All articles tagged: OBGYN & Women's Health

The mean cost of developing a new drug for the U.S. market is estimated to be $879.3 million when both drug development failure and capital costs are considered, according to a study published online June 28 in JAMA Network Open.Aylin Sertkaya, Ph.D., from Eastern Research Group Inc., in Lexington, Massachusetts, and colleagues ass

Distinct phenotypic and urine biological characteristics are seen for patients with interstitial cystitis/bladder pain syndrome (IC/BPS) with a history of ulcerative Hunner lesions (UIC) and those with no lesions (NHIC), according to a study recently published in the American Journal of Clinical and Experimental Urology.Bernadette M.M.

A small number of surgical procedures, including orthopedic procedures and cesarean delivery, account for a large proportion of opioid prescriptions dispensed after surgery, according to a study published online June 26 in JAMA Network Open.Dominic Alessio-Bilowus, from Michigan Medicine in Ann Arbor, and colleagues examined the surgica

For patients with early-stage cervical cancer, disease-free and overall survival are lower for patients undergoing minimally invasive versus open radical hysterectomy, according to a study published online June 25 in the Journal of Clinical Oncology.Pedro T. Ramirez, M.D., from the Methodist Hospital in Houston, and colleagues compared

The U.S. Supreme Court has ruled that, for now, emergency abortions be allowed in Idaho when a woman's health is at risk.Importantly, the opinion issued Thursday only dismissed the case on procedural grounds, sta

Many sexually transmitted diseases are on the rise in the United States, and a nationwide poll indicates that ignorance about how they're transmitted could be fueling their spread.About a third of Americans (34%) falsely believe sexually transmitted infections (<a href="https://www.healthday.com/a-to-z-health/infectious-diseases/most-common-st

Echocardiography during pregnancy or early postpartum can assist in identifying women with preeclampsia at greater risk of future hypertension, according to a study presented at the American Society of Echocardiography's 35th Annual Scientific Sessions, held from June 14 to 16 in Portland, Oregon.Anushree Puttur, M.D., from Allegheny General

The Dobbs v Jackson Women's Health Organization decision, allowing states to strengthen restrictions on abortion access, was associated with declines in prescription fills for oral contraceptives, according to a study published online June 26 in JAMA Network Open.Dima M. Qato, Pharm.D., M.P.H., Ph.D., from the University of

Multiple brands of ice cream are being recalled by the maker, Totally Cool Inc., due to concerns over Listeria contamination.The full list of brands and recalled products can be found online, but include multiple products by Friendly's, Abylin's Frozen, some Hershey's i

mRNA COVID-19 vaccination during pregnancy is not associated with an increased risk of adverse pregnancy outcomes, according to a study published in the June issue of&nbsp;Obstetrics &amp; Gynecology.Kimberly K. Vesco, M.D., M.P.H., from Kaiser Permanente Center for Health Research in Portland, Oregon, and colleagues evaluated the asso

Psychostimulants may help opioid use disorder (OUD) outcomes in pregnant women, according to a study published online June 11 in&nbsp;Nature Mental Health.Kevin Y. Xu, M.D.,&nbsp;M.P.H., from the Washington University School of Medicine in St. Louis, and colleagues used U.S. multistate administrative data to examine the risks and benef

A 10-week acupuncture intervention significant reduces endocrine symptoms and hot flashes among women with breast cancer receiving endocrine therapy (ET), according to a study published online June 24 in Cancer.Weidong Lu, M.P.H., Ph.D., from the Dana Farber Cancer Institute in Boston, and colleagues enrolled 158 patients with stage 0 t

Just two injections a year of a new HIV drug protected young women in Africa from infection with the sexually transmitted disease, new trial results show.In announcing the findings, Gilead Sciences Inc. said its HIV medication lenacapavir demonstrated 100% efficacy as a prev

The U.S. Food and Drug Administration has approved Keytruda (pembrolizumab) plus chemotherapy as treatment for adult patients with primary advanced or recurrent endometrial carcinoma. This is the third FDA-approved indication for Keytruda in endometrial carcinoma.The approval is for Keytruda, an anti-programmed death receptor-1&nbsp;(anti-PD-1)

Regional neonatal brain volumes are associated with elevated maternal psychological distress, according to a study published online June 20 in&nbsp;JAMA Network Open.Susan Weiner, from Children’s National Hospital in Washington, D.C., and colleagues examined the association between the pandemic and rising maternal psychological distress

The cumulative risk for advanced gastric cancer varies from 6.5 to 10.3 percent for carriers of germline CDH1 pathogenic/likely pathogenic (P/LP) variants, according to a study published online June 14 in the Journal of the American Medical Association to coincide with presentation at the International Gastric Cancer Linkage Consortiu

From 2021 to 2022, there was a decrease in the percentage of adults who used telemedicine in the past 12 months, according to the June 20 National Vital Statistics Reports, a publication from the National Center for Health Statistics.Jacqueline W. Lucas, M.P.H., and Xun Wang, from the National Center for Health Statistics in Hyattsvil

Women with perinatal depression (PND) have an elevated long-term risk for cardiovascular disease (CVD), according to a study published online June 18 in the European Heart Journal.Donghao Lu, Ph.D., from the Karolinska Institutet in Stockholm, and colleagues conducted a nationwide population-based matched cohort study involving 55,53

Drug-related infant mortality increased significantly from 2018 to 2022, according to a study published online May 22 in the&nbsp;Journal of Perinatal Medicine.Panagiota Kitsantas, Ph.D., from Florida Atlantic University in Boca Raton, and colleagues used data from the Centers for Disease Control and Prevention Wide-ranging Online Da

In 2023, 7.6 percent of the U.S. civilian noninstitutionalized population was uninsured, according to early estimates from the National Health Interview Survey, 2023, released by the National Center for Health Statistics.Robin A. Cohen, Ph.D., from the National Center for Health Statistics in Hyattsville, Maryland, and colleagues used data from

Continuing metformin and adding insulin in early pregnancy does not significantly alter the risk for nonlive birth or live birth with congenital malformations compared with switching to insulin monotherapy, according to a study published online June 18 in the Annals of Internal Medicine.Yu-Han Chiu, M.D., Sc.D., from the Harvard T.H. C

In a success story for Americans seeking affordable healthcare coverage, tax credits put in place during the pandemic helped millions gain health insurance, a new report found.Trouble is, the credits are set to expire at the end of 2025, noted a research team from the nonprofit Robert Wood Johnson Foundation (RWJ).According to RWJ's <a h

Paternal use of metformin in monotherapy is not associated with an increased risk for major congenital malformations (MCMs), according to a study published online June 18 in the Annals of Internal Medicine.Ran S. Rotem, Sc.D., from the Harvard T.H. Chan School of Public Health in Boston, and colleagues examined the association between p

For pregnant individuals, the prevalence of chronic hypertension more than doubled between 2008 and 2021, according to a study published online June 17 in Hypertension.Stephanie A. Leonard, Ph.D., from the Stanford University School of Medicine in California, and colleagues analyzed commercial insurance claims from 2007 to 2021 and asse

In postmenopausal women, chronic kidney disease (CKD) may be associated with tooth loss, according to a study published online June 11 in&nbsp;Menopause.Na-Yeong Kim, from the Chonnam National University School of Dentistry in Gwangju, South Korea, and colleagues evaluated the association between CKD and tooth loss in postmenopausal wom

Past-year Papanicolaou testing rates were lower in 2022 than in 2019, overall, and lower rates were seen in rural versus urban women, according to a study published in online June 14 in JAMA Network Open.Tyrone F. Borders, Ph.D., and Amanda Thaxton Wiggins, Ph.D., from the University of Kentucky in Lexington, examined receipt of a Papan

Factors aside from neighborhood deprivation are responsible for increased breast cancer mortality among Black women, according to a study published online June 12 in&nbsp;JAMA Network Open.Lauren E. Barber, Ph.D., from the Emory University Rollins School of Public Health in Atlanta, and colleagues investigated whether neighborhood depri

Health care spending growth is projected to outpace that of the gross domestic product (GDP) during the coming decade, according to a study published online June 12 in Health Affairs.Jacqueline A. Fiore, Ph.D., from the Centers for Medicare &amp; Medicaid Services in Baltimore, and colleagues projected growth in national health expend

Women with a history of low birth-weight (LBW) delivery may have poorer cognition, according to a study published online June 12 in Neurology.Diana C. Soria-Contreras, Ph.D., from the Harvard T.H. Chan School of Public Health in Boston, and colleagues examined the extent to which a lifetime history of LBW delivery is associated with c

The U.S. Supreme Court on Thursday threw out a case that aimed to curb access to the controversial abortion drug mifepristone, saying the plaintiffs who brought the case to the court had no legal standing to do so.In a unanimous vote, the nine judges <a href="https://www.supremecourt.gov/op

Johnson &amp; Johnson will pay $700 million to settle claims from 42 states and the District of Columbia that the company continued to market its talcum powder products even as evidence tied them to a heightened risk for cancer.J&amp;J did not admit to any wrongdoing in settling with the states, which were led by Florida, Texas and North Carol

The burden of adverse effects of medical treatment (AEMT) is increasing, with the proportion of all cases accounted for by the increasing rates seen in older adults, according to a study published online June 11 in BMJ Quality &amp; Safety.Liangquan Lin, from the Chinese Academy of Medical Sciences &amp; Peking University Medical Col

Generation X is experiencing larger per-capita increases in the incidence of cancers than Baby Boomers, according to a study published online June 10 in JAMA Network Open.Philip S. Rosenberg, Ph.D., and Adalberto Miranda-Filho, Ph.D., from the National Cancer Institute in Bethesda, Maryland, estimated invasive cancer incidence trends

The U.S. Preventive Services Task Force (USPSTF) recommends screening for osteoporosis for women aged 65 years and older and for postmenopausal women younger than 65 years with one or more risk factors. These recommendations form the basis of a draft recommendation statement published online June 11.Researchers reviewed the evidence from 138 st

Women with early menopause have a two times greater risk for breast cancer and a nearly four times higher risk for ovarian cancer, according to a study presented at the annual meeting of the Endocrine Society, held from June 1 to 4 in Boston.Kristina&nbsp;L. Allen-Brady, Ph.D., M.P.H., from University of Utah in Salt Lake City, and colleagues i

Implementation of artificial intelligence (AI) into a population-based mammography screening program reduced the overall workload of radiologists while improving screening performance, according to a study published online June 4 in&nbsp;Radiology.Andreas D. Lauritzen, Ph.D., from University of Copenhagen in Denmark, and colleagues com

There was an increase in hypertensive disorders of pregnancy and most associated risk factors between 2010 and 2021 overall in the entire U.S. pregnant population, according to a research letter published online June 10 in the&nbsp;Journal of the American Medical Association.Mariam K. Ayyash, M.D., from the Columbia University Irving Me

The prevalence of iron deficiency varies significantly with three different definitions, according to a study published online June 7 in JAMA Network Open.James C. Barton, M.D., from the University of Alabama at Birmingham, and colleagues compared the prevalence of iron deficiency among women using three different definitions based on d

Empiric vitamin D supplementation is suggested for those aged 1 to 18 years, those older than 75 years, those who are pregnant, and those with high-risk prediabetes, according to an Endocrine Society clinical practice guideline published online June 3 in the Journal of Clinical Endocrinology &amp; Metabolism.Marie B. Demay, M.D., from M

Only half of individuals disclose or believe they should disclose having a sexually transmitted infection (STI) prior to sexual intercourse, according to a literature review published online June 5 in the&nbsp;Journal of Sex Research.Kayley D. McMahan, Ph.D., and Spencer B. Olmstead, Ph.D., from the University of Tennessee in Knoxville,

One in six adult primary care patients report using cannabis, according to a study published online June 5 in&nbsp;JAMA Network Open.Lillian Gelberg, M.D., from the UCLA David Geffen School of Medicine in Los Angeles, and colleagues examined prevalence of past three-month cannabis use and reasons for cannabis use. Analysis included 175,7

Early resistance exercise following surgery for early-stage breast cancer improves shoulder range of motion (ROM) and strength at one month and six months postsurgery, according to a study published online June 5 in&nbsp;JAMA Surgery.Jihee Min, Ph.D., from the National Cancer Center in Goyang-si, South Korea, and colleagues investigated

Germline variation does not predict the risk of taxane-induced peripheral neuropathy (TIPN) in Black women receiving paclitaxel (once weekly) or docetaxel (every three weeks) for early-stage breast cancer, according to a study published online June 3 in the Journal of Clinical Oncology to coincide with the annual meeting of the American Society

For glucose and lipid profiles during early childhood, the impact of frozen embryo transfer (FET) is comparable to that of fresh embryo transfer, according to a study published online June 6 in PLOS Medicine.Wei Zhou, from Shandong University in Jinan, China, and colleagues compared the metabolic profiles of children born after frozen ve

Heavy cannabis use is associated with a significantly increased risk for cardiovascular disease (CVD) mortality among women, according to a study published online June 6 in JAMA Network Open.Alexandre Vallée, M.D., Ph.D., from Foch Hospital in Suresnes, France, examined sex-stratified associations of cumulative lifetime cannabis use wi

In clinical guidelines issued by the U.S. Centers for Disease Control and Prevention and published June 4 in the agency's Morbidity and Mortality Weekly Report, recommendations are presented for the use of doxycycline postexposure prophylaxis (doxy PEP) for preventing sexually transmitted infections (STIs) in gay, bisexual, and other men who

Many women are unhappy with the state of U.S. maternal health care, but a major new poll finds most Americans don’t understand how badly the nation lags behind other wealthy countries in this area.Only about 2 in 5 (42%) women currently pregnant or ever pregnant strongly felt they had access to the best possible medical care while pregnant, do

Maternal mortality rates in the United States continue to exceed those in other wealthy nations, with most women dying during pregnancy and childbirth in ways that were preventable, a new report shows.In 2022, U.S. women had a death rate from complications of pregnancy and childbirth of 22 deaths per 100,000 live births, researchers found.<p

In 2021, 9.6 percent of medical visits took place via telehealth, with a higher percentage seen for mental health visits, according to a research letter published online June 4 in the Annals of Internal Medicine.Sandra L. Decker, Ph.D., from the Agency for Healthcare Research and Quality in Rockville, Maryland, and colleagues describe te

Individuals with preeclampsia have an increased risk for young-onset dementia, according to a research letter published online May 30 in JAMA Network Open.Valérie Olié, Ph.D., from Santé Publique in Saint-Maurice, France, and colleagues obtained data from the nationwide prospective Conception study, which included all deliveries in Franc

Maternal serum alpha-fetoprotein (AFP) levels are higher in Black than White pregnant women, supporting the use of accounting for these differences in prenatal open neural tube defect (ONTD) screening, according to a study published online May 23 in Clinical Chemistry.Geralyn Messerlian, Ph.D., from the Women &amp; Infants Hospital and t

The mean age at menarche has decreased and time to cycle regularity has increased with increasing birth year, according to a study published online May 29 in JAMA Network Open.Zifan Wang, Ph.D., from the Harvard T.H. Chan School of Public Health in Boston, and colleagues examined temporal trends and disparities in menarche and time to re

Increases in physical activity increase the odds of menopause-related hot flashes, according to a study published online May 28 in&nbsp;Menopause.Sarah Witkowski, Ph.D., from Smith College in Northampton, Massachusetts, and colleagues examined the association between acute changes in physical activity, temperature, and humidity and 24-ho

The COVID-19 pandemic had a transient negative effect on breast cancer screening overall and a prolonged negative effect on follow-up screening, according to a study published in the May/June issue of the Annals of Family Medicine.Andrew Chung, from Pennsylvania State University in University Park, and colleagues evaluated the pandemic

For analyzing negative screening digital breast tomosynthesis (DBT) examinations, patient characteristics influence the case and risk scores of an artificial intelligence (AI) algorithm, according to a study published online May 21 in Radiology.Derek L. Nguyen, M.D., from the Duke University School of Medicine in Durham, North Carolina

At-school vaccination may be a useful tool to increase human papillomavirus (HPV) vaccination coverage among adolescents, according to a study published online May 23 in JAMA Network Open.Nathalie Thilly, Ph.D., from Université de Lorraine in Nancy, France, and colleagues examined the effectiveness of a three-component intervention (ed

There are no differences in creative thinking at age 4.5 years for children of women with epilepsy (WWE) and children of healthy women (HW), but fetal antiseizure medication (ASM) exposure-dependent effects are seen for executive function in children of WWE, according to a study published online May 29 in Neurology.Kimford J. Meador,

From 2007 to 2019, there was an increase in inflation-adjusted health care spending, largely due to increasing contributions to premiums, according to a research letter published online May 28 in JAMA Internal Medicine.Sukruth A. Shashikumar, M.D., from the Beth Israel Deaconess Medical Center in Boston, and colleagues conducted a cro

Women with premenstrual disorders (PMD) do not have increased risk of early death overall, but the risks of suicide and the risks for women with diagnosis before 25 years are elevated, according to a study published online May 28 in JAMA Network Open.Marion Opatowski, Ph.D., from the Institute of Environmental Medicine at the Karolins

Early-life air and noise pollution exposure are prospectively associated with three common mental health problems from adolescence to young adulthood, according to a study published online May 28 in&nbsp;JAMA Network Open.Joanne B. Newbury, Ph.D., from University of Bristol in the United Kingdom, and colleagues examined the longitudin

The combination of breast cancer and chemotherapy contributes to accelerated functional decline in older women with early-stage breast cancer, according to a study published online April 28 in the&nbsp;Journal of Cancer Survivorship.Mina S. Sedrak, M.D., from the University of California Los Angeles David Geffen School of Medicine, an

The annual meeting of the American College of Obstetricians and Gynecologists was held from May 17 to 19 in San Francisco and was attended by more than 4,000 clinicians, academicians, allied health professionals, and others interested in obstetrics and gynecology. The conference highlighted recent advances in the prevention, detection, and treatmen

A novel natural language understanding (NLU) pipeline can identify the rates of lymphedema and node positivity among women with estrogen receptor-positive (ER+), clinically node-negative (cN0) breast cancer, according to a study published online May 22 in JCO Clinical Cancer Informatics.Neil Carleton, from the UPMC Hillman Cancer Center

There are systemic disparities in definitive cancer treatment delivery at minority-serving hospitals (MSHs) versus non-MSHs, according to a study published online May 27 in Cancer.Edoardo Beatrici, M.D., from Brigham and Women's Hospital in Boston, and colleagues used data from the National Cancer Database for 2010 to 2019 to examine pa

Conjugated equine estrogen (CEE) taken alone for menopause may increase the risk for developing and dying from ovarian cancer, according to a study presented at the annual meeting of the American Society of Clinical Oncology, held from May 31 to June 4 in Chicago.Rowan T. Chlebowski, M.D., Ph.D., from the Lundquist Institute in Torrance, Califor

Preterm and early-term birth rates increase after heat waves, according to a study published online May 24 in JAMA Network Open.Lyndsey A. Darrow, Ph.D., from the University of Nevada School of Public Health in Reno, and colleagues examined changes in daily rates of preterm and early-term birth after heat waves in a cohort study of singl

Primary human papillomavirus (HPV) screening intervals could be extended, with the risk for cervical precancer or worse (CIN2+) eight years after negative HPV screening comparable to risk after three years in cytology cohorts, according to a study published online May 22 in Cancer Epidemiology, Biomarkers &amp; Prevention.Anna Gottschlic

A once-daily dose of donepezil does not improve cognitive function among breast cancer survivors exposed to chemotherapy one to five years earlier, according to a study published online May 6 in the Journal of Clinical Oncology.Stephen R. Rapp, Ph.D., from the Wake Forest University School of Medicine in Winston-Salem, North Carolina, an

Prenatal exposure to endocrine-disrupting chemicals (EDCs) is associated with adverse metabolic health in children, according to a study published online May 23 in JAMA Network Open.Nuria Güil-Oumrait, from the Barcelona Institute for Global Health in Spain, and colleagues examined associations of prenatal exposure to EDC mixtures with t

Epidural analgesia during labor is associated with a reduction in severe maternal morbidity (SMM), according to a study published online May 22 in The BMJ.Rachel J. Kearns, M.D., from the Glasgow Royal Infirmary in Scotland, and colleagues conducted a population-based study to examine the effect of labor epidural on SMM in 567,216 women

Louisiana has become the first state to pass a law that designates abortion pills as dangerous controlled substances.Once Gov. Jeff Landry signs the bill into law, as he is expected to do, possession of the drugs mifepristone and <a href="https://www.dr

Most survivors of stage 0 to III breast cancer who attempt pregnancy postdiagnosis are able to become pregnant and have a live birth, according to a study presented at the annual meeting of the American Society of Clinical Oncology, held from May 31 to June 4 in Chicago.Kimia Sorouri, M.D., M.P.H., from the Dana-Farber Cancer Institute in Bosto

Human papillomavirus (HPV) vaccination is associated with reduced odds of several types of HPV-related cancers, not just cervical cancer, according to a study presented at the annual meeting of the American Society of Clinical Oncology, held from May 31 to June 4 in Chicago.Jefferson DeKloe, from Thomas Jefferson University in Philadelphia, and

A deep learning model using tumor dynamic contrast-enhanced breast magnetic resonance imaging (MRI) has high sensitivity for identifying lymph node metastasis, according to a study published online April 12 in Radiology: Imaging Cancer.Dogan S. Polat, M.D., from the University of Texas Southwestern Medical Center in Dallas, and colleag

Life expectancy and age-standardized disease burden are expected to continue improving between 2022 and 2050, according to the Global Burden of Disease (GBD) study, published in the May 18 issue of The Lancet.Stein Emil Vollset, M.D., M.P.H., and colleagues from the GBD 2021 Forecasting Collaborators provide a reference forecast and a

Prenatal fluoride exposure is associated with increased neurobehavioral problems, according to a study published online May 20 in JAMA Network Open.Ashley J. Malin, Ph.D., from the University of Florida in Gainesville, and colleagues examined associations of third-trimester maternal urinary fluoride (MUF) with child neurobehavior at age

Infertility treatment is associated with an increased risk for hospitalization due to heart disease, according to a study published in the May issue of the Journal of Internal Medicine.Rei Yamada, M.D., from Rutgers Robert Wood Johnson Medical School in New Brunswick, New Jersey, and colleagues examined the association between infertili

There is a positive association between use of intimate care products, including genital talc, and ovarian cancer, according to a study published online May 15 in the Journal of Clinical Oncology.Katie M. O'Brien, Ph.D., from the National Institutes of Health in Research Triangle Park, North Carolina, and colleagues examined the associa

Fezolinetant is safe and effective for moderate-to-severe vasomotor symptoms (VMS), according to a study presented at the annual European Congress of Endocrinology, hosted by the European Society of Endocrinology from May 11 to 14&nbsp;in Stockholm.Angelica Lindén Hirschberg, M.D., Ph.D., from the Karolinska Institutet in Stockholm, and colleague

In an American Academy of Pediatrics clinical report published online May 20 in Pediatrics, recommendations are presented for breastfeeding among people living with and at risk for HIV.Lisa Abuogi, M.D., from the University of Colorado School of Medicine in Aurora, and colleagues examined feeding practices for infants born to people livi

Glucose above the diagnostic threshold at the time of gestational diabetes diagnosis is associated with worse neonatal outcomes, according to a study presented at the annual European Congress of Endocrinology, hosted by the European Society of Endocrinology from May 11 to 14&nbsp;in Stockholm.Catarina Cidade-Rodrigues, M.D., from Centro Hospitala

Women receive worse primary care-based chronic kidney disease (CKD) management than men, according to a research letter published online May 16 in the Journal of the American Medical Association to coincide with the annual meeting of the Society of General Internal Medicine, held from May 15 to 18 in Boston.Jorge A. Rodriguez, M.D., from

There is a high level of approval for use of polygenic embryo screening, according to a study published online May 14 in JAMA Network Open.Rémy A. Furrer, Ph.D., from the Center for Bioethics at Harvard Medical School in Boston, and colleagues surveyed U.S. adults to examine general attitudes, interests, and concerns relating to use of P

In a practice guideline issued by the American Academy of Neurology, along with the American Epilepsy Society and the Society for Maternal-Fetal Medicine, recommendations are presented for the use of antiseizure medications (ASMs) among people with epilepsy of childbearing potential (PWECP). The guideline was published online May 15 in Neurology</em

For women with obesity, the risk for breast cancer is reduced after bariatric surgery, according to a study published online May 15 in JAMA Surgery.Felipe M. Kristensson, M.D., from the Sahlgrenska Academy at the University of Gothenburg in Sweden, and colleagues examined whether bariatric surgery is associated with breast cancer incid

In its biennial Cancer Disparities Progress Report published today, the American Association for Cancer Research presents the latest statistics on disparities in cancer progress experienced by ethnic-minority groups and other medically underserved populations in the United States.Robert A. Winn, M.D., from the Virginia Commonwealth Un

Both acute hepatitis C (AHC) and hepatitis C virus (HCV)-related cirrhosis incidence were up substantially globally from 1990 to 2019 in reproductive-aged women, according to a study published online April 19 in the&nbsp;Journal of Global Health.Yanzheng Zou, from the School of Public Health at Nanjing Medical University in China, and

The U.S. Food and Drug Administration has approved a kit that will allow women to collect their own vaginal sample for HPV screening, a move that could increase early detection in those at risk for cervical cancer.Women will be able to swab thems

While some states have moved to severely curb women's access to abortion, including abortion pills, over 8,000 women living in those states are getting the pills by mail each month from states without such restrictions.That's according to new data from a <a href="https://societyfp.org/wp-content/uploads/2024/05/WeCount-report-6-May-2024-Dec-2023

Fat-enlarged axillary nodes on screening mammograms can predict the risk for cardiovascular disease (CVD), according to a study presented at the annual meeting of the American Roentgen Ray Society, held from May 5 to 9 in Boston.Jessica Rubino, M.D., from the Dartmouth Hitchcock Medical Center in Lebanon, New Hampshire, and colleagues used elect

Women with disabilities have a low likelihood of perceiving a risk for harm from weekly cannabis use, according to a study recently published online in&nbsp;Cannabis and Cannabinoid Research.Panagiota Kitsantas, Ph.D., from Florida Atlantic University in Boca Raton, and colleagues examined the perceived risk for harm from weekly cannabi

San Francisco is on the verge of passing a ban on "forever chemicals" in the protective clothing firefighters wear while battling blazes.City lawmakers are expected to pass an ordinance on Tuesday&nbsp

At the individual level, there is high predictability for measles antibody dynamics from birth, according to a study published online May 13 in Nature Microbiology.Wei Wang, from the Key Laboratory of Public Health Safety in Shanghai, and colleagues reconstructed antibody trajectories from birth by combining serological data from 1,505 i

Physicians with disabilities (PWDs) are significantly more likely to experience depersonalization but not emotional exhaustion when compared with their peers without disabilities, according to a research letter published online May 9 in&nbsp;JAMA Network Open.Lisa M. Meeks, Ph.D., from the University of Michigan Medical School in Ann Arb

Mail-order pharmacy dispensing of mifepristone for medication abortion is effective, acceptable, and feasible, according to a study published online May 13 in JAMA Internal Medicine.Daniel Grossman, M.D., from the University of California, San Francisco, and colleagues estimated the effectiveness, acceptability, and feasibility of dispen

Metabolic syndrome (MetS) and obesity have independent and distinct associations with breast cancer subtypes and mortality, according to a study published online May 13 in Cancer.Rowan T. Chlebowski, M.D., Ph.D., from The Lundquist Institute in Torrance, California, and colleagues examined the associations of MetS and obesity with postme

Large language models (LLMs) appear to fall short in classification of breast imaging, which can have a negative impact on clinical management, according to a study published online April 30 in Radiology.Andrea Cozzi, M.D., Ph.D., from the Ente Ospedaliero Cantonale in Lugano, Switzerland, and colleagues examined the agreement between hu

Ascension, a major U.S. health care system with 140 hospitals in 19 states, announced late Thursday that a cyberattack has caused disruptions at some of its hospitals."Systems that are currently unavailable include our electronic health records system, MyChart (which enables patients to view their medical records and communicate with their provid

For individuals with limited English proficiency, there are disparities in telehealth access, as well as worse video visit experiences, according to a research letter published May 9 in&nbsp;JAMA Network Open.Jorge A. Rodriguez, M.D., from Brigham and Women's Hospital in Boston, and colleagues used data from 24,453 adult participants in

Gestational diabetes is associated with an increased risk for subsequent diabetes, with higher risk for gestational diabetes in second pregnancy and in both first and second pregnancies, according to a study published online May 9 in JAMA Network Open.Joseph Mussa, from McGill University in Montreal, and colleagues compared the hazards

For patients with breast cancer, there are racial and ethnic differences in treatment declination, according to a study published online May 9 in JAMA Network Open.Jincong Q. Freeman, M.P.H., from the University of Chicago, and colleagues examined trends and racial and ethnic disparities in treatment declination and overall survival usi

There are high rates of harassment behaviors within the obstetrics and gynecology (OB-GYN) specialty, according to a review published online May 8 in JAMA Network Open.Ankita Gupta, M.D., M.P.H., from the University of Louisville Health in Kentucky, and colleagues conducted a systematic review of the prevalence of sexual harassment, bul

Perimenopausal women have an increased risk for depressive symptoms and diagnoses, according to a review published in the July 15 issue of the Journal of Affective Disorders.Yasmeen Badawy, from University College London, and colleagues conducted a systematic review and meta-analysis to estimate the risk for developing clinical depressi

The first-trimester Fetal Medicine Foundation (FMF) screening test predicts 63.1 percent of preterm preeclampsia cases and 77.3 percent of early-onset preeclampsia cases, according to a study published online May 6 in Hypertension.Paul Guerby, M.D., Ph.D., from Université Laval in Quebec City, and colleagues conducted a prospective coh

Military health beneficiaries, especially active-duty personnel, more often have excessive gestational weight gain (GWG), according to a study published in the May issue of Obesity.Rebecca A. Krukowski, Ph.D., from the School of Medicine at the University of Virginia in Charlottesville, and colleagues obtained data for 48,391 TRICARE ben

Planters Honey Roasted Peanuts and Planters Deluxe Lightly Salted Mixed Nuts, sold at Publix and Dollar Tree in five states, are being recalled due to the risk for Listeria contamination.So far, there have been no reports of illness linked to the recalled products, according to the manufacturer, Hormel."The products were shipped t

Women experiencing surgical premature menopause (PM) have a higher likelihood of developing musculoskeletal disorders, according to a study published online April 30 in&nbsp;Menopause.María S. Vallejo, M.D., from Universidad de Chile in Santiago, and colleagues compared muscle disorders among women with PM (176) or normal age of menopaus

Female nurses identifying as lesbian or bisexual have markedly earlier mortality than heterosexual nurses, according to a study published online April 25 in the&nbsp;Journal of the American Medical Association.Sarah McKetta, M.D., Ph.D., from Harvard Medical School and the Harvard Pilgrim Health Care Institute at Harvard University in Bo

Combining time-restricted eating (TRE) with high-intensity functional training (HIFT) may have superior effects on body composition, lipid profile, and glucose regulation among inactive women with obesity compared with diet or exercise interventions alone, according to a study published online May 1 in PLOS ONE.Ranya Ameur, from Universi

Cancer survivors with elevated loneliness have a higher mortality risk, according to a study published online April 25 in the Journal of the National Comprehensive Cancer Network.Jingxuan Zhao, M.P.H., from the American Cancer Society in Atlanta, and colleagues identified a longitudinal cohort of cancer survivors aged 50 years and older f

Text messaging women after initial outreach for breast cancer screening increases mammogram completion rates, according to a study published online May 6 in JAMA Internal Medicine.Shivan J. Mehta, M.D., from the Perelman School of Medicine at the University of Pennsylvania in Philadelphia, and colleagues conducted two concurrent trials in

From 1990 to 2021, there were persistent health differences between females and males, according to a study published online May 1 in The Lancet Public Health.Vedavati Patwardhan, Ph.D., from the University of California, San Diego, and colleagues compared disability-adjusted life year (DALY) rates among females and males aged older than

Among participants with high-risk nonmetastatic breast cancer, daily aspirin use did not improve the risk for breast cancer recurrence or survival in early follow-up, according to a study published online April 29 in the Journal of the American Medical Association.Wendy Y. Chen, M.D., from the Dana-Farber Cancer Institute in Boston, and c

The overall risk for cancer is not increased for children born after medically assisted reproduction (MAR), according to a study published online May 2 in JAMA Network Open.Paula Rios, M.D., Ph.D., from the French National Agency for Medicines and Health Products Safety in Saint-Denis, and colleagues compared the risk for cancer overall a

In 2020, there were major gaps in screening clients at federally qualified health centers (FQHCs) for various types of cancer when compared with the general population, according to a study published online April 29 in&nbsp;JAMA Internal Medicine.Trisha L. Amboree, Ph.D., from the University of Texas MD Anderson Cancer Center in Houston,

Among postmenopausal women with inflammatory bowel disease (IBD), there is no higher risk for cardiovascular disease (CVD) compared with women without IBD, although the risk for ischemic stroke may be higher, according to a study published online April 29 in&nbsp;Digestive Diseases and Sciences.Ruby Greywoode, M.D., from the Montefiore Me

FRIDAY, May 3, 2024 (HealthDay News) --&nbsp;Adherence to physical activity guidelines during middle age appears to improve health-related quality of life among women, according to a study published online May 2 in PLOS Medicine.Binh Nguyen, Ph.D., of the University of Sydney, and colleagues evaluated data from 11,336 participants in the Australian Longitudinal Study on Women's

More than half of women who smoke before pregnancy quit while pregnant, according to research published in the May 2 issue of the U.S. Centers for Disease Control and Prevention Morbidity and Mortality Weekly Report.Lauren Kipling, Ph.D., from the CDC in Atlanta, and colleagues used data from the 2021 Pregnancy Risk Assessment Monitorin

In 2022, there was a decrease in maternal mortality rates, according to a report published in the May Health E-Stats, a publication of the U.S. Centers for Disease Control and Prevention National Center for Health Statistics.Donna L. Hoyert, Ph.D., from the National Center for Health Statistics in Hyattsville, Maryland, examined materna

A machine learning algorithm can identify patients with common variable immunodeficiency disease (CVID) from their electronic health records, according to a study published in the May 1 issue of Science Translational Medicine.Due to the low prevalence and extensive heterogeneity in CVID phenotypes, resulting in delayed diagnoses and tre

The longitudinal Women's Health Initiative trials do not support hormone therapy for cardiovascular disease prevention, calcium and vitamin D supplementation for universal fracture prevention, or a low-fat diet for cancer prevention, according to a review published online May 1 in the Journal of the American Medical Association.JoAnn E.

Johnson &amp; Johnson announced Wednesday that it would pay out more than $6.5 billion over the next 25 years to settle existing lawsuits claiming that its talc-containing products caused ovarian cancer.The settlement still awaits approval from claimants.Claims from consumers that baby powders and other J &amp; J talc-based products cause

For sexual-minority (SM) females, cardiovascular health (CVH) varies across race and ethnicity, according to a study published online May 1 in JAMA Network Open.Nicole Rosendale, M.D., from the University of California San Francisco, and colleagues used the American Heart Association Life's Essential 8 measure to examine differences in

Adherence to healthy lifestyles can largely overcome the genetic risk for a shorter lifespan, according to a study published online April 29 in BMJ Evidence Based Medicine.Zilong Bian, from the Zhejiang University&nbsp;School of Medicine in&nbsp;Hangzhou, China, and colleagues investigated associations of genetic and lifestyle factors

The U.S. Food and Drug Administration has approved Pivya (pivmecillinam) tablets for the treatment of female adults with uncomplicated urinary tract infections (UTIs).The approval is for UTIs caused by susceptible isolates of Escherichia coli, Proteus mirabilis, and Staphylococcus saprophyticus. The most common side

The U.S. Preventive Services Task Force (USPSTF) recommends breast cancer screening for women aged 40 to 75 years, but evidence is insufficient for older women and for supplemental screening for women with dense breasts. These recommendations form the basis of a final recommendation statement published online April 30 in the Journal of the Americ

Individuals seen for sexually transmitted infections (STIs) by clinicians in a private U.S. health care setting are less likely to receive recommended treatment than those seen in a public health clinic, according to a study published online in the May issue of Sexually Transmitted Diseases.Brian E. Dixon, Ph.D., from Indiana Universi

The risk for second primary cancer (SPC) after breast cancer (BC) varies with gender, age, and socioeconomic status, according to a study published online April 24 in The Lancet Regional Health: Europe.Isaac Allen, from the National Health Service England in London, and colleagues estimated standardized incidence ratios (SIRs) for com

Physicians are increasingly seeing cases of syphilis that do not present with typical symptoms, such as rash or skin ulcers, according to a new report presented last week at the 2024 Epidemic Intelligence Service Conference in Atlanta.Instead, patients are presenting with headaches or disruptions in their vision or hearing, said a team co-led b

Laboratory tests used by millions of Americans are soon to be classified as medical devices, and as such be regulated by the U.S. Food and Drug Administration, the agency announced Monday.The new rule does not apply to tests and kits made by big medical device manufacturers -- those already face FDA review. Instead, the agency is widenin

More intensive hypertensive therapy significantly reduces the excess risk for cardiovascular disease (CVD) events associated with earlier hypertension diagnosis in women, but not men, with type 2 diabetes, according to a study published online April 24 in Diabetes Care.Hongwei Ji, M.B.B.S., Ph.D., from Tsinghua University in Beijing, a

Global vaccination efforts have saved an estimated 154 million lives, including 101 million infants, a new study led by the World Health Organization (WHO) shows.Immunization has contributed more to the health and survival of newborns than any other medical advance, researchers concluded.The <a href="https://www.healthday.com/a-to-z-heal

In 2023, birth rates in the United States were down, according to an April Vital Statistics Rapid Release provisional report, a publication from the National Center for Health Statistics.Brady E. Hamilton, Ph.D., from the National Center for Health Statistics in Hyattsville, Maryland, and colleagues examined provisional 2023 data on U.

Administration of antenatal corticosteroids to persons at risk for late preterm delivery is not associated with adverse childhood neurodevelopmental outcomes at age 6 years or older, according to a study published online April 24 in the Journal of the American Medical Association.Cynthia Gyamfi-Bannerman, M.D., from the University of C

Hypertensive disorders of pregnancy (HDPs) are strong risk factors for pregnancy-associated mortality due to cardiovascular disease (CVD) at delivery through one year postpartum, according to a study published online in the March issue of Paediatric and Perinatal Epidemiology.Rachel Lee, from the Rutgers Robert Wood Johnson Medical S

The percentage of women experiencing impaired fecundity did not change between 2011 and 2019, according to a study published online April 24 in National Health Statistics Reports, a publication from the National Center for Health Statistics.Colleen N. Nugent, Ph.D., and Anjani Chandra, Ph.D., from the National Center for Health Stati

Active-duty servicewomen in the United States appear to have an increased occurrence of low-birth-weight babies compared with nonservice women, according to a review published online April 22 in BMJ Military Health.Kirsten A.L. Morris and Martin McKee, M.D., from the London School of Hygiene &amp; Tropical Medicine, conducted a syste

A semiautonomous breast cancer screening system reduces false positives with screening mammograms, according to a study published online April 10 in Radiology: Artificial Intelligence.Stefano Pedemonte, Ph.D., from Whiterabbit.ai in Santa Clara, California, and colleagues evaluated the ability of a semiautonomous artificial intellige

Prenatal opioid exposure seems not to be associated with a meaningful increase in the risk for neuropsychiatric disorders in offspring, according to a study published online April 24 in The BMJ.Jiseung Kang, Ph.D., from the University of Oxford in the United Kingdom, and colleagues conducted a nationwide birth cohort study to examine

Young-onset breast cancer (YOBC) with germline BRCA pathogenic variants (PVs) is associated with an increased risk for all-cause mortality if diagnosed within 10 years after childbirth, according to a study published online April 19 in JAMA Network Open.Zhenzhen Zhang, Ph.D., M.P.H., from the Oregon Health &amp; Science Uni

Middle-aged Black women with better heart health are less likely to show a decline in mental function, according to a study published online April 24 in the Journal of the American Heart Association.Imke Janssen, Ph.D., from the Rush University Medical Center in Chicago, and colleagues sought to determine the impact of cardiovascula

Anne Helms is one busy mom, constantly juggling the demands of working from home with parenting two young children.Despite that whirl of activity, Helms says she often feels isolated and lonely.“I work from home full time and I actually have a job where I’m on camera a lot and I’m Zoom calling people very often,” Helms, who lives in C

Only 4 percent of cancer survivors are fully adherent to current American Cancer Society (ACS) nutrition and physical activity guidelines, according to a study published online April 18 in JAMA Oncology.Carter Baughman, M.D., from Beth Israel Deaconess Medical Center in Boston, and colleagues conducted a cross-sectional study using da

Higher diet quality at diagnosis of breast cancer is associated with a lower risk for cardiovascular disease (CVD) events and death, especially the Dietary Approaches to Stop Hypertension diet quality index, according to a study published online April 17 in JNCI Cancer Spectrum.Isaac J. Ergas, Ph.D., M.P.H., from Kaiser Permanente Nor

Younger women are less likely to develop musculotendinous injury (MTI) relative to total injuries when compared with men, according to a study published online in the March issue of&nbsp;Medicine &amp; Science in Sports &amp; Exercise.Luis A. Rodriguez II, from the University of Texas at Dallas, and colleagues sought to characterize t

In a Society of Radiologists in Ultrasound expert consensus statement published online April 9 in Radiology, recommendations are presented for the diagnosis and management of endometriosis.Scott W. Young, M.D., from Mayo Clinic Arizona in Phoenix, and colleagues conducted a comprehensive literature review combined with a modified Delph

Measles infections continue to spread across the country, with 125 cases now reported in 18 states, new U.S. government data shows.That is more cases than were reported in all of 2022, the most recent annual peak for&nbsp;measles infections, the U.S. Centers of Disease Control and Prevention <a href="https://www.cdc.gov/measles/cases

Two common PFAS "forever chemicals" have been deemed hazardous substances by the Environmental Protection Agency.The new designation, enacted under the country's <a href="https://www.epa.gov/laws-regulations/summary-comprehensive-environmental-response-compensation-and-liability-act#:~:text=The%20Comprehensive%20Environmental%20Response%2C%20Co

Neighborhood disadvantage is associated with shorter breast cancer-specific survival, according to a study published online April 18 in JAMA Network Open.Neha Goel, M.D., M.P.H., from the University of Miami Miller School of Medicine, and colleagues examined whether neighborhood disadvantage is associated with shorter breast cancer-spe

FRIDAY, April 19, 2024 (HealthDay News) – More than half of premenopausal women report menstrual migraine (MM), according to a study presented at the annual meeting of the American Academy of Neurology, held from April 13 to 18 in Denver.Jessica Cirillo, from Pfizer in New York City, and colleagues estimated the prevalence of MM and identified characteristics of women with MM. The analy

All expecting mothers should get a blood test for syphilis three times during pregnancy, new guidance issued by the American College of Obstetricians and Gynecologists recommends.The practice advisory calls on doc

Nearly one-fifth of fresh, frozen, and canned fruits and vegetables that Americans eat contain concerning levels of pesticides, posing significant risks from produce such as strawberries, green beans, bell peppers, blueberries, and potatoes, according to a review published by Consumer Reports."One food in particular, green beans, had

For patients with early-stage triple-negative breast cancer (TNBC) who undergo surgery without chemotherapy, tumor-infiltrating lymphocyte (TIL) abundance is associated with improved survival, according to a study published online April 2 in the Journal of the American Medical Association.Roberto A. Leon-Ferre, M.D., from the Mayo Cl

Deep-seated racial and ethnic disparities persist in health care across the United States, even in states considered the most progressive, a new report shows.For example, California received a score of 45 for the care its health system provides Hispanic Americans. The Commonwealth Fund report gives each state a 0-to-100 score for each populat

Women who experience any of five major adverse pregnancy outcomes have increased mortality risks, which remain elevated during long-term follow-up, according to a study published online April 15 in JAMA Internal Medicine.Casey Crump, M.D., Ph.D., from the University of Texas Health Science Center in Houston, and colleagues examined

Patients with untreated and new-onset hypertension have an increased risk for newly reported fibroid diagnosis, according to a study published online April 16 in JAMA Network Open.Susanna D. Mitro, Ph.D., from Kaiser Permanente Northern California in Oakland, and colleagues examined associations of hypertension, antihypertensive treat

Young breast cancer (BC) survivors (40 years or younger) without a pathogenic variant (PV) have a low risk for developing second primary BC (SPBC), according to a study published online April 11 in JAMA Oncology.Kristen D. Brantley, Ph.D., M.P.H., from the Harvard T.H. Chan School of Public Health in Boston, and colleagues estimated t

Use of menopausal hormone therapy beyond age 65 years is associated with risk reductions in mortality as well as specific cancers and cardiovascular diseases, according to a study published online April 9 in Menopause.Seo H. Baik, Ph.D., from the U.S. National Institutes of Health in Bethesda, Maryland, and colleagues examined the eff

Working-age adults in the United States are dying at higher rates than their peers in high-income countries, according to a study published online March 21 in the&nbsp;International Journal of Epidemiology.Jennifer Beam Dowd, Ph.D., from the University of Oxford in the United Kingdom, and colleagues synthesized cause-specific mortalit

A text-embedding-ada-002 (ADA) machine learning model can identify posttraumatic stress disorder following childbirth (CB-PTSD) from maternal childbirth narratives, according to a study published online April 11 in Scientific Reports.Alon Bartal, Ph.D., from Bar-Ilan University in Ramat Gan, Israel, and colleagues examined the effecti

A transient increase in contraceptive use was seen following the Dobbs v Jackson Women's Health Organization decision, with a return to overall downward trends through the end of 2022, according to a research letter published online April 15 in JAMA Network Open.Julia Strasser, Dr.P.H., M.P.H., from the Milken Institute School

A significant proportion of young women with breast cancer experience diagnostic delay, most often related to patient factors, according to a study presented at the annual meeting of the American Society of Breast Surgeons, held from April 6 to 10 in Orlando, Florida.Katherine Fleshner, M.D., from the University of Calgary in Alberta, Canada, a

Prenatal cannabis use disorder (CUD) is associated with a higher risk for subsequent neurodevelopmental disorders in offspring, according to a study presented at the annual congress of the European Psychiatric Association, held from April 6 to 9 in Budapest, Hungary.Abay Woday Tadesse, from Curtin University in Perth, Australia, and colleagues

A single low dose of esketamine after childbirth reduces depressive episodes at 42 days postpartum among mothers with prenatal depression, according to a study published online April 10 in The BMJ.Shuo Wang, M.D., from Peking University First Hospital in Beijing, and colleagues conducted a randomized, double-blind trial with two parall

Mailed at-home self-sampling for&nbsp;human papillomavirus&nbsp;(HPV) testing&nbsp;increases cervical cancer screening participation in underscreened populations by almost threefold, according to a study presented at the annual meeting of the American Association for Cancer Research, held from April 5 to 10 in San Diego.Jane R. Montealegre, Ph.

Among women aged 50 to 74 years, specific adverse social determinants of health (SDOH) and health-related social needs (HRSNs) are associated with not having had a mammogram in the past two years, according to research published in the April 9 early-release issue of the U.S. Centers for Disease Control and Prevention Morbidity and Mortality Week

Mistreatment during childbirth is common in the United States, according to a study published online April 4 in JAMA Network Open.Chen Liu, from the Columbia University Mailman School of Public Health in New York City, and colleagues estimated the prevalence of mistreatment by health care professionals during childbirth in a represen

In sibling control analyses, acetaminophen use during pregnancy was not associated with children's risk for autism, attention-deficit/hyperactivity disorder (ADHD), or intellectual disability, according to a study published online in the April 9 issue of the Journal of the American Medical Association.Viktor H. Ahlqvist, Ph.D., from

Premastectomy radiotherapy (PreMRT) and regional node irradiation (RNI) followed by immediate breast reconstruction (IMBR) is feasible and safe, according to a study published online April 5 in&nbsp;JAMA Network Open.Mark V. Schaverien, M.D., from University of Texas MD Anderson Cancer Center in Houston, and colleagues assessed the

Labor induction with vaginal misoprostol achieves vaginal delivery rates comparable to induction with oral misoprostol, according to a study published in the February issue of Obstetrics &amp; Gynecology.Emily H. Adhikari, M.D., from the University of Texas Southwestern Medical Center in Dallas, and colleagues conducted a single-cen

The Environmental Protection Agency announced Wednesday that it has finalized a first-ever rule that will drastically lower the amount of PFAS, also known as "forever chemicals," in the nation's drinking water.“Drinking water contaminated with PFAS has plagued communities across this country for too long,”&nbsp;EPA Administrator <a href="htt

A significant proportion of artificial intelligence (AI) responses to primary care-related questions are "accurate with missing information," according to a study recently published online in the&nbsp;American Journal of Preventive Medicine.Joseph Kassab, M.D., from the Cleveland Clinic Foundation, and colleagues assessed the capacity

Social isolation is associated with altered brain processing of food cues in premenopausal women, according to a study published online April 4 in&nbsp;JAMA Network Open.Xiaobei Zhang, Ph.D., from the University of California, Los Angeles, and colleagues examined the association between perceived social isolation and brain reactivity t

Accelerated aging (AA) is increasing and is associated with an increased incidence of early-onset solid tumors, according to a study presented at the annual meeting of the American Association for Cancer Research, held from April 5 to 10 in San Diego.Ruiyi Tian, M.P.H., from the Washington University School of Medicine in St. Louis, and colleag