hunger hormone" ghrelin through ablation of the gastric fundus lining shows promise for weight loss, a small study found.

Reducing the release of the "hunger hormone" ghrelin through ablation of the gastric fundus lining shows promise for weight loss, a small study found.

A retrospective study reported a 0.1% aspiration rate in adults taking GLP-1 receptor agonists and undergoing esophagogastroduodenoscopy, despite a 9.4% rate of retained gastric contents.

Replacing meat with plant-based proteins for just one meal can benefit patients with liver disease by lowering harmful ammonia levels linked to cirrhosis and HE.

New research suggested that screening colonoscopy intervals may be safely extended to 15 years in low-risk individuals whose first colonoscopy is negative for CRC.

For patients with obesity and nonalcoholic fatty liver disease (NAFLD) compensated cirrhosis (CC), liver stiffness measurement (LSM) by magnetic resonance elastography (MRE) is significantly higher than acoustic radiation force impulse (ARFI) for those with varices, according to a study published online April 23 in Abdominal Radiology.

For patients with obesity and nonalcoholic fatty liver disease (NAFLD) compensated cirrhosis (CC), liver stiffness measurement (LSM) by magnetic resonance elastography (MRE) is significantly higher than acoustic radiation force impulse (ARFI) for those with varices, according to a study published online April 23 in Abdominal Radiology.

Relative to fecal immunochemical testing, the multitarget stool RNA test ColoSense showed a significant improvement in sensitivity for colorectal cancer and advanced adenomas.

The prevalence of colorectal cancer (CRC) is low for patients undergoing colonoscopy after an episode of uncomplicated diverticulitis, according to a study published online April 24 in Clinical Gastroenterology and Hepatology.Walker D. Redd, M.D., from the University of North Carolina in Chapel Hill, and colleagues used data from the Gas

The integration of biomarkers and patient-reported outcomes (PROs) improves prediction of interstitial cystitis (IC)/bladder pain syndrome, according to a study published online April 24 in Urology.

Inflammatory bowel disease (IBD) is a complex condition that requires individualized care to meet the needs of the patient's current disease state. With available medications sometimes causing serious side effects or losing their efficacy over time, many researchers have been exploring new, more targeted ways of delivering medications or other beneficial compounds, such as probiotics.

Physical activity could be a modifiable risk factor against inflammatory bowel disease.

Using clips to anchor a fully covered self-expandable metal stent reduces the occurrence of migration among patients with biliary strictures undergoing ERCP.

A novel high-resolution manometry (HRM) score can stratify the risk and severity of gastroesophageal reflux disease (GERD), according to a study published online March 27 in the&nbsp;UEG Journal.Stefano Siboni, M.D., from IRCCS Policlinico San Donato in Milan, and colleagues built and externally validated a manometric score (Milan Score)

A novel high-resolution manometry (HRM) score can stratify the risk and severity of gastroesophageal reflux disease (GERD), according to a study published online March 27 in the UEG Journal.

A robotic bronchial endoscopic system has been engineered to reduce side effects and provide prompt intervention during emergencies involving airway blockages in infants, young children, or the elderly caused by food or foreign substances. This innovative system is expected to be highly beneficial in emergency scenarios, as it has the potential to decrease the requisite medical personnel needed to

From 1990 to 2021, there were persistent health differences between females and males, according to a study published online May 1 in The Lancet Public Health.Vedavati Patwardhan, Ph.D., from the University of California, San Diego, and colleagues compared disability-adjusted life year (DALY) rates among females and males aged older than

Underassessment and undertreatment of chronic hepatitis B virus (HBV) is seen globally, according to a study published online May 1 in the&nbsp;Journal of Hepatology.Sahith Kudaravalli, from Stanford University in Palo Alto, California, and colleagues examined rates of evaluation and treatment in patients from the Real-world&nbsp;Effectiv

Among postmenopausal women with inflammatory bowel disease (IBD), there is no higher risk for cardiovascular disease (CVD) compared with women without IBD, although the risk for ischemic stroke may be higher, according to a study published online April 29 in&nbsp;Digestive Diseases and Sciences.Ruby Greywoode, M.D., from the Montefiore Me

For individuals without a family history of colorectal cancer (CRC), increasing the interval between colonoscopies for those with a first colonoscopy with negative findings seems safe and can avoid unnecessary colonoscopies, according to a study published online May 2 in JAMA Oncology.Qunfeng Liang, from the German Cancer Research Center

Inulin, a type of fiber found in certain plant-based foods and fiber supplements, causes inflammation in the gut and exacerbates inflammatory bowel disease in a preclinical model, according to a new study by Weill Cornell Medicine investigators. The surprising findings could pave the way for therapeutic diets that may help ease symptoms and promote gut health. 

The roles of the nervous system and the gut microbiome need to be more carefully considered when treating gastrointestinal disorders, say experts.

The roles of the nervous system and the gut microbiome need to be more carefully considered when treating gastrointestinal disorders, say experts.

Researchers have identified significant and specific variations in the microbial universe of the small intestine in overweight or obese adults compared with normal-weight peers.

Novel therapeutics could offer clinicians an additional tool in developing their patient treatment plans, particularly for those with no response or resistance to existing therapies.

IBD doesn't have a cure, and treatments are often limited. But, in recent years, gastrointestinal researchers have sharply focused on solutions for the disease overall and Crohn's in particular.

A machine learning algorithm can identify patients with common variable immunodeficiency disease (CVID) from their electronic health records, according to a study published in the May 1 issue of Science Translational Medicine.Due to the low prevalence and extensive heterogeneity in CVID phenotypes, resulting in delayed diagnoses and tre

In patients with cirrhosis, probiotics reduce HE and improve liver function scores, quality of life, and gut flora, a systematic review and meta-analysis finds.

Conflicting research and divisive logic dominate the quest to answer a critical question: Do cancer tumors have their own microbiomes, and what would that mean for an eventual cure?

Inflammatory bowel disease (IBD) is a common chronic gastrointestinal disorder and current treatment strategies can cause adverse effects. Thus, there is a need to identify alternative compounds to treat IBD. Similarly, the dose-related toxicity and efficacy of anticancer drugs needs to be monitored accurately to improve the treatment outcomes.

Reduced vancomycin susceptibility is impacting clinical responses among adults with Clostridioides difficile (C. difficile) infection, according to a study recently published in Clinical Infectious Diseases.Taryn A. Eubank, Pharm.D.,&nbsp;from the University of Houston College of Pharmacy, and colleagues examined if

For people with HIV (PWH), semaglutide is effective for metabolic dysfunction-associated steatotic liver disease (MASLD), according to a research letter published online April 30 in the Annals of Internal Medicine.Jordan E. Lake, M.D., from UTHealth Houston, and colleagues designed a pilot study to examine the effect of semaglutide on

The incidence of distant- and regional-stage colorectal cancer (CRC) has been increasing in individuals aged 46-49 years, a cross-sectional study of stage-stratified CRC found.

Patients with IBS-C and moderate to severe bloating achieved reductions in bloating after receiving plecanatide, but those with mild bloating showed no improvement.

The U.S. Department of Agriculture is clamping down on salmonella bacteria found in breaded, stuffed raw chicken products, with the agency issuing a final rule on the issue Friday.The agency's Food Safety and Inspect

Use of acid-suppression therapy is associated with higher odds of migraine or severe headache, according to a study published online April 24 in Neurology: Clinical Practice.Margaret Slavin, Ph.D., from the University of Maryland in College Park, and colleagues examined the association between migraine and severe headache prevalence an

The Pediatric Emergency Care Applied Research Network (PECARN) intra-abdominal injury and traumatic brain injury rules show a high degree of accuracy in pediatric emergency departments, according to a study published in the May issue of The Lancet Child &amp; Adolescent Health.James F. Holmes, M.D., from University of California Davis

A healthy liver filters all the blood in your body, breaks down toxins and digests fats. It produces collagen to repair damaged cells when the liver is injured. However, a liver can produce too much collagen when an excess accumulation of fat causes chronic inflammation, a condition called metabolic dysfunction-associated steatohepatitis (MASH). In an advanced state, MASH can lead to cirrhosis, li

The diffused presence of fat within the pancreas was the single most important driver for diseases of both the exocrine pancreas and endocrine pancreas, a recent study reported.

A large study reveals an increased risk for adverse cardiovascular events but not for liver disease progression in adults with MASLD disease and HIV infection.

More harm reduction strategies are needed to help eliminate hepatitis C by 2030, according to researchers.

Northeastern U.S. seafood consumers may be exposed to per- and polyfluoroalkyl substance (PFAS) concentrations that potentially pose a health risk, according to a study published online April 12 in Exposure and Health.Kathryn A. Crawford, Ph.D., from the Environmental Studies Program at Middlebury College in Vermont, and colleagues

Some companies claim they can identify and treat gastrointestinal problems with proprietary technology and products — experts disagree.

Microbes in the mammalian gut can significantly change their hosts' amino acid and glucose metabolism, acting almost like an extra liver, according to a new preclinical study by Weill Cornell Medicine investigators.

Growing evidence suggests invasive procedures may not be needed to confirm a celiac disease diagnosis.

Growing evidence suggests invasive procedures may not be needed to confirm a celiac disease diagnosis.

The update included background on the relationship between GLP-1 receptor agonists and endoscopic procedures, followed by clinical strategies for patients taking these medications.

Patients have lower hospital mortality and readmission rates when treated by female physicians, with a larger benefit observed for female patients, according to a study published online April 23 in the Annals of Internal Medicine.Atsushi Miyawaki, Ph.D., from the School of Public Health at The University of Tokyo, and colleagues conduc

A growing body of research suggests that manipulating gut bacteria may offer a promising approach to managing inflammatory bowel disease (IBD), a chronic and debilitating condition affecting millions of people worldwide.

Aspirin may promote an immune response against cancer, with fewer nodal metastases and higher infiltration of tumor-infiltrating lymphocytes among aspirin users with colorectal cancer (CRC), according to a study published online April 22 in Cancer.Ottavia De Simoni, M.D., from Veneto Institute of Oncology IOV‐IRCCS in Padova, Italy, an

Colorectal cancer (CRC) is the second most common cancer in the United States. This highlights the importance of early detection and treatment of precancerous lesions like large polyps. Endoscopy offers a minimally invasive approach to removing these polyps, reducing the need for traditional surgery.

Two common PFAS "forever chemicals" have been deemed hazardous substances by the Environmental Protection Agency.The new designation, enacted under the country's <a href="https://www.epa.gov/laws-regulations/summary-comprehensive-environmental-response-compensation-and-liability-act#:~:text=The%20Comprehensive%20Environmental%20Response%2C%20Co

A gastroenterologist reviewed the data about probiotics at the Francophone Days of Hepatology, Gastroenterology, and Digestive Oncology.

The recent guidance from AGA includes 12 best practices that address dietary options, enteral and parenteral nutrition, patient monitoring, and the need for multidisciplinary care.

Hypnosis, mindfulness meditation, and cognitive-behavioral therapy have shown particular benefits in irritable bowel syndrome.

Community Helicobacter pylori (HP) testing in high-risk individuals is technically feasible, according to a study published online April 3 in Clinical Gastroenterology and Hepatology.

National Accreditation Program for Rectal Cancer (NAPRC)-accredited hospitals have lower risk-adjusted mortality and morbidity for patients undergoing major rectal cancer surgery, according to a study published online March 28 in the Journal of the American College of Surgeons.Calista M. Harbaugh, M.D., from the University of Michigan

Subcutaneous administration of vedolizumab is now approved for maintenance therapy in adults with moderate to severe active Crohn's disease after induction therapy with intravenous vedolizumab.

A study conducted at the University of Gothenburg found that with dietary adjustments, more than 7 out of 10 irritable bowel syndrome (IBS) patients had significantly reduced symptoms, compared with medications. The work is published in The Lancet Gastroenterology & Hepatology journal.

Younger Italian kids or those with family celiac history get quicker diagnoses; others with vague symptoms face delays.

A new clinical practice update from AGA includes nine pieces of advice that address procedure optimization, evaluation of suspected premalignancy, and postprocedure follow-up evaluation.

Although CADe did not increase burden of colonoscopy, real-world adenoma detection rates cast doubt on the generalizability of positive findings from randomized trials, according to a meta-analysis.

In proof-of-concept study, high-pressure liquid spray showed promise for collecting cytology specimens from the stomachs of patients undergoing endoscopy for gastric cancer screening or surveillance.

Researchers found a high prevalence of eating disorders in patients with major types of immune-mediated GI diseases, especially in pediatric patients diagnosed with ulcerative colitis.

The U.S. Centers for Disease Control and Prevention warns of possible Salmonella contamination of Trader Joe's fresh organic basil sold in 29 states. Twelve people have been sickened, one of whom required hospitalization."Throw away any Infinite Herbs organic basil purchased from Trader Joe's," the agency said, and wash and sanitize

Community Helicobacter pylori (HP) testing in high-risk individuals is technically feasible, according to a study published online April 3 in&nbsp;Clinical Gastroenterology and Hepatology.Shria Kumar, M.D., from the University of Miami, and colleagues evaluated the results of community-based HP testing in an at-risk, underse

Propofol sedation during colonoscopy seems to be associated with improved detection of serrated polyps, according to a study published online April 17 in Anesthesiology.Aurora N. Quaye, M.D., from Maine Medical Center in Portland, and colleagues conducted a retrospective cohort study using observational data for patients aged older t

Although the overall incidence remains low, patients on GLP-1s have a 33% higher chance of aspiration pneumonia after endoscopic procedures, according to a new large population-based study.

A new clinical practice update from AGA covers cannabinoid hyperemesis syndrome that is triggered by chronic cannabis use and manifests with GI symptoms. Underdiagnosis remains a challenge.

Certain demographic, clinical, and genetic factors heighten the risk for extraintestinal manifestations (EIMs) with inflammatory bowel disease (IBD), according to a study published online March 13 in&nbsp;Gastroenterology.Michelle Khrom, from Cedars-Sinai Medical Center in Los Angeles, and colleagues investigated the clinical, serol

Subclassification of individuals at high risk for pancreatic adenocarcinoma (PC) can enable the development of surveillance approaches better tailored to risk, according to a study published online April 16 in the Journal of the National Comprehensive Cancer Network.George Zogopoulos, M.D., Ph.D., from McGill University Health Cente

Certain demographic, clinical, and genetic factors heighten the risk for extraintestinal manifestations (EIMs) with inflammatory bowel disease (IBD), according to a study published online March 13 in Gastroenterology.

A proprietary essential amino acid supplement in adolescent girls with obesity and polycystic ovary syndrome improved multiple liver-related outcomes.

Use of pancreatic enzyme therapy (PERT) is associated with a reduction in the incidence rate of acute pancreatitis (AP) among children with pancreatic sufficient acute recurrent pancreatitis (ARP) or chronic pancreatitis (CP), according to a study published online March 22 in the American Journal of Gastroenterology.A. Jay Freedman, M

Patients with suspected inflammatory bowel disease (IBD) could benefit from better testing protocols that would reduce the need and lengthy wait for potentially unnecessary colonoscopies, a new study has found.

Innovative carbon beads, invented by researchers at UCL, reduce bad bacteria and inflammation in animal models, which are linked to liver cirrhosis and other serious health issues.

For individuals with class II obesity, endoscopic sleeve gastroplasty (ESG) is cost saving compared with semaglutide, according to a study published online April 12 in JAMA Network Open.Muhammad Haseeb, M.D., from Brigham and Women's Hospital in Boston, and colleagues examined the cost-effectiveness of semaglutide versus ESG over five

Significantly higher hepatitis C virus cure rates are seen for patients receiving opioid treatment program-integrated facilitated telemedicine versus off-site hepatitis specialist referral, according to a study published online April 3 in the Journal of the American Medical Association.Andrew H. Talal, M.D., M.P.H., from the Jacobs Sch

Patients using glucagon-like peptide 1 receptor agonists (GLP-1 RAs) undergoing endoscopic procedures have an increased risk for aspiration pneumonia, according to a study published online March 27 in Gastroenterology.Yee Hui Yeo, M.D., from Cedars-Sinai Medical Center in Los Angeles, and colleagues examined the incidence and risk for

Adenoma detection rates were shown to be comparable between 45-49-year-olds and 50-54-year-olds.