In a shifting landscape in dementia risk factors, cardiovascular health (or the health of your heart and blood vessels) is now taking precedence over other factors.

The increase in the disease burden results more from premature deaths than from the disability associated with the pathology, research suggested.

In newly diagnosed, drug-naive patients with T2D, initial TCT lowered A1c levels with a better safety profile over 2 years than conventional stepwise add-on therapy.

The double-bolus thrombolytic gave a higher rate of excellent functional outcomes in the RAISE trial.

The MUC-1 vaccine, when added to standard neoadjuvant systemic therapy, led to significant improvements in distant relapse-free survival & overall survival rates in BC patients.

Research shows elite athletes experience pain differently than everyday people. Here’s why, and how we can learn to deal with adversity and chronic pain every day.

Eliminating sick notes, adding AI aides, and other steps may cut down on the 18.5 million annual hours spent on "unnecessary" paperwork.

Academic pediatric practices have the highest Medicaid acceptance rate.

"What a waste of everybody's time." -- Sabin Dang, MD, of the Retina Institute in Missouri, on long waits for insurers to respond to prior authorization requests in ophthalmology. "I'm not going to tell patients to stop their...

TTHealthWatch is a weekly podcast from Texas Tech. In it, Elizabeth Tracey, director of electronic media for Johns Hopkins Medicine in Baltimore, and Rick Lange, MD, president of the Texas Tech University Health Sciences Center...

"Good morning, Dr. Holmes. It's so nice to meet you. Tell me, how will the medical school assure me that I can author 25 publications so I can secure a residency position in neurosurgery?" While the details are altered, this...

The genetic risk of developing Alzheimer's disease is more strongly influenced by the mother's side than the father's side, a recent study has discovered.

More than 1,700 pregnant women in South Australia have reportedly been given the wrong "due date" due to a technical error in their computerized medical records. This has prompted concerns some women may have had an early induction of labor as a result.

Intrauterine devices (IUDs) are a highly effective and long-lasting form of birth control placed in the uterus. Research shows that many people who get IUDs experience moderate to intense pain during the insertion. But it wasn't until recently that providers began to acknowledge this and do something about it.

With school out for the summer and temperatures rising across the country, many families will visit the beach, lake or local swimming pool. Now is the time to review safety tips to keep children safe around water.

You passed medical training, now see if you can pass our weekly quiz

Early last week, Donald Trump suggested that Joe Biden would be on performance-enhancing drugs for the presidential debate and demanded a drug test. The claim was widely laughed off as Trumpaganda, creating another fact-free...

Findings from a new mouse study suggest that elenolic acid, a natural compound found in olives, can lower blood sugar levels and promote weight loss. The research could pave the way to the development of safe and inexpensive natural products for managing obesity and type 2 diabetes in people.

People with higher intakes of calcium and zinc in the three months before they conceived were significantly less likely to suffer hypertensive disorders during their pregnancy compared with those who had lower intakes of these essential minerals, according to new research.

Surgeon General Vivek Murthy, MD, MBA, recently discussed the dangers of social media in a thought-provoking New York Times op-ed, and called for warning labels on social media platforms. His concerns about social media fostering...

In a survey of low-income adults across Arkansas, Kentucky, Louisiana, and Texas, one in eight respondents who were enrolled in Medicaid at some point since March 2020 reported no longer having Medicaid coverage by late 2023, with nearly half of that pool reporting being currently uninsured, according to a study by Harvard T.H. Chan School of Public Health.

Several people across the country have recently been hospitalized after consuming mushroom gummies distributed by Australian brand Uncle Frog and made in the United States. Their reported symptoms included elevated heart rate, nausea, anxiety and hallucinations.

A study performed in mice has uncovered a potential new tool to combat the escalating issue of childhood obesity. The research suggests that a simple dietary change, in the form of a fish oil supplement taken by fathers, might help address this pressing health concern.

An experimental monoclonal antibody has been engineered to target the deadly Nipah virus, an emerging zoonotic pathogen with a human mortality rate ranging as high as a staggering 90%.

A new pill that slowly releases ketamine could treat people with severe depression without giving them the psychedelic side effects of the often-misused drug, early trial results suggested on Monday.

A small number of surgical procedures, including orthopedic procedures and cesarean delivery, account for a large proportion of opioid prescriptions dispensed after surgery, according to a study published online June 26 in JAMA Network Open.

Large language model (LLM)-based classifiers can accurately detect guardian authorship of messages sent from an adolescent patient portal, according to a research letter published online June 25 in JAMA Network Open.

So-called cannabis clubs will be allowed to sell the drug legally in Germany starting Monday, but in practice it will be some time before the associations get up and running.

Almost 90 percent of medical centers report cancer drug shortages, which often impact clinical trials, according to the results of a National Comprehensive Cancer Network survey.Following data published one year ago and six months ago illustrating shortages of crucial cancer drugs, the National Comprehensive Cancer Network published new results

An individualized, progressive walking and education intervention is beneficial for prevention of recurrence of low back pain, according to a study published online June 19 in The Lancet.Natasha C. Pocovi, Ph.D., from Macquarie University in Sydney, and colleagues examined the clinical effectiveness and cost-effectiveness of an individu

A small number of surgical procedures, including orthopedic procedures and cesarean delivery, account for a large proportion of opioid prescriptions dispensed after surgery, according to a study published online June 26 in JAMA Network Open.Dominic Alessio-Bilowus, from Michigan Medicine in Ann Arbor, and colleagues examined the surgica

Large language model (LLM)-based classifiers can accurately detect guardian authorship of messages sent from an adolescent patient portal, according to a research letter published online June 25 in JAMA Network Open.April S. Liang, M.D., from the Stanford University School of Medicine in Palo Alto, California, and colleagues examined th

Legal and clinical experts around the country agreed that a recent Supreme Court ruling did not not materially change the status of abortions in Idaho or anywhere else in the nation. On Thursday, the high court ruled 6-3 to...

Lower cognitive function in adolescence is associated with increased risk of early-onset stroke, according to a study published online June 27 in the Journal of Epidemiology & Community Health.Aya Bardugo, M.D., from the Hebrew University in Jerusalem, and colleagues examined the association between adolescent cognitive function and

The median price of a newly launched drug in 2023 was $300,000 a year, up from $2,115 in 2008. A tangle of manufacturers, insurers, pharmacy benefit managers, wholesalers, and pharmacies wrestle over their share of the cost in...

Overuse of antibiotics early in life may increase the risk for bronchopulmonary dysplasia (BPD) or mortality in very premature infants, a national cohort study from China found. Among 6,510 such newborns considered to be at...

Patients with severe asthma initiating biologics exhibit clinical responses and super-responses, but 40 to 50% do not meet response criteria, according to a study published online June 22 in Allergy.

A more selective risk-stratified approach to postpartum enoxaparin (Lovenox) thromboprophylaxis for venous thromboembolism (VTE) was linked to reduced rates of wound hematomas without increasing the rate of VTE, according to...

A better way to repair torn rotator cuffs could be found by looking into a python's mouth, researchers said. While these animals are known for squeezing their prey to death, they also rely on peculiarly shaped teeth to keep...

Children born to parents who had obesity at age 17 had a much higher probability of having obesity at the same age, an Israeli cohort study suggested. Among nearly 450,000 offspring, 76.6% of 17-year-olds whose parents had obesity...

With a 5-4 vote in Harrington v. Purdue Pharma, the U.S. Supreme Court rejected oxycodone hydrochloride (OxyContin) maker Purdue Pharma's bankruptcy settlement, ending an agreement between victims and state and local governments...

The hepatocyte-targeted small interfering RNA lowers triglyceride and other lipoprotein levels, and even reduces liver fat, report trial investigators.

The CDC's Advisory Committee on Immunization Practices (ACIP) endorsed new COVID-19 and influenza vaccines for the 2024-2025 respiratory virus season on Thursday. In a unanimous 11-0 vote, the ACIP recommend that everyone 6...

Withanolides, a class of naturally occurring compounds found in plants, have long been a focus of cancer research due to their ability to inhibit cancer cell growth, induce cell death and prevent metastasis. These compounds are important in developing new cancer treatments. However, the difficulty of obtaining enough of these compounds from plants has hindered research and therapeutic development.

Promising results with an investigational CAR T-cell therapy in triple-negative breast cancer and non-small cell lung cancer (NSCLC) were tempered by an unexplained death in a phase I trial, Lyell Immunopharma reported. Merck...

The anti-obesity drug is associated with significant reductions in a key inflammatory marker linked to major cardiovascular events, according to SELECT clinical trial investigators.

Nearly 200 people have been charged in a sweeping nationwide crackdown on healthcare fraud schemes with false claims topping $2.7 billion, the Justice Department said on Thursday. Attorney General Merrick Garland announced the...

The following is a transcript of the podcast episode: Rachael Robertson: Hey everybody! Welcome to MedPod Today, the podcast series where MedPage Today reporters share deeper insight into the week's biggest healthcare stories...

Doctors are prescribing antibiotics to most kids and teens who have pink eye, despite guidelines that discourage their use, researchers reported. More than two-thirds of U.S. children and teens who saw a doctor for conjunctivitis...

Precision-guided treatment improves outcomes for children with high-risk cancer, according to a study published online June 6 in Nature Medicine.Loretta M.S. Lau, M.B.B.S., Ph.D., from the Children's Cancer Institute at the University of New South Wales Sydney, and colleagues reported data from 384 patients with high-risk pediatric canc

Metabolic surgery is associated with significantly lower risk of major adverse cardiovascular events (MACE) compared with nonsurgical management among patients with moderate-to-severe obstructive sleep apnea (OSA) and obesity, according to a study published online June 21 in the Journal of the American College of Cardiology.Ali Aminian,

For patients with early-stage cervical cancer, disease-free and overall survival are lower for patients undergoing minimally invasive versus open radical hysterectomy, according to a study published online June 25 in the Journal of Clinical Oncology.Pedro T. Ramirez, M.D., from the Methodist Hospital in Houston, and colleagues compared

Patients with severe asthma initiating biologics exhibit clinical responses and super-responses, but 40 to 50 percent do not meet response criteria, according to a study published online June 22 in Allergy.Eve Denton, M.B.B.S., from Alfred Health in Melbourne, Australia, and colleagues examined responsiveness to biologics in a real-worl

In a clinical practice guideline issued by the American Society for Radiation Oncology and published online June 18 in Practical Radiation Oncology, recommendations are presented for the use of radiation therapy (RT) for management of human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC).Danielle N. Margali

Chronic loneliness is associated with increased risk of stroke after adjustment for depressive symptoms and social isolation, according to a study published online June 24 in eClinicalMedicine.Yenee Soh, Sc.D., from the Harvard T.H. Chan School of Public Health in Boston, and colleagues conducted a prospective cohort study using data fr

Rheumatoid arthritis (RA) patients with mono- or oligo-arthritis and high Patient Global Assessment (PGA) at diagnosis remain the most fatigued, according to a study published in the June issue of Rheumatology.Anna M.P. Boeren, from the Leiden University Medical Center in the Netherlands, and colleagues studied Disease Activity Sco

The revised criteria, which define Alzheimer's as a biologic process and identify diagnostic biomarkers, offer a foundation for formal clinical guidelines expected in 2025.

The U.S. Supreme Court on Thursday struck down a controversial settlement that drug maker Purdue Pharma had reached with victims of the opioid epidemic.The ruling threatens a massive bankruptcy plan that would have protected the Sackler family, which controls the compan

Rheumatoid arthritis (RA) patients with mono- or oligo-arthritis and high Patient Global Assessment (PGA) at diagnosis remain the most fatigued, according to a study published in the June issue of Rheumatology.

The investigational tyrosine kinase inhibitor (TKI) BAY 2927088 induced responses in previously treated HER2-mutant non-small cell lung cancer (NSCLC) and had a favorable safety profile, according to phase I data presented at...

Most people, when they think about pythons, visualize the huge snake constricting and swallowing victims whole. But did you know that pythons initially hold onto their prey with their sharp, backward-curving teeth?

Researchers at Baylor College of Medicine, the University of Cambridge in the U.K. and collaborating institutions have shown that serotonin 2C receptor in the brain regulates memory in people and animal models. The findings, published in the journal Science Advances, not only provide new insights into the factors involved in healthy memory but also in conditions associated with memory loss, like A

Note that some links may require registration or subscription. Sen. Dick Durban (D-Ill.) underwent hip replacement surgery and is recovering in his home state. (AP) In other D.C. news, the House Ways and Means Committee passed...

Moderna's mRNA vaccine mRESVIA has been recommended for a marketing authorization in the EU to protect against respiratory syncytial virus in older adults.

Many studies have shown the health benefits of running, for both physical and psychological well-being. The researchers hope that, by identifying the features that are attractive to runners, they can help policymakers create environments that will promote an active and healthy lifestyle. Trail running has the added benefit of being immersed in nature, which is known to offer health benefits.

Iowa's highest court on Friday upheld the US state's six-week abortion ban, two years after the federal right to the procedure was overturned and with the topic a key issue in the US presidential election.

Osteoarthritis (OA) represents the most prevalent form of chronic degenerative joint disease worldwide. The dynamic interplay between cartilage and subchondral bone is essential for preserving joint structural and functional integrity. In addition to cartilage degeneration, pathological alterations within the subchondral bone significantly contribute to OA progression. Therefore, there is an urgen

The positive opinions pave the way for new treatment options in Europe for urothelial carcinoma, prostate cancer, lymphoma, and leukemia.

Healthcare issues played a big role in Thursday night's first presidential debate, which spanned topics from handling of the COVID pandemic to abortion to the candidates' physical fitness. The mention of healthcare issues began...

Osteoporosis is so difficult to detect in early stage it's called the "silent disease." What if artificial intelligence could help predict a patient's chances of having the bone-loss disease before ever stepping into a doctor's office?

Although you may not always realize it, many of the jobs you do can put strain on, and even cause damage to, your nerves.

A group has proposed a new concept of mechanobiomaterials, which is inspired by the natural phenomenon that biomechanics mediate tissue repair and regeneration. The rationale behind this new concept is to program the biological functionalities of biomaterials by leveraging mechanics—geometry—biological function relationships.

As a summer wave of COVID infections rolls across the country, U.S. health officials have recommended that all Americans over the age of 6 months get one of the updated COVID vaccines when they become available this fall.The recommendation was issued Thurs

The spread of H5N1 avian flu to dairy cows has health experts and many Americans on edge, and now a new study finds the virus stays viable on milking equipment for at least an hour.“Dairy cows have to be milked even if they are sick, and it has not been clear for how long the virus contained in residual milk from the milking process remains stab

A study from Michigan Medicine's Kresge Hearing Research Institute was able to produce supranormal hearing in mice, while also supporting a hypothesis on the cause of hidden hearing loss in humans.

In countries with an aging population, neurodegenerative disorders such as Parkinson's disease (PD) and dementia with Lewy bodies (DLB) are becoming more prevalent. These conditions, for which no definitive cure currently exists, are extremely difficult to diagnose accurately while the affected person is still alive. This has proved to be a major roadblock for researchers seeking to assess potenti

Bone marrow adipocytes (BMAds) are situated within the bone microenvironment, in close proximity to bone cells, vascular structures, and hematopoietic tissues. The shift of bone marrow stromal/stem cells (BMSCs) lineage towards committed adipogenic progenitors at the expense of osteoprogenitors is driven by abnormal signaling within the bone microenvironment due to pathophysiological conditions.

When a cancer cell doesn't respond to traditional therapies, doctors may turn to a sort of viral biological warfare, by deploying "troops" in the form of viral agents that are specifically engineered to target and eliminate cancer cells. The mode of attack is to transform the tumor into an immunologically "hot" environment, making it more visible and recognizable to our immune system.

Drugs for ALS, age-related macular degeneration, and Duchenne muscular dystrophy did not get the green light due to lack of evidence.

Tampere University researchers developed a method to map mechanistic connections between diseases, revealing deeper associations beyond traditional classifications based on affected organs and symptoms. This multi-dimensional approach presents a paradigm shift in disease classification and drug discovery, potentially leading to more personalized and effective medical treatments.

Results from a national survey, appearing in JAMA Network Open, indicate that many Americans, 61%, are unaware that primary care physicians can prescribe medications for opioid use disorder, and 13% incorrectly believed that they could not.

Loosening local, state and federal regulations on cannabis and psychedelics has increased Americans' interest in microdosing, according to a study from researchers at the University of California San Diego.

Winrevair improves exercise capacity in patients with the condition while taking background therapy.

As a summer wave of COVID infections rolls across the country, U.S. health officials have recommended that all Americans over the age of 6 months get one of the updated COVID vaccines when they become available this fall.

A nasal spray could help overcome obstacles to using autoinjectors for rapid treatment of anaphylaxis, the European Medicines Agency said.

A new model developed by researchers could help inform guidelines and improve evidence-based advice on the risks and benefits of fish consumption, especially during pregnancy.

The intervention was feasible and showed promise for improving psychological well-being among allogeneic hematopoietic stem cell transplant survivors.

A study found no significant pain reduction benefit from adding intranasal ketamine to fentanyl for out-of-hospital acute trauma care.

A pilot study shows promise for a new treatment option for individuals with memory impairments caused by multiple sclerosis (MS). The article, "Exploring the efficacy of a remote strategy-based intervention for people with multiple sclerosis with everyday memory impairments: A pilot study," was published online on May 27, 2024, in the American Journal of Occupational Therapy.

Remarkable new research by a University of Virginia undergraduate may help explain recurrent Crohn's disease in children and open the door to new ways to treat or even cure the devastating condition. The work is published in the journal Scientific Reports.

An interdisciplinary study led by researchers at the University of South Florida and Indiana University has uncovered significant findings on the long-term effects of one of the most common forms of chemotherapy on cancer survivors.

The Korea Research Institute of Standards and Science (KRISS) has developed the world's first reference material to improve the accuracy of body fat measurements conducted through MRI and CT scans. The study is published in the journal Metrologia.

The U.S. Food and Drug Administration has sent a warning letter to one of America's biggest bakeries, asking the company to stop claiming there are allergens such as sesame or nuts in products when in fact they are not there.

My early TV viewing preferences were perhaps a clue that I'd make a career researching psychological trauma. I spent my youth watching the American war comedy drama M*A*S*H*, which followed a team of doctors and support staff stationed at the 4077th Mobile Army Surgical Hospital in Uijeongbu, South Korea, during the Korean war. In my 20s, I became a fan of the Chicago-based emergency room drama ER

New analysis has revealed many Australian aged care residents are not receiving the levels of care they need and are entitled to.

The popularity of processed foods and plant-based dairy alternatives are contributing to an increased risk for iodine deficiency across much of Europe, experts said.

A whistleblower alleged that three cardiothoracic surgeons delegated key aspects of surgery to "unqualified medical residents."

New research, by the Department of Psychology at Durham University, has found that negative social contact among people of differing societal or cultural groups can have a disproportionate negative effect on broad social cohesion within communities.

A heart attack is a life-threatening condition, with patients remaining at risk of premature death long after the actual attack—50% to 60% of patients die subsequently as a result of sudden cardiac death, triggered by cardiac arrhythmia.

The Surgeon General's call for a warning label on social media use in children has some applauding it and others questioning whether it would have any real benefit.

Older GPs are more likely to prescribe antibiotics than their younger colleagues. A more cautious approach will not degrade treatment—and it can help fight antibiotic resistance that could soon kill millions of people annually. The discovery was made in a new study from the Department of Economics at the University of Copenhagen.

Pathological analysis has been the gold standard of disease detection, especially in tumor diagnosis. Traditional digital pathology relies on high-precision movement of a high numerical aperture (NA) objective to obtain the entire field of view (FOV) for a tissue slide, whose high cost severely hinders its widespread applications.

A loss of salt and body fluid can stimulate kidney regeneration and repair in mice, according to a new study led by USC Stem Cell scientist Janos Peti-Peterdi and published in the Journal of Clinical Investigation.

A Mass General team has developed modified criteria that may help health care professionals more accurately identify anaphylaxis, a potentially life-threatening allergic reaction, in infants and young children.

Heat blanketed Chicago during the summer of 2022, with hot, sticky days followed by sweltering nights.

A study led by Western nursing professor Kimberley Jackson shows the power of arts-based research to relay scientific findings and raise awareness about a pervasive public health concern: intimate partner violence (IPV) and, specifically, IPV in pregnancy.

Bringing a puppy home is usually a happy event, but sometimes the life change that comes with it can provoke significant negative emotions. In a study now published in npj Mental Health Research, researchers found that almost half of dog owners experience anxiety, weariness or frustration during their dog's puppyhood stage.

A large team of neuroscientists, biochemists and Alzheimer's specialists affiliated with institutions in the U.S. and Iceland has created a protein map to look for patterns in cerebrospinal fluid that may serve as markers for the onset of Alzheimer's disease decades before diagnosis.

AZD0780 — the first oral PCSK9 inhibitor — is lowering LDL cholesterol levels, report phase 1 trial investigators, but specialists are questioning the early findings.

A team of biomedical researchers from the U.S. and the U.K. has identified two groups of neurons that take part in the process of feeling full—one before eating and one after. In their study, published in the journal Science, the group conducted experiments with mice to learn more about factors in the brain that lead to feelings of fullness after eating.

An exponential rise in the prevalence of diabetic retinopathy points to the need for more vigilance in vision screenings for people with diabetes, experts said.

While plenty of happy couples can trace their meet-cute moment to an online dating app, many others find the never-ending process of likes, swipes, taps and awkward DMs that go nowhere to be exhausting—leading to a phenomenon known as "dating app burnout."

Wonder what medical support staff is getting paid across the country? A new report dives into what medical leaders pay their support positions.

Johns Hopkins research sheds new light on how mammals track their position and orientation while moving, revealing that visual motion cues alone allow the brain to adjust and recalibrate its internal map even in the absence of stable visual landmarks.

Smokers seeking to conquer their addiction may have a new treatment option following the results from a clinical trial led by Monash University, which found a combination of varenicline and nicotine lozenges significantly improved smoking abstinence when compared with varenicline alone. The work is published in the journal JAMA Network Open.

Work by the team of Dr. Frédéric Charron recently published in The Journal of Neuroscience, identifies the fundamental role of a family of proteins, the β-arrestins, in the development of the nervous system at the embryonic stage.

A Finnish study, appearing in the journal Psychopathology, shows that people are commonly given misleading information about depression. According to the researchers, inaccurate information makes it harder for people to understand the causes of their distress.

Researchers from Children's Hospital of Philadelphia (CHOP) revealed the mechanisms behind one particular molecule's involvement in regulating insulin sensitivity. The findings, which were translated from a preclinical animal model into a human study, may serve as the basis for a potential therapeutic target for obesity-related type 2 diabetes.

Researchers from the Icahn School of Medicine at Mount Sinai have shed valuable light on the nuanced functions and intricate regulatory methods of RNA editing, a critical mechanism underlying brain development and disease.

A study found gaps in the high-risk period after discharge from a hospital stay for mental health issues.

Black individuals showed an increased incidence of dermatofibrosarcoma protuberans.

A study showed that each extra hour spent waiting in the ER significantly increased the chances of delirium or agitation, particularly among seniors and those with dementia.

Abigail Arellano keeps her son Samuel's medical bills in a blue folder in a cabinet above the microwave. Even now, four months after the 11-year-old was shot at the Kansas City Chiefs Super Bowl parade, the bills keep coming.

The Alzheimer's Association has published revised criteria for the diagnosis and staging of Alzheimer's disease that are based on the biology of the disease and reflect recent advancements in research, diagnostics and treatment.

Study finds inverse relationships between age-related macular edema and diabetic retinopathy severity, as well as glycemia and lipid levels.

While chemotherapy can stimulate antitumor immunity, it may also impair immune cell function and induce lymphodepletion, reducing the effectiveness of subsequent immunotherapy. Thus, nanoparticle-based drug delivery systems have been developed for their improved drug biodistribution and reduced toxicity, striking a delicate balance between efficacy and safety.

Investigators in the CATALYST trial said the findings suggest a potential paradigm shift in managing patients with uncontrolled diabetes.

Results of the longitudinal study, "Prognostic value of tissue bridges in cervical spinal cord injury," have the potential to change clinical practice. They have been published in The Lancet Neurology.

Physician scientists from City of Hope, one of the largest cancer research and treatment organizations in the United States, found that people with metastatic kidney cancer who orally took a live biotherapeutic product called CBM588 while in treatment with immunotherapy and enzymatic tyrosine kinase inhibitors experienced improved health outcomes.

In a policy statement issued by the American Academy of Pediatrics and published online June 27 in Pediatrics, recommendations are presented for optimizing advanced imaging use for pediatric patients in the emergency department.

Florida is one of 39 states that is seeing an increase or likely seeing an increase in COVID infections, according to the U.S. Centers for Disease Control and Prevention.

Alzheimer's disease is a progressive disorder that causes brain cells to waste away and die. Alzheimer's disease is the most common cause of dementia, which is a term used to describe a group of symptoms that affect memory, thinking and social abilities severely enough to interfere with daily function.

When Michael Pirovolakis received an individualized gene therapy in a single-patient clinical trial at The Hospital for Sick Children (SickKids) in March 2022, the course of his condition was dramatically altered.

Researchers at Weill Cornell Medicine with an international team have used liver biopsies to identify cellular and molecular markers that can potentially be used to predict whether and when pancreatic cancer will spread to an individual's liver or elsewhere, such as the lung.

Artificial intelligence models often play a role in medical diagnoses, especially when it comes to analyzing images such as X-rays. However, studies have found that these models don't always perform well across all demographic groups, usually faring worse in women and people of color.

Second-generation basal insulins improved the glycemic parameters in patients with type 2 diabetes when added to or used as a substitute for GLP-1 therapy.

The US Supreme Court on Thursday rejected Purdue Pharma's $6 billion opioids settlement immunizing the Sackler family, which controlled the drugmaker, from future litigation.

Here's a look at the state of COVID-19 in the U.S. as the Centers for Disease Control and Prevention establishes its latest advice on vaccinations.

With fresh COVID-19 cases bubbling up in some parts of the country, health officials are setting course for a fall vaccination campaign.

Doctors are prescribing antibiotics to most kids and teens who have pink eye, despite guidelines that discourage their use, researchers reported Thursday.

Japanese health supplement maker Kobayashi Pharmaceutical said Friday it was probing 76 more deaths possibly linked to its tablets containing red yeast rice, meant to lower cholesterol.

Japanese health supplement maker Kobayashi Pharmaceutical said Friday it was probing 76 more deaths possibly linked to its tablets containing red yeast rice, or "beni koji", meant to lower cholesterol.

Several medical associations issued advanced imaging recommendations to improve pediatric emergency department care and reduce risks, such as radiation exposure and false-positives results.

Despite being highly processed, plant-based meat alternatives have a better cardioprotective profile than animal meat does, a new review suggested.

Marstacimab shows long-term safety and efficacy in preventing bleeding events in patients with hemophilia A and B without inhibitors, potentially expanding treatment options.

A new study brings fresh revelations about the connection between early-life exposure to air pollution and lung health later in life. A research team led by the Keck School of Medicine of USC has shown that exposure to air pollution during childhood is directly associated with bronchitis symptoms as an adult.

Tantrums are part of growing up. How these outbursts of anger or frustration are managed, however, can impact children's emotional development.

Only about a quarter of adults who needed treatment for opioid use disorder (OUD) received recommended medications, survey data showed. In 2022, the National Survey on Drug Use and Health (NSDUH) found that 3.7% of U.S. adults...

The FDA on Thursday granted marketing authorization to the first point-of-care test for hepatitis C virus (HCV), enabling at-risk adults to be rapidly diagnosed and immediately linked to care if needed. The test -- the Xpert...

Only one-quarter of adults who needed opioid use disorder (OUD) treatment in 2022 received medications for OUD, according to research published in the June 27 issue of the U.S. Centers for Disease Control and Prevention Morbidity and Mortality Weekly Report.Deborah Dowell, M.D., from the CDC in Atlanta, and colleagues characterized U.

The overall burden of cardiovascular disease (CVD) remained high during 2000 to 2019 in the United Kingdom, according to a study published online June 26 in The BMJ.Nathalie Conrad, Ph.D., from the University of Glasgow in the United Kingdom, and colleagues conducted a population-based study in the United Kingdom to examine the incide

In a policy statement issued by the American Academy of Pediatrics and published online June 27 in Pediatrics, recommendations are presented for optimizing advanced imaging use for pediatric patients in the emergency department.Jennifer R. Marin, M.D., from the University of Pittsburgh School of Medicine, and colleagues provide guidel

Patients who received protocol waivers in a clinical trial of targeted anticancer therapy had outcomes similar to those who met all enrollment criteria, a large retrospective review showed. Patients who received waivers had...

Undiagnosed heart valve disease was highly prevalent in a large community study of otherwise healthy people recruited from primary care in the U.K., researchers found. There was a 28.2% prevalence of mild, moderate, or severe...

Welcome to MedAI Roundup, highlighting the latest news and research in healthcare-related artificial intelligence each month. ChatGPT-4 answered 85% of complicated medical oncology exam questions correctly in a cross-sectional...

Value-based care -- in which medical practices are paid based on the value of their care, not on volume -- is a good idea but the Centers for Medicare & Medicaid Services (CMS) need to improve its implementation, doctors...

Young women who survived cervical cancer and leukemia were less likely to give birth and, when they did, sustained greater risk of serious obstetric complications, according to results from a retrospective cohort study. Among...

Children conceived by using egg or sperm donors have the same well-being outcomes as non-donor-conceived people. However, they are more likely to have identity difficulties and issues with trust, says a new study.

The following contains links to social media websites including X, TikTok, Instagram, Facebook, and LinkedIn. Jenn Tran, the upcoming lead on "The Bachelorette," addressed a common question from her followers: is she dropping...

Several indicative factors, including junior rank, male sex, and younger age, are strongly linked to 'harmful gambling' among serving UK military personnel, finds an analysis of survey responses, published online in the journal BMJ Military Health.

A lower level of mental ability during the teenage years may be linked to as much as a tripling in the risk of having a stroke before the age of 50, finds research published online in the Journal of Epidemiology and Community Health.

The loss of social memories caused by sleep deprivation could potentially be reversed using currently available drugs, according to a study in mice presented at the Federation of European Neuroscience Societies (FENS) Forum 2024.

In this exclusive video, Claire Panosian Dunavan, MD, professor of medicine emeritus at the University of California Los Angeles, interviews Steffanie Strathdee, PhD, co-author of The Perfect Predator: A Scientist's Race to Save...

The FDA has sent a warning letter to an Indiana eye bank for accepting tissue from five donors who all had a documented diagnosis or clinical evidence of sepsis, which should have rendered them ineligible, the agency said. FDA...

More than one in 10 households in the United States last year did not have access to adequate and nutritious food, according to the U.S. government. Further, food and nutrition insecurity lead to a higher risk of poor pregnancy outcomes.

Welcome to "The Hypocritical Oath," my MedPage Today series where I explore professional, educational, and ethical failures in medicine, from shortcomings in medical culture to abuses of power and patient harm. I try to give...

Idaho hospitals must continue to provide emergency abortions if the mother's life is in danger, the Supreme Court ruled on Thursday. The court decided that it got involved too early in a case on whether the state's law banning...

A new study in the Journal of Neuroscience has discovered underlying sex differences in the molecular pathways that drive reward-related behaviors. In particular, the study found differences and similarities in the ways males and females strengthened connections between two brain regions—the hippocampus and the nucleus accumbens—involved in reward signaling.

As patients with lung cancer live longer, the risk of long-term cardiac side effects of radiation therapy has been increasing, despite advances that reduce the radiation dose to the heart. New research uses machine learning to mine data from standard lung-cancer scans and predict patients most likely to have heart damage from radiation treatment later in life. If confirmed by future tests, this ap

Prenatal use of alcohol, tobacco and cannabis has all been independently associated with adverse health impacts on the baby. But many people who use these substances during pregnancy aren't using them in isolation.

New research challenges the notion that good looks are the key to happiness. It turns out that an attractive appearance leads to more risky behavior among young people. The more attractive a teenager is, the greater the likelihood that they will party and drink more alcohol than others. According to Professor Colin Peter Green at the Department of Economics at the Norwegian University of Science a

Potassium channels are openings that allow charged potassium atoms to cross the cell membrane. Voltage-gated potassium channels—which open only when a specific voltage is reached across the cell membrane—are essential for the electrical impulses that nerve cells or neurons use to communicate. Dysfunction of these channels is implicated in diseases like epilepsy, autism and schizophrenia.

Our health, well-being and behavior are shaped by our childhood experiences.

Suicide is a leading cause of death during pregnancy and in the months after delivery in the United States, but many of these deaths may be preventable, say University of Michigan researchers.

A year of treatment with a medicine made of an antibody and chemotherapy drug has proven highly effective in preventing stage 1 HER2-positive breast cancer from recurring in patients, a team led by Dana-Farber Cancer Institute researchers has found.

The protein Foxp3 is vital to the function of immune cells called regulatory T cells, which control immune system activation. Despite its importance, how Foxp3 regulates the immune system using environmental cues has remained unclear.

Just 25% of people battling opioid use disorder are getting medications aimed at helping them quit and potentially avoid an overdose, new data shows.

A session at the recent American Thoracic Society (ATS) annual meeting focused on the effect that the environment has on lung health. It included a presentation from Gregory P. Downey, MD, executive vice president of academic...

A California radiologist accused of trying to kill his family by driving off a cliff along the Northern California coast will receive mental health treatment instead of standing trial, a judge ruled. Prosecutors charged Dharmesh...

Oklahoma doctor Amy Darter, MD, was accused of stealing an ambulance from a hospital. Darter's medical license had been suspended 5 months earlier, after an investigation of patient complaints against her. (News 9) A Florida...

A few years ago, plastic surgeon Edmond Cabbabe, MD, was preparing for a follow-up cosmetic procedure on his wife. Mercy Hospital South, a major hospital in St. Louis, Missouri, had put her on the operating room schedule, just...

Bisphenol A (BPA) administration is associated with reduced peripheral insulin sensitivity among healthy adults, according to a study presented at the annual meeting of the American Diabetes Association, held from June 21 to 24 in Orlando, Florida.Adam Seal, Ph.D., from the California Polytechnic State University in San Luis Obispo, and collea

Immunoglobulin replacement therapy (IgRT) is associated with reductions in hypogammaglobulinemia, infections, severe infections, and associated antimicrobial use among real-world patients with chronic lymphocytic leukemia (CLL) or non-Hodgkin lymphoma (NHL), according to a study published online June 21 in Blood Advances.Jacob D. Soum

For adults with obesity, without diabetes, combining exercise with the glucagon-like peptide-1 receptor agonist (GLP-1 RA), liraglutide, is effective for weight loss, while preserving bone health, according to a study published online June 25 in JAMA Network Open.Simon Birk Kjær Jensen, Ph.D., from the University of Copenhagen in Denm

Inhaled insulin is associated with improved hemoglobin A1c (HbA1c) levels over 16 weeks among adults with type 1 diabetes when compared to usual care, according to a study presented at the annual meeting of the American Diabetes Association, held from June 21 to 24 in Orlando, Florida.Irl B. Hirsch, M.D., from the University of Washington in S

An investigational targeted immunotherapy for Guillain-Barré syndrome more than doubled improvement in disability after 8 weeks and showed sustained benefit at 26 weeks.

For children with eosinophilic esophagitis, dupilumab results in a significantly higher percentage of histologic remission, according to a study published in the June 27 issue of the New England Journal of Medicine.Mirna Chehade, M.D., M.P.H., from Icahn School of Medicine at Mount Sinai in New York City, and colleagues randomly assig

PIK3CA mutational status may be beneficial for predicting response to addition of the cyclooxygenase 2 (COX-2) inhibitor celecoxib to standard adjuvant chemotherapy in stage III resected colon cancer, according to a study published online June 18 in the Journal of Clinical Oncology.Jonathan A. Nowak, M.D., Ph.D., from Brigham

In this video, Mikhail Varshavski, DO, who goes by "Dr. Mike" on social media, reviews research on the common practice of burning candles. Following is a partial transcript of the video (note that errors are possible): Varshavski...

Rare predicted loss-of-function (pLOF) variants and a polygenic risk score (PRS) are associated with increased atrial fibrillation (AF) risk, according to a study published online June 26 in JAMA Cardiology.Oliver B. Vad, M.D., from Copenhagen University Hospital–Rigshospitalet in Denmark, and colleagues examined rare pLOF variants as

The Supreme Court on Thursday rejected a nationwide settlement with oxycodone hydrochloride (OxyContin) maker Purdue Pharma that would have shielded members of the Sackler family who own the company from civil lawsuits over the...

For patients with rheumatoid arthritis (RA), a detectable level of high-sensitivity cardiac troponin T (hs-cTnT) is associated with increased risk of major adverse cardiovascular events (MACE) and all-cause mortality, according to a research letter published online June 15 in the Journal of Rheumatology.Brittany N. Weber, M.D., Ph.D.,

Patients with retinal diseases often waited days or even weeks for insurers to respond to prior authorization requests to approve anti-vascular endothelial growth factor (VEGF) intravitreal injections, though most requests were...

A subgroup analysis of the CARTITUDE-4 study, which was recently presented at the American Society of Clinical Oncology (ASCO) annual meeting, showed that ciltacabtagene autoleucel (cilta-cel; Carvykti) improved outcomes compared...

Summer is in full swing, and some parts of the U.S. have already experienced record-high temperatures. Exposure to extreme heat—the leading cause of weather-related deaths—can lead to heat exhaustion, heat stroke and added strain on the heart and kidneys, exacerbating underlying conditions such as cardiovascular disease and respiratory illnesses.

The US Supreme Court on Thursday cleared the way for women experiencing medical emergencies to obtain abortions in Idaho, but the ruling's narrow scope meant it was a muted victory for reproductive rights activists.

Drug development is typically slow: the pipeline from basic research discoveries that provide the basis for a new drug to clinical trials to production of a widely available medicine can take decades. But decades can feel impossibly far off to someone who currently has a fatal disease.

The hypothalamus is a small region of the human brain typically associated with regulating body temperature, hunger, thirst, fatigue, and sleep. But it also has another important role: helping the brain and body switch between different and opposing survival behaviors such as hunting prey and escaping predators.

What happens when the measles virus meets a human cell? The viral machinery unfolds in just the right way to reveal key pieces that let it fuse itself into the host cell membrane.

Opioid-related drug overdoses cause 130 deaths per day in the U.S. Access to treatment and prevention programs are key to addressing the opioid crisis, as is access to overdose reversal drugs like naloxone, which has emerged as one of the most effective tools for saving the lives of people struggling with opioid addiction.

A common algorithm to check for endometrial cancer is not reliable for Black women, according to a new study published today in JAMA Oncology.

Researchers at the Optics and Photonics Research Center (CePOF) in Brazil and collaborators at the University of Toronto and Princess Margaret Cancer Center in Canada have reported for the first time the effective use of a specific type of phototherapy to eradicate ocular melanoma in mice. Based on a pulsed laser, the technique involves the application of a large amount of light in a short period

New revelations, published in Nicotine and Tobacco Research, reveal the recent activities of Philip Morris International (PMI) and its Japanese affiliate, Philip Morris Japan (PMJ).

The FDA approved inhaled ensifentrine (Ohtuvayre) as maintenance treatment for chronic obstructive pulmonary disease (COPD) in adults, drugmaker Verona Pharma announced on Wednesday. A first-in-class dual phosphodiesterase 3...

Note that some links may require registration or subscription. Supreme Court justices ruled that the Biden administration did not violate the First Amendment by asking social media companies to take down COVID-19 misinformation...

A UT Southwestern Medical Center study of hundreds of underserved women has shown that depression and anxiety, in addition to physical factors such as a higher body mass index and previous births, are associated with lingering postpartum urinary incontinence. The findings, published in Urogynecology, shine a spotlight on these conditions that can carry stigmas but are largely treatable, researcher

People living in lower-income neighborhoods and in areas without local food stores eat more snacks and sweets than those in higher-income areas and in neighborhoods with many food stores, a new study shows. The findings are published in The Journal of Nutrition.